ELLEN KOVNER SILBERGELD, Ph.D.

I.

Qualifications
Dr. Silbergeld is an environmental scientist and toxicologist who

is the Chief Toxicologist for the Environmental Defense Fund and a Research
Scientist in the Reproductive Toxicology Laboratory of the National Institutes
of Health in Bethesda, Maryland.
II.

Her curriculum vitae is attached.

Subject Matter
Dr. Silbergeld will testify in the following areas:
A. Receptors/TCDD, including:
1. the receptor model and its role in physiology;
2. the detection of receptors and the mode of how
receptors are linked to function;
3. the mode by which receptors recognize TCDD, that
is, e.g. structural "fine-tuning";
4. the existence of receptors in humans, and in their
various organs, with the implications of their
presence for TCDD potency;
5. its occupancy by the TCDD ligand and its relation­
ship to the biological effects of TCDD at the
subcellular level, specifically;
a. DNA-RNA directed proteinsynthesis;
b. enzyme induction;
c. pleiotrophic changes in the cell.
B. Animal toxicology, and more specifically the extrapolations
between animal data, and its predictive qualities in humans,
including:
1. biological bases for interspecies comparision;
2. mathematical models for such extrapolation;
3. physiological chemistry among mammalian systems
(including humans);
4. relevant studies on derived cell lines from humans.
C. Reproductive toxicology, and more specifically the effects of
TCDD and 2,4,5-T on reproductive physiology in the male and
female, including:
1. Gonadotoxicity;
2. Endocrine toxicity;
3. Alteration in hormonal metabolism;

4. Teratology;
5. Feto-toxicity;
6. Significance and persistence of such effects
in animals and humans;
7. Sensitivity of the reproductive system, both
endocrine and gonadal, to the receptor-mediated
effects of TCDD.
D. Neurotoxicology, and more specifically the various effects of
2,4-D, TCDD and 2,4,5-T on peripheral and central nerous system
functions, including:
1. Neuromuscular control;
2. Nerve conductive dynamics;
3. CNS function (including cognitive, motor, and
affective aspects);
4. Experimental and clinical studies with particular
emphasis on:
a. dose-response mechanisms;
b. acute versus chronic exposure;
c. early versus long latency effects.
5. Methods for assessing nervous system functions in animal
and humans, including:
a. neurochemistry;
b. electrophysiology;
c. neurobehavioral techniques.
6. Interrelationships between effects on other organ systems
and the nervous system, particularly with respect to altered
porphyrin metabolism, including:
a. the effects of decreased cellular energy
b. the effects of decreased heine-synthesis on
the integrity of myelin;
c. the neuroactive properties of certain
porphyrin precursors.
III.

Scientific Principles
See General Statement of Scientific Principles and Assumed Facts

attached.

IV.

Substance

of Opinions

A. That animal data has and can be used, particularly with
respect to 2,4-D, 2,4,5-T, and TCDD to demonstrate their
potential and real toxicity, neuro-toxicity, reproductive
toxicity, and carcinogenicity in humans.
B. That TCDD receptors exist in human cells, and in their various
organs, which are similar, if not identical, to the TCDD
receptor described in rodents; that this fundamental cellular
mechanism explains scientifically many of the toxic (including
carcinogenic) effects of TCDD, and moreover provides a scientific
basis for predicting similar toxic effects in humans as in
experimental animals; that this receptor explains the very great,
indeed exceptionalpotency of TCDD as an acute and chronic
toxin (including carcinogen).
C. That TCDD and 2,4,5-T can and, under certain circumstances,
will cause male-mediated transmittable damage manifesting in
birth defects, miscarriages, and other untoward pregnancy outcomes.
D. That 2,4-D, TCDD, and 2,4,5,-Td are neuro-toxic.
V.

Grounds for each Opinion
A. General
The bases for Dr. Silbergeld's testimony as to various facts
and opinions include: educational background; professional
training and experience; personal research; review of clinical
data as set forth in attachments; review of the medical and
scientific literature.
B. Specific
1. As to opinion IV A, i.e. animal toxicology, see list
of references and other grounds under "Animal Toxicology"
attached.
2. As to opinion IV B,i.e. role of receptors in the presence
of TCDD, see list of references and other grounds under
"Receptors/TCDD" attached.
3. As to opinion IV C, i.d. as to male-mediative genetic damage,
see list of references and other grounds under "Reproductive
Toxicology" attached.
4. As to opinion IV D, i.e. as to neuro-toxicity of Agent
Orange, see list of references and other grounds under
"Neurotoxicology" attached.

SILBERCLED - NEUROTOXICOLOGY

Bleiberg, Walon, Brodken and Applebaum, 1964; Archives of Dermatology,
Volume 89, p. 793.
Poland and Smith, 1971, Archives of Environmental Health; Volume 22, p. 316.
Kimbrough, 1974, CRC Critical Reviews in Toxicology, p. 445.
Lucier, Sonawane, McDaniel and Hook, 1975, Chemical Biological Interaction,
Volume 11, p. 15.
Oliver, 1975, British Journal of Industrial Medicine, Volume 32, p. 49.
Sjoden and Soderberg, 1975, Physiological Psychology, Volume 3, p. 175.
Jerosek, Kolenski, Kubek, Pasturova and Lucash, 1976, Ha„far7l.________________
Volume 27, p. 328.
Kociba, Keeler, Park and Gehring, 1976, Toxicology and Applied Pharmacology,
Volume 35, p. 553.
Allan, Barsotti, Van Miller, Abrahamson and Lalich, 1977, Food, Cosmetics and
Toxicology, Volume 15, p. 401.
Elovaara, Savolainen, Parkki, Aitio and Vanio, 1977, Research Communications,
Chemical Pathology and Pharmacology, Volume 18, p. 487.
Farrah, 1977, Teratology, Volume 16, p. 365.
McConnel, Moore, Harris and Haseman, 1977 , Environmental Health Perspectives,
Volume 20, p. 245.
Kociba, Keys, Beyer, Carreon, Wade, et al., 1978, Toxicology and Applied
Pharmacology, Volume 46, p. 297.
Marcilos, Terronon and Aitio, 1978, Zenobiotica, Volume 8, p. 397.
Bogen, 1979, Journal of the American Medical Association, Volume 242, p. 2391.
Field, 1979, Lancet, Volume 1, p. 1342.
Nienstedt, et al., 1979, Toxicology, Volume 13, p. 233.
Strik, 1979, Annals, New York Academy of Sciences, Volume 320, p. 308.
Strik and Koeman, 1979, "Chemical Porphyria in Man."
Zach and Suskind, 1980, Journal of Occupational Medicine, Volume 22, p. 11.
Cantoni, Salmona and Rizzardini, 1981, Toxicology and Applied Pharmacology,
Volume 67, p. 156.
Pazderova, Lucas, Pickova and Jirasek, 1981, Archives of Environmental Health,
Volume 36, p. 5.

13606

In ter nat io nal Society for Ne ur och e m i st r y and International
Research O r g a n i za ti o n Meetings on N e u r o t o x i co l o g y
Editor, Journals on Ne uro t o x i co l o g y
T ox ic ol o gy and Terat olo gy

and

Res ear ch

for T ox ico lo gy

at NIH and Natio nal

Center

Neurobehavioura1

Research

Brain

SILBERGELD - RECEPTORS/TCDD

Vos, Moore and Zinkl, 1973, Environmental Health Perspectives, Volune 5, p. 149.
Kouri, Ratrie, Atlas, Niwa and Nebert, Life Sciences, Volume

15, p. 1585.

Vos, Moore and Zinkl, 1974, Toxicology and Applied Pharmacology, Volume 29, p. 229.
Beatty and Neal, 1975, Toxicology and Applied Pharmacology, Volume 33, p. 151.
Kimbrough, 1974, CRC Critical Reviews in Toxicology, p. 445.
Kupfer, 1975, CRC Critical Reviews in Toxicology, Volume 4, p. 83.
Oliver, 1975, British Journal of Industrial Medicine, Volume 32, p. 49.
Poland and Glover, 1975, Molecular Pharmacology, Volume 11, p. 389-398.
Barry, Zacharia, Namkung and Juchau, 1975, Toxicology and Applied Pharmacology,
Volume 36, p. 569.
Goldstein, McKinney, Lucier, Hickman, Burgman and Moore, 1976, Toxicology and
applied Pharmacology, Volume 36, p. 81.
Alastair Hay, 1981, "The Chmeical Scythe."
Kimbrough, Editor, 1980, Halogenetic Biphenyls, Terphenyls, Naphthalenes,
Dibenzodioxins and Related Products.
Poland and Kende, 1976, Federation Proceedings, Volume 35.
McConnel, Moore, Haseman and Harris, 1978, Toxicology and Applied Pharmacology,
Volume 44, p. 335.
McConnel, Moore, Harris and Haseman, 1977, Environmental Health Perspectives,
Volume 20, p. 245.
Kociba, Keys, Beyer, Carreon, Wade, et al, 1978, Toxicology and Applied
Pharmacology, Volume 46, p. 297.
Boobis, Nebert and Paelkonen, 1979,

Biochemical Pharmacology, Vo Ikbb 28, p. 11.

Carlstedt-Duke, Elstrom, Hogburg and Gustofsun, 1979, Journal of Biochemistry,
Carlstedt-Duke, 1979, Cancer Research,

Volume 39, p. 3172.

Gasiewicz and Neal, 1979, Toxicology and Applied Pharmacology, Volune 51,
p. 329.
Greenly and Poland, 1979, Journal of Biological Chemistry,

Volume 254, p. 9814.

Gunther, Fysh and Nebert, 1979, Pharmacology, Volume 19, p. 12.

13608

Kociba, Keys, Beyers, Carreon and Gehring, 1979, New York Academy at Sciences,
Volume 320, p. 204.
.J

i_ _

j .. _ i

Poland

& Smith,

1971,

Archives

of

Environmental

Health,

Vol.

22,

p.

Huff, Moore, Saracci and Tomatis, 1980, Environmental Health Perspectives,
Volume 36, p. 221.
Strik, 1979, Annals, New York Academy of Sciences, Volume 320, p. 308.
Strik and Koeman, 1979, "Chemical Porphyria in Man."
Olson, Gasiewicz and Neal, 1980, Toxicology and Applied Pharmacology,
Volume 56, p. 78.
Olson, Hoscher and Neal, 1980, Toxicology and Applied Pharmacology, Volume 65,
p. 67.
Poland and Glover, 1980, Molecular Pharmacology, Volume 17, p. 86.
Eisen, Hanna, Legraverend, Okey and Nebert, 1983, Journal of Biological
Chemistry,
Legraverend, Hanna, Eisen, Owens, Nebert and Henkens, 1982, Journal of
Biological Chemistry, Volume 257, p. 6402.
Tukey, Hanna, Negishi, Nebert and Eisen, 1982, Cell, Volume 31, p. 275.
Okey, Bonde, Mason and Nebert, 1980, Journal of Biological Chemistry.

Participation as invited Speaker and participant in International Symposia
on TCDD conducted by Rockefeller University (October, 1983).
Current Research in the Reproductive Toxicology Section NICHD NIH
Papers in Preparation describing’ this research.
Training and Research experience at Johns-Hopkins and the NIH in receptor and
cellular biochemistry and toxicology.
Society for Occupational and Environmental Health (December, 1983)

13609

316

SILBERGELD - REPRODUCTIVE TOXICOLOCY

Courtney, Daler, Hogan, ec al., 1970, Teratogenic Evalation of 2,4,5-T; Science
Volume 168, p. 864.
Sparschu, Dunn and Rowe, 1970, Toxicology and Applied Pharmacology; Volume 17,
p. 317.
Courtney and Moore, 1971, Toxicology and Applied Pharmacology; Volume 20, p. 369.
Khera and McKinley, 1972, Toxicology and Applied Pharmacology; Volume 22, p. 14.
Moore, Glupta, Zinkl and Vos, 1973, Environmental Health Perspectives, Volume 5,
p . 81.
Neubert, Zens, Rothenwallner and Merker, 1973, Environmental Health Perspectives,
Volume 5, p. 67.
Kimbrough, 1974, CRC Critical Reviews in Toxicology, p. 445.
Kupfer, 1975, CRC Critical Reviews in Toxicology, Volume 4, p. 83.'
Lucier, Sonawane, McDaniel and Hook, 1975, Chemical Biological Interaction,
Volume 11, p. 15.
Oliver, 1975, British Journal of Industrial Medicine, Volume 32, p. 49.
Gjoden and Soderberg, 1975, Physiological Psychology, Volume 3, p. 175.
Barry, Zacharia, Namkung and Juchau, 1976, Toxicology and Applied Pharmacology,
Volume 36, p. 569.
Courtney, 1976, Bulletin of Environmental Contamination and Toxicology,
Volume 16, p. 674.
Alastair Hay, 1981, "The Chemical Scythe"
Kimbrough, Editor, 1980, Halogenetic Biphenyls, Terphenyls, Naphthalenes,
Dibenzodioxins and Related Products.
Kociba, Keeler, Park and Gehring, 1976, Toxicology and Applied Pharmacology,
Volume 35, p. 553.
Smith, Schwetz, and Nitschke, 1976, Toxicology and Applied Pharmacology,
Volume 38, p. 518.
Allan, Barsotti, Van Miller, Abrahamson and Lalich, 1977, Food, Cosmetics and
Toxicology, Volume 15, p. 401.
Earry, Slaga, Wilson, Zacharia, Namkung, et al. , 1977 , Biochemical Pharmacology,
Volume 26, p. 1383.

13610

Farrah,

1977,

Teratology,

Volume

McConnel, Moore, Harris and
Perspectives, Volume 20, p.
Kociba,
Applied

16,

Haseman,
245.

Keys, Beyer, Carreon, Wade,
Pharmacology, Volume 46, p.

p.

365.

1977,

Environmental Health

et al.,
297.

1978,

Toxicology and

Barsotti, Abrah ams on and Allan, 1979, Bulletin, Enviroanental
Co nt ami na tio n and Toxicology, Volume 21, p. 463.
Bogen, 1979 , Journal
p. 2391.
Field,

1979,

of the Am erican

Lancet , Volume

1,

p.

Medical

Associaffi«.,

Volume

242,

1342.

Kociba, Keys, Beyers, Carreon and Gehring,
of Sciences, Volume 320, p. 397.

1979,

New

Tork Academy

Murray, Smith, Nitscheke, Humaston, Kociba and Schwetcz, 1979 ,
To xi co lo gy and Applied Pharmacology, Volume 50, p. 2 741.
Schantz, Barsotti, and Allan, 1979,
Pharmacology, Volume 48, p. 360.

Toxico lo gy

Cook, TowHsend , Opst, and Silverstein,
Medicine, Volume 22, p. 530.

1980,

McNolte, Pomerantz,
Volume 19, 0. 57.

and

Remotti,

Bionco,

Virgilis,

Farrell,

1981,

1981,

Food,

Townsend, Bodner, Van Peenen, Olsen and
Epidemiology, Volume 115, p. 695.

Institute

Researc h

Repro duc ti ve

Toxico lo gy

Cook,

Experiment a 1

arnd Applied

Placerntz, Volume

2,

p.

1982,

^American Journal

Journal

o:’f Toxicology and

of Health
Section

or' Occupational

Cosmetic cs, Toxicology

1981,

Lamb, Marx, Gladen, Allen and Moore, 1981,
Enviorn me nta l Health, Volume 8, p. 825.

at Na tional

and

T o x i co l o g y

and Candiani,

Research

A [ P plied

Journ al

Lee and Suzuki, 1980, Journal of P h a r m a c ol o g y
Therapeutics, Volume 215, p. 501.
Cantoni, Salmona, and Rizzardini,
Pharmacology, Volume 67, p. 156.

and

NICHD

SILBERGELD - ANIMAL TOXICOLOGY

Bleiberg, Walon, Brodken and Applebaum, 1964; Archives of Dermatology,
Volume 89, p. 793.
Poland and i>mith, 1971, Archives of Environmental Health; Volume 22,
p. 14.
Moore, Glupta, Zinkl and Vos, 1973, Environmental Health Perspectives,
Volume 5, p. 81.
Vos, Moore and Zinkl, 1973, Environmental Health Perspectives, Volume 5,
p. 149.
Kouri, Ratrie, Atlas, Niwa and Nebert, Life Sciences, Volume 15, p. 1585.
Vos, Moore and Zinkl, 1974, Toxicology and Applied Pharmacology, Volume 29,
p. 229.
Carter, Kimbrough, Liddel and Cline and Zach, 1975 , Science, Volume 188,
p. 738.
Kimbrough, 1974, CRC Critical Reviews in Toxicology, p. 445.
Oliver, 1975, British Journal of Industrial Medicine, Volume 32, p. 49.
Poland and Glover, 1975, Molecular Pharmacology, Volume 11, p. 389-398.
Goldstein, McKinney, Lucier, Hickman, Burgman and Moore, 1975, Toxicology
and Applied Pharmacology, Volume 36, p. 8L.
Alastair Hay, 1981, "The Chemical Scythe"
Kimbrough, Editor, 1980, Halogenetic Biphenyls, Terphenyls, Naphthalenes,
Dibenzodioxins and Related Products.
Jerosek, Kolenski, Kubek, Pasturova and Lucash, 1976, Hautarzt___________ ,
Volume 27, p. 328.
Farrah, 1977, Teratology, Volume 16, p. 365.
McConnel, Moore, Harris and Haseman, 1977, Environmental Health Perspectives,
Volume 20, p. 245.
Crow, 1978, Annals, Occupational Hygiene, Volume 21, p. 297.
Kociba, Keys, Beyer, Carreon, Wade, et al., 1978, Toxicology and Applied
Pharmacology, Volume 46, p. 297.
Marcilos, Terronon and Aitio, 1978, Zenobiotica, Volume 8, p. 397.
McConnel, Moore, Haseman and Harris, 1978, Toxicology and Applied Pharmacology,
Volume 44, p. 335.

Bogen, 1979, Journal of the American Medical Association, Volume 242, p. 2391.

Gasiewicz and Neal, 1979, Toxicology and Applied Pharmacology, Volume 51, p. 329.
Kociba, Keys, Beyers, Carreon and Gehring, 1979, New York Academy of Sciences,
Volume 320, p. 397.
Luster, Face and Lawson, 1979, Drug and Chemcial Toxicologies, Volume 2, p. 49.
Neal, Beatty and Gasiewicz, 1979, Annals, New York Academy of Sciences, Volume 320,
p. 204.
Nolan, Smith and Hefner, 1979, Toxicology and Applied Pharmacology, Volume 48, p. 16
Strik, 1979, Annals, New York Academy of Sciences, Volume 320, p. 308.
Strik and Koeman, 1979, "Chemical Porphyria in Man."
Huff, Moore, Saracci and Tomatis, 1980, Environmental Healthi Perspectives,
Volume 36, p. 221.
Okey, Bonde, Mason and Nebert, 1980, Journal of Biological Chemistry.
Poland and Glover, 1980, Molecular Pharmacology, Volume 17, p. 86.
Zach and Suskind, 1980, Journal of Occupational Medicine, Volume 22, p. 11.
Pazderova, Lucas, Pickova and Jirasek, 1981, Archives of Environmental Health,
Volume 36, p. 5.
Lamb, Marx, Gladen, Allen and Moore, 1981, Journal of Toxicology and
Environmental Health, Volume 8, p. 825.
Tukey, Hanna, Negishi, Nebert and Eisen, 1982, Cell, Volume 31, p. 275.

A t t e n d a n c e Intern ati on al
(Oct., 1983)
Member
Service
Revi ew
Mo .

EPA Expert
EPA Expert
Clinical

Symposium

Co mmittee

on Dioxin

Co mmittees

Data,

on TCDD,

Nitro,

Exp er i e nc e

in Risk Assessment

Exp er i e nc e

in t oxi co lo gy

(July,

on Several

R o ck ef el le r University

1983)

Toxins

W . V a . , S e v e s o , Italy,

& toxicology

assessment

Times

Beach,

RAYMOND SINGER, Ph.D.

I.

QUALIFICATIONS
Dr. Raymond Singer, Ph.D., is a neurotoxicologist and neuropsycholo­

gist practicing at Occupational Health Consulting, Inc., New York, New York.
Dr. Singer's curriculum vitae is attached.

II.

SUBJECT MATTER
Dr. Singer will testify to the toxic effects of toxic chemicals,

Agent Orange, PCDD and TCDD on the human nervous system and the consequences
thereof.

Dr. Singer will testify to various studies, including a study conducted

by Dr. Singer, which demonstrate the nervous disorders resulting from exposure
to Agent Orange and TCDD.

His testimony will also include an explanation of

the method using nerve conduction velocity studies to show the resulting nervous
disorders and the results of the examination of each representative plaintiff.

III.

GENERAL SCIENTIFIC PRINCIPLES
The effects of phenoxv herbicides and related contaminants have

been studied in a number of research efforts in both animals and humans.
include case reports and epidemiological reports.

These

Occupational health studies

are often helpful in determining the toxicity of chemicals.

13614

The doctor will testify to a review of the literature concerning
the evidence of toxicity in humans to the central nervous system and the peri­
pheral nervous system.
Dr. Singer will not testify on the biochemical process within the
body by which the nervous system results are produced, but merely on the pre­
sence of those results in the literature and the fact that there are deficits
in mental and nervous function that can be related to herbicide toxicity.
Some of the specific areas are set out below in relation to his opinions.

IV.

SUBSTANCE OF OPINIONS
Dr. Singer's opinions are as follows:
1.

Agent Orange and its contaminant TCDD can cause nervous system

damage in humans, which will vary from individual to individual.
2.

Agent Orange and its contaminant TCDD produce central nervous

system effects which include:
a.

Irritability.

b.

Nervousness.

c.

Sleep Disorders.

d.

Memory Problems.

e.

Other Mental Dysfunctions.

They also produce neuropsychological results which include distortions of per­
ceptual function and cognitive reaction time.
3.

Agent Orange and its contaminant TCDD produce peripheral ner­

vous system effect, which include:

13615

4.

a.

Numbness.

b.

Loss of Feeling.

c.

Weakness.

d.

Pain.

The neurophysiological results include a slowing in nerve

conduction velocity and a probable reduction in amplitude.
5.

The nerve conduction velocity tests are the most reliable method

of determining the presence of peripheral nervous system effects.
6.

The opinion testimony to be offered in relation to each of the

representative plaintiffs is set forth in the individual reports Dr. Singer
has prepared for each.

V.

GROUNDS FOR EACH OPINION
Attached is a copy of Dr. Singer's article entitled Nerve Conduction

Velocity Studies Of Workers Employed In The Manufacture Of Phenoxv Herbicides.
The article reports the test results which the doctor obtained from review of
plant workers in Jacksonville, Arkansas.

Either at the time of the study or

previously thereto, the plant was owned by defendant Hercules.
In addition, he has and will rely upon certain unpublished data
from tests he conducted of another group of workers at the Nitro, West Virginia
plant of defendant Monsanto Chemical Company in 1981.
Also , below is a list of references which Dr. Singer will rely upon.
A.

Opinion IV(1)

(Ref. Nos. 8, 26, 29, 35)

B.

Opinion IV (2)

(Ref. Nos. 2, 15, 19, 31, 37, 44)

1361^

c.

Opinion IV (3)

(Reference Nos • 3, 31, 35, 3-7)

D.

Opinion IV (4)

(Reference Nos • 9, 10, 35)

E.

Opinion IV (5)

(Reference Nos . 5, 12, 13, 41-4 3, 45, 46)

In addition, Dr. Singer may rely upon some: or all of the following
as the basis £or his opinions:
(Reference Nos. 1, 4, 6-7, 11-12, 14, 16-18, 20-25, 27-28, 30,
32-34, 36, 38-40, 47-52.)

1.

2.
3.

3.

4.
5.
6.
7.

8.
9.

10.

11 .

12 .
13.

14.

15.
16.
17.
18.
19.

20.

Anastasi, A. (1976). "Psychological Testing,” 4th cd. Macmillan Co., New York.
Ashe. W., and Suskind, R. R. (1950). "R epons on Chioracne C ases.” Monsanto Chemical Co., Nitro,
West Virginia. Department of Environmental Health, University o f Cincinnati College of
Medicine.
Bauer, H., Schulz, K. H., and Spiegelberg, U. (1961). Berufliche Vergif tungen bei der Herstellung
von Chlorphenol-Verbindungen. Arch. Gewerbephathol. Gewerbehyg. 18, 538—555. Reported in
IARC (1978). Long-term hazards of polychlorinated dibenzodioxins and polychlorinated dibenzofurans.
Behse, F., and Buchthal. F. (1971). Normal sensory conduction in the nerves of the leg in man. J.
Neurol. Neurosurg. Psychiatry 34, 404—414.
Behse, F., and Buchthal, F. (1978). Sensory action potentials and biopsy o f the sural nerve in
neuropathy. Brain 101, 473 —493.
Berkeley, M., and Magee, K. (1963). Neuropathy following exposure to a dimethyiine salt of 2.4-D.
Arch. lnt. M ed. I l l , 351-353.
Berwick, P. (1970). 2,4-Dichlorophenoxyacetic acid poisoning in man. J. Am er. M ed. Assoc. 214(6),
1114-1117.
Blei'oerg, J., Wallen, M ., Brodkin, R., et al. (1964). Industrially acquired porphyria. Arch. Derm atol.
89, 793 -7 9 7 .
Boeri. E. (1980). "Cross-Sectional Neurological Study of a TCDD-Exposed Population in the Seveso
Area Compared with an Unexposed Population.” Unpublished report, Instituto Neurologico,
Milano, Italy.
Boeri. E., Bordo, B ., Crenna, P., et al. (1978). Preliminary results of a neurological investigation of the
population exposed to TCDD in the Seveso region. Riv. Pat. N erv. M eat. 99, III —128.
Bucher, N . L. R. (1946). Effects of 2,4-dichlorophenoxyacetic acid on experimental animals. Proc.
Soc. Exp. Biol. M ed. 63, 204-205.
Buchthal, F., and Behse. F. (1979). Electrophysiology and nerve biopsy in men exposed to lead. Brit.
J. Ind. M ed. 36, 135-147.
Buchthal, F., Rosenfalck. A ., and Behse, F. (1975). Sensory potentials of normal and diseases nerves.
In "Peripheral Neuropathy" (P. J. Dyck, P. K. Thomas, and E. H. Lambert, Eds.), Vol. I, pp.
442 —464. Saunders. Philadelphia.
f
Buiatti. E.. Cecchini, S., Ronchi, O., Dolara, P., and Bulgareili, G. (1978). Relauonship between
clinical and electromyographic findings and exposure to solvents, in shoe and leather workers.
Brit. J. Ind. Med. 35, 168-173.
Cochrane, W ., Singh. J., Miles. W., Wakeford. B.. and Scott, T. (1980). Analysis of technical and
formulated products of 2,4-dichlorophenoxy acetic acid for the presence of chlorinated dibenzop-dioxins. Presented at the workshop Impact of Chlorinated Dioxins and Related Compounds on
the Environment, Rome, October 22-24, 1980.
Creso, E., De Marino, V., Donatelli. L.. and Pagini. G. (1978). Effette neuropsicofarmacologici della
TCDD. Boll. Soc. It. Sper. 54, 1592-1596.
Crow, K. D. (1970). Chioracne. A critical review including a comparison of two series o f cases of acne
from chlomaphthalene and pitch fumes. Trans. St. Johns H osp. Derm atol. Soc. 56, 79—99.
D’Amour, M. L-, Shahani, R. R. Y ., and. Bird. K. T. (1979). The importance of studying sural nerve
conduction and late responses in the evaluation of alcoholic subjects. N eurology 29, 1600—1604.
de Jesus, P. V ., Jr., Hausmanowa-Petrusewicz. I., and Barchi, R. L. (1973). The effect of cold on
nerve conduction of human slow and fast nerve fibers. N eurology 23, 1182—1189.
Desi, I.. Sos, J., Suie, F., and Markus. V. (1962). Nervous system effects of a chemical herbicide.
Arch. Environ. Health 4, 101 —108.
EIo, H. A ., and Ylitaio, P. (1979). Distribution of 2-methyl-4-chiorophenoxyacetic acid and 2.4dichlorophenoxyacedc acid in male rats: Evidence for the involvement of the central nervous
system in their toxicity. Toxicol. Appl. Pharmacol. 51, 439—446.

21.

Elovaara. E., Savolainen, F ,arkki. M. G., Aitio. A., and Vainio, ' 1977). Neunahemicai effects
of 2.3,7.S-tetrachlorodibenzo-'7-dioxin in Wistar and Gann rats. Res. Com m wuChem . Pathol.
Pharmacol. 18, 3.
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23.. Goldstein, N ., Jones, P., and Brown, J. (1959). Peripheral neuropathy after exposoe to an ester of
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Hay, A. W. M. (1977). Tetrachlorodibenzo-p-dioxin release at Seveso disasters. Disasers 1,289—308.
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Nielson, V. K. (1973). Sensory and motor conducrion in the median nerve in nornai subjects. Acta
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35. Pazderova-Vijlupkova. J., Nem cova, M., Pickova, J., Jiresek, L., and Lukas, E.. (US1). The devel­
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Sauerhoff, M., Braun, W„ Blau. W.. and Gehring, P. (1977). The fate of 2.4-dichlo¡roB»:noxyactic acid
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neurotoxicity of /j-pentane, /i-hexane, and /i-heptane in the rat. Brit. J. Ind. M ed. 37, 241—247.
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environmental research 29. 297-311 (1982)

Nerve Conduction Velocity Studies of Workers
Employed in the Manufacture of Phenoxy Herbicides

R a y m o n d S in g e r , M a r io n M o s e s , J o sé V a l c iu k a s . R u t h L i u s ,
a n d I r v in g J. S e u k o f f
Environmental Sciences Laboratory, Mount Sinai School of Medicine.
One Gustave L. Levy Place. New York. New York 10029
Received June 24, 1981
Conduction velocities (NCV) of the median motor, median sensory, and surai nerves wtre
measured in 56 workers employed in the manufacture of 2,4.5-trichlorophenoxy acetic acid
(2.4.5-T) and 2.4-dichlorophenoxy acetic acid (2,4-D). Mean age was 35 years and mean
duration of employment was 7 years. The control group consisted of 25 subjects without
exposure to neurotoxic agents. When compared with controls, slowing was noted in the
sural nerve (mean = 34.0 vs 40.1 m/sec. P < 0.02). All values were then adjusted for age and
temperature and were transformed to Z values (mean = 0, standard deviation = 1), where­
upon slowing was seen in the sural (-2.21 vs -0.52, P < 0.0001) and median motor nerves
(0.19 vs 0.91, P < 0.03). Duration of employment was significantly correlated with slowing
of sural velocity (r = -0.40. P < 0.004). Altogether. 46% of the study group had one or more
slowed nerve conduction velocity, versus 5% of the control group P < 0.001).
INTRODUCTION

The phenoxyaliphatic acid herbicides 2,4.5-trichlorophenoxyacetic acid
(2,4,5-T) and 2,4-dichlorophenoxyacetic acid (2,4-D) have been widely used in
maintenance of right of ways and in forest, range, and crop management for over
30 years. These compounds are readily metabolized and excreted (Kohli et al.,
1974; Sauerhoff et al., 1977) and their acute mammalian toxicity is low. The LD,0
of 2,4.5-T is reported to be 300 and 100 mg/kg in the rat and dog, respectively, and
that of 2.4-D ranges from 300 to 1000 mg/kg in rats, guinea pigs, and rabbits
(Herbicide Handbook, 1979). However, during the manufacture of these her­
bicides undesirable byproducts such as chlorinated dioxins have been found to
contaminate the final products. 2.3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7.8TCDD), which contaminates 2,4.5-T, is thought to be the most toxic contami­
nant. 2.3,7,8-TCDD has an LD50 of 0.6 ¿ig/kg in the guinea pig and is an animal
carcinogen and teratogen in very low doses (Huff et al., 1980). 2,4-D may also be
contaminated with chlorinated dioxins. However, the highly toxic 2,3,7,8-TCDD
was not found in 2,4-D (Norstrom et al.. 1979). Recently some Canadian formu­
lations of 2,4-D have been found to be contaminated with 1,3,6,8-TCDD (Coch­
rane et al., 1980).
A 1:1 combination of the n-butyl esters of 2,4,5-T and 2,4-D comprised Agent
Orange, a defoliant widely used by the U.S. military in South Vietnam from 1965
to 1970 (Younger al., 1978). In 1971, the U.S. Environmental Protection Agency
suspended most food crop uses of 2.4,5-T and most other uses were suspended in
297

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Copyright (0 1982 by Academic Press. Inc.
All rights of reproduction in any form reserved.

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SINGER ET AL.
1978 based upon unresolved questions regarding effects ot'low-levei exposures to
chlorinated dioxins on human health (U.S. Environmental Protection Agency,
1978). 2,4,5-T is no longer being manufactured in the United States.
HUMAN HEALTH EFFECTS

There have been many reports of adverse effects on human health ffqm expo­
sure to 2,4,5-T and its contaminants in relation to industrial accidents (Huffer al.,
1980). The first known accident occurred in 1949 in the United States when a trichlorophenol reactor exploded. Similar accidents occurred in 1952 and 1953 in
Germany, in 1963 in Holland, and in 1968 in England. In 1976 an explosion oc­
curred at a chemical plant in northern Italy, resulting in release of a toxic cloud
over the surrounding community. Evacuation of the town of Seveso, which was
heavily contaminated with 2,3,7,8-TCDD, was ordered (Homberger et al., 1979).
Health effects are also known to occur from the manufacturing process itself when
overexposure occurs unrelated to an explosion, most notably in the United States
in 1962 (Bleiberg et al., 1964) and 1964 (Hay, 1977), and in Czechoslovakia in 1965
to 1968 (Pazderova-Vijlupkovaer al., 1981). Adverse health effects have also been
alleged in Vietnam veterans and in South Vietnamese exposed to Agent Orange
but few data are available for evaluation of the problem and it is not yet known
whether 2,3,7,8-TCDD is a factor in the reported effects.
While there is no pathognomonic syndrome related to exposure to 2,3,7,8TCDD, effects on the skin, liver, and nervous system have been reported in
workers exposed in several industrial accidents (Huff et al., 1980). A consistently
reported effect has been chloracne, a refractory follicular dermatosis of varying
extent and severity depending on the duration and amount of exposure. Central
and peripheral nervous system effects also have been frequently reported and are
reviewed below.
Ashe and Suskind (1950) examined four workers who developed chloracne fol­
lowing exposure to the contents of an overheated reactor accidently released in
1949 during the manufacture of trichlorophenol for the production of 2,4,5-T. Irri­
tability, nervousness, insomnia, loss of libido, and impotence were reported.
Symptoms of peripheral neuropathy included pain and weakness in the lower ex­
tremities. Histopathologic examination of several small cutaneous nerves in one
case showed destruction of myelin sheaths and nerve fibers with replacement by
connective tissue. In a follow-up study (Suskind, 1953) of 11 affected workers
exposed at the 1949 accident and 25 affected workers from the 2,4.5-T production
area, 35 of whom had shown chloracne. symptoms of peripheral neuropathy were
found in 27 cases. Fatigue, nervousness, irritability, and decreased libido were
also found.
Bauer et al. (1961) studied workers who had developed chloracne while em­
ployed in the manufacture of 2,4,5-T. Fatigue, muscle weakness, and pain, mostly
in the lower extremities, were prevalent symptoms. Paresthesia and hyperesthesia
(sensory neuropathy) were found, as well as inability to concentrate, memory
deficits, decreased drive, intolerance to alcohol and sleep disturbances, including
increased somnolence.

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NCV AND exposure to phenoxy herbicide
Poland et al. (1971) studied 73 current employees at a 2,4,5-T and 2.4-D man­
ufacturing plant. 13 of whom had chloracne. An increased prevalence of
neurological findings was not reported. A positive correlation between severity of
chloracne and score on the hypomania scale of the Minnesota Multiphasic Per­
sonality Inventory was found.
Kleu and Goltz (1971) conducted a follow-up study of ten workers acutely
exposed to TCDD 15 years earlier and reported fatigue, muscle weakness, de­
creased libido, alcohol intolerance, and memory loss.
Goldmann (1972) studied 42 workers involved in an accidental venting of steam
during the manufacture of trichlorophenol. Seven showed signs or symptoms of
central nervous system (CNS) involvement and three of polyneuropathy.
Pazderova-Vijlupkova et al. (1981) examined 55 of 80 workers employed at a
plant manufacturing 2,4,5-T who were exposed from 1965 through 1968 and were
examined during the years 1967 to 1973. Peripheral nervous system involvement
was indicated by symptoms such as muscle weakness and pain in the lower ex­
tremities. Abnormal nerve conduction velocities were found in 17 cases (31%).
Mild Schwann ceil pathology was found at autopsy in the most severely affected
worker. CNS effects were indicated by symptoms such as fatigue, sleep disorders,
headache, and sexual dysfunction. Abnormal electroencephalographic responses
were found in 27% of 34 cases examined, with borderline findings in an additional
21%. On the basis of severity of CNS symptoms, a subsample of 36 workers were
examined by a psychiatrist, who characterized 35 as "neurasthenic” or "depres­
sive.”
Boeri et al. (1978) utilized nerve conduction velocity to assess the presence of
possible neurophysiologic dysfunction resulting from chemical exposure as­
sociated with the Seveso accident. They compared two groups which differed in
degree of TCDD contamination: 470 from the more contaminated zone and 152
from the zone at lower risk. NCV of the ulnar and peroneal motor nerves was
measured. A relatively high prevalence of abnormalities was found in both popu­
lations (19.8 versus 13.2%). The authors attributed the increased prevalence in
pan to the prior exposure of the less heavily exposed population to chemicals
associated with the industries of the area: woodworking, metalworking, and
chemical industries. Still, a greater prevalence of polyneuropathy was found in the
group living closer to the site of the accident.
In a follow-up examination of the Seveso population (Boeri, 1980) a subgroup of
the exposed population (N = 277) was compared with residents of an unexposed
town GV = 380) for signs and symptoms of peripheral neuropathy. Motor nerve
conduction velocity was measured on the ulnar and peroneal nerves. A 4.5%
frequency of peripheral neuropathy was found in the Seveso population for which
no other etiology (such as diabetes) could be found. A significantly greater preva­
lence of peripheral neuropathy was found in the Seveso population than in the
control group. Sensory nerve conduction velocities were not assessed.
A few reports are available concerning the human health effects of 2,4-D.
Goldstein et al. (1959) found severe sensory and motor disorders in three cases of
percutaneous exposure to 2,4-D used as a spray. Cases of neuropathy following
exposure to 2,4-D have also been reported by Todd (1962), Berkeley and Magee

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SINGER ET AL.
(1963), Berwick (1970), and Wallis et al. (1970). In all of these cases the exposure
was to the already formulated product. Chloracne has not been reported with
exposure to 2,4-D. The only reports in which chloracne had been found in 2.4-D
workers occurred with concomitant exposure to 2,4,5-T (Bleiberg et al., 1964:
Poland et al., 1971).
ANIMAL STUDIES

'

While there have been a large number of studies of chlorinated benzo-p-dioxins
and related compounds in experimental animals, very few have focused on the
nervous system. Elovaara et al. (1977) administered a single intragastric dose of
2,3,7,8-TCDD to rats, and found anomalous CNS function in some of the treated
rats. Creso et al. (1978) found that 2,3,7,8-TCDD administered intraperitoneally or
orally in rats resulted in CNS symptoms of irritability, restlessness, and increased
aggression. Bucher (1946) and Hill and Carlisle (1947) found that mice, rats, rab­
bits, guinea pigs, and monkeys exposed to 2,4-D could develop myotonia, motor
disorders, and paralysis of extremities. Desi et al. (1962) found that parenteral
administration of 2.4-D in rats resulted in electroencephalographic abnormalities
and decrements of rat performance, associated with pathology in the spinal cord.
Elo and Ylitalo (1979) and Way (1969) presented additional histological evidence
of nervous system susceptibility to 2,4-D.
NERVE CONDUCTION VELOCITY

Nerve conduction velocity (NCV) assessment has been used by many inves­
tigators in studies of toxic agents such as lead, mercury, and solvents (Spencer
and Schaumberg, 1980: Seppalhlinen et al.. 1978, 1979, 1980; Buiatti et al., 1978).
Buchthai et al. (1975) and Behse and Buchthal (1978) have studied the association
of slowed NCV with symptoms of neuropathy and histological findings and pro­
vide evidence concerning the importance of electrodiagnosis in the evaluation of
toxic neuropathies. NCV measurement is well suited for epidemiological studies
since (T) the technique is noninvasive. (2) it can be performed quickly and accu­
rately on large numbers of people, and (3) the results are quantitative (in continual
and can be related to other quantitative, continuous variables such as duration of
exposure or biological indicators of exposure when available.
An important aspect of NCV assessment is its sensitivity to toxic changes
before other signs or symptoms are present. When rats are injected with a
neurotoxic agent such as «-hexane. NCV slowing is found before signs of overt
neuropathy such as weakness and paralysis appear (Takeuchi et al., 1980). Presymptomatic NCV slowing is also found among diabetics before symptoms or
other signs of neuropathy (Thomas, 1980). Since NCV slowing is an early indi­
cator of neuropathy, measurement of NCV is being used increasingly to assess
subclinical dysfunction in studies of environmental and occupational toxic expo­
sures.
PRESENT STUDY

In April 1979, chlorinated dibenzo-p-dioxin contamination was found in loca­
tions away from a chemical plant producing 2,4,5-T and 2.4-D in Jacksonville.

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Arkansas, a small community near Little Rock. The source of the contamination
was found to be toxic wastes leaking from drums stored above ground at the
93-acre plant site. Levels of 40 ppm of 2,3,7,8-TCDD were found in the wastes and
2 ppb in a sewer system outlet at the plant that discharged into the city system.
The problem was investigated by the Arkansas State Department of Health, and
the Governor’s office ordered production of 2,4,5-T suspended until the health
and safety implications of the findings were investigated and evaluated. ^,4,-D,
however, continued to be produced.
2,4,5-T and 2,4-D had been produced at this plant since 1957. In the late 1960s
more than 14 million pounds of Agent Orange (a 1:1 combination of the n-butyi
ester of 2,4,5-T and 2,4-D) were manufactured at this site. Phenoxy herbicides had
been the exclusive product of this plant since 1971, when the manufacture of other
organic acid herbicides was discontinued.
In 1974 there was a reactor accident during the manufacture of trichlorophenoi
resulting in an outbreak of chloracne in the crew assigned to do the cleanup.
Except for this episode, which involved fewer than a dozen workers, chloracne
had not been a serious problem at this facility.
In July 1979, at the request of the Arkansas State Health Department, a health
survey of current and former workers at this plant was conducted by the Envi­
ronmental Sciences Laboratory of the Mount Sinai School of Medicine. While
2,4,5-T production had ceased at the plant in April, nonetheless, some workers
were involved in redrumming of contaminated wastes in leaking drums. All work­
ers were exposed to 2,4-D which was still being produced.
NCV AND EXPOSURE TO PHENOXY HERBICIDE

METHODS

Subjects. During July 1979 a health survey was conducted of 190 active, retired,
and former workers of the piant. All 88 current workers were invited to participate
and 76 did so, representing 86% of the active work force. Workers were included
for NCV assessment if no positive history of diabetes, neurological disease, or
excess alcohol consumption was found in the screening interview. Because of
time limitations, NCV was measured in only 55 of these workers (53 active, 2
retirees).
All workers were at risk for exposure to phenoxy herbicides to some degree.
Subjects were interviewed regarding exposure to other toxic chemicals, since
some of these might affect NCV. Concurrent exposure to other neurotoxic agents
was not found in any of the workers studied. Nine workers were found to have had
possibly significant prior exposure to such agents, which included pesticides,
solvents, and—in two workers—2,4-D.
The original protocol included examination of workers who had had minimal or
no direct exposure to 2,4,5-T or 2,4-D. However, due to time limitations, this was
not done. The electrophysiologic team remained unaware of the exposure history
of the individual subjects.
The control group consisted of 17 Environmental Sciences Laboratory staff and
8 brake workers examined as part of a survey of asbestos-exposed workers (N —
25). All subjects were screened prior to testing for exposure to neurotoxic agents,
history of diabetes, stroke, other neurological disease, and alcohol use. No con-

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SINGER ET AL.

trol subject had significant exposure to neurotoxic agents. Control subjects were
excluded if alcohol consumption exceeded four drinks per day. Exposed workers
were interviewed concerning alcohol use and an index of weekly consumption was
computed. Only limbs that had suffered no significant trauma were tested. If the
back had been injured, or if disk disease or “sciatica” were reported, the subject’s
sural nerve velocity was not measured.
Conduction velocities of the median motor, median sensory, and silral nerves
were assessed. Median motor velocity was measured in 53 cases and 25 controls;
median sensory velocity in 54 cases and 23 controls; and sural sensory velocity in
50 cases and 20 controls. All stimulation was supramaximal. Sensory stimulation
was antidromic. Latency was measured in the motor nerves at the first point of
negative deflection, and for the sensory at the peak negative deflection. Waveform
measurement was conducted without knowledge of the subject’s employment
history.
The recording electrode for the median motor nerve was affixed at the center of
the thenar eminence over the adductor pollicis brevis, and the reference electrode
ringed its tendon of insertion at the thumb. The nerve was stimulated proximally
medial to the aponeurosis musculi bicipitis brachii, and distally at the wrist be­
tween the palmaris longus and the flexor carpi radialis tendons. The median sen­
sory evoked potential was recorded using a ring electrode around the middle
interphaiangeal joint of the index finger, and the reference electrode was affixed
around the distal interphaiangeal joint. The nerve was stimulated at the distal
median motor stimulation point. The recording electrode for the sural was a ring
electrode shaped into a strip and taped so that one end touched the lateral mal­
leolus and the distal end pointed toward the posterior tip of the calcaneus. The
reference electrode was placed approximately 2 cm distal and parallel to the
recording electrode. The stimulation site for the sural varied somewhat, since
occasionally the evoked potential could not be detected without varying the
stimulation site. The initial site chosen for each subject was slightly distal to the
midsection of the two heads of the gastrocnemius. If the evoked potential was
inadequately defined, the nerve was stimulated more distally in a fine extending
from the initial stimulation site toward the recording electrode. Stimulation and
recording procedures were rechecked if the sural evoked response was not elic­
ited. The distance between the stimulation site and the recording etectrode was
never less than 11 cm.
A Teca TE42 electromyograph with digital averager was used in the field re­
search. The unit had been calibrated by the manufacturer prior to the study. The
calibration trace was printed on each EMG trace. The unit remained in calibration
throughout the study.
Skin temperature of the limb was measured using a Rochester Electro-Medical
thermistor probe applied to the skin surface successively at three points on the
arm (the proximal and distal stimulation sites, and at the thenar eminence of the
palm) and at two points on the leg (over the stimulation and recording electrode
sites). The temperature values were averaged for each limb.
The distance of the nerve segment was assessed using flexible myfar measuring
tape. The shortest distance between the points was followed, and the tape mea-

303
sure was in contact with the skin at ail points along the surface of the tape
measure. Care was taken not to stretch the skin by pressing too hard on the tape
measure. Nor was the distance shortened by pulling the tape measure so that
contact with the skin was lost. (Relatively short distances can have a large effect
on the actual calculation of the NCV for a given nerve.) A difference of 1 mm
was acceptable for inter-rater reliability, a procedure conducted on half the cases.
A Disa 1500 electromyographic system was used for the examination of some of
the control subjects. Since it was possible that the two units might not be measur­
ing in concordance, both units were compared using volunteer subjects at the
Environmental Sciences Laboratory. Nine sural, two median motor, and one
median sensory nerves were used. Each nerve was examined using both the Teca
and Disa units, utilizing their respective recording electrodes. The units had been
recently calibrated by the manufacturer, and the calibrations were frequently
checked. The Teca stimulating electrode was used throughout the study, since in­
dentations remain temporarily on the surface of the skin—this is more convenient
for marking the points of stimulation. The correlation between the measurement
of the two units, using the same points of stimulation and pickup, was calculated to
be +0.97, .P < 0.0001. Therefore, the two units were measuring evoked potentials
in concordance.
NCV AND EXPOSURE TO PHENOXY HERBICIDE

ANALYSIS

In this group, chloracne was infrequent and could not serve as a variable in the
analysis.
Limb temperature. Nerve conduction velocity is affected by temperature at the
approximate rate of 2 m/sec/°C (Goodgold and Eberstein, 1978; de Jesus et al.,
1973; Halar et al., 1980). Limb temperature is a function of many variables not
related to exposure to neurotoxic agents, such as room temperature, outdoor
temperature, the amount of clothing worn, blood circulation, and the subject’s
age. Limb temperature can vary to the extent that interpretation of significant
differences between two groups can be compromised; a mean temperature differ­
ence of only 2°C could lead to false conclusions concerning true group differences.
To reduce the variance produced by temperature on nerve conduction velocity,
some investigators warm the limb to a standard temperature. However, this is not
a practical technique in the field when many subjects must be examined and time
is limited. An approach currently used by some investigators (Halar et al., 1980;
de Jesus et al., 1973) is the mathematical adjustment of all velocities to that
expected at a standard temperature. The equations were derived from experi­
mental manipulation of limb temperature in the laboratory. The equations pre­
sented by de Jesus et al. (1973) were used in this study to adjust each velocity to
36°C (Appendix A). This temperature was chosen following the approach of
Rosenfalk (1975), who reported norms based upon the heating of limbs to
35-37°C.
Age. Nerve conduction velocity declines with age at the approximate rate of 1.5
m/sec/decade depending upon the nerve examined (Behse and Buchthal, 1971;
Nielsen, 1973; Rosenfalk. 1975; Buchthal et al., 1975). Investigators who have
considered the effect of age upon nerve conduction velocity usually attempt to

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SINGER ET AL.
match each subject with an appropriate control when comparing two groups.
However, under some circumstances the appropriate control data may not be
available. An additional shortcoming of the matching procedure is that the control
data are based upon a single observation. Assuming linearity of the age effect
upon conduction velocity, a regression equation can be constructed which is
based upon many data points, that is. all subjects in the data pool.
In a recent study of lead-exposed workers, Buchthai and Behse (1979) used
regression equations to determine the expected nerve conduction velocity of a
theoretical matched control. The mean difference in velocity between the subjects
and the regression-produced “ matched control” was calculated. The significance
of the difference between the groups was evaluated with the t test for correlated
means.
Z-score standardization. The Z-score transformation is widely used when com­
paring values from distributions with different means and standard deviations,
since after transformation the distributions have a mean of zero and a standard
deviation of one (Anastasi, 1976; Valciukas and Lilis, 1980). This transformation
can be applied to reduce the contribution of confounding variables, such as age,
by determining the departure of an observed value from that expected on the basis
of confounding variables.
All conduction velocity values were converted to Z values in this study by using
the equation
observed velocity - velocity predicted on the basis of age
the standard error of estimate
The velocity predicted on the basis of age is derived from the regression equations
presented by Buchthai et ai. (1975) for the sensory nerves and by Nielsen (1973)
for the median motor. Velocity was adjusted to that expected at 36°C, as discussed
above (Appendix A).
The study and control groups were compared in two ways: prevalence of
slowed nerve conduction velocities and comparison of means. The study group
was further analyzed by examining velocity as a function of duration of employ­
ment. A Z value corresponding with the 0.01 (one-tailed test) or less probability
level was designated as a slowed value.
RESULTS
Forty-six percent of the study group had one or more slowed nerve conduc­
tion velocities, versus 5% of the control group (x2 = 17.1, P < 0.001). Twenty-four
of the 50 sural nerves measured fell below the first percentile, versus 2 of the 20
control sural nerves, using the equation presented by Buchthai et ai. (1975). One
subject's sural nerve evoked potential was absent.
The effect of alcohol on nerve conduction velocity within the study group was
examined. In general, alcohol consumption was low, averaging 2.7 drinks per
week. There was no difference {P < 0.39) in the alcohol consumption of those
subjects with a slowed velocity when compared with that of subjects with nor­
mal velocities. The correlation of reported alcohol consumption and nerve con-

305
duction velocity in the three nerves was not significantly different from zero.
Therefore, the effect of alcohol consumption is unlikely to have produced the
observed group differences.
Table 1 presents the r-test analyses of theZ scores of the study versus control
populations.
The probability of a one-tailed r value is shown, since the study group is
hypothesized to have slower velocities than the control group. The meat} vel­
ocities of the median motor and sural sensory nerves were significantly slower in
the study group than in the control group. (The nerve conduction velocity values
before the adjustment for age and temperature are presented in Appendix B.)
The mean sural velocity Z value of the study group is approximately 1.3 stan­
dard deviation units below that of the control group. This difference corresponds
with a mean slowing of approximately 5.2 nv'sec. For the median motor nerve, the
mean velocity slowing was approximately 1.9 m/sec.
Additional r-test analyses were conducted with the study population reduced
by removing eight individuals who reported consuming more than 28 alcoholic
drinks per week. Also removed was the one case of mild diabetes. The results of
the r tests are presented in Table 2.
The mean velocities of the median motor and sural sensory nerves were still
significantly slower in the study group than in the control group, suggesting that
the slowed velocities were not due to consumption of alcoholic beverages.
A correlation coefficient was computed to assess the association of velocity
(age and temperature adjusted) with duration of employment (Table 3). Sural
nerve conduction velocity was highly correlated with duration of employment (r =
—0.40, P < 0.004), while the velocities measured in the median motor and median
sensory were not correlated with duration of employment.
Further r-test analyses were performed after removing the nine workers with
NCV AND e x po su r e t o ph e n o x y h e r b ic id e

TABLE I

M ean N erve C o n d u c tio n V elo cities o f S tu d y V ersus C o n tro l G roups '*

Nerve
Median motor
Median sensory
Sural

Group

S

Mean
Z value

SD

r

Prob, t (one-tailed)

Study
Control

53
25

0.20
0.91

1.19
1.70

1.89

0.03

Study
Control

54
22

-0.16
-0.04

1.15
0.81

0.52

0.30

Study
50
0.0001
-2.21
1.09
4.28
Control
20
-0.52
1.62
“ Based upon Z values which represent the velocity expected on the basis of age subtracted from
the temperature corrected observed velocity, divided by the standard deviation.

306

SINGER ET AL.
TABLE 2

M ean N erve C o n d u c tio n V elo cities o f S tu d y V ersus C o n tro l G roups "

Nerve
Median motor
Median sensory

Group

.V

Mean
Z value

SD

t

Prob, t (one-tailed)

Study
Control

44
25

0.28
0.91

1.26
1.02

1.77

0.04

Study
Control

45
23

-0.10
-0.04

1.15
0.81

0.22

0.41

Sural

1.04
41
4.13
0.0002
Study
-2.17
Control
-0.52
1.62
20
" Based upon Z values which represent the velocity expected on the basis of age subtracted from
the temperature corrected observed velocity, divided by the standard deviation. The data of subjects
who consumed more than 28 alcoholic beverages per week (N = 8) and the one subject with slight
diabetes were removed from these analyses.

possibly significant prior exposure to neurotoxic agents. Removal of these cases
did not affect the previous findings (Table 4). The correlation of sural NCV with
duration also was essentially the same (r = -0.42, P = 0.006).
It was possible that a residual effect of age upon sural NCV remained after the
standardization process. Such an etfect could have spuriously increased the cor­
relation between NCV and duration of employment. This possibility was explored
by computing the partial correlation of sural NCV (standardized) with duration of
employment, controlling for age. A significant relationship was still found (r =
-0.32, P < 0.03), supporting the previously described negative correlation of
exposure with sural NCV.
In theory, the variance of sural velocity can be better modeled as a function
of age. skin temperature, and duration of exposure, without using statistical
parameters derived from calculations based upon other samples. Such a model
is expected to reflect more accurately the partial correlation of the dependent
variables within this sample since the parameters are based upon variation within
the study sample. This model was tested by computing the multiple correlation
of age, skin temperature, and duration of employment with unstandardized sural
velocity.
TABLE 3

Y ears o f E m plo y m en t V ersus N erve C o n d u ctio n V elo city A d justed
for a c e a n d T em pera tu re

Sural
Median sensory
Median motor
-0.40
r
-0.04
-0.10
0.00»
p
0.48
0.80
50
54
N
53
Note. Mean years of employment = 7.0. standard deviation = 6.2. range = 1-28 >«ars.

13630

307

NCV a n d e x po s u r e to ph e n o x y h e r b ic id e
TABLE 4

M ean N erve C o n d u c t io n V elo cities of S tu d y V ersus C o n tro l G roups “

Nerve
Median motor
Median sensory

Group

¡V

Mean
Z value

SD

i

Prob, t
(one-tailed)

Study
Control

44
25

0.11
0.92

1.17
1.02

2.29

0.01

Study
Control

44
23

-0.23
0.04

1.06
0.81

1.01

0.15

»

Sural

41
Study
1.17
0.0001
-2.11
4.58
Control
20
-0.52
1.62
" Based upon Z values which represent the velocity expected on the basis of age subtracted from
the temperature corrected observed velocity, divided by the standard deviation. Nine subjects with
possibly significant previous exposure to neurotoxic agents were removed.

The multiple correlation coefficient was computed to be 0.52 (P < 0.002), which
exceeded the correlation of duration of employment and standardized sural NCV
(as described above, r = -0.40. P < 0.04). The t test for difference between
correlated r 's showed that the correlation coefficients differed significantly (/ =
2.08. P < 0.05). As expected, the model using unstandardized sural NCV pro­
vided better tit for these data. When comparing the relative contribution of age,
skin temperature, and duration of employment to the multiple correlation coef­
ficient. it was found that the variable contributing most to the correlation coeffi­
cient was duration of employment (accounting for 83% of the total sum of squares).
The partial correlation of sural NCV with duration of employment in this model
was essentially the same as that found when correlating standardized sural NCV
with duration of employment.
DISCUSSION

An increased prevalence of slowed nerve conduction velocities was found
among chemical workers exposed to the phenoxy herbicides 2,4,5-T and 2.4-D
and related contaminants (chlorinated dioxins). Conduction velocities of the me­
dian motor and sural sensory nerves were significantly slower in the study versus
the control group. Slowed sural sensory velocity was significantly correlated with
duration of employment.
The sural nerve seemed to be especially affected in this study. In other studies,
toxic susceptibility of neurons has been associated with increased fiber length and
smaller nerve diameter (Thomas, 1980). Since the center of neuron metabolism for
the sural nerve can reside over a meter from the axon site, and the fibers are few,
have smaller diameter, and less myeiination, the sural nerve may be especially
vulnerable to disruption of normal nervous tissue metabolism and function.
Other researchers have indicated the importance of assessing the sural nerve
response in studies of both alcohol toxicity and polyneuropathy of varied etiology.
Behse and Buchthal (1978) found, in a study of 167 patients with polyneuropathy

SINGER ET AL.
308
of varied etiology, that abnormal electrophysiologic responses were more fre­
quent in the sural nerve than in the median sensory. (Findings in the sural and
superficial peroneal were similar.) D’Amour et al. (1979) compared the NCV of
four motor and two sensory nerves with the sural NCV in alcoholic subjects, and
found that abnormalities of the sural nerve were most likely to be detected.
Although the dioxins are known to be highly toxic, the significant findings here
may also be due to 2,4-D exposure. This possibility is being investigated by
studies of another group of workers who had been exposed to 2,4,5-T (contami­
nated with dioxins) but not exposed to 2,4-D.
In addition to occupational exposure, important public health questions are
raised regarding environmental presence of these chemicals. Much public debate
and concern was evident among the citizens of Arkansas in response to the toxic
waste problem at the Jacksonville plant, while worldwide concern was stimulated
by the episode in Seveso, Italy. Early detection of adverse health effects can help
to provide guidance concerning implementation of preventive and control mea­
sures. Since slowed nerve conduction velocity can be an important early indicator
of toxic exposure, the study of the relationship of such signs of neurological im­
pairment to adverse effects in other body systems, either concomitant or delayed,
remains an important clinical and scientific endeavor.

APPENDIX A. EQUATIONS FOR TEMPERATURE AND AGE

VMMT = VMM x
VMST = VMS x (iff*-01* «
VSST = VSS x ( » »*"► «<»),
VMMP = 69.5 - (0.18 x age),
VMSP = 59.5 -(0.15 x age),
VSSP - 57.4 - (0.05 x age).
ZMM = (VMMT-VMMPV3.4,
ZMS = (VMST-VMSPV4.6.
ZSS = (VSST-VSSPV3.7,
where
VMMT = velocity median motor temperature adjusted.
VMST = velocity median sensory temperature adjusted.
VSST = velocity sural temperature adjusted.
VMM = velocity median motor observed.
VMS = velocity median sensory observed,
VSS = velocity sural observed.
VMMP = velocity median motor predicted on the basis of age,
VMSP = velocity median sensory predicted on the basts of age,
VSSP = velocity sural predicted on the basts of age.
ZMM = standardized median motor velocity, age and temperature adjusted.
ZMS = standardized median sensory velocity, age and temperature adjusted.
ZSS = standardized sural velocity, age and temperature adjusted.

309

NCV AND EXPOSURE TO PHENOXY HERBICIDE

APPENDIX B. MEAN NERVE CONDUCTION VELOCITIES (m/sec) OF STUDY
VERSUS CONTROL GROUPS

Age
34.3
32.8

Mean
Velocity
57.0
57.6

SD
3.26
5.20

t
0.56

Pa
0.29

Study
Control

N
53
25
54
23

34.4
37.2

47.8
46.8

5.36
4.47

0.81

0.21

Study
Control

50
20

34.0
40.1

40.3
42.8

3.48
4.90

2.05

0.02

Nerve
Median motor

Group
Study
Control

Median sensory
Sural4

“ One-tailed test.
* The controls are significantly older for the comparison of sural NCV.
ACKNOWLEDGMENTS

We wish to express our thanks to Robert Whipple, Albert Einstein College of Medicine. New York
City, for his most generous and expert guidance. We thank David Nicholson and Michael Moses for their
diligent assistance during the data collection phase. We also wish to thank the City University of New
York Computing Center and the Department of Biostatistics. Mount Sinai School of Medicine, for
their continuing support in computer operations. Funded in part by a NIEHS center grant (ES00928)
and by fellowship support from training grant S T32 ES07010-03.
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1978.

THEODOR D. STERLING, Ph.D.

I.

Qu al if ic a ti on s
Dr.

Studies

Sterling

is a Professor

and Department

Vancouver,

of

Co mputing

British Columbia,

Sterling

is pr esently

on

that

regard;

Computation;

Computers

advanced

II.

Matter

Subject
Dr.

Sterling

epi dem iologist;
existing

her bi ci d es
Dr.

and

Sterling

collection

and

Simon

Interdisc ip lin ar y

Fraser University,

His C u rr i c u lu m Vitae

sabbatical;
and

he teaches when
Public

is a mat he mat ic ian ,
Dr.

analyses

impurities,

has

of

Policy;

is attached.

active

in

Statistics;

topics.

as well,

data and

Faculty

Science,

Canada.

Dr.

and various

in the

Sterling

is

intimately

concerning

the

effects

e.g.,

devoted much

analysis

of

statistician,

familiar with
phenoxy

2 , 3 , 7 , 8-TCDD , co ntained therein.

of his

data

of

and

and

teaching
their

use

and

research to the

for

scientific

inference.

III.

Scientific Principles

See General Statement of Scientific Principles and Assumed Facts
attached.

IV.

Substance of Opinions

V.

Grounds for Each Opinion

1. Report of the National Academy of
Dr. Sterling will testify
Sciences Committee on 2,4,5-T,
to the Administrator of the Envir­
that there exists a considerable body of
onmental Protection Agency, May 7,
1971 (of which Dr. Sterling was
medical and scientific evidence which
a member).
demonstrates that the preparations
2. Summary of Evidence presented
of 2,4,5-T and 2,4,-D are toxic, terato­
to The Royal Commission Hearings
on Herbicides and Pesticides,
July 16, 1974.
genic and carcinogenic. That part of Dr.
A.

Sterling's testimony is based on the reviews

3.

Hearings of the Assembly Committee
on Natural Resources of the State
of Wisconsin, March 19, 1975.

4.

Hearings: Emergency Suspension
Order for 2,4,5-T and Silvex, FIFRA,
Docket 409-410, April 23, 1979.

5.

Submissions to Environmental Appeal
Board of British Columbia, Canada,
May 18 and July 20, 1982.

6.

Evaluation of Data Submitted by
Vietnamese Investigators in Inter­
national Group of Experts.

7.

Sterling, T. and Arundel, A.,
The Epidemiology of 2,4,5-T (from
1969 to the present)., Journal of
Northwest Coalition for Alternative
to Pesticides, (in print), April,
1984.

of the literature and critical evaluation
of data pertaining to the health effects
of 2,4,5-T and 2,4-D on animals and humans
and is contained in documents of which Dr.
Sterling is the sole or contributing
author.

B.

Further, there is no

1.

This is based on Dr. Sterling's
analysis of data in Kociba, R.J.,
et al., Toxicology and Applied
Pharmacology, 35, 553-574, 1976,
and Rose, J.Q., et al., Toxicology
and Applied Pharmacology, 36,
209-226, 1976.

2.

IARC. Monographs on the Evaluation
of the Carcinogenic Risk of
Chemical to Humans

3.

Nicholson, William J., 1976.
Occupational Carcinogenesis.
New York Academy of Sciences.
271: 152-169

1.

Tofilan, P.J., Piper, W.N. 1982
2,3,7,8-TCDD. Mediated Depression
of Rat Testicular Heme Synthesis
and Micromal Cytochrome P. 450
Biochem. Parmacol. 31: 3663-3666

2.

Constable, J., Hatch, M., Herbicide
Exposure and Reproductive Outcome.
In: Herbicides in War: The Long
Term Effects for Man and Nature,
A .W . Westing, ed. New York:
Taylor and Francis, 1984 (in press)

credible scientific evidence of a
no effect level; said another way,
as a carcinogen, there is no safe
level and therefore a single
exposure years ago may be respon­
sible for human cancer which develops
today.

C.

In addition, Dr.

Sterling will testify that there is
ample evidence that exposure to
2,4,5-T is teratogenic in humans when
the mother is exposed, and convincing
evidence is not extant that the out­
come of pregnancy is influenced by expo­
sure of the father alone.

1.

Besides review documents
1. Nguyen Thi, et al., International
Symposium on Herbicides and De­
listed above, additional evidence on
foliants in War, Ho Chi Minh City,
January 13-20, 1983.
teratogenic properties of 2,4,5-T for
2. Nguyen Can, et al., International
Symposium on Herbicides and De­
exposed mothers comes from two recent
foliants in War, Ho Chi Minh City,
studies from Vietnam and one from
January 13-20, 1983.
Italy:

3.

Bisanti, L., et al., Malformation
Registry, Department of Seveso,
Italv, June 28, 1982.

13638

2.

Evidence of birth de­

fects of children of fathers exposed to

1.

Ton Due Lant, et al. , Interna­
tional Symposium on Herbicides
and Defoliants in War, Ho Chi
Minh City, January 13-20, 1983.

2,4,5-T comes from:
Hguyen Can, et al., Internation;
Symposium on Herbicides and
Defoliants in War, Ho Chi Minh
City, January 13-20, 1983.
Report to the Ministers for
Veterans Affairs: Case-Control
Study of Congenital Anomalies an
Australian Publishing Service,
Canberra, January, 1983.

IV. D. and V. D.
Most especially, Dr. Sterling will testify of the incidence of
subjective symptoms and/or medical records documenting such symptoms.

These

symptoms are those which have been compiled by the National Center For
Health Statistics, and will be compared, to the extent available, to those
symptoms of the Vietnam veterans, particularly those of the représentatif
plaintiffs.

The purpose will be to ascertain the incidence of such symptoms

in the general population so as to analyze statitically the symptoms of the
plaintiffs.

The product of such overall incidence will be calculated to

examine the possibility or likelihood of such a constellation of Agent Orange/
dioxin related symptom complex to occur in a random fashion.

Statistical analysis

is based on data provided by Health Interview Survey of the National Center for
Health Statistics.

Tapes for the years 1969 through 1975 have been obtained by

Dr. Sterling from the National Center for Health Statistics.

The Health Interview

Survey is a probability sample of the U. S. population consisting of ongoing

interviews of approximately AO,000 families per year.

(so that Dr. Sterling's

analyses is based on interviews of approximately 240,000 U.S. families).

Dr.

Sterling's projection of the probability of various symptoms in the U. S.
population is based on the analysis of the HIS Data for the frequency with which
these certain symptoms have been observed, singly or in combination.
include:

The symptoms

lraphomas, soft tissue sarcomas, malignancy, various skin rashes,

chloracne, eye light sensitivity, orthopedic impairment, especially of joint and
of multiple sites, certain nervous symptoms memory lapse or temporary loss of memory,
headache (but not migraine), depression, insomnia and tremors.
Besides the review of data listed here, the bases or grounds for
the facts and opinions of Dr. Sterling's testimony are:

educational and professional

background; publications regarding the subject p’
nenoxy herbicides; review of the
applicable nedical and scientific literature; attendance and participation in
various symposia dealing with the scientific issues in question; training
as a mathematician, statistician, and epidemiologist; and training and experience
in the computer sciences.

FURTHER REFERENCES.

1.

TCDD is toxic, teratogenic and carcinogenic:

That part of Dr. Sterling's testimony is based on reviews of the
literature and critical evaluation of data pertaining to the health
effects of 2,4,5-T and 2,4-D on animals and humans and is contained
in documents of which Dr. Sterling the sole or contributing author:
1.

Report of the (National Academy of Sciences) Committee on 2,4,5-T
to the Administrator of the Environmental Protection Agency, May
7, 1971 (of which Dr. Sterling was a member).

2.

Summary of Evidence presented to The Royal Commission Hearings
on Herbicides and Pesticides, July 16, 1974.

3.

Hearings of the Assembly Committee on Natural Resources of
the State of Wisconsin, March 19, 1975.

4.

Hearings:

Emergency Suspension Orders for 2,4,5-T and Sylvex,

FIFRA Dockets 409 and 410, April 23, 1979.

5.

Submissions to Environmental Appeal Board in British Columbia,
Canada, May 18 and July 20, 1982.

6.

Evaluation of data submitted by Vietnamese investigators to
international group of experts.

7.

Sterling, T., and Arundel, A.,

The Epidemiology of 2,4,5-T

(From 1969.to the Present),

Journal of the Northwest Coalition for Alternatives to Pesticides,
in print, April, 1984.

2.

There is no known safe level nor is there "no effect" level:

This is based on Dr. Sterling's analysis of data in Kociba, R.J.,
et al, Toxicology and Applied Pharmacology, 35, 553-574, 1976, and
Rose, J. Q., et al, Toxicology and Applied Pharmacology, 36, 209226, 1976.

3.

TCDD is teratogenic:

Besides review documents listed above, additional evidence on
teratogenic property of 2,4,5-T for exposed mothers comes from
two recent studies from Vietnam and one from Italy:
1. Nguyen Thi, et al, International Symposium on Herbicides and
Defoliants in War, Ho Chi Minh City, January 13-20, 1983.

2. Nguyen Can, et al.

International Symposium on Herbicides

and Defoliants in War, Ho Chi Minh City, January 13-20,
1983.

3. Bisanti, L., et al.

Malformation Registry, Department of

Seveso, Italy, June.28, 1983.

Evidence of birth defects of children of fathers exposed to
2,4,5-T comes from:
1. Ton Due Lang, et al, International Symposium on Herbicides
and Defoliants in War, Ho Chi Minh City, January 13-20, 1983

2. Nguyen Can, et al, International Symposium on Herbicides
and Defoliants in War, Ho Chi Minh City, January 13-20, 1983

3. Report to the Minister for Veteran's Affairs: Case-control
study of congenital anomalies and Vietnam Service (Birth
Defects Study), Australian Publishing Service, Canberra,
January, 1983.

4.

Further sut^orf for the "constellation" or

ymptoms:

Statistical analysis is based on data provided by the Health Interview
Survey of the National Center for Health Statistics.

Tapes for the

years 1969 to 1975 have been obtained by Dr. Sterling from the National
Center for Health Statistics.

The Health Interview Survey is a

probability sample of the U.S. population consisting of ongoing
interview of approximately 40,000 families per year.

(So that Dr.

Sterling's analysis Is based on interviews of approximately 240,000
U.S. families.)

Dr. Sterling's projection of the probabilities of

various symptoms in the U.S. population is based on the analysis of
the HIS data for the frequency with which these certain symptoms have
been observed, singly or in combination.

The symptoms include:

lymphomas, sarcomas, malignancies, various skin rashes, chloracne,
eye light sensitivity, orthopedic impairment, especially of joints
and of multiple sites, certain nervousness symptoms, memory lapse
or temporary loss of memory, headaches (but not migraine), depression,
insomnia and tremors.

AGENT ORANGE TRIAL TESTIMONY /
DAY 9
'XO
MOYER V DOW
CO

f

p H• M
'¥■ A f i ,

' ,iY-

UNITED STATES DISTRICT COURT
EASTERN DI STRICT OF NE W YORK

In re

MDL No. 381
(All Cases)

¡1

"Agent

M A G I S T R A T E ’S
PRETRIAL OR DER
N o . 21

Orange"

li
Product

¡1

Li ability Litigation,

After
plaintiffs
; those
Court

receiving

and defendants,

proposals,
adopt

pr oposed voir

it is

and

dire

hearing

questionnaires
oral

argument

re sp ectfully re co mmended

the at tached

voir

dire

that

from

on
the

questionnaire.

^

//L

i./8hir a A . Sche ind lin
United States Magistrate

ii D a t e d

Brooklyn, New York
April 6, 1984

I
P -049

’I t "
il

r P f - M 4 9 -----( » 0 - 8 0 - 2 5 0 M - 3 5 6 3

INSTRUCTIONS

TO

VOIR

DIRE

QUESTIONNAIRE

The attached questionnaire

is to be filled out by you

| in order to assist

the Court and counsel

! task of selecting

!j

a jury in the

jj concerning "Agent

Orange,"

a product

ji the Vietnam War.

You are

to answer all of

j■iI

j: the best of your ability,

in the important.

trial of a lawsuit

without

that was used

help

during

the questions

to

from any other

!! person.
•

We are requesting this

information

from you only to

limited extent necessary to select a fair and

the

impartial jury

j in this litigation. Only the Court and counsel in this
i| litigation will know your identity.
.
.
After the questionnaire
|i

'i

;j has been reviewed,

you will be called back

to Court

for

■| further questioning.

ji

ji

The issues

in this

case will be fully explained to you

I by the Court at a latter date.

The case will

j

! deal of scientific,

medical

; need not be expert

in any of these

■i on this

Jj

and statistical
fields

involve a good

testimony.

You

in order to serve

jury.

The Court and counsel are aware

| certain beliefs

ii

Nonetheless

and prejudices

you should

answer

that

every person has

concerning many things.
the questionnaire with your

13647
P-Q49

y P I - M A R ------1. 3 0 - 8 0 - Z 5 Û M - 3 5 6 3

true

feelings,

whatever

any of your answers

i j serving on this jury.
!

you

can hear

may be.

will qualify
The

ii

j or not

those

the

Do not assume

you or disqualify

test

for being

evidence

fairly

a juror

and

that

you

from

is whether

impartially

and

j that de termina tion will be made by the Court and counsel

j;i! during jury selection.
Please
■j ability.

j!

j j question.

fully

answer

Take as much
The

q ue st io nna ir e

Court

each

question

time as

has

you need

approved

and requests

your

to

the

full

the

best

to answer

use

of your
each

of this

cooperation.

ii

!:
i|

13648

I.

QUESTIONS

ABOUT

YOU

AND

YOUR

FAMILY

1.

Your s e x
( ) m ale
( ) fem ale

2.

Y ear o f b i r t h :

3.

M arital s t a t u s
(
) sin g le
(
) m a r r ie d or p erm anent com panion
(
) d iv o rced or sep arated
(
) w id ow

4.

S ch ools ( la s t sch o o l)
(
) grade sch ool
(
) h igh sc h o o l grad u ate
(
) som e c o l l e g e
(
) c o lle g e graduate
(
) trade school
(
) graduate sch o o l

5.

Do y o u h a v e a d e g r e e i n
(
) sc ie n c e or en g in eerin g
(
) b u sin ess
(
) la w -rela ted f ie ld
(
) h ea lth -rela ted fie ld
(
) other

6.

H ave y o u e v e r t a k e n a n y c o u r s e s i n c h e m i s t r y ?
(
) yes
(
) no

i.

7.

Do y o u h a v e a n y c h i l d r e n ?
I f yes: l i s t ages for
fem ales:
,
,
,
,
m a les:
,
,
,
,

8.

What i s t h e c u r r e n t y e a r l y in c o m e o f y o u r h o u s e h o l d ?
(
) Up t o $ 1 5 , 0 0 0
(
) $15,001 - $24,000
(
) $24,001 - $ 39,000
(
) $ 3 9 ,0 0 1 or more.

9.

What i s y o u r p r e s e n t o c c u p a t i o n ? : _________________________

1 0 . Name o f e m p l o y e r : _______________________________ _
11. L is t your p r io r o c cu p a tio n s:

1 2 . What i s t h e o c c u p a t i o n o f y o u r s p o u s e ?

13. L is t th e o ccu p a tio n s o f a l l your c h ild r e n .
C h i l d #1 _________________________________________
C h i l d #2 _________________________________________
C h i l d #3 _________________________________________
C h i l d #4 _________________________________________
C h i l d #5 __________________________________________
O thers
1 4 . Have y o u e v e r w o r k e d f o r an y a g e n c y o f t h e F e d e r a l
g o v e r n m e n t i n an y c a p a c i t y o t h e r t h a n m i l i t a r y s e r v i c e ?
No (
)
I f y e s , what agency
______________________________________________

-2-

1 38 5 0

1 5 . Have y o u e v e r w o r k e d f o r an i n s u r a n c e com pany?
( ) no
( ) yes
If y es:
In

w hat c a p a c ity ?

1 6 . Have y o u e v e r d o n e a n y c l a i m s a d j u s t m e n t work f o r a n y
em ployer?
( ) yes
( ) no
1 7 . I f y o u a r e n o t e m p l o y e d o u t s i d e t h e hom e, a r e y o u :
I f s o , how l o n g ?
(
) a hom em aker
(
)a student
I f s o , how l o n g ?
I f s o , how l o n g ?
(
)retired
I f s o , how l o n g ?
(
) d isab led
I f s o , how l o n g ?
(
) s e e k i n g work
(
)other (sp ecify )
1 8 . What a r e y o u r h o b b i e s ?

1 9 . How many y e a r s h a v e y o u l i v e d a t y o u r p r e s e n t a d d r e s s ? _
2 0 . Do y o u r e n t o r own y o u r home?
( ) rent
( ) own
21. Is anybody in your fa m ily
— a m ed ical doctor?
(
) yes
(
) no
- - in law en fo rcem en t?
(
) yes

‘

’ no

1 3
-

3 -

651

t
— a nurse or o th er h e a lth atten d an t?
(
) yes
(
) no
- - a law yer or em p loyee o f a law firm ?
(
) yes
(
) no
2 2 . Have y o u o r y o u r s p o u s e o r c o m p a n i o n e v e r r e c e i v e d
v e t e r a n s d i s a b i l i t y c o m p e n s a tio n paym ents from th e
governm ent?
(
) n o t t o my k n o w l e d g e
(
) y es, for p a r tia l d is a b ilit y
(
) y es, for to ta l d is a b ilit y
2 3 . Have y o u o r y o u r s p o u s e o r c o m p a n i o n e v e r b e e n d e n i e d
v e te r a n s d i s a b i l i t y com p en sation paym ents, to your
know ledge?
(
) yes
(
) no
2 4 . Have a n y o f y o u r c h i l d r e n o r t h e i r s p o u s e s o r c o m p a n i o n s
e v e r r e c e i v e d v e t e r a n s d i s a b i l i t y c o m p en sa tio n paym ents
fr o m t h e g o v e r n m e n t ?
(
) n o t t o my k n o w l e d g e
(
) y es, for p a r tia l d is a b ility
(
) y es, for to ta l d is a b ilit y
2 5 . Have a n y o f y o u r c h i l d r e n o r t h e i r s p o u s e s o r c o m p a n i o n s
ever been d en ied v e te r a n s d i s a b i l i t y com p en satiion
p aym ents, t o your know ledge?
(
) yes
(
) no

-4-

13652

II.

QUESTIONS

ABOUT

SERVICE

IN

THE ARMED

FORCES

1.

Have y o u e v e r s e r v e d i n t h e arm ed f o r c e s ?
( ) yes
( ) no
If yes :
a) In what branch
( ) Army
( ) Navy
( ) A ir F orce
( ) M arines
( ) C o a s t Guard
( ) N a t i o n a l G uard
( ) R eservist
( ) O ther
b ) D u r i n g w h i c h y e a r s : 19 __ t o 19 __
c ) What was y o u r r a n k _____________________________
d) D i d y o u s e r v e i n :
(
) W orld War I I
(
) Korea
(
) V ietnam
e ) H ave y o u s u f f e r e d a n y i l l e f f e c t s fr o m
your m ilita r y se r v ic e ?
(
) yes
(
) no
f) I f y e s , what i l l e f f e c t s ?

2

D id any f a m i l y mem bers, c l o s e f r i e n d s , o r r e l a t i v e s e v e r
s e r v e i n t h e arm ed f o r c e s ?
( ) yes
( ) no
If yes:
a ) D i d a n y o f th e m e v e r s e r v e i n
(
) W orld War I I
(
) Korea
(
)V i e t n a m
-5-

b)

If

D id

any o f

fro m

th e ir

th e m s u f f e r
m ilita ry

(

) yes

(

) no

any

i l l

e ffe c ts

s e rv ic e ?

yes:
a)

What i l l

e ffe c ts

w ere

s u ffe re d ?

b)

P lease s ta te th a t p erso n 's r e la tio n s h ip
t o y o u ______________________________________________

3.

Have y o u , o r y o u r s p o u s e o r c o m p a n i o n , o r a r e l a t i v e , o r
c l o s e f r ie n d ev er been in a V etera n s H o sp ita l?
(
) yes
(
) no
If yes:
P lea se s ta te th a t p erso n 's r e la tio n s h ip to
y o u ________________________________________________________

4.

Have y o u , y o u r s p o u s e o r c o m p a n i o n o r a n o t h e r member o f
y o u r f a m i l y e v e r b e e n a member o f o n e o f t h e f o l l o w i n g
v e te r a n s org a n iza tio n s? ..
(
) yes
(
) no
I f y e s , c h eck w hich o n e s:
(
) A m e r ic a n L e g i o n
(
) V e t e r a n s o f F o r e i g n Wars
(
) A m v e ts
(
) D i s a b l e d A m erican V e te r a n s
(
) V ietnam V e te r a n s o f A m erica
(
) O t h e r ( f i l l i n ):

5.

Has

anyone

in ju re d ,

or

c lo s e

to

s u ffe re d

you b een

k ille d

a s e rio u s

or

d is e a s e

s e rio u s ly
d u rin g

m ilita ry

s e rv ic e ?

(
(
-6-

) yes
) no

13654

If yes:
(
(
(

)K illed
) S e r io u sly in ju red
) S eriou s d is e a s e

(
(
(
(

) V ietnam
) Korea
) W orld War I I
) O ther ( f i l l i n ) :

Where?

6.

Do y o u b e l i e v e t h a t t h e g o v e r n m e n t b e n e f i t s made
a v a i l a b l e to V ietnam v e t e r a n s a r e :
(
) t o o low
(
) to o h igh
(
) about r ig h t
(
) don 11 know

I I I . QUESTIONS ABOUT CONTACT WITH CHEMICALS
1.

Have y o u , y o u r s p o u s e o r c o m p a n i o n , e v e r h a d a j o b
w orking in c o n t a c t w ith c h e m ic a ls ?
(
) yes
(
) no
If yes:
a ) Has a n y o f them s u f f e r e d a n y i l l
e f f e c t s fr o m t h e s e c h e m i c a l s ?
(
) yes
(
) no
If yes:
What i l l e f f e c t s ?

2.

Do y o u h a v e a n y c l o s e f r i e n d s o r r e l a t i v e s who h a v e e v e r
had a j o b w o r k i n g i n c o n t a c t w i t h c h e m i c a l s ?
( ) yes
( > no
13655
-7-

If yes:
a ) Has an y o f th e m s u f f e r e d an y i l l e f f e c t s
fr o m t h e s e c h e m i c a l s , t o y o u r k n o w l e d g e ?
( ) yes
( ) no
I f y e s : What i l l e f f e c t s ?

3.

Have y o u , y o u r s p o u s e o r c o m p a n i o n , o r o n e o f y o u r
c h i l d r e n , r e l a t i v e s or c l o s e f r i e n d s e v e r worked f o r any
c h e m i c a l com pany?
( ) yes
( ) no
I f y e s , w hich one?

4.

H ave y o u h a d an y p e r s o n a l e x p e r i e n c e w i t h p e s t i c i d e s o r
o th e r c h e m ic a ls in th e c o u r se o f farm ing, g a r d e n in g ,
t e n d i n g t h e l a w n s o r some l i k e a c t i v i t y ?
( ) none
( ) a little
(
) som e
(
)q u ite a lo t

5.

To y o u r k n o w l e d g e , h a v e y o u o r a n y member o f y o u r f a m i l y
e v e r p u r c h a s e d o r u s e d a n y c h e m i c a l m a n u f a c t u r e d by t h e
d e f e n d a n t c h e m i c a l c o m p a n i e s l i s t e d on t h e n e x t p a g e ?
(
)yes
(
) no

-8-

I f y e s , p l e a s e ch eck t h o s e com panies whose
c h e m ic a ls you have p urchased or u se d .
(
) Dow
(
) M o n sa n to
(
) H ercules
( ) T-H A g r i c u l t u r e
( ) D iam ond S h am rock
(
) U niroyal
(
) Thompson C h e m i c a l
6.

H ave y o u o r an y member o f y o u r f a m i l y e v e r ow n ed o r w o r k e d
f o r a com pany w h i c h m a n u f a c t u r e s o r s e l l s h e r b i c i d e s
( p l a n t an d w e e d k i l l e r s ) ?
(
) yes
(
) no
I f y e s , p l e a s e name t h a t com pany:

7.

Do y o u b e l i e v e y o u h a v e e v e r b e e n e x p o s e d t o A g e n t O r a n g e ,
a h e r b i c i d e s p r a y e d by t h e A m e r ic a n m i l i t a r y i n V ie t n a m ?
( ) yes
( ) no

8.

Do y o u know a n y o n e who b e l i e v e s h e o r s h e h a s e v e r b e e n
e x p o s e d t o A gent Orange?
(
) yes
(
) no
I f y e s , i s h e o r s h e a:
(
) s p o u s e or com panion?
(
) ch ild ?
(
) clo se rela tiv e?
(
) c lo s e frien d ?
(
) acq u ain tan ce?

9.

Have y o u a n y v i e w s a b o u t t h e u s e o f A g e n t O r a n g e ?
( ) yes
( ) no
-9-

13Ot 0 0

3

.0

•1

I f y e s , what are th o se view s?

1 0 . Do any o f y o u r c l o s e f r i e n d s o r f a m i l y h a v e a n y v i e w s
c o n c e r n in g t h e u s e o f A gen t Orange?
( ) yes
( ) no
I f y e s , what are th o se view s?

11. I f you have answ ered y e s to th e p r e v io u s q u e s t io n , w i l l
th e v iew s o f th o s e f r ie n d s an d /or r e l a t i v e s a f f e c t your
v ie w s a b o u t th e u s e o f Agent Orange?
(
)yes
(
) no
12. W ill your view s or th o se o f fa m ily or fr ie n d s a f f e c t your
a b i l i t y t o be f a i r and im p a r t ia l in d e c id in g th e i s s u e s
in t h i s ca se?
(
)yes
(
) no
IV.

QUESTIONS ABOUT CHEMICAL CORPORATIONS AND BIG CORPORATIONS IN 1*
GENERAL
1.

How do y o u f e e l g e n e r a l l y a b o u t b i g c o r p o r a t i o n s ?
(
) I l i k e th em
(
) I do n o t l i k e th e m
(
) I h a v e no s t r o n g f e e l i n g s
o n e way o r t h e o t h e r

-10-

1365S

<c

2.

How do y o u f e e l a b o u t c o r p o r a t i o n s i n t h e c h e m i c a l
in d u stry?
(
) I l i k e th em
(
) I do n o t l i k e th e m
(
) I h a v e no s t r o n g f e e l i n g s
o n e way o r t h e o t h e r

3.

W ould y o u r f e e l i n g s a b o u t b i g c o r p o r a t i o n s a f f e c t y o u r
a b i l i t y t o b e f a i r a n d i m p a r t i a l i n d e c i d i n g t h e i s s u e s in.
th is case?
(
) yes
(
) no

4.

Do y o u own any s t o c k s , b o n d s o r o t h e r s e c u r i t i e s ?
(
) yes
(
) no
If yes:
(
) I own j u s t a f e w .
(
) I own m a n y .
(
) I own some b u t w o u l d s a y I
f a l l so m e w h e r e i n b e t w e e n
t h e f i r s t tw o a n s w e r s .

5.

A re y o u a s h a r e h o l d e r o r s t o c k h o l d e r i n a n y c h e m i c a l
com panies?
(
) yes
(
) no

6.

A re y o u a s h a r e h o l d e r o r s t o c k h o l d e r i n an i n s u r a n c e
c o m p an y?
(
) yes
(
) no

7.

Do y o u own s t o c k i n o r h a v e y o u w o r k e d f o r a n y com pany
w hich t o your know ledge d oes b u s in e s s w ith th e U n ite d
S t a t e s governm ent?
( ) yes
( ) no
-11-

fs

8.

V.

D o e s an y member o f y o u r f a m i l y own s t o c k i n , o r b e e n
e m p l o y e d b y , an y com p an y w h i c h t o y o u r k n o w l e d g e d o e s
b u s in e s s w ith th e U n ite d S t a t e s governm ent?

QUESTIONS ABOUT YOUR HEALTH
1.

Would y o u s a y y o u r h e a l t h ( c o n s i d e r i n g y o u r a g e , e t c . )
is
) ex cellen t
) o .k .
) n ot to o good

2.

I f y o u h a v e e x p e r i e n c e d an y o f t h e i l l n e s s e s o r sym ptom s
on t h e a t t a c h e d l i s t p l e a s e p l a c e an "X" t h r o u g h t h a t
illn ess :
C loracn e; p o rp h y ria cu ta n e a ta rd a ; h y p erp ig m en ta tio n ;
h y p e r k e r a t o s is ; h i r s u t i s m ; a s t h e n i a ; w eak n ess in low er
ex trem ities; lo ss of strength; easy fa tig a b ility ;
f a t ig u e ; head ach es; p e r ip h e r a l neuropathy;
p olyn eu rop ath y; in to le r a n c e to c o ld ; o th er n e u r o lo g ic a l
d e f i c i t s ; i r r i t a t i o n t o e y e s ; im pairm ent o f s i g h t ;
im pairm ent o f h e a r in g ; im p airm en t o f s m e ll; im p airm en t o f
t a s t e ; lo s s o f w eigh t; lo s s o f a p p e tite ; a n o rex ia ; lo s s
of sexu al d rive; sle e p d istu rb a n ces; o r th o s ta tic
h y p o te n s io n ; abdom inal p a in ; n a u sea ; v o m itin g ; d ia r r h e a ;
oth er g a s t r o in t e s t in a l d iso r d e r s; n eu rasth en ia;
d ep ressio n ; v io le n t b eh avior; o th er p sy ch o b eh a v io ra l
d is o r d e r s ; m yocard ial in f a r c t io n ; a t h e r o s c le r o s is ; o th er
c a r d i o v a s c u l a r d i s o r d e r s ; l i v e r d am age; p a n c r e a t i c
d y s fu n c tio n ; kid n ey d is o r d e r s ; u r in a r y t r a c t d is o r d e r s ;

-12-

pulm onary p a t h o l o g i e s ; o t h e r r e s p i r a t o r y d i s o r d e r s ; f a t
m etab olism d is o r d e r s ; ca rb oh yd rate m etab olism d is o r d e r s ;
c h o la n g io c a r c in o m a ; o th e r l i v e r ca n cers; k id n ey can cer;
b la d d e r c a n c e r ; p a n c r e a t i c c a n c e r ; c o lo n c a n c e r ; stom ach
ca n cer; o th e r g a s t r o i n t e s t i n a l c a n c e r s; lu n g ca n cer;
fib r o sa r c o m a ; leiom yosarcom a; lip o sa r c o m a ;
rhabom yosarcom a; m y o fib ro sa rco m a ; n eu ro fib ro sa rco m a ;
f ib r o u s h is t io c y t o m a ; r e t r o p e r i t o n e a l n e u r o g e n ic sarcom a;
fib ero sa rco m a to u s m esotheliom a; o th e r s o f t - t i s s u e
sarcom as; leu k em ia; an giosarcom a; o th e r b lo o d c a n c e r s ;
h e p a t o m a ; lym phom a; sq u am ou s c e l l c a r c i n o m a o f s k i n ;
oth er sk in ca n cers; th y ro id cancer; oth er glan d u lar
ca n cers; ca n cer o f tongue; can cer o f hard p a la t e ; o th er
c a n c e r s o f m o u th ; c h r o n i c l y m p h o c y t i c l e u k e m i a , v a r i o u s
b r a in c a n c e r s; isc h e m ic h e a r t d is e a s e ; lu n g f i b r o s i s ;
l o s s o f body w e ig h t; l o s s o f lym phoid t i s s u e ; l o s s o f
th y m u s t i s s u e ; s e n s i t i v i t y t o i n f e c t i o n s ; immune s y s t e m
d istu r b a n ce s; b rain cancer; m u ltip le s c l e r o s i s ;
t e s t i c u l a r c a n c e r ; DNA d i s t u r b a n c e s ; RNA d i s t u r b a n c e s ;
s k i n e r u p t i o n s and c y s t s ; s l o w i n g o f n e r v e i m p u l s e s ;
h y p e r te n sio n ; e le v a t e d b lood l i p i d l e v e l s ; e le v a t e d
c h o l e s t e r o l l e v e l s ; p r e d i a b e t i c and d i a b e t i c s t a t e s ;
abnormal c e l l p r o l i f e r a t i o n s ; organ e n la r g e m e n ts;
c e l l u l a r atrophy; d ecreased c e l l p r o lif e r a t io n ; b ir th
d e f e c t s in o f f s p r in g ; m is c a r r ia g e s ; in c r e a s e d w h ite blood
c e l l c o u n t s ; e l e v a t i o n o f e o s i n o p h i l ; d e c r e a s e i n IgM and
IgD ; d e c r e a s e i n B - c e l l and T - c e l l c a p a b i l i t i e s ; s k i n
r a sh ; s c a lp tum ors; a c h in g m u s c le s ; b le p h a r o ­
c o n j u n c t i v i t i s ; p o r p h y r ia ; untow ard p reg n a n cy ou tco m es,
in c lu d in g b ir th d e f e c t s or m a lfo rm a tio n s, m is c a r r ia g e s ,
s p o n a n e o u s a b o r t i o n s , and s t i l l b i r t h s ; i n t o l e r a n c e t o
a lco h o l; in s e n s it iv it y to lig h t , i . e . p h o to s e n s itiv ity ;
m u sc le spasm ; j o i n t p a in ; m u sc le p a in ; e a r i n f e c t i o n s ;
b a s a l c e l l c a r c i n o m a ; m a l i g n a n t lym phom a; n i g h t s w e a t i n g ;
memory l o s s ; r e c t a l b l e e d i n g ; e p i l e p t i c s e i z u r e s ;
b l a c k - o u t s ; o t h e r s k i n p r o b l e m s ; m i g r a i n e h e a d a c h e s,-:
b lu rred v is io n ; a u to to n ic neuropathy.

3.

Do a n y o f t h e c o n d i t i o n s w h i c h y o u c h e c k e d o f f a b o v e
p r e v e n t y o u fr o m f u n c t i o n i n g n o r m a l l y i n d a y t o d a y l i f e
now?
( ) yes
( ) no

4.

I f your s p o u s e , com p an ion , c l o s e r e l a t i v e o r c l o s e f r i e n d
h a s e x p e r i e n c e d a n y o f t h e i l l n e s s e s o r sym p tom s on t h e
a t t a c h e d l i s t , p l e a s e p l a c e an "X" t h r o u g h t h a t i l l n e s s :
C loracn e; p orp h yria cu ta n ea tard a; h y p erp igm en tation ;
h y p e r k e r a t o s is ; h ir s u t is m ; a s t h e n ia ; w eakness in low er
e x tr e m itie s; lo s s of stren gth ; easy f a t ig a b ilit y ;
f a t ig u e ; h ead ach es; p e r ip h e r a l neuropathy;
p olyn eu rop ath y; in t o le r a n c e to c o ld ; o th er n e u r o lo g ic a l
d e f i c i t s ; i r r i t a t i o n t o e y e s ; im pairm ent o f s i g h t ;
im pairm ent o f h e a r in g ; im pairm ent o f s m e ll; im p airm en t o f
t a s t e ; lo s s of w eigh t; lo s s of a p p e tite ; an orexia; lo s s
of sexu al d riv e; s le e p d istu rb a n ces; o r th o s ta tic
h y p o t e n s io n ; abdom inal p a in ; n a u sea ; v o m it in g ; d ia r r h e a ;
oth er g a s t r o in t e s t in a l d iso rd ers; n eu rasth en ia;
d ep ressio n ; v io le n t b eh avior; o th er p sych ob eh avioral
d is o r d e r s ; m yocard ial in f a r c t io n ; a t h e r o s c le r o s is ; o th er
c a r d i o v a s c u l a r d i s o r d e r s ; l i v e r dam age; p a n c r e a t i c
d y s fu n c tio n ; k id n ey d is o r d e r s ; u r in a r y t r a c t d is o r d e r s ;
pulm onary p a t h o l o g i e s ; o t h e r r e s p i r a t o r y d i s o r d e r s ; f a t
m etab olism d is o r d e r s ; carb oh yd rate m etab olism d is o r d e r s ;
c h o la n g io c a r c in o m a ; o th e r l i v e r ca n cers; kid n ey can cer;
b la d d e r c a n c e r ; p a n c r e a t i c c a n c e r ; c o lo n c a n c e r ; stom ach
ca n c e r ; o th e r g a s t r o i n t e s t i n a l c a n c e r s; lu n g c a n cer;
fib ro sa rco m a ; leiom yosarcom a; lip o sa rco m a ;
rhabom yosarcom a; m yofib rosarcom a; n eu ro fib ro sa rco m a ;
f ib r o u s h is tio c y to m a ; r e t r o p e r it o n e a l n e u r o g e n ic sarcom a;
fib ero sa rco m a to u s m esoth eliom a; o th er s o f t - t i s s u e

-14-

13662

sarcom as; leu k em ia ; angiosarcom a; o th e r b lo o d c a n c e r s;
h e p a t o m a ; lym phom a; sq u a m o u s c e l l c a r c i n o m a o f s k i n ;
oth er sk in ca n cers; th y ro id cancer; oth er glan d u lar
ca n c e r s; ca n cer o f ton gu e; can cer o f hard p a la t e ; oth er
c a n c e r s o f m o u th ; c h r o n i c l y m p h o c y t i c l e u k e m i a , v a r i o u s
b r a in c a n c e r s ; is c h e m ic h e a r t d is e a s e ; lu n g f i b r o s i s ;
l o s s o f body w e ig h t; l o s s o f lym phoid t i s s u e ; l o s s o f
th y m u s t i s s u e ; s e n s i t i v i t y t o i n f e c t i o n s ; immune s y s t e m
d istu rb a n ces; b rain cancer; m u ltip le s c le r o s is ;
t e s t i c u l a r c a n c e r ; DNA d i s t u r b a n c e s ; RNA d i s t u r b a n c e s ;
s k i n e r u p t i o n s an d c y s t s ; s l o w i n g o f n e r v e i m p u l s e s ;
h y p e r te n sio n ; e le v a t e d blood l i p i d l e v e l s ; e le v a t e d
c h o l e s t e r o l l e v e l s ; p r e d i a b e t i c an d d i a b e t i c s t a t e s ;
abnormal c e l l p r o l i f e r a t i o n s ; organ en la r g e m e n ts;
c e l l u l a r atrophy; d ecreased c e l l p r o lif e r a t io n ; b ir th
d e f e c t s in o f f s p r in g ; m is c a r r ia g e s ; in c r e a s e d w h ite b lood
c e l l c o u n t s ; e l e v a t i o n o f e o s i n o p h i l ; d e c r e a s e i n IgM and
IgD ; d e c r e a s e i n B - c e l l and T - c e l l c a p a b i l i t i e s ; s k i n
rash ; s c a lp tum ors; a ch in g m u sc le s; b le p h a r o ­
c o n j u n c t i v i t i s ; p o r p h y r ia ; untow ard p reg n a n cy o u tco m es,
in c lu d in g b ir th d e f e c t s or m alform ation s, m is c a r r ia g e s ,
s p o n a n e o u s a b o r t i o n s , and s t i l l b i r t h s ; i n t o l e r a n c e t o
alcoh ol; in s e n s it iv it y to lig h t, i . e . p h o to se n sitiv ity ;
m u sc le spasm ; j o i n t p a in ; m u sc le p a in ; e a r i n f e c t i o n s ;
b a s a l c e l l c a r c i n o m a ; m a l i g n a n t lym phom a; n i g h t s w e a t i n g ;
memory l o s s ; r e c t a l b l e e d i n g ; e p i l e p t i c s e i z u r e s ;
b la c k - o u t s ; o th e r s k in problem s; m ig r a in e h ea d a ch es;
b lu rred v is io n ; a u to to n ic neuropathy.
5.

Do a n y o f t h e c o n d i t i o n s w h i c h y o u c h e c k e d o f f a b o v e
p r e v e n t y o u r s p o u s e , com panion, c l o s e f r i e n d or c l o s e
r e l a t i v e f r o m f u n c t i o n i n g i n day t o d a y l i f e now?
( ) yes
( ) no

-15-

«

6.

Are y o u s e n s i t i v e t o c h e m i c a l s ?
(
) yes
(
) no
(
) I d o n ' t know

7.

Are y o u s e n s i t i v e t o d u s t and o t h e r t h i n g s i n t h e a i r ?
(
) yes
(
) no
(
) I d o n ' t know

8.

Do y o u h a v e any a l l e r g i e s ?
(
) yes
(
) no
a)
I f y e s , w h a t sym ptom s do y o u
suffer?

9.

Do y o u sm oke?
(
(
(

V I.

) no
) so m e w h a t
)h eavily

QUESTIONS ABOUT THIS CASE
1.

Many p e o p l e a r e s y m p a t h e t i c t o p e o p l e who h a v e i n j u r i e s o r
a r e d i s a b l e d . How i m p o r t a n t w o u l d s u c h s y m p a t h y b e t o t h e
way y o u w o u l d w e i g h t h e e v i d e n c e and d e c i d e a s a j u r o r i n
th is case?
(
) E xtrem ely
(
) Very
(
) Som ew hat
(
) Not to o
(
) Not a t a l l

13664

-16-

2.

I f th e Judge i n s t r u c t s you t h a t sym pathy s h o u ld n o t a f f e c t
your v e r d i c t , c o u ld you f o llo w such d i r e c t i o n s ?
( ) yes
( ) no

3.

A ssum e t h e r e a r e b a d l y i n j u r e d p e o p l e i n c l u d i n g c h i l d r e n
who t e s t i f y i n t h i s c a s e . I f t h e e v i d e n c e s h o w s t h a t t h e y ,
p l a i n t i f f s , a r e n o t e n t i t l e d t o a r e c o v e r y , w o u l d y o u be
a b le to render a v e r d ic t a g a in st the p l a i n t i f f s ?
(
) yes
(
) no
(
) I d o n ' t know

4.

I f th e e v id e n c e shows t h a t d e f e n d a n t s , c h e m ic a l co m p a n ies,
a r e a t f a u l t f o r p l a i n t i f f s ' i n j u r i e s , w ould you be a b le t o
render a v e r d ic t a g a in st defendants?
( ) yes
( ) no
(
) I d o n ' t know

5.

P l a i n t i f f s a r e m a k in g c l a i m s f o r m oney d a m a g e s i n t h i s
c a s e . Do y o u h a v e a n y f e e l i n g s a b o u t p e o p l e m a k in g c l a i m s
f o r m oney d a m a g e s ?
( ) yes
( ) no

6.

P l a i n t i f f s c l a i m t h e d e f e n d a n t s h a v e c a u s e d th e m s e r i o u s
i n j u r i e s . I f you f i n d in f a v o r o f t h e p l a i n t i f f s , w ould
y o u h a v e a n y h e s i t a t i o n i n a w a r d i n g t h e p l a i n t i f f s money
d a m a g e s , e v e n i f s u c h sum o f m oney was v e r y l a r g e ?
( ) yes
( ) no

7.

Do y o u r e a d a n y n e w s p a p e r s on a r e g u l a r b a s i s ?
( ) yes
( ) no
e ft
-17-

I f y e s , which newspapers?

8.

Do y o u r e a d an y m a g a z i n e s on a r e g u l a r b a s i s ?
( ) yes
( ) no
I f y e s , which m agazines?

9.

How o f t e n do y o u w a t c h TV ne ws and news d o c u m e n t a r i e s ?
(
) never
(
)rarely
(
)fa ir ly regularly
(
)very frequently

1 0 . A b o u t how many n e w s p a p e r , TV o r r a d i o s t o r i e s h a v e y o u
s e e n o r h e a r d t h a t d i s c u s s e d A g e n t O ra ng e ?
(
) none
(

)one or two

(
(

) 3 t o 10
) more t h a n 10

1 1 . Have y o u s e e n a m o v i e o r TV sh o w w i t h i n t h e p a s t tw o o r
t h r e e y e a r s t h a t rem inds you o f or i s s i m i l a r t o i s s u e s
c o n c e r n i n g th e u s e o f Agent Orange?
(
) yes
(
) no
I f y e s , w h i c h m o v i e s o r TV s h o w s ?

-18-

13666

12.

Would a n y t h i n g y o u h a v e r e a d o r s e e n c o n c e r n i n g A g e n t
O r a ng e a f f e c t y o u r a b i l i t y t o f a i r l y d e c i d e t h i s c a s e ?
( ) no
( ) y e s ( p l e a s e s t a t e how)

13. L i s t a l l t h e o r g a n i z a t i o n s you have b e lo n g e d t o in t h e l a s t
20 y e a r s o f a c i v i c , p o l i t i c a l , s o c i a l o r f r a t e r n a l t y p e :

V I I . QUESTIONS ABOUT YOUR EXPERIENCE WITH THE LAW
1.

Have y o u e v e r b e e n a j u r o r b e f o r e i n a t r i a l ?
( ) yes
(
) no
If yes:
a) In a b o u t how many c r i m i n a l t r i a l s ? # ____
In a b o u t how many c i v i l t r i a l s ?
#____
I f yo u w e r e a j u r o r i n a c i v i l t r i a l , w h a t
was t h e m o s t r e c e n t o n e a b o u t ?

Did th e jury d e l i b e r a t e ?
( ) yes
( ) no

136G7
-19-

I f yes, did i t reach a v erd ict?
( ) yes
( ) no
I f you were a ju r o r in a c i v i l t r i a l b e f o r e
t h e o n e j u s t d e s c r i b e d , w h a t was t h a t
e a r l i e r c a se about?

b)

Did th e ju ry d e l i b e r a t e ?
(
) yes
(
) no
If y es, did i t reach a v e r d ic t?
(
) yes
(
) no
I f you were a ju r o r in c r im in a l t r i a l s , what
were th ey about?

Did th e ju ry d e l i b e r a t e ?
( ) yes
( ) no
If y e s, did i t reach a v e r d ic t?
( ) yes
( ) no
Have y o u o r a n o t h e r member o f y o u r f a m i l y e v e r s u e d
so m e b o d y f o r money i n a c o u r t ?
( ) yes
( ) no
If yes:
a)
What was i t a b o u t ?

- 2 0 -

1 36 6 8

3.

4.

b)

How

did

the

case

end?

c)

Would t h a t o u t c o m e a f f e c t y o u r a b i l i t y
t o b e a f a i r and i m p a r t i a l j u r o r i n
th is case?
(
)yes
(
) no

Have y o u o r a n o t h e r member o f y o u r f a m i l y e v e r b e e n s u e d
by so m e b o d y ?
(
)yes
(
) no
If yes:
a) What a b o u t ?
b)

How d i d t h e c a s e o r c a s e s e n d ?

c)

Would t h a t o u t c o m e a f f e c t y o u r a b i l i t y
t o b e a f a i r an d i m p a r t i a l j u r o r i n
th is case?
(
) yes
(
) no

Have y o u o r a n o t h e r member o f y o u r f a m i l y e v e r made a
c la im a g a i n s t someone f o r a p e r s o n a l i n j u r y , ev en though
no l a w s u i t was b r o u g h t ?
(
) yes
(
) no
If yes:
a) What a b o u t ?

- 2 1 -

b)

What

was

the

outcome?

c)

5.

Would t h a t o u t c o m e a f f e c t y o u r a b i l i t y
t o b e a f a i r an d i m p a r t i a l j u r o r i n
th is case?
(
) yes
(
) no
Have y o u e v e r b e e n a w i t n e s s a t t r i a l ?
(
) yes
(
) no
If yes, p lease describe:

6.

Do y o u f e e l t h a t y o u know a g r e a t d e a l a b o u t t h e l a w ?
(
) no
(
) a b o u t some p a r t s o f i t
(
) yes

7.

Would y o u f u l l y d i s c u s s t h e c a s e w i t h y o u r f e l l o w j u r o r s
d u rin g ju ry d e l i b e r a t i o n which o ccu rs a t th e end o f th e
case?
(
) yes
(
) no

8.

Would y o u b e w i l l i n g t o c h a n g e y o u r mind i f y o u w e r e
c o n v i n c e d t o do s o a s a r e s u l t o f d i s c u s s i o n s w i t h y o u r
fello w jurors?
(
) yes
(
) no

9.

Would y o u b e w i l l i n g t o s t i c k w i t h y o u r v i e w s i f y o u w e r e
n o t c o n v i n c e d t o c h a n g e the m a f t e r d i s c u s s i o n w i t h y o u r
fello w jurors?

( )Yes
(

- 2 2 -

) no

13670

■*

V

9r

1 0 . How i m p o r t a n t t o y o u a r e f a c t s when y o u d e c i d e s o m e t h i n g ?
(
) extrem ely
(
) very
(
) so m e w ha t
(
) not too
(
) not at a ll
1 1 . How i m p o r t a n t a r e h u n c h e s when y o u d e c i d e s o m e t h i n g ?
(
) extrem ely
(
) very
(
) s om e w h at
(
) not too
(
) not at a ll
1 2 . When s o m e o n e i s s e r i o u s l y i n j u r e d , do y o u b e l i e v e h e o r
s h e s h o u l d be c o m p e n s a t e d r e g a r d l e s s o f w h a t t h e e v i d e n c e
shows?
(
) yes
(
) no
1 3 . T h e r e a r e d i f f e r e n c e s o f o p i n i o n c o n c e r n i n g t h e amo unt o f
environm ental r e g u la t io n th e government sh ou ld i n s i s t on.
Would y o u s a y
(
) t h e r e a r e a l r e a d y t o o many
regulations
(
) t h e amount i s a b o u t r i g h t
(
) t h e r e s h o u l d b e more
(
) no o p i n i o n
1 4 . Have y o u h e a r d o t h e r s i n y o u r f a m i l y o r among y o u r
f r i e n d s and a c q u a i n t a n c e s e x p r e s s an o p i n i o n a s t o t h e
m erits of th is case?

- 23-

13671

1 9 . T h e r e w i l l b e t e s t i m o n y i n t h i s c a s e on c o m p l e x m e d i c a l
q u e s t i o n s w i t h many t e c h n i c a l w o r d s and t e r m s y o u h a v e
p r o b a b ly n ever h eard o f . T h eir meaning w i l l be e x p l a i n e d
t o y o u a t t r i a l . Do yo u f e e l t h i s w o u l d a f f e c t y o u r
a b i l i t y t o be a ju r o r in t h i s c a s e ?
(
)yes
(
) no
2 0 . Do y o u , a c o m p a n i o n , a n y o n e i n y o u r f a m i l y o r an y c l o s e
f r i e n d h a v e any f e e l i n g s a b o u t c h e m i c a l c o m p a n i e s t h a t
would p r e v e n t you from h e a r in g th e e v i d e n c e in t h i s c a s e
im partially?
(
) yes
(
) no
If yes, describe these fe e lin g s:

2 1 . Do y o u , a c o m p a n i o n , a n y o n e i n y o u r f a m i l y o r an y c l o s e
f r i e n d h a v e any f e e l i n g s a b o u t t h e V i e t n a m War t h a t w o u l d
p r e v e n t you from h e a r in g t h e e v i d e n c e in t h i s c a s e
im partially?
( ) yes
( ) no
If yes, describe these fe e lin g s:

2 2 . I s t h e r e any p e r s o n a l , o c c u p a t i o n a l , m e d i c a l , e m o t i o n a l
o r o t h e r r e a s o n t h a t yo u s h o u l d n o t be s e l e c t e d a s a
j u r o r i n t h e A g e n t O r a n g e c a s e w h i c h may l a s t f o r
s e v e r a l months?
( ) yes
( ) no

-25-

1 36 7 3

If yes, please state:

23.

I s t h e r e a n y t h i n g y o u w o u l d l i k e t o add t o y o u r
resp o n ses th a t might a id the cou rt in s e l e c t i n g a f a i r
and i m p a r t i a l j u r y i n t h i s c a s e ?

THANK

- 26-

YOU

13674

• AGENT ORANGE JURY QUESTIONAIRE

1.

What is your name?

2.

What is your address?

3.

What is your date of birth?

4.

What is your occupation?

5.

Who is your employer?

6.

For how long have you had your present job?

7.

Please describe your prior job.

8.

Education you have completed:

F I L E D

IN CLERK’S OFFICE
u. s. DISTRICT COURT E.D. N.Y.
1 /^ 4

Grade School High School College Post graduate 9.

Family:
Spouse's name Spouse's occupation Childrens names, ages and occupations -

10.

Do you or any members of your family belong to any organizations?
ones.

If so, which

11.

Are you or any members of your family an officer, director or trustee in any of
the above organizations? If so, please identify.

12.

Have you ever been a juror before?

13.

Are you now or have you ever made a claim for personal injuries caused by accidents
of any kind? If so, please describe giving the type of claim and if it is still
pending.

14.

Have any members of your family made claims for personal injuries caused by accident
of any kind? If so, please describe giving the type of claim and if it is still
pending.

15.

Have you ever had a claim brought against you?
type of claim and if it is still pending.

16.

Have any members of your family had a claim brought against them?
describe giving the type of claim and if it is still pending.

If so, where, when and what kind of case?

If so, please describe giving the

136,75
If so, please

17.

Are you now or have you ever been an officer, director, stockholder, shareholder
or in any way interested in any insurance company insuring against claims for
personal injury?

18.

Are any members of your family now or have they ever been an officer, director,
stockholder, shareholder or in any way interested in any insurance company insuring
against claims for personal injury?

19.

Have you or any members of your family ever testified in Court?
describe the circumstances.

20.

Do you have any hobbies?

21.

Have you ever taken any courses in chemistry?

22.

Are you now or have you ever worked in any occupation involving chemistry or
chemicals?

23.

Have any members of your family, now or in the past, ever worked in any occupation
involving chemistry or chemicals?

24.

Are you now or have you ever worked for a chemical company?

25.

Have any members of your family, now or in the past, ever worked for a chemical
company? If so, please describe.

26.

Are you now or have you ever owned or worked for a company which did business with
any chemical companies? If so, please describe.

27.

Have any members of your family, now or in the past, ever owned or worked for a
company which did business with any chemical company? If so, please describe.

28.

Are you now or have you ever owned or worked for a company which manufactured or sole
herbicides (plant killers)?
If so, please describe.

29.

Have any members of your family, now or in the past, ever owned or worked for a
company which manufactured or sold herbicides (plant killers)?
If so, please descrik

30.

Have you or any members of your family ever used herbicides (plant killers)? If
so, please describe the type of use and the product used.

31.

To your knowledge, have you or any members of your family ever purchased or used any
product or products manufactured by the defendant chemical companies? If so, please
describe in detail.

32.

To your knowledge, have you or any members of your family ever purchased or used any
chemicals manufactured by the defendant chemical companies? If so, please describe
in detail.

33.

Have you or any members of your family ever lived or worked on a farm?
you know whether herbicides (plant killers) were used?

If so, do

34.

Have you or any members of your family ever served in the armed forces?
please describe by name, years and place of service.

If so,

If so, please

If so, please so state,

2

If so, please describe.

35.

Do you now or have you ever owned any stocks and bonds?

36.

Do you now or have you ever owned any stocks and bonds in chemical companies?

37.

Do you now or have you ever owned any stocks and bonds in any companies doing
business with chemical companies?

38.

Do you now or have you ever owned or ’
worked for a company which did business with
the Government?

39.

Have any members of your family, now or in the past, ever owned or worked for a
company which did business with the Government?

40.

If you were selected as a juror in the Agent Orange case, and if the trial lasted
for several months, would you be able to be a juror?

Dated:

April 2, 1984
Respectfully submitted,
PLAINTIFFS' MANAGEMENT COMMITTEE

DAVID J. DEAN, ESQ.
DEAN, FALANGA & ROSE, ESQS.
One Old Country Road
Carle Place, New York 11514
(516) 248-9888

CERTIFICATE OF SERVICE
On t h i s , t h e 2nd d a y o f A p r i l , 1 9 8 4 , t h e u n d e r s i g n e d
ca u sed t h e annexed pro p o sed Agent Orange Jury Q u e s t i o n n a i r e t o
b e s e r v e d u p o n t h e a t t a c h e d s e r v i c e l i s t by r e g u l a r m a i l , w i t h
t h e e x c e p t i o n o f t h e s e r v i c e u p o n t h e Chambers o f J u d g e W e i n s t e i n ;
Hon. S h i r a S c h e i n d l i n ; N a n c y P e t r i l l o , D e p u t y C l e r k an d R i v k i n ,
L e f f , She rm an & R a d l e r , E s q s . , who w e r e s e r v e d b y ha nd t h i s 2nd
day of A p r i l , 1984.

DAVID J . DEAN

» «M
■ *'
t

SERVICE LIST #1
RIVKIN, LEFT, SHE?:-* AN & RADLER, ESQS
Leonard R ivk in , E sq.
A t t o r n e y s f o r Dow C h e m i c a l
100 Garden C it y P la za
G a r d e n C i t y , New York 1 1 5 3 0
(516) 746-7500

AP.THÜP, DRY & KALIS H , P . C .
Thomas A. B e c k , E s q .
A ttorneys for U niroyal
1230 Avenue o f t h e A m ericas
New Y o r k , New York 1 0 0 2 0
(212) 8 4 1 -9300

CADWALADER, WICKERSHAM & TATT, ESQS.
M ich a el Gordon, Esq.
A t t o r n e y s f o r Di a mo nd Sham rock
One W a l l S t r e e t
New Y o r k , New York 1 0 0 0 5
(212) 908-7000
r \
i
TOWNLEY & UPDIKE, ESQS.
John S a b e tta , Esq.
A t t o r n e y s f o r Monsanto
405 L e x i n g t o n Avenue
New Y o r k , New York 1 0 1 7 4
(212) .6 8 2 -4 5 6 7

SHEA & GOULD, ESQS.
Richard G o ld s t e in , Esq.
330 M a d i s o n A v e n u e
15th Floor
New Y o r k , New Y o r k 1 0 0 1 7
(212) 370-8000

CLARK, GAGLIARDI & MILLER, ~ESQS
M o r t o n B. S i l b e r m a n , E s q .
A t t o r n e y s f o r Thomp son Haywood
The I n n s o f C o u r t
99 C o u r t S t r e e t
W h i t e P l a i n s , New Y o r k 1 0 6 0 1
(914) 946-8900

CLERK OF THE PANEL
JUDICIAL PANEL ON
MULTIDISTRICT LITIGATION
1 1 2 0 V e r m o n t A v e n u e , N.W.
S u i t e 1002
W ash in gton , D.C. 20005
(202) 653-6090

KELLEY, DRYE & WARREN, ESQS.
W i l l i a m K r o h l e y , E sq .
A ttorneys for H ercules
101 Park Avenue
New Y o r k , New York 1 0 1 7 8
(212) 808-7800

NANCY PETRILLO, DEPUTY CLERK
ill s : D i s t r i c t C o u r t
E a s t e r n D i s t r i c t o f New Y o r k
2 2 5 Cadman P l a z a E a s t
B r o o k l y n , New York 1 1 2 0 1

BUDD, LARNER, KENT, GROSS,
PICILLO & ROSENBAUM, ESQS.
D a v i d R. G r o s s , Es q.
A t t o r n e y s f o r Th om pso n C h e m i c a l
33 W a s h i n g t o n A v e n u e
N e w a r k , New J e r s e y 0 7 1 0 2
(201) 6 2 2 -7 4 0 0
ARVIN MASKIN
U. S . D e p a r t m e n t o f J u s t i c e
T r ia l A t t o r n e y , T o rts Branch
C ivil D ivision
Safeway B u ild in g
521 1 2th S t r e e t
W a sh in g to n , D.C. 20530
(202) 7 2 4 -6 7 4 3

SPECIAL MASTER SOL SCHREIBER
M i l b e r g , W e i s s , Ber s h a d
and S p e c t h r i e , E s q s .
One Pen n P l a z a
New Y o r k , New York
(212) 5 9 4 -5300

ALLAN FREIDMAN
CHAMBERS OF JUDGE WEINSTEIN
U. S . D i s t r i c t C o u r t
E a s t e r n D i s t r i c t o f New Y o r k
2 2 5 Cadman P l a z a E a s t
B r o o k l y n , New York 1 1 2 0 1
♦ Chambers g e t s t w o c o p i e s
HOW. SHIRA SCHEINDLIN
uT r . D i s t r i c t C o u r t
E a s t e r n D i s t r i c t o f New Y o r k
2 25 Cadman P l a z a E a s t
Room 285
B r o o k l y n , New Yo rk 1 1 2 0 1
(212) 330 -2 1 9 6

13673

UNITED STATES DI STRICT COURT
EASTERN DI STRICT OF NEW YORK

X
In re
MDL
(All

"AGENT ORANGE
Product Liability

381
Cases)

Li ti ga t i o n
x

PLAINTIFFS' SECOND AMENDED LIST OF
FACT WITN ES SES IN SUPPORT OF CLAIMS

April

3,

1984

PLAINTIFFS' M AN AGE ME NT COMMITTEE
Room 304
26 Court Street
Brooklyn, NY
11242
(212) 330-0900

13680

PLAINTIFFS' SECOND AMENDED LIST OF
FACT WITNESSES IN SUPPORT OF CLAIMS

P l a i n t i f f s s u b m i t t h e f o l l o w i n g l i s t o f p o t e n t i a l w i t n e s s e s t o be
c a l l e d a t t r i a l p u r s u a n t t o t h e M a g i s t r a t e ' s P r e t r i a l Or de r No.
1 8 , d a t e d March 2 6 , 1 9 8 4 , r e s e r v i n g t h e r i g h t t o s u p p l e m e n t t h i s
l i s t w i t h a d d i t i o n a l names and a d d r e s s e s from t i m e t o t i m e as
a d d i t i o n a l i n f o r m a t i o n and w i t n e s s e s a r e d i s c o v e r e d .
T h o s e w i t n e s s e s d e s i g n a t e d w i t h an a s t e r i c k "*" h a v e b e e n d e p o s e d
i n t h e s e p r o c e e d i n g s . T h e i r a d d r e s s e s and t h e n a t u r e o f r e l e v a n t
p o r t i o n s o f t h e i r te stim o n y are as e q u a lly w ell-k n ow n to the
d e fe n d a n ts as to the p l a i n t i f f s .
The w i t n e s s e s
follow s:

not covered

by t h e

above

reservations,

are,

as

DR. THOMAS ABOUD
Toledo C lin ic
4235 Secor
T o l e d o , Ohio

C a r d i o l o g i s t f o r M r s. Ford
T r e a t e d Danny Fo rd f o r
hypertension.

EDWARD E ADAMS
S t . L o u i s , Mo.

G o v t . W i t n e s s , T-H
A griculture

GORDON A. ANDER SO N*

102 H i c k o r y Lane
Naugatuck, C on n ecticu t
IRENE ANTONIK
8 12 S u s s e x
A u s t i n , TX 7 8 7 4 5

Texas D i s a b i l i t y O ffic e r
and f r i e n d o f J o r d a n s '

LOUIS B .A R N O L D I *

EUGENE BAK*
DONALD K. BALLMAN*
7722 R e v e lle D rive
La J o l l a , C a l i f o r n i a

13681

DONALD

EPA

BARNES

E. D. BAUMGARTNER
R. E. BAYNARD
JEANNIE BEAVERS
Flower H o sp ita l
P e r so n n e l Department
S y l v a n i a , Ohio

Knows t h e h o s p i t a l a nd
b u s in es s s t r a i n re
Danny Ford

BILLIE MARIE BELL
4404 B onnie D rive
F t . W o r t h , TX 7 6 1 1 6

Danny J o r d a n ' s

m other

CLOYCI G. BELL
4404 B onnie D rive
F t . W o r t h , TX 7 6 1 1 6

Danny J o r d a n ' s S t e p Father

BELL TELEPHONE OF PA.
1 Pa rk Way
P h i l a d e l p h i a , P a . 1 9 10 1

Personnel records of
George Ewalt

W. B. BELLS
A tte m p tin g

to

Locate

PETER S . BING*
ETCYL H. BLAIR*

Dow E m p l o y e e
Deposed tw ic e

JOHN BLISH
A ttem pting to Locate

Contract O fficer
re Monsanto

A. A. BLOCK
KANSAS CITY, MO.
A ttem pting to Locate

G o v t. W it n e s s re
T-H A g r i c u l t u r e

WILLIAM BLUMENAUER
A ttem pting to Locate
JOSEPH L. BOLTON
A ttem pting to Locate

G o v 't C o n tra c tin g
O ffic e r P a rtic u la rly
re ; H e rc u le s

JACK BORRER*
12920 Wellswood T r a il
C h e s t e r f i e l d , Ohio 4 4 0 2 6
H i gh S c h o o l f r i e n d o f
L a m b i o t t e ' s who was w i t h
him i n V i e t n a m

AL BOTHWELL
610 Hu ds on T e r r a c e
N e w p o r t N e w s , Va. 2 3 6 0 5

13882"

2

JAMES E. BOWERS
ST. LOUIS, MO.
A ttem pting to Locate
DANIEL BRAXTON
c / o B e l l T e l e p h o n e o f PA
100 E. Armât
P h i l a d e l p h i a , PA.
BOB BROWN
A ttem p tin g

to

Locate

BROWN, SGT.
A ttem pting to Locate
DAVE BUNIN

JOHN S .

BUSH,

G ovt. W itness
A g ric u ltu re

re

T-H

George E w a lt 's Foreman,
1975

Served w it h
in Vietnam

Dan.

W ith Danny Ford
sprayed areas

Jordan

in

E con om ist - W i l l
s u p p l y a d d r e s s and
s um ma ry m a t e r i a l s
J r.*

WILLIAM CALLAHAN
West V i r g i n i a
A tte m p tin g to L ocate

Was w i t h

E w alt

in

V ietn am

MELVIN CALVIN*
2 6 8 3 Buena V i s t a Way
B erkeley, C alifornia

Former member o f PSAC
and d i r e c t o r o f Dow
Chemical re govern m en t
know ledge v s . Dow's
k n o w l e d g e and f a i l u r e
to warn.

RICHARD CASEY
C i n c i n n a t i , Ohio
A ttem pting to Locate

T e s t i m o n y from p o i n t o f
view of "Ranchhander"
concerning fa c ts of
s p r a y i n g and d e f o l i a t i o n

ELLIS CASH
A tte m p tin g to L ocate

Govt. C on tractin g O ffic e r
re H e r c u le s

EDWARD LEE CHANDLER*
EDWARD E. CHAPMAN*
6 7 4 8 N. E u c l i d
G ladstone, M issouri
J . G. CHARLTON
ROBERT L. CHONOLES*
23 C a r m e l l a D r i v e
E d i s o n , New J e r s e y
EMIL CHRISTOFANO*

Re H e r c u l e s ' l i a b i l i t y

13683

GEORGE F. COLLINS

D ir e c t o r o f procurem ent
P r o d u c t i o n , Richm ond, V a .
( P r o c u r e m e n t , s u p p l y a nd
f a i l u r e to warn is s u e s )

J . G. COPELAND, J r .
A ttem pting to L ocate

A s s t . G en . M a n a g e r , ' 6 4
Gen. Mgr. S y n t h e t i c s ,
6 5 - 7 2 (Re H e r c u l e s )

DIANE COURTNEY*

Government e x p e r t
w i t n e s s on c a u s a t i o n

GEORGE & MARGE CRAWFIS
49 Heck Rd .
K e n n e s s a w , Ga.

Saw c h a n g e s i n Danny Ford
C h r i s ' s B r o t h e r and S i s t e r
i n Law

JOHN CRAWFIS
1 1 7 9 B e a c h V a l l e y Rd .
A tla n ta , Georgia

Chris' B rother

OWEN & BETTY CRAWFIS
6 1 - 8 3 W h i t e f o r d C e n t e r Rd .
T o l e d o , Ohio

M ot he r and dad o f C h r i s .
Used t o t a k e Danny f o r
tr e a tm en t (6138?)

ROBERT CROCKER
A ttem pting to Locate

Amou nts - d o i n g away o f
herbs - has t a p e s to
determ ine exposure
to V eterans I I ' s

EUGENE D. CRITTENDEN, J r . *

D ir. S a le s , 66-67
A s s t . G e n . Mgr. S y n t h e t i c s
67-68
908 Du P on t Road
W ilm ington, D e l . 19807

ROBERT CROCKER
A ttem pting to L ocate
WARREN CRUMMETT*
808 C r e s c e n t D r i v e
M idland, Michigan

Dow s c i e n t i s t ; e v i d e n c e
c o n c e r n i n g Dow l i a b i l i t y
issues.

GENE CUMMINGS
A ttem pting to L ocate

Served w ith Jordan in
Vietnam

BILL CURTIS

Evidence con cern in g
eyew itness observations
as to the c o n d itio n
of the country of
Vietnam, e x t e n t of
r e s i d u a l d e f o l i a t i o n and
p o ssib le photographic
exhibits; in vestigation

c/o CBS News

524 W e st 5 7 t h S t r e e t
New Y o r k , New York 1 0 0 1 9

13634
&

continues

THOMAS P. DALBY

Govt. C ontracting O ffic e r
re H e r c u le s

S . S . DANIELS
U . S . D . A . L i a s o n NACA

L. L. DANIELSON
Attem pting to Locate
EDWARD DEBOLT
A ttem pting to Locate
DIAZ, STAFF SGT.
Attem pting to Locate

Wit h E w a l t i n V i e t n a m

CHARLES DILLEY
A ttem pting to Locate
KANSAS CITY, MO.

Govt. C on tractin g O ffic e r
r e T-H A g r i c u l t u r e

LINDA DIMOLA
42 G i b b s Pond Rd.
N e s c o n s e t t , NY 1 1 7 6 7

Kerry R yan's B a b y s i t t e r

CHARLES DISHNER
Govt. C ontract O ffic e r
re U n iroyal

M DOJNY
OWEN DOLIN*
5 2 2 5 Sun V a l l e y D r i v e
C h a r l e s t o n , Wes t V i r g i n a
LAWRENCE E. DOTSON*
WILLIAM DUFFIELD
CHARLES L. DUNN*

C h a i r m a n , NACA; e v i d e n c e
re l i a b i l i t y i s s u e s
a f f e c t i n g many d e f e n d a n t s
in a d d itio n to H e r c u le s.

JOSEPH DUQUETTE
96 H a l l o c k S a n d i n g R d .
R o c k e y P o i n t , NY 1 1 7 7 8

On S u f f o l k C o u n t y P o l i c e
F o r c e w i t h Mike Ryan

J . M. EAGAN*
JACK D. EARLY*
8 0 2 4 L a k e n h e a t h Way
Potom ac, Maryland 20854
WAYNE EDWARD*

13685
5

PLATOON SGT. ELLY
Attempting to Locate

Was w i t h E w a l t i n s p r a y
areas.

DONALD ELMORE
Attem pting to Locate

Government C o n tr a c tin g
O ffic e r re H ercu les

GEORGE W. & EUNICE EWALT SR.
731 Penn P i n e s B l v d .
C l i f t o n H e i g h t s , Pa.

P a ren ts o f George Ewalt
and f a m i l i a r w i t h
fam ily s itu a tio n

TEN EYCK
A ttem pting to Locate

I n s p e c t o r re Monsanto

WILLIAM A. FAIRCLOUGH*
2 4 8 7 1 V i a San F e r n a n d o
M is s io n V i e j o , C a l i f o r n i a 92692
Wit h Danny Ford i n s p r a y e d
areas

FRED FALANA
A ttem pting to Locate
WILLIAM F. FALSEY*
6706 Lakeview D rive
Lake C i t y , M i c h i g a n
OTIS E. FANCHER
A ttem pting to Locate

B i o - T e s t Labs

FARMER, CAPT.
Attem pting to Locate

With Danny Ford i n s p r a y e d
areas

L. E. FAST
WILLIAM FENNER*
J . R. FISCHER
HERCULES, INC.
JACKSONVILLE, ARK.
BETTY FMAYDA
1 8 9 9 R a p i d s Road
H i r a m , Ohio

Chris F ord 's B u sin ess
p a r t n e r and g o o d f r i e n d
( S e e Smayda)

THOMAS FORBES
M o n estary Avenue
P h i l a d e l p h i a , Pa.

F r i e n d o f G e o r g e E w a l t who
s e r v e d i n same a r e a i n
Vietnam

JOHN J . FORD*
15 W i n t e r b u r y C i r c l e
W ilm ington, Delaware
B r o t h e r o f Danny Ford

KERRY & JEANETTE FORD
6507 S ec o r e Rd.
L a m b e r t v ille , Michigan

6

RAY & ROSE FORD
13478 South County Line
H ig hw ay
O tt o w a L a k e , M i c h . 4 9 2 6 7

Danny F o r d ' s P a r e n t s

MARGARET FORLANO
F irst Street
Ft. Dix, N .J.

S i s t e r o f George Ewalt

JOSEPH W. FOWLER
Attem pting to Locate

Govt. C ontract O ffic e r
r e T-H A g r i c u l t u r e

E / 4 FRANKS
( in j a i l )

423d Combat S u p p l y ,
w ith L am biotte in
Vietnam

JOHN P. FRAWLEY*

Chief t o x i c o l o g i s t
H e r c u l e s , r e many
l i a b i l i t y and
causation issu es

H. G. FREDERICKS*
VAL K. GAERTNER
JESSE GERSHBERG
A ttem pting to Locate

Govt. C ontract O ffic e r
re Monsanto

E r . D. G l a d n e y
E a s t S t . L o u i s , Mo.
Attem pting to Locate

Wit h E w a l t i n V i e t n a m

A. W. GLENN
HAROLD GILL*

Dow a n a l y t i c a l c h e m i s t
who a l l e g e d l y d e v e l o p e d
a n a l y t i c a l method fo r
determ ination of
2 , 3 , 7 , 8 TCDD i n ' 6 4 .

CHERYL GONDEK
40 0 9 S h a w n e e T r a i l
F t . W o r t h , TX 7 6 1 3 5

Danny J o r d a n ' s s i s t e r

CHARLES E. GRANITO*
RAYMOND A. GUIDI*
420 E s s e x P l a c e
Memphis, T e n n e s s e e
Was w i t h E w a l t i n s p r a y
area

COLONEL HAIG
Attem pting to Locate
WALTER D. HARRIS*
n

1 99 ALLERTON RD.
NAUGATUCK, CONN.
E. ROSS HART
DAVID G. HELM*
5009 F o r e st
Kansas C it y , Kansas
RICHARD HICKMAN*
R o u t e 4 , No. 10 Yocum R d .
R ogers, Arkansas

Dow g o v e r n m e n t s a l e s
Mgr. r e D o w ' s a t t e m p t s
to s e l l p r o d u c ts
including h erb icid es
to the government

JESSE HILSEN
PAUL E. HOFFMAN*
1 2 0 2 Lake S h o r e D r i v e N o r t h
B arrington, I l l i n o i s
GRAYDON HOLDEMAN*
BENJAMIN B. HOLDER*
5 2 0 3 BLOOMFIELD ST.

Dow M e d i c a l D i r e c t o r r e
h e a lth e f f e c t s in w o rk e rs ,

MIDLAND, MICH.

f a i l u r e t o w a r n a nd l a c k
o f minimum e f f e c t l e v e l .

HARRY HOLLAND
1 6 2 6 D r y d e n Way
C r o f t o n , MD

F rien d

RAY HOLMES*

of

L a m b io tte 's

Dow p l a n t s u p e r v i s o r
who c o n t r a c t e d
c h lo ra cn e; re h e a lth
e f f e c t s and f a i l u r e t o
warn o f Dow k n o w l e d g e
o f D i o x i n i n end
p r o d u c ts in 1964

G. HOLSING
DONALD HOLT
c / o B e l l T e l e p o n e o f PA
100 E a s t Armat
P h i l a d e l p h i a , PA

G e o r g e E w a l t ' s Foreman ' 8 0

VERNON HOUCK

CDL

F. GERARD & VADA HUKILL
220 W. T y l e r
Magnum, O k l . 7 3 5 5 4

Danny J o r d a n ' s I n - L a w s

8

THOMAS R. HUNT
RAPHAEL H. HUSTON
Attem pting to Locate
PETER INFANTE
A ttem pting to Locate

NIOSH

GEORGE JACKSON
c / o B e l l T e l e p h o n e o f PA
100 E a s t Armat
P h i l a d e l p h i a , PA

G e o r g e E w a l t ' s Foreman
l a t e '70s to e a r ly '80s

JOHN JENNINGS
Apt. B
12 La ns do w n e A v e n u e
Lansdowne, Pa.

Hi gh S c h o o l f r i e n d o f
G e o r g e E w a l t who was
i n V i e t n a m a t same
t i m e and knows h i s
m edical problem s.

DAVID JORDAN*
LYNNE

KELLER

208 B r a e s w o o d
A u s t i n , TX 7 8 7 0 4

F r i e n d o f Danny J o r d a n ' s

R. EMMET KELLY*
665 SO. SKINNER
ST. LOUIS, MO.

Monsanto

VAN A. KELLY
P h i l a d e l p h i a , Pa.
Atem pting to Locate

W it h E w a l t i n V i e t n a m

GEORGE C. KEMPSON*
143 S o u t h Gore
Webster G roves, M issou ri
EUGENE E. KENAGA*
12 8 1 N. Wagner Road
E s s e x v i l l e , Michigan

Dow e m p l o y e e re
environm ental
persistance, to x icity
and l i a b i l i t y i s s u e s

FRANCIS KENNEDY*
WILLIAM KIDD
CARL & CARLA KING
3 3 - 4 2 Romaker
T o l e d o , Ohio

C lo s e s t fr ie n d s of the
(Danny) F o r d s ; s h e was
w i t h C h r i s when t h e y
f o u n d o u t t h a t Danny
F o r d ' s l e g wa s c a n ­
c e r o u s and how much
p a i n he was i n . A d d r e s s
may a l s o be 3 3 2 0

Romaker

Road

J . 0 . KING*
J . M. KIRGIS
A. Y. KISTNER
KANSAS CITY, MO.
A ttem pting to Locate
FRANK W. KLEMAN
ST. LOUIS, MO.
A ttem pting to Locate

Govt. C on tractin g O ffic e r
r e T-H A g r i c u l t u r e

GEORGE KLINE
J . KLINGMAN
PHILIP LANDRIGAN*
JULES LAM
39 B r a n d o n R d .
Newport News, V a .

David L a m b io t t e 's U ncle

MICHAEL LAMBIOTTE
18 M e l f o r d Rd.
Newport News, Va. 23601

B roth er o f David
Lambiotte

J . K. LEASURE*
R. R. N o. 2 - Box 157
M aka nda , I l l i n o i s
FRANK LEMAK*
P. R. LITTLE
HAROLD A. LLOY
DR. ANNETTE LYNCH
W issahicken & Schoolhouse
Lane
Philadelphia, Pa.

Ew alt's daughter's
psychologist

J . R. MALLET
W. MALONEY
DAVE MANN
Box 26
K i t t e r y P o i n t , Me. 0 3 9 0 5

Employer o f L a m b io tte
b e f o r e and a f t e r
Vietnam

THOMAS MARKWOOD*
Jeep Corp.
940 N. C o e . B l v d .

P a y r o l l R e c o r d s and l o s t
i n c o m e r e Danny Ford

lUSSt)
10

Toledo,

Ohio

T-H A g r i c u l t u r e ; l i a b i l i t y
issues

ROBERT E. MASKILL*
41 E a s t 5 3 r d S t r e e t
Kansas C i t y , M isso u ri
RICHARD J . MARRESE*
JAMES MASON
JOHN MASON*
12 T a n n e r s Dean
Leatherhead, Surrey
England
L. G. MAUREY
A ttem pting to L ocate

I n s p e c t o r re Monsanto

PAUL MAYFIELD
A ttem pting to Locate
M. McCALLEY
A ttem pting to Locate
WILLIAM J . McCARVILLE*
12 R i d g e C r e s t C o u r t
C h e s te r fie ld , M issouri

Deposed February 1 1 , 1983

DONALD McCOLLISTER*
5522 W h it e h a ll S t r e e t
M idland, Michigan

D e p o s e d March 3 0 , 1 9 8 3 .

william d .

Mc e l r o y *
9 6 5 1 BLACK GOLD RD.
CALIFORNIA

Deposed J u l y 1 3 , 1983

JUDY McKINSEY
1 8 9 9 R a p i d s Road
H i r a m , Ohio

B u sin ess p artner o f Chris
Ford and c l o s e f r i e n d
( S e e McKimnley)

SGT. TIMOTHY MEDDOR

Served w ith Jordan in
Vietnam

COL. BRUCE MEYERS
6 9 1 4 W. MERCER WAY
ST. LOUIS, MO.
I n s p e c t o r , re Monsanto

ROY MEYERS
A ttem p tin g

to

CHARLES

MTNARTCK*

E.

Locate

Ranch Hand W i t n e s s

RONALD MOODY

13691

li

SHERRY MOSHER
1 8 4 3 3 5 W i n c h e s t e r Rd.
T o l e d o , Ohio

B u s i n e s s m an ag er o f t h e
k e n n e l . S t r e s s and
s t r a i n on C h r i s Ford
A d d r e s s may a l s o be

DEBDAS MUKERJEE*
Was w i t h E w a l t i n V i e t n a m

BOB NOBER
71 Lempa Road
H o l l a n d , Pa
WILLIAM R. NUMMY*
711 W. Meado wbr ook D r i v e
M idland, Michigan

Photographic e x h ib its
JACKIE OCHS
c / o GREEN MOUNTAIN POST FILMS & p e r s o n a l o b s e r v a t i o n s
& investigations
P. 0 . BOX 229
TURNER FALLS, MA.
F r i e n d o f t h e Ryan s

BRIAN O'CONNOR
5545 N e t h e r la n d Ave.
Bronx, N.Y.
J . F. O'CONNOR

Served w ith Jordan in
V i et na m

SGT. THOMAS O'DONNELL
DR. OERTNER
J . E. PALLARD
FRANCIS PANNETON
L. A. PARDEE
PHIL PENN

Amou nts - d o i n g away
o f herbs - has tapes
to determ ine exposure
to V eterans I I ' s

REBECCA PEPPER
6718 S i l v e r m i n e D r iv e
#1004
A u s t i n , TX 7 8 7 3 6

Neighbor of Jo rd a n 's

JACK E. PETERSON
664 F o r e s t Gr o ve C i r c l e
B r o o k fie ld , W isconsin

Former Dow e m p l o y e e who
addressed industry
rep resen ta tiv es at
March, 1965 m e e tin g
c o n c e r n in g r a b b it ear
testing

13632

12

F. H. PLACET
Attem pting to Locate

G ovt. C o n tr a c t O f f i c e r re
Uniroyal

WILLIAM L. POPHAM

C o n s u l t a n t t o NACA

DONALD PURDY*
160 F r e d e r i c k s b e r g D r i v e
Avon L a k e , Ohio
THOMAS RAFFERTY
2 2 2 1 56 D r i v e
B r o o k l y n , NY 1 1 2 3 4

W it h Mike Ryan i n
Vietnam

VIRGIL B. ROBINSON*
2620 Q uail H i l l D r iv e
Upper S t . C l a i r , P a . 1 5 2 4 1
V. K. ROWE*

Dow's former C h ie f
T oxicologist - lia b ilit y
i s s u e s as w e l l as
c a u s a t i o n q u e s t i o n s ; Dow's
knowledge o f extrem e
t o x i c i t y and f a i l u r e t o
warn.

ROBERT R. RUMER*
CECIL RUSSELL*
46 W i n g f i e l d Row
G l e n d a l e , MO.
MAUREEN RYAN
82 F i f t h A v e .
K i n g s P a r k , New York

S c h o o l P r i n c i p a l who
knows K e r r y ' s e d u c a t i o n

MICHAEL RYAN
54 W o o d s d a l e A v e .
K i n g s P a r k , N.Y .

Mike R y a n ' s F a t h e r

VICKY RYAN
54 W o o d s d a l e A v e .
K i n g s P a r k , N .Y .

K e r r y 's Grandmother

HENRY SADLER
Florida

Boy ho od f r i e n d o f
L a m b i o t t e ' s who was
w i t h him i n V i e t n a m

UMBERTO SAFFIOTTI*

Government c a u s a t i o n
w itn e ss with fa c tu a l
te s t im o n y re governm ent
contract defense,
l i a b i l i t y i s s u e s and
issuance of B io n etics
L aboratories Report.

13693
13

DR. SALTER
97 York S t r e e t
Y o r k , M ai ne 0 3 9 0 9

Dr . who t o l d L a m b i o t t e
to sto p w orking.

ED SAWGRASS
SUSAN SCANLON
Riplen S tr e e t
P h i l a d e l p h i a , Pa.

S i s t e r o f George Ewalt

WILLIAM R. SCHAMBRA*
1 4 1 1 W. S t . A n d r e w s
M idland, M ichigan

Dow f o r m e r e m p l o y e e re
f a i l u r e t o warn and
business of s e llin g
h e r b ic id e s to the
governm ent.

ARTHUR J . SCHLESSINGER
OLGA SCHNELL
78 U n i v e r s i t y H e i g h t s Dr .
S to n y Brook, N.Y. 11790

N e i g h b o r o f t h e Ry an s

W. SCHUBACK
LAPIN 0 . SCOTT
R. B. SCOTT

H ercules em ployee.

RICHARD SCOTT

Drafted w ith Lambiotte
and saw i n V i e t n a m

SGT. SHARKEY

David L a m b io t t e 's
platoon Sergeant
in Vietnam

DEXTER B. SHARP*
13042 W e a th e r fie ld D rive
S t . L o u i s , Mo.
A. E. SIDWELL*

H ercules em ployee.

LARRY SILVERSTEIN

Dow f o r m e r e m p l o y e e r e
March, 1965 m e e t i n g s a t
Dow and o t h e r l i a b i l i t y
i s s u e s and h e a l t h
e f f e c t s t o Dow e m p l o y e e s .

BETTY SMAYDA
1899 R apids Rd.
Hayram, Ohio

B u sin ess p a r tn e r s - Chris
F o r d 's , p lu s good f r i e n d .
What F o r d s w e n t t h r o u g h
and p e r s o n a l s t r a i n s

J . G. SMERALDI*

136S4
14

CAPT. SMITH

Wit h E w a l t i n s p r a y a r e a s

PLATOON LT. SMITH

W it h E w a l t i n s p r a y a r e a s

TOM K. SMITH
ROBERT SNODGRASS
H u n t i n g t o n , W. V a.

With Danny Ford i n S p r a y e d
areas

HOWARD C. SPENCER*
1 1 0 0 8 Cameo D r i v e
Sun C i t y , A r i z o n a 8 5 3 5 1

Developed ra b b it ear t e s t
i n 1 9 4 1 w h i l e a Dow
em ployee.

L. P. SEITZ
A. JOHN SPEZIALE*
311 N. U m b e r l a n d A v e n u e
Redwood C i t y , C a l i f o r n i a 9 4 0 6 1
JOHN A. STEPHENS*
800 N. L i n d b e r g h B l v d .
S t. L ouis, M issouri
FREDERICK G. STEWARD*
173 W oo dl an d F o r e s t , S e c t i o n 3
T u s c a l o o s a , Alabama 3 5 4 0 5
CHARLES N. STEWART*
MICHAEL STRANGE
521 Bomber Road
F t . Worth T e x a s

F r i e n d o f Danny J o r d a n

FREDERICK STRANSKY
53 S. M a l l a r d
S e l d e n , N.Y.

Mike R y a n ' s B r o t h e r - i n Law

SGT. STRAWBERRY

Was w i t h E w a l t i n s p r a y
areas

DEIRDRE STRANSKY
24 Alma A v e .
S e ld e n , N.Y.

T e a c h e r - know s K e r r y Ryan
- a s p e c i a l i s t in le a r n i n g
d isab ilities

PATRICIA STRANSKY
53 S . M a l l a r d
S e l d e n , N.Y.

N u r s e and F a m i l y
C o u n s e l l e r f o r Ryan
fam ily

JACK STRUM*
7 12 S h o r t S p o on C i r c l e
North C a r o lin a
JOHN S . SULLIVAN

WINFIELD W. SUNDERLAND*
5300 W e s t p a t h Way
B e t h e s d a , Maryland
DANIEL W. SWEET*
MILTON A. TAVES*
210 N. S p r i n g V a l l e Road
W ilm ington, Delaware
CLINTON TAYLOR
309 P i e z A v e .
Newport

News,

Business p a r t n e r o f
D avid L a m b i o t t e 's
Va.

R. D. THOMPSON
WILLIAM THOMPSON*
318 GEORGINA AVE.
SANTA MONICA, CAL.
H ercules em ployee. Depos­
ed .

A. L. TREISBECK

U n i o n c o m m i s s i o n man a t
Danny F o r d ' s j o b . A l s o
a f r i e n d o f D a n ' s . Has
in fo rm a tio n about union
c o n t r a c t ( c u r r e n t ) and
p e r s o n n e l m a t t e r s . See
also T w iff.

DAN TWI SS
Woodland S t r e e t
S y l v a n i a , Ohio

C o m m i t t e e man a t AMC J e e p
See Twiss above

DAN T W I F F

4910 Woodland
S y l v a n i a , Ohio

WILLIAM R. UDELL
60 T e a l w o o d
C r e v e C o e u r , MO.
T-H l i a b i l i t y i s s u e s
D e p o s e d A p r i l 7 , and
A p r il 8, 1983

EDWIN T. UPTON
W. VANDERVENTER*
JANE WARD
3 5 2 7 M. 151
Temperance, Mich. 48182

N eighbor

of

Fords

ROBERT T. WEBBER*
4 Media D r i v e
S t . L o u is , M isso u r i 63146

13698
16

*m

ADAM WENKUS
R o u t e 5 - Box 904
W a up a c a, W i s c o n s i n

S u p p l y and d i s t r i b u t i o n ,
d e f e n d a n t s ' f a i l u r e to
warn; f o r m e r D e f e n s e
M ilit a r y Supply O ffic e
em ployee.

BUTCH WESTERLAND

Served w ith Jordan in
Vietnam

HARTLEY WILDER
S e r v e d w i t h Danny J o r d a n
in Vietnam

SGT. J . WILLIS
MARK G. WILTSE*
N. WIRZ

U n i o n S t e w a r t a t Danny
F o r d ' s - knew Dan when
he had t h e c a n c e r and
the wages at th e tim e
and t h e c h a n g e s i n Dan

WILBUR WOHLGAMUTH
49-21 Barton P lace
S y l v a n i a , Ohio
L. K. WOOLFOLK
JOHN WRIGHT
R. WRIGHT
Attem pting to Locate

G o v t . I n s p e c t o r re
Monsanto

R. T. YATES
YORK HOSPITAL
15 H o s p i t a l D r .
Y o r k , M aine

Former e m p l o y e r o f
Lambiotte

MITCHELL ZARON
K e t t e r i n g Labs
3 2 2 3 Eden A v e .
C in c in n a t i, Ohio.
CHARLES P. ZORSCH*
R o u t e 5 , b o x 30
P a c i f i c , MO.

13697

The names a b o v e w i t h o u t i d e n t i f y i n g i n f o r m a t i o n a r e
l i s t e d on t h e p a r t i e s ' p r i o r i t y l i s t s and w i l l b e d e p o s e d a t
future d ates.
I t is the p l a i n t i f f s ' un d erstan d in g th a t th e se
l i s t s may be s u p p l e m e n t e d a s t h e d e p o s i t i o n s a r e t a k e n .
AGENT ORANGE PLAINTIFFS'
MANAGEMENT COMMITTEE

17

■ *#
A■

■

EDWARD
was

duly

C E R TI F I C AT E OF SERVICE

F. HAYES,

served upon

below

Dated:

1984

3,

hereby

the parties

at the addresses

April

III,

certifies

this

that

the foregoing

date by Federal

Express

listed:

SERVICE LIST

Rivkin, Leff, Sherman & Radler
Attorneys for Dow Chemical Co.
100 Garden City Plaza
Garden City, N.Y. 11530

Townley & upaiKe
Attorneys for Monsanto Co.
405 Lexington Avenue
New York, N.Y. 10017

Cadwalader, Wickersham & Taft
Attorneys for Diamond-Shamrock
One Wall Street
New York, N.Y. 10005
*
Shea & Gould
Attorneys for Uniroyal, Inc.
330 Madison Avenue
New York, N.Y. 10017

Arthur, Dry & Kalish
Attorneys for Uniroyal,Inc
1230 Avenue of the Americas
New York, N.Y. 10020

Budd, Larner, Kent, Gross,
Picillio & Rosenthal
Attorneys for Thompson Chemical
33 Washington Street
Newark, N.J. 17102

United States Attorney's Office
United States Dept, of Justice
Attorneys for United States
Safeway Building, Rm 9040
Washington, D.C. 20530

Clark, Gagliardi & Miller
Attorneys for T&H Agriculture
99 Court Street
White Plains, N.Y. 10601

Kelley, Drye & Warren
Attorneys for Hercules, Inc.
101 Park Avenue
New York, N.Y. 10178

/•?. ;
S, ;
■ •
’.«jyj

••' •■rfvtvj

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

X
IN RE

MDL No. 381
(All Cases)
"AGENT ORANGE

PRODUCT LIABILITY LITIGATION
X

SECOND LIST OF MONSANTO FACT WITNESSES

T o w n l e y & U p d i KE
CHRYSLER
405

BUILDING

LEXINGTON

NEW

AVENUE

Y O R K , N . Y. 1 0 1 7 4

TELEPHONE
(2121 6 8 2 - 4 5 6 7

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK
-------------------------------------- X
MDL No. 381
(All Cases)

IN RE
"AGENT ORANGE"
PRODUCT LIABILITY LITIGATION
X

SECOND LIST OF MONSANTO FACT WITNESSES
Defendant Monsanto Company ("Monsanto"), pursuant to
the schedule established by Magistrate Scheindlin, hereby
submits a second list of fact witnesses who might give
testimony at trial in support of Monsanto's claims.

This list

supplements the First List of Monsanto Fact Witnesses
Identified Pursuant to Order of the Court Dated January 10,
1984, which was served on February 29, 1984.
Monsanto reserves the right to amend the descriptions
that follow of the general nature of the testimony to be given,
should Monsanto's continuing trial preparation indicate any
such amendment is appropriate.
1.

Richard A. Atkinson.
4242 Kanawha Turnpike
South Charleston, West Virginia
Monsanto's production of 2,4,5-T in the 1960's;
Monsanto's efforts to reduce worker exposure to its
2,4,5-T process; Monsanto's efforts to reduce or to
remove dioxin in its 2,4,5-T process; the health
experience of Monsanto workers involved in the 2,4,5-T
process.

1 3 ’7 o o

2.

Philip B. Balderson.
101 Stewart Park
Cross Lanes, West Virginia
Monsanto's analytic efforts to detect and to measure
the presence of dioxin in its 2,4,5-T.

3.

Robert Baynard.
231 Jeffrey Lane
Newton Square, Pennsylvania
The marketing and sale of herbicides containing
Monsanto-manufactured 2,4,5-T, both to the United
States Government and to commercial customers; the
health experience of persons who used or were
otherwise exposed to herbicides containing 2,4,5-T.

4.

Stanley C. Beach.
760 Sotano Drive
Sacramento, California

95833

The methods and procedures used to aerially
disseminate herbicides in Vietnam; the duties and
responsibilities of a flight mechanic of a C-123
airplane during herbicide operations in Vietnam; the
health experience of persons in Vietnam who used or
were otherwise exposed to herbicides containing
2,4,5-T.
5.

Donald J. Birmingham.
19811 Wedgewood Drive
Gross Point Woods, Michigan
The United States Government's investigation of the
health experience of Monsanto workers involved in the
2,4,5-T process in the 1950's and/or exposed to the
materials formed during a runaway reaction in the
manufacture of sodium trichlorophenate at Monsanto's
Nitro, West Virginia plant in 1949.

nu 11
-2-

6.

Russell Bishop.
Ambler, Pennsylvania
The health experience of commercial formulators of
2,4,5-T produced by Monsanto.

7.

Carl D. Bohl.
455 Wildwood Parkway
Ballwin, Missouri
The historical knowledge of the toxicity of herbicides
containing 2,4,5-T and the toxicity of dioxin; the
health experience of Monsanto workers involved in the
2,4,5-T process; Monsanto's efforts to reduce or to
remove dioxin from its 2,4,5-T process and to reduce
worker exposure to that process.

8.

John S . Bush, Jr .
2232 North Military Road
Arlington, Virginia
Monsanto's contracts with the United States Government
for the production of Agent Orange and other military
herbicides; the Government's plan to build and to
operate an Agent Orange plant at Weldon Spring,
Missouri.

9.

Robert E. Cox.
203 East Belerest Road
Bel Air, Maryland
Visit to Monsanto's Nitro plant in connection with the
proposed manufacture of Agent Orange by the United
States Government.

10.

Eugene A. Cutright.

137

1474 Maplewood Drive
Macon, Georgia
Monsanto's production of 2,4,5-T in the 1960‘s;
Monsanto's efforts to reduce worker exposure to its

13702
_r>_

2,4,5-T process; Monsanto's efforts to reduce or to
remove dioxin in its 2,4,5-T process; the health
experience of Monsanto workers involved in the 2,4,5-T
process.
Burnie R. Dallas, Jr.
1775 East 20th Street
Apt. D-8
San Bernardino, California
The methods and procedures used to aerially disseminate
herbicides in Vietnam; the duties and responsibilities
of a flight engineer of a C-123 airplane during
herbicide operations in Vietnam; the health experience
of persons in Vietnam who used or were otherwise
exposed to herbicides containing 2,4,5-T.
Stewart D. Daniels.
Monsanto Singapore Co. PTE Ltd.
2601-2606 Clifford Center
Raffles Place
Singapore
The manufacture, marketing, and sale of herbicides
containing 2,4,5-T, both to the United States
Government and to commercial customers; the health
experience of persons who used or were otherwise
exposed to those herbicides.
Robert A. Darrow.
7613 Baltimore National Pike
Frederick, Maryland
The United States Government’s development, testing,
and use of Agent Orange; the Government's
specifications for Agent Orange.
Robert Dennis.
Route 6, Box 302
Yakima, Washington
The methods and procedures used to aerially
disseminate herbicides in Vietnam; the duties and

—4—

13704

responsibilities of a pilot of a C-123 airplane during
herbicide operations in Vietnam; the health experience
of persons in Vietnam who used or were otherwise
exposed to herbicides containing 2,4,5-T.
15.

Jon R. Dudenhoeffer.
5639 King Road
Erie, Pennsylvania
The methods and procedures used to aerially disseminate
herbicides in Vietnam; the duties and responsibilities
of a navigator of a C-123 airplane during herbicide
operations in Vietnam; the duties and responsibilities
of a targeting officer for herbicide operations in
Vietnam; the health experience of persons in Vietnam
who used or were otherwise exposed to herbicides
containing 2,4,5-T.

16.

Jack D. Early.
8024 Lakenheath Way
Potomac, Maryland
Monsanto's contacts with the United States Government
in the 1960's regarding pesticide regulation; the
activities of the National Agricultural Chemicals
Association.

17.

Henry Good.
The methods and procedures used to aerially disseminate
herbicides in Vietnam; the duties and responsibilities
of a pilot of a C-123 airplane during herbicide
operations in Vietnam; the duties and responsibilities
of a targeting officer for herbicide operations in
Vietnam; the health experience of persons in Vietnam
who used or were otherwise exposed to herbicides
containing 2,4,5-T.

18.

Paul D. Halley.
The involvement of the West Virginia occupational
health authorities in an investigation of the runaway
reaction that occurred in 1949 during the manufacture

13705
-5-

s

i

of sodium trichlorophenate at Monsanto’s Nitro, West
Virginia plant, including efforts to identify and to
determine the toxicity of materials formed during that
reaction; the health experience of Monsanto workers
exposed to those materials and/or the 2,4,5-T process
in the 1950's.
.19.

!i

Frank Helmer.
2825 FlamevoC'd Drive
Monsanto’s manufacture of 2,4,5-T at its Nitro, West
Virginia plant; improvements in Monsanto's
manufacturing process for 2,4,5-T.

20.

Paul F. Hoffman.
1202 Lakeshore Drive North
Barrington, Illinois
Monsanto's marketing and sale of herbicides containing
2,4,5-T in the 1960's, both to commerical customers
and to the United States Government; the health
experience of persons who used or were otherwise
exposed to herbicides containing 2,4,5-T.

21.

Charlie Hubbs.
Camp Springs, Maryland
The methods and procedures used to aerially disseminate
herbicides in Vietnam; the duties and responsibilities
of a pilot of a C-123 airplane during herbicide
operations in Vietnam; the health experience of persons
in Vietnam who used or were otherwise exposed to
herbicides containing 2,4,5-T.

22.

Allan M. Jokela.
1511 North Rock 38th Road
Rock, Michigan
The methods and procedures used to aerially
disseminate herbicides in Vietnam; the duties and

13706

responsibilities of a navigator of a C-123 airplane
during herbicide operations in Vietnam; the duties and
responsibilities of a targeting officer for herbicide
operations in Vietnam; the health experience of
persons in Vietnam who used or were otherwise exposed
to herbicides containing 2,4,5-T.
23 . George C. Kempson.
Monsanto’s marketing and sale of herbicides containing
2,4,5-T, both to the United States Government and to
commercial customers; the health experience of persons
who used or were otherwise exposed to herbicides
containing 2,4,5-T.
24.

Kettering Laboratory.
University of Cincinnati
Cincinnati, Ohio
Work performed for Monsanto by the Kettering
Laboratory in the 1950‘s regarding the health
experience of Monsanto workers exposed to materials
formed during a runaway reaction in the manufacture of
sodium trichlorophenate at Monsanto's Nitro, West
Virginia plant in 1949 and/or to the 2,4,5-T process,
including the treatment of affected workers and
efforts to determine the toxicity of the materials
formed during the runaway reaction and of 2,4,5-T and
its process intermediates.

25.

Paul Lacey.
117 Rosetta Court
Springdale, Ohio
The methods and procedures used to aerially disseminate
herbicides in Vietnam; the duties and responsibilities
of a flight mechanic of a C-123 airplane during
herbicide operations in Vietnam; the health experience
of persons in Vietnam who used or were otherwise
exposed to herbicides containing 2,4,5-T.

-7 -

26.

John S. Leary, Jr.
2002 Sea Cove Court
Nassau Bay, Texas
Contacts in the 1960's between Monsanto and the United
States Government regarding the toxicity of 2,4,5-T.

27.

Charles F. Luecke.
12747 Spruce Pond Drive
St. Louis, Missouri
Monsanto’s manufacture, marketing, and sale of
herbicides containing 2,4,5-T, both to the United
States Government and to commercial customers; the
health experience of Monsanto workers involved in the
2.4.5- T process and persons who used or were otherwise
exposed to herbicides containing 2,4,5-T; the United
States Government's specifications for Agent Orange
and Monsanto's compliance with them; the historical
knowledge of the toxicity of herbicides containing
2.4.5- T and of the toxicity of dioxin; Monsanto's
efforts to identify impurities, including dioxin,
created in its manufacture of 2,4,5-T.

28.

Charles E. Minarik.
P.O. Box 682
W. Harwich, Massachusetts
The United States Government's development, testing,
and use of Agent Orange; the Government's
specifications for Agent Orange.

29.

John Mullendore.
1020 Grove
Evanston, Illinois
Monsanto's manufacture of phenoxy herbicides; contact
with the United States Government regarding dioxin.

13708
_o_

30.

Verne

L.

Rhodes.

2120 Windport Lane
St. Louis, Missouri
Monsanto's production of 2,4,5-T in the 1960's;
Monsanto's efforts to reduce worker exposure to its
2,4,5-T process; Monsanto's efforts to reduce or to
remove dioxin in its 2,4,5-T process.
31.

Frank S. Serdy.
13275 Windy Gate Lane
Creve Coeur, Missouri
The United States Government's field testing of
herbicides in Thailand; the health experience of
persons who used or were otherwise exposed to
herbicides containing 2,4,5-T.

32.

Robert G. Sido.
7611 Shirley Drive
Clayton, Missouri
The United States Government's specifications for
Agent Orange and Monsanto's compliance with them;
registration of Monsanto products containing 2,4,5-T.

33.

Anthony Sinclitico.
7800 William Road
Baltimore, Maryland
The United States Government's specifications for
Agent Orange.

34.

Milt Smid.
#3 Zinzer Court
St. Louis, Missouri
The United States Government's specifications for
Agent Orange and Monsanto's compliance with them.

13709
n

C;

Tom K. Smith.
Monsanto's contracts with the United States Government
for sale of herbicides containing Monsanto-manufactured
2,4,5-T; Monsanto's manufacture and sale of herbicides
containing 2,4,5-T.
Robert E. Soden.
15998 Kettington Road
Clarkson Valley, Missouri
The health experience of Monsanto workers exposed to
the 2,4,5-T process in the 1950's; Monsanto's efforts
to determine the toxicity of 2,4,5-T and its process
intermediates; Monsanto's efforts to reduce worker
exposure to the 2,4,5-T process.
John R. Spey.
850 Tarpon Drive
Fort Walton Beach, Florida
The methods and procedures used to aerially disseminate
■'rbicides in Vietnam; the duties and responsibilities
a pilot of a C—123 airplane during herbicide
operations in Vietnam; the health experience of
persons in Vietnam who used or were otherwise exposed
to herbicides containing 2,4,5-T.
James E. Springgate.
13060 East Sunset Drive
Los Altos Hills, California
Monsanto's production of 2,4,5-T in the 1960's;
Monsanto's efforts to reduce worker exposure to its
2,4,5-T process; the health experience of Monsanto
workers involved in the 2,4,5-T process.
Earl Spurrier.
Madison Building, Suite 301
1155 15th Street N.W.
Washington, D.C.
The methods and procedures used to apply herbicides
obtaining 2,4,5-T for weed control in the United

-1 0 -

13720

States; the health experience of persons who used or
were otherwise exposed to herbicides containing

2 ,4 ,5-T.

40.

Jack C. Strum.
712 Short Spoon Circle
Rocky Mount, North Carolina
Monsanto's production of 2,4,5-T in the 1960‘s;
Monsanto's efforts to reduce worker exposure to its
2,4,5-T process; Monsanto's efforts to reduce or to
remove dioxin in its 2,4,5-T process; the health
experience of Monsanto workers involved in the 2,4,5-T
process.

41.

Frank E. Take, Jr.
480 Hillbrook Drive
Ballwin, Missouri
Monsanto's manufacture of 2,4,5-T at its Nitro, West
Virginia plant; the United States Government's
specifications and Monsanto's compliance with them;
Monsanto's efforts to identify impurities, including
dioxin, created in its manufacture of 2,4,5-T;
Monsanto's efforts to reduce or remove dioxin in its
2,4,5-T process; the health experience of Monsanto
workers involved in the 2,4,5-T process.

42.

Wayne E. Vandeventer.
The United States Government's specifications for
Agent Orange and Monsanto's compliance with them.

43.

Richard C. Wallace.
P.O. Box 230
St. Albans, West Virginia
The health experience of Monsanto workers involved in
the 2,4,5-T process.

13711

44.

Robert

T.

Webber.

4 Media Drive
St. Louis, Missouri
Monsanto's efforts to reduce worker exposure to its
2,4,5-T process.
45.

Elmer P. Wheeler.
110 Cool Springs Drive
Camden, South Carolina
Monsanto's efforts to identify impurities, including
dioxin, created in its manufacture of 2,4,5-T;
Monsanto's efforts to determine the presence of dioxin
in its 2,4,5-T process and to reduce or remove it from
that process; the historical knowledge of the toxicity
of herbicides containing 2,4,5-T and the toxicity of
dioxin; the health experience of Monsanto workers
involved in the 2,4,5-T process and of persons who
used or were otherwise exposed to herbicides
containing 2,4,5-T; contacts with United States
Government representatives and others outside Monsanto
concerning all of the above.

46.

Herbert Woodcock.
The methods and procedures used to aerially disseminate
herbicides in Vietnam; the duties and responsibilities
of a navigator of a C-123 airplane during herbicide
operations in Vietnam; the health experience of
persons in Vietnam who used or were otherwise exposed
to herbicides containing 2,4,5-T.

47.

Younger Laboratories.
Monsanto's efforts to determine the toxicity of
2,4,5-T and its process intermediates.

New York, New York
March 26, 1984
TOWNLEY & UPDIKE
By :

‘

y ,

jo

(Ì.

/tA„
A Member of the Firm

Attorneys for Defendant
Monsanto Company
405 Lexington Avenue
New York, New York 10174
(212) 682-4567
-12-

137

CERTIFICATE

OF

SERVICE

I HEREBY AFFIRM THAT I am an attorney duly admitted
to practice in the State of New York and in the Eastern
District of New York.

I HEREBY CERTIFY that on March 26, 1984

I caused to be served a true and correct copy of the Second
List of Monsanto's Fact Witnesses by courier on all counsel on
the attached service list.

DANIEL COBRINIK

137

AGENT

ORANGE

SERVICE

LIST

Wendell B. Alcorn, Esq.
Cadwalader, Wickersham & Taft
One Wall Street
New York, N.Y. 10005

Morton G. Silberman, Esq.
Clark, Gagliardi St Miller
The Inns of Court
99 Court Street
White Plains, N.Y.
10601

Leonard L. Rivkin, Esq.
Rivkin, Leff, Sherman & Radler
100 Garden City Plaza
Garden City, N.Y. 11530

Richard Goldstein, Esq.
Shea & Gould
330 Madison Avenue
New York, N.Y. 10017

Thomas Beck, Esq.
Arthur, Dry & Kalish, P.C.
1230 Avenue of the Americas
New York, N.Y. 10020

Howard Lester, Esq.
Lester Schwab Katz St Dwyer
120 Broadway
New York, N.Y. 10005

William Krohley, Esq.
Kelley, Drye & Warren
101 Park Avenue
New York, N.Y. 10178

David R. Gross, Esq.
Budd, Larner, Kent, Gross,
Picillo St Rosenbaum
33 Washington Street
Newark, New Jersey 07102

Paul V. Esposito, Esq.
Lewis, Overbeck & Furman
135 South LaSalle Street
Suite 1060
Chicago, Illinois 60603
PLAINTIFFS
David J. Dean, Esq.
Dean, Falanga, Sinrod & Rose
1 Old Country Road
Carle Place, N.Y. 11514

Benton Musselwhite, Esq.
Law Offices of Benton
Musselwhite, Inc.
609 Fannin - Suite 517
Houston, Texas 77002

Thomas Henderson, Esq
Baskin St Sears
Frick Building - 10th Floor
Pittsburgh, Pa. 15219

Stephen J. Schlegel, Esq.
Schlegel St Trafelet, Ltd.
One North LaSalle Street
Suite 3900
Chicago, Illinois 60602

Victor J. Yannacone, Jr., Esq.
Yannacone St Yannacone
Post Office Drawer #109
62 Rose Avenue
Patchogue, New York 11772

Irving Like, Esq.
Reilly, Like St Schneider
200 West Main Street
Babylon, New York 11700

V. •

GOVERNMENT COUNSEL
Hon. Raymond J. Dearie
United States Attorney
By: L. Kevin Sheridan"
Executive Assistant
U.S. Attorney
U.S. District Court
Brooklyn, New York 11201

Arvin Maskin, Esq.
Department of Justice
Safeway Building -.Room 904 D
521 12th Street, N.W.
Washington, D.C. 20530

OTHERS
Clerk of Panel
Judicial Panel on
Multidistrict Litigation
1120 Vermont Avenue, N.W.
Suite 1002
Washington, D.C. 20005

Sol Schreiber, Esq.
Special Master
Milberg, Weiss, Bershad,
Specthrie & Lerach
One Penn Plaza Suite 4915
New York, N.Y. 10119

Hon. Shira Scheindlin
Magistrate
U.S. Courthouse
225 Cadman Plaza East
Brooklyn, N.Y. 11201
Agent Orange Plaintiffs' Management Committee
26 Court Street, Room 905
Brooklyn, New York 11242

-2-

5

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK
x

In re

u- s.

P' j
toi

MDL No. 3
J ft

"AGENT ORANGE"
Product Liability Litigation

X

T-/:.- ''».AJ

c° " * r

!>h13

DEFENDANT DIAMOND SHAMROCK
CHEMICALS COMPANY'S SUPPLEMENTAL
. LISTING OF FACT. WITNESSES___
Pursuant to Magistrate's Pretrial Order No. 16 and
Magistrate's directions at the March 7, 1984 pretrial conferer
defendant Diamond Shamrock Chemicals Company ("Diamond Shamroc
sets forth below its list of fact witnesses who may g
testimony at trial in support of Diamond Shamrock's claims ;
defenses.

Diamond Shamrock also joins in Defendants' List

Fact Witnesses dated March 26, 1984, which is being served a
filed under separate cover.

Diamond Shamrock reserves the right to supplement a

amend this list based on information developed in continui:
discovery proceedings or other trial preparations, and to call
a live witness or use the deposition testimony of any pers
listed by any other party.

Diamond Shamrock also reserves t

right to supplement and amend this list in the "witness list
section of the pretrial order following receipt and review

plaintiffs' final fact witness list, now due on March 27, 1984.

13716 _ /

Name and
Present Address

Description of General
Nature of Testimony__

Louis Anderson
220 E. 17th Street
Chicago Heights, Illinois 60411

Testimony concerning purchases by
Riverdale Chemical Company of 2,4,5-T
acids and esters supplied by Diamond
Shamrock.

Eugene Bak*
Dr. Donald J. Birminghan*
19811 Wedgewood Drive
Gross Point Woods, Michigan

Testimony concerning research and
investigation of chloracne by U.S.
Public Health Service in the 1950's
and 1960's, including visits to
Diamond Shamrock's former Newark
plant.

Jack A. Borror*
Dr. Roger H. Brodkin
769 Northfield Avenue
West Orange, New Jersey 07052

Testimony concerning medical condi­
tions at the Newark plant, including:
communications with and investigations
by the U.S. Public Health Service; and
preparation and publication of the
article by Bleiberg, _g£.al. (1964).

Lawrence L. Cecil, Jr.
12825 S.W. 69 Gourt
Miami, Florida 33156

Testimony concerning foreign sales of
Diamond Shamrock's 2,4,5-T products,
including sales in Colombia.

Edward L. Chandler*
Robert L. Chonoles*
Diamond Shamrock Chemicals
Company
Berry Avenue at Route 17 North
Carlstadt, New Jersey 07072

Testimony concerning manufacturing
operations at Diamond Shamrock's
former Newark plant, including: the
removal of dioxin from trichlorophenol; and the U.S. Public Health
Service stud/ of the Newark workers in
1968-69.

i
*
Howard E. Everson
Raymond A. Guidi*
Alfred M. Hauser
Diamond Shamrock Chordeals
Company
Berry Avenue at Route 17 North
Carlstadt, New Jersey 07072
*

Testimony concerning Diamond Sham­
rock's contractual arrangements with
the United States for the sale of
Agent Orange.

.
Witnesses designated by an asterisk (*) have been deposed m MDL No.

381.

- 2-

13717

Name and
Present Address

Description of General
Nature of Testimony

Melvin Hochberg*
Stanley B. Honour*
829 Eggleston
Port Collins, Colorado 80524

Testimony concerning foreign sales of
Diamond Shamrock's 2,4,5-T products,
including sales in Oolanbia.

Francis R. Kenned/*
2711 Bernadette Lane
Houston, Texas 77043

Testimony concerning manufacturing
operations at Diamond Shamrock's
former Newark plant, including: the
development, installation and opera­
tion of a method for removing dioxin
from trichlorophenol; visits to the
Newark plant by the ULS. Public Health
Service in the 1960's; and the produc­
tion and shipment of Agent Orange
pursuant to contracts with the United
States.
!

j
i

Dr. Marcus M. Ke/*
University of Texas Health
Science Center
P.O. Box 20186
Houston, Texas 77025

Testimony concerning research and in- ;
vestigation of chioracne by U.S. Pub­
lic Health Service in the 1960's,
including visit to Diamond Shamrock's I
former Newark plant.
j

James 0. King*
P.O. Box 900
Alpharetta, Georgia

Testimony concerning domestic and !
foreign sales of Diamond Shamrock's
2,4,5-T products, including sales of
Agent Orange pursuant to contracts
with the United States.

Jane Lewis*
5125 Tsnple Hills Road
Tsnple Hills, Maryland 20748

Testimony concerning the procurement j
and production of Agent Orange pur- !
suant to the Defense Production Act,
including directives and priority rat- :
ings issued by the United States.

!

•

,

,

Rlchard J. Marrese

*

Dr. Richard W. McBurney
315 Steeple Chase Drive
Irving, Texas 75062

Testimony concerning medical conditions at the Newark plant, including
communications with U.S. Public Health
Service and with treating physicians
at Newark.

-3 -

Name and
Present Address

Description of General
Nature of Testimony

Dr. Älan P. Poland*
2918 Nottingham Way
Madison, Wisconsin

Testimony concerning medical study of
the workers at Diamond Shamrock's
former Newark plant in 1968-69, and
research and investigation of trichlo- (
rophenol, 2,4,5-T and dioxin at j
National Communicable Disease Center
in the 1960's.

Dr. Paul A. Fossick*
46 Winding Way
Woodcliff Lake, New Jersey

Testimony concerning medical study of
the workers at Diamond Shamrock's
former Newark plant in 1968-69.

Donald M. Purdy*
F. Gordon Steward*
Diamond Shamrock Agricultural
Chemicals Inc.
P.0. Box H
Tuscaloosa, Alabama 35404

Dated:

Testimony concerning manufacturing
operations at Diamond Shamrock's
former Newark plant, including: the
development, installation and opera­
tion of a method for removing dioxin
from trichlorophenol; the U.S. Public
Health Service study of the Newark
workers in 1968-69; and the production
and shipment of Agent Orange pursuant
to contracts with the United States.

New York, New York
March 26, 1984
Respectfully submitted,
CADWALADER, WICKERSHAM & TAFT
ByifJ lS rzfc 'fy A
\2/1
A Member of the F i r m - y ^ ^
Attorneys for Defendant
Diamond Shamrock Chemicals
Company
One Wall Street
New York, New York 10005
(212) 908-7000

-4 -

13719

AFFIDAVIT OF SERVICE
STATE OF NEW YORK

)
: ss.:
COUNTY OF NEW YORK )
JEFFREY SAPER, being duly sworn, deposes and says:
1.

I am not a party to this action, am over 18 years

of age and reside in Queens County, New York.
2.

On March 26, 1984, I served the annexed Defendant

Diamond Shamrock Chemicals Company's Supplemental Listing of
Fact Witnesses on each of the persons named on the annexed list
by depositing a true copy of same enclosed in a postpaid properly
addressed wrapper, in an official depository under the exclusive
care and custody of the United States Postal Service within the
State of New York.

The copy to the Agent Orange Plaintiffs'

Management Committee was sent by Federal Express.

7

%fxev ----------------Saper

Sworn to before me this
day of March, 1984 .

Notary Public

MICHAEL MACKIN GORDON

Notary Public, State of New York
No. 31-4646965

Qualified In New York County n /—
Commission Expires March 30, l9.v. j*

l372i

•SERVICE LIST

r

FOR DEFENDANTS
Leonard L. Rivkin
Rivkin, Leff, Sherman & Radler
(for DOW CHEMICAL)
100 Garden City Plaza
Garden City, New York 11530
Morton G. Silberman
Clerk, Gagliardi & Miller
(for T H AGRICULTURE &
NUTRITION COMPANY, INC.)
The Inns of Court
99 Court Street
White Plains, New York 10601
John C. Sabetta
Townley & Updike
(for MONSANTO)
405 Lexington Avenue
New York, New York 10174
William Krohley
Kelley Drye & Warren
(for HERCULES, INC.)
101 Park Avenue
New York, New York 10178
John M. Fitzpatrick
Dilworth, Paxson, Kalish & Levy
(for HOOKER PLASTICS &
CHEMICALS CORP.)
2600 The Fidelity Building
Philadelphia, Pennsylvania 19109
Richard Goldstein
Shea & Gould
330 Madison Avenue
New York, New York

10017

Thomas Beck
Arthur, Dry & Kalish, P.C.
(for UNIROYAL)
1230 Avenue of the Americas
New York, New York 10020
David R. Gross
Budd, Larner, Kent, Gross,
Picillo & Rosenbaum
(for THOMPSON CHEMICALS)
33 Washington Street
Newark, New Jersey 07102

Arvin Maskin
Department of Justice
(for THIRD PARTY DEFENDANT US
Safeway Building
521 12th Street, N.W.
Washington, D.C. 20530
L. Kevin Sheridan
Executive Assistant
U.S. Attorney
Eastern District of New York
United States Courthouse
225 Cadman Plaza East
Brooklyn, New York 11201
COPIES OF ALL DOCUMENTS MUST
BE SENT TO:_________________
Clerk of the Panel
Judicial Panel -on Multidistrict
Litigation
1120 Vermont Avenue, N.W.
Suite 1002
Washington, D.C. 20005
FOR PLAINTIFFS
Victor J. Yannacone, Jr.
Yannacone & Yannacone
Post Office Drawer #109
Patchogue, New York 11772
Stephen J. Schlegel
Schlegel & Trafelet, Ltd.
One North LaSalle Street
Suite 3900
Chicago, Illinois 60602
Benton Musselwhite
Law Offices of Benton Musselwh
Inc.
Suite 517
609 Fannin
Houston, Texas 77002
Thomas Henderson
Henderson & Goldberg
1612 Frick Building
Pittsburgh, PA 15219
David J. Dean, Esq.
Dean, Falanga & Rose
1 Old Country Road
Carle Place, New York

11514

Agent Orange Plaintiffs'
Management Committee
26 Court Street, Suite 304-8
Brooklyn, N.Y. 1 1 2 ^

^ JL

M

UNI T E D STATES D I S T R I C T COURT
EASTERN D I S T R I C T OF NEW YORK
x
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re

UAGENT ORANGE"
Product

ÏÏfyc- . ' 1 .Ç inD
^

L ia b ility

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x

PLAINTIFFS'

MARCH 1 5 ,

I N I T I A L L I S T OF FACT . WI TNESSES
I N SUPPORT OF CLAI MS

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-m

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P L A I N T I F F S ' MANAGEMENT COMMI TTEE
26 C o u r t S t r e e t
B r o o k l y n , NY
11242
( 2 1 2 ) 330 - 0 900

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3-TÏ

PLAINTIFFS'

INITIAL

WI TNESSES

P lain tiffs

submit

witnesses

to

For

Completion

the

P lain tiffs

be c a l l e d

reserve

individuals
\

m:

by

as
'

p la in tiffs

right

tria l

as

the

to

as

upon

the

for

of

fact

each

witnesses,

each.

We

the

obvious

need

to

connection

m e mo r a n d a

are

and

preju dicial

to

Pursuant

interview ed

w ill

the

them

the

right

at

on

reserve

the

the

organization

reduce

the

amount

party

to

the

at

this

Court's

to

relevant

to

call

them

lis t

promptly

the

that

at

such

of

of

most

prelim inary

right

of

testimony

deposed,

excerpts

preparation

any

of

their

that

reservation

and

give

previously

present

The

not

tria l.

portions

been

are

at

can

indicate

defendants

the

witnesses

tending

to

of

reserve

p la in tiffs ,

of

the

depositions

this

least

have

by

of

!

witnesses

supplement

called

at

the

any

to

orders.

7

lists

call

or

w ith

No.

named i n d i v i d u a l s

reserve

be

who

to

those

p la in tiffs

suggest

r ■ 1 • r ui c ■•

such

might

witnesses

listed

and

list

inform ation

by

extent

below

this

of

of

in

the

1984.

p la in tiffs

p la in tiffs

named

- ' 'iL io n ,

Order

10,

inform ation,

receipt

been

the

which '

appears

witnesses

of

1

it

there

any

No.

extent;

witnesses

call

potential

relevant

thee x t e n t

that

dated January

^ • r' graph

To

of

Scheduling

•"to

are

those

not

e lic it

the

.>

but

of

done

depose.

P lain tiffs

the

whom h a v e

Order

lis t

to

tria l.

deposition

Since
of

to

at

w ell.

additional

most

to

testimony,

trial

right

supplement

further

factual

the

w e l l . To

produced

ofDiscovery

P retrial
wish

following

t r i a l pursuant

i.:\ 1 "

individuals

the

at

OF FACT

SUPPORT OF CLAI MS

the

witness

t o •1

M agistrate's

those

a

IN

LIST

to

either
the

that

testimony

references

of

parties'

rights

is

call

testimony

those

such

of

lists

from

the

of

w ill

a nd
be

pretrial
therefore

time.

instructions

and

perm ission,

13723
i

addresses
below

have

who

have

convenience
reporters,

is

7,

deposed

a nd

endeavoring

an

this
"as

been
been

a

of

February

and

not

As

as

whom

lis t

received"

The

to

a p rio rity
w ill

be

deposed
those

no

basis

to

of

witnesses

for

by

&

Wa g e r

between

is

locate
to

the

Attached

witnesses

address

supplemented

include

Court's

S p in elli,

June
who

listed,
the

the

29,
have

court

1982

a nd

not

been

p la in tiffs

accurate
that

named

are

addresses,

inform ation

on

basis.

additional

reservations,

some

prepared

witnesses

1984 .
to

for

deposed.

listin g

all

on

given

are,

as

witnesses

not

covered

by

the

above

follows:

DR. THOMAS ABOUD
Toledo C l i n i c
T o l e d o , Ohio

C a r d i o l o g i s t f o r M rs . Ford
T r e a t e d Danny Ford f o r
hypertension.

EDWARD E ADAMS
GORDON A. ANDERSON
102 H i c k o r y Lane
Naugatuck, Connecticut
Texas D i s a b i l i t y O f f i c e r
a nd f r i e n d o f J o r d a n s '

I RENE ANTONI K
812 Sussex
A u s t i n , TX 7 8 7 4 5
EUGENE BAK
DONALD K. BALLMAN
7722 R e v e l l e D r i v e
La J o l l a , C a l i f o r n i a
DONALD BARNES
E.

D.

BAUMGARTNER

R.

E.

BAYNARD

JEANNI . E BEAVERS
Flower H o s p ita l
Personnel Department
S y l a w i a , Ohio

Knows t h e h o s p i t a l a nd
business s t r a i n re
Danny F o r d

B I L L I E MARI E BELL
4404 Bonnie D r i v e
F t . W o r t h , TX 7 6 1 1 6

Danny J o r d a n ' s

mother

13
2

CLOYC.I G. BELL
4404 Bonnie D r i v e
F t . W o r t h , TX
75116

Denny J o r d a n ’ s S t e p Father

BELL TELEPHONE OF PA
1 P a r k Way
P h i l a d e l p h i a , Pa. 19101

Personnel records
George E w a l t

W.

B.

of

BELLS

ETCYL H.

BLAIR

JOHN B L I S H
A . A. BLOCK
KANSAS C I T Y ,
WI LLI AM

MO.

BLUMENAUER

JOSEPH L .

BOLTON

JACK BORRER
12920 Wellswood T r a i l
C h e s t e r f i e l d , Ohio 44025
AL BOTHWELL

High School f r i e n d o f
L a m b i o t t e ' s who was w i t h
him i n V i e t n a m

JAMES E. BOWERS
S T . L O U I S , MO.
D A N I E L BRAXTON

George
1975

BOB BROWN

Served w i t h
in Vietnam

BROWN,

W i t h Danny F o r d
sprayed areas

SGT

DAVE BUNI N
JOHN

S.

BUSH,

Ew alt's

Foreman

Dan.

Jordan

in

E c o n o mi s t
Jr.

W I L L I A M CALLAHAN
West V i r g i n i a

Was w i t h

ME L V I N CAL V I N
2 6 8 3 Bu e n a V i s t a Way
Berkeley, C a lifo rn ia

F o r m e r member o f PSAC
a nd d i r e c t o r o f Dow
Chemical re government
knowledge v s . Dow's
k n o w l e d g e and f a i l u r e
to warn.

3

Ewalt

in

Vietnam

RICHARD
ELLIS

CASEY

CASH

EDWARD LEE CHAMDLER
EDWARD E. CHAPMAN
5743 N . E u c l i d
G ladstone, Missouri
J.

G.

CHARLTON

R0 8 SRT L . CHONOLES
23 C a r m e l l a D r i v e
E d i s o n , New J e r s e y
E MI L

GEORGE

J.

Re

CHRI STOFANQ
F.

COPELAND,

DI ANE

COURTNEY

lia b ility

D ir e c t o r of procurement
P r o d u c t i o n , Richmond, Va.
( P r o c u r e m e n t , s u p p l y and
f a i l u r e to warn is s u e s )

COL L I NS

G.

Hercules'

A s s t . Gen. M a n a g e r , ' 3 4
Gen. Mgr. S y n t h e t i c s ,
5 5 - 7 2 ( Re H e r c u l e s )

Jr.

Government e x p e r t
w i t n e s s on c a u s a t i o n

GEORGE & MARGE CRAWFAS
40 Hoc k R d .
Kennessaw, Ga.

Saw c h a n g e s i n D a n n y F o r d
C h r i s ' s B r o t h e r and S i s t e r
i n Law

JOHN CRAWFAS
Beach V a l l e y Rd.
A t l a n t a , Georgia

Chris'

OWEN & BETTY CRAWFI S
51-33 W hiteford Center
T o l e d o , Ohio

Rd.

CRI TTENDEN,

M o t h e r a nd d a d o f C h r i s .
Used t o t a k e D a n n y f o r
t r e a t m e n t (5133?)
Amount s - d o i n g away
h e r b s - ha s t a p e s t o
determ ine exposure
to V e t e r a n s I I ' s

ROBERT CROCKER

EUGENE D.

Brother

Jr.

of

D ir . Sales, 55-57
A s s t . Gen. Mgr . S y n t h e t i c s
57-53
9 5 3 D u P o n t Road
W i l m i n g t o n , D e l . 19307

«

ROBERT CROCKER
WARREN CRUMMETT
803 C r e s c e n t D r i v e
M idland, Michigan

Dow s c i e n t i s t ; e v i d e n c e
c o n c e r n i n g Dow l i a b i l i t y
issues.

GEME CUMMI NGS

Served w ith
Vietnam

B I L L CURTIS
c / o CBS News
5 2-1 W e s t 5 7 t h S t r e e t
New Y o r k , New Y o r k 1 0 0 1 9

Evidence concerning
eyewitness observations
as t o t h e c o n d i t i o n
of the c o u n try o f
Vietnam, extent of
r e s i d u a l d e f o l i a t i o n and
p o ssible photographic
exhibits; investigation
continues.

THOMAS

P.

Jordan

in

DALBY

S.

S.

DAN I E L S

L.

L.

DANI ELSON

U.S.D.A.

Liason

NACA

EDWARD DEBOLT
DIAZ,

STAFF

SGT.

With

Ewalt

in

Vietnam

CHARLES D I L L E Y
KANSAS C I T Y , MO.
LINDA

DI MOLA

CHARLES

Kerry

Ryan's

Babysitter

DI SHNER

M DOJNY

OWEN DOLI M
5 22 5 Sun Va 1 1 e y D r i v e
C h a r l e s t o n , West V i r g i n a
LAWRENCE

E.

D0TS0N

WI LLI AM

DUFFIELD

CHARLES

L.

C h a i r m a n , NACA; e v i d e n c e
re l i a b i l i t y issues
a f f e c t i n g many d e f e n d a n t s
i n a d d i t i o n to H e r c u l e s .

DUNN

On S u f f o l k

JOSEPH DUQUETTE

5

County

Police

Force
J.

M.

with

Mike

Ryan

FAGAN

JACK D. EARLY
307.4 L a k e n h e a t h Way
Potomac, M a r y la n d 20854
WAYNE EDWARD
PLATOON S G T .

ELLY

Was w i t h
areas.

Ewalt

in

spray

P a r e n ts o f George
and f a m i l i a r w i t h
fam ily s itu a tio n

Ewalt

DONALD ELMORE
DENNI S

ELMOVS

GEORGE W. & EUNI CE EWALT SR.
7 3 1 Penn P i n e s B l v d .
C l i f t o n H e i g h t s , Pa.
TEN

EYCK

W I L L I A M A . FATRCLOUGH
7 4 0 7 1 V i a San F e r n a n d o
Mission V i e j o , C a l if o r n i a
FRED FALANA

02592
W i t h Danny
areas

Ford

in

sprayed

W i t h Da n n y
a r ea s

Ford

in

sprayed

W I L L I A M F . FALSEY
5705 L a k e v i e w D r i v e
Lake C i t y , M i c h i g a n
OTIS

E.

FARMER,

L.

E.

FANCHER
CAPT.

FAST

WI LLI AM

FENNER

J . R. FI S CHE R
HERCULES, I N C .
J A C K S O N V I L L E , ARK.

1 8 9 9 R a p i d s Road
Hi r a m, Ohi o

C hris F o rd 's Business
p a r t n e r and g o o d f r i e n d
( S e e Smayda)

THOMAS FORBES
M o n e s t a r y Avenue
P h i l a d e l p h i a , Pa.

Friend of
served in
V i etnam

BETTY

FMAYDA

George E w alt
same a r e a i n

who

13728

JOHN J . FORD
15 W i n t e r b u r y C i r c l e
W ilm ington, Delaware
KERRY & JEANETTE
5507 Secore Rd.

FORD

Brother

of

Danny

Ford

Lambertvi11e , Michigan
RAY & ROSE FORD
1 3 d 78 S o u t h C o u n t y
Highway

Danny

Ford's

Parents

Line

Ottowa Lake, Mich. 49257
MARGARET FORLAND
First Street
Ft. Dix, N.J.
JOSEPH W.
E/4

Sister

H.

G.

Ewalt

4 2 3 d Co mb a t S u p p l y ,
w ith L a m b io tte in
V i etnam

FRANKS

P.

George

FOWLER

(in j a i l )

JOHN

of

Chief to x ic o lo g is t
H e r c u l e s , r e many
l i a b i l i t y and
causation issues

FRAWLEY

FREDERI CKS

VAL K.

GAERTNER

J ESSE GERSHBERG
E r . D. G l a d n e y
East S t. L o uis,

with

Ewalt

in

Vietnam

Mo.

A. W. GLEMN
HAROLD G I L L

Dow a n a l y t i c a l c h e m i s t
who a l l e g e d l y d e v e l o p e d
a n a l y t i c a l method f o r
determ ination of
2 , 3 , 7 , 8 TCDD i n ' 5 4 .

CHERYL GONDEK
4 0 0 9 S h a wn e e T r a i l
F t . W o r t h , TX 7 5 1 3 5

Danny J o r d a n ' s

CHARLES

E.

GRAM TTO

RAYMOND A. G U I D I
420 Essex P l a c e
Memphis, Tennessee

sister

Was w i t h
area

COLONEL HAI G

Ewalt

in

spray

WALTER D. HARRI S
1 9 9 ALLERTON RD.
NAUGATUCK, CONN.
E.

ROSS HART

DAV I D G. HELM
5009 F o r e s t
Kansas C i t y , Kansas
RI CHARD HI CKMAN
R o u t e 4 , No. .10 Yocum
Rogers, Arkansas

J ESSE

Rd.

Dow g o v e r n m e n t s a l e s
Mgr. re Dow's a t t e m p t s
to s e l l p r o d u c ts
including herbicides
to th e g o v e r n m e n t

HI L S S N

PAUL E. HOFFMAN
1202 Lake Shore D r i v e
Barrington, I l l i n o i s

North

GRAYDON HOLDEMAN
BENJAMI N B. HOLDER
5 2 0 3 BLOOMFI ELD S T .

Dow M e d i c a l D i r e c t o r r e
h e a lth e f f e c t s in w orkers,

MI D L A N D ,

f a i l u r e t o w a r n and l a c k
o f mi n i mu m e f f e c t l e v e l .

MI CH.

HARRY HOLLAND

Friend

RAY HOLMES

Dow p l a n t s u p e r v i s o r
who c o n t r a c t e d
c h lo r a c n e ; re h e a l t h
effects

G.

of

Lam biotte's

HOLSI NG

DONALD HOLT

George

Ew alt's

Foreman

Danny

Jordan's

In-Laws

VERNON HOUCK

F . GERARD K, VADA Ml IK T LL
2 2 0 W. T y l e r
Magnum , O k l .
THOMAS R.
RAPHAEL

H.

73554

HUNT
HUSTON

3

' SO

PETER

INFANTE

GEORGE JACKSON

G e o r g e E w a l t ' s Foreman
l a t e '70s to e a r l y '80s
High School f r i e n d o f
G e o r g e E w a l t who was
i n V i e t n a m a t same
t i m e and k nows h i s
medical problems.

JOHN J ENNI NGS
Apt. B
12 L a n s d o w n e A v e n u e
Lnnsdowne, Pa.

DAV I D JORDAN
LYNNE KELLER
2 08 B r a e s w o o d
A u s t i n , TX 7 ^ 7 0 4

Friend

R. EMMET KELLY
8 85 SO. SKI NNER
S T . L O U I S , MO.

Monsanto

VAN A. KELLY
Philadelphia,

With

of

Ewalt

Danny J o r d a n ' s

in

Vietnam

Pa.

GEORGE C. KEMPSON
1 43 S o u t h G o r e
Webster G roves, M is s o u ri
EUGENE E. KEMAGA
1 23 1 N. -Wagner Road
E s s e x v ille , Michigan

FRANCI S

KENNEDY

WI LLIAM

K I DD

Dow e m p l o y e e r e
envi ronmental
persistance, to x ic ity
a nd l i a b i l i t y i s s u e s

CARL & CARLA KI MG
3 3 —42 R o m a k e r
T o l e d o , Ohio

J.

M.

C lo s e s t f r i e n d s o f the
( D a n n y ) F o r d s ; s h e was
w i t h C h r i s when t h e y
f o u n d o u t t h a t Da n n y
F o r d ' s l e g was c a n ­
c e r o u s a nd how much
p a i n he was i n . A d d r e s s
may a l s o be 3 3 2 0
R o m a k e r Road

KI RG I S

A. Y . K I S T NE R
KANSAS C I T Y , MO.
FRANK W. KLEMAN
S T . L O U I S , MO.

o

«

*

GEORGE
J.

KLINE

KLIMGNAN

PHILIP
JULES

LANDRTGAN
LAM

MICHAEL

David

LAMBÌOTTE

J. K. LEASURE
R. R. No. 2 - 3ox
Makanda, Illinois
FRANK

LEMAK

P. R.

LITTLE

HAROLD A.

R.

N.

MALONEY

Uncle

Brother of David
Lambiotte

157

LLOY

Ewalt's daughter's
psycholog ist

DR. ANNETTE LYNCH
School houso Lane
Philadelphia, P a .
J.

Lam bi ott e' s

MALLET

DAVE MANN

Employer of Lamb io tte
before and after
Vietnam

THOMAS MA RKWOOD
Jeep Corp.
940 N. Coe. Blvd.
Toledo , Ohio

Payroll Records and lost
income re Danny Ford

ROBERT E. MASKILL
41 East 53rd Street
Kansas City, Missouri

T-H Agri cu ltu re ;
issues

RICHARD J.

liabi lit y

MARRESE

JAMES MASON
JOHN MASON
12 Tanners Dean
Leatherhead, Surrey
Eng land
L. G. MAIJREY

ri{ O'O O

PAUL MAYFIELD

10

<*

«

M. McCALLEY
W IL LI AM J. M cC ARV IL LE
12 Ridge Crest JCourt
Chesterfield, Missouri
DONALD .McCOLLISTER
5522 Whitehall Street
Midland, Michigan

Dow

d . Mc e l r o y
9551 BLACK GOLD RD.
C ALI FO RNI A

william

JUDY McKINSEY
1899 Rapids Road
Hiram, Ohio

Business partner of Chris
Ford and close friend
(See McKimnley)

SGT.

served with Jor da n
Vietnam

TIMOT HY MEDDOR

in

COL. BRUCE MEYERS
59 1-1 W. MERCER WAY
ST. LOUIS, MO.
ROY MEYERS
CHARLES

E. MINARI CK

SHERRY MOSHER
18 4 3 35 ’
W inchester
Toledo, Ohio

Business m an age r of the
kennel.
Stress and
strain on Chris Ford
Address may also be 1950
W in che st er

Rd.

DEBDAS MUKERJEE

Go ve rn m e n t

BOB NOBER
71 Lempa Road
H o .1land , Pa

Was with

WI L L IA M R. NUMMY
711 W. Mea dow br oo k
Midland, Mi chigan
JACK IE OCHS
c/o GREEN MO UNTAIN
P. 0. BOX 229
TUR NER FALLS, M A .

expert

Ewalt

in Vi et nam

Drive

POST FILMS

Photo gr aph ic ex hibits
& personal o b s e r va ti o ns
& inv es tig at ion s

Friend of

BRIAN O' CONNOR
J. F. O' CON NO R

I I

the Ryans

SGT.

THOMAS O 'D ON NE LL

DR.

OERTNER

J.

E.

PANNETON

PARDEE

PHIL PENN

Amounts - doing away .
of herbs - has tapes
to de termine exposu re
to Ve te ran s I I 's

REBECCA PEPPER

67.18 Si lvermine
81004
Austin,

TX

JACK

PETERSON

E.

Ne ighbor

of J o r d a n 's

Drive

78776

66 4 Forest Grove Circle
Brookfield, Wisc on si n

F. H.

in

PALLARD

FRANCIS
L. A.

Served with Jo r da n
Vietn am

Former Dow em pl oye e who
ad dressed industry
r e pre se nta ti ves at
March, 1965 meeting
co ncerning rabbit ear
testing

PLACET

WILLI AM

L.

POPHAM

DON ALD PURDY
160 F re der ic ksb er g
Avon Lake, Ohio

Drive

THOMAS RAFERTY
New York City

With .Mike Ryan
V i et n a m

in

VIRGIL B. ROBINSON
2620 Quail Hill Drive
Upper St. Clair, Pa. 15241
V.

K.

ROWE

ROBERT R.

Dow's former Chief
T o x i c o l o g i s t - li ability
issues as well as
c a us at ion questions; Dow's
knowledge of extreme
toxicity and failure to
warn
RUMER

*

*

CECIL RUSSELL
4 5 W I N G F I E L D ROW
GLENDALE, MO.
MAUREEN

RYAN

School Principal who
knows Kerry's education

M IC HA EL

RYAN

Mike

VICKY

RYAN

Ryan's

Father

Kerry's Gr an dmo th er

HENRY SADLER

Boyhood friend of
Lainbiotte's who was
with him in V i etn am

UMBERTO SAFFIOTTI

G o v e rn m e n t caus at ion
witne ss with factual
testimony re g o v e rn m en t
co ntract defense,
liab il ity issues and
issuance of B i on et ic s
Labor at ori es Report.

DR.

Dr. who told La mbiotte
to stop working

F lo r id a

SALTER

ED SA WGRASS
SUSAN SCANLON
Riplen Street
Philadelphia,
WI LLI AM

R.

Sister

George

Ewalt

Pa.
Dow f o r m e r e m p l o y e e
f a i l u r e t o w a r n and
business of s e l l i n g
h e r b i c i d e s to the
government

SCHAMBRA

.1411 W. St. Andrews
Midland, Michigan

ARTHUR J.

of

re

S CH L E SS I N G ER
Neighbor

OLGA SCHNELL

of

the

Ryans

SCHUBACK
LAPIN 0.
R. B.

SCOTT

SCOTT

RICHA RD SCOTT

Drafted with Lam bi ot te
and saw in V i e t n a m

SGT.

David

SHARKEY l

L a mb io tt e' s

4K
l? _

platoon Sergeant
in V i etn am
DEX TER B. SHARP
13042 We ath e r fi e l d
St. Louis, Mo.
A.

Drive

E . SIDWELL

LARRY SI LVE RSTEIM

Dow former employee re
March, 1955 m e e t i ng s at
Dow and other liability
issues and health
effects to Dow empl oye es

BETTY SMAYDA
1399 Rapids R d .
Hayram, Ohio

Business pa rtners - Chris
Ford's plus good friend.
What Fords went through
and personal strains

J.

G.

CAPT.

SMERALDI
SMITH

PLATOON

LT SMITH

TOM X.

SMITH

ROBERT

SNODGRASS
W. V a .

With

Ewalt

in spray areas

With

Ewalt

in spray areas

Huntington,

With Danny Ford
areas

HOWARD C. SPENCER
11008 Cameo Drive
Sun City, Arizona

Developed rabbit ear
in 1941 while a Dow
employee

35351

in Sprayed

test

L.P.SEITZ
A. JOHN SPEZIALE
311 N. Umberland Avenue
Redwood City, Califo rn ia

94031

JOHN A. STEPHENS
800 N. Lindbergh Blvd.
St. Louis, Missouri
FREDERICK G. S T EWA RD
173 Woodla nd Forest, Section
Tuscaloosa, Alabama 35405
CHARLES

N.

3

STEWART

M IC HA EL STRANGE
521 Bomber Road
Ft. Worth Texas

Friend

of D a n n y Jordan

1 3 7 '¿5

*

«

FR EDERICK STRANSKY

Mike
Law

SGT.

Was with
areas

STRAWBERRY

Ryan's

Bro the r-i n-

Ewalt

in spray

DEIRDRE STRANSKY

Teacher - knows Kerry Ryan
- a sp ecialist in learning
disab il iti es

PATRICIAL STRANSKY

Nurse and Family
Co unseller for Ryan
family

JACK STRUM
712 Short Spoon Circle
North Carolina
JOHN

S.

SULLIVAN

W IN F I E L D W. S UN DER LA ND
5300 Westpath Way
B e t h e s cla , Maryland
DANIEL W.

SWEET

MILTON A. TAVES
210 M. Spring Va ll e Road
Wilmington, Delaware
Bu siness partner of
David Lambiot te 's

CLINTON TAYLOR

R. D. THOMPSON
W ILL IA M THOMPS ON
31 S G E O RG IN A AVE.
SANTA MONICA, CAL.
A.

L. TREI SB EC K

DAN TWIFF
Woodla nd Street
Slyvian, Ohio

Union c o mm i s s io n man at
Danny Ford's job.
Also
a friend of Dan's.
Has
information about union
co ntract (current) and
personnel matters. See
also Twiss.

DAN TWISS
4910 Woodland
Sylvania, Ohio

Comm it tee man at AMC Jeep
See Twiff above

15

W IL LI A M R. UDELL
SO TE ALW OO D
CREVE COEUR, MO.
EDWIN T.
W.

UPTON

T-H l i ab il ity

issues

VAMDERVENDOR

JANE WARD

Neighbor

of Fords

3527 M . 151
Temperance,

Mich.

43102

ROBERT T. WEB BE R
4 Media Drive
St. Louis, Missouri
ADAM WENKUS
Route 5 - Box 904
Waupaca, Wi sconsin

BUTCH WESTERLAND

5 3.14 5
Supply and distri but ion ,
defendants' failure to
warn; former Defense
M i l i t a r y Supply Office
employee.
Served with Jordan

V ie tn a m

in

HARTLEY WILD ER
S G T . J.

WILLIS

Served w ith
in Vietnam

Danny J o r d a n

MARK G. W I L T S E
N.

WTR7.

WIL BUR WOMLG AM UTH
4 9-21 Bar ton Place
Slyvian, Ohio

Union Stewa rt at Danny
Ford's - knew Dan when
he had the cancer and
the wages at the time
and the chang es in Dan

L. K. WO OLF OL K
JOHN WRIGHT
R. WRIGHT
R.

T. YATES

YORK

HOSPITAL

M I T CH EL L ZAVON
KET TER IN G LABS
CINCINNATI, 0.

Former employer
Lambiotte

of

«

*

CHARL ES P. ZORSCH
ROUTE 5, BOX 30
PACIFIC, MO.

AG EN T ORANGE PLAINTIFFS'
M A N A GE M E N T C O MM IT TEE
By

March

15,

1934

17

vji iû spinelli

certified shorthond reporters

Page

Date Taken
June 29, 1982
June 30, 1982
July 1, 1982
July 8, 1982
July 13, 1982
July 15, 1982
July 19, 1982
July 20, 1982
July 21, 1982
July 26, 1982
July 27, 1982
July 27, 1982
July 28, 1982
July 29, 1982
July 30, 1982
August 3, 1982
August 4, 1982
August 16, 1982
August 17, 1982
August 26, 1982
August 27, 1982
September 8, 1982
September 9, 1982
September 15, 1982
September 16, 1982
September 21, 1982
September 22, 1982
September 23, 1982
September 29, 1982
September 30, 1982
October 5; 1982
October 6, 1982
October 14, 1982
October 19, 1982
October 20, 1982
October 21, 1982
November 3, 1982
November 9, 1982
November 10, 1982
November 16, 1982
November 17, 1982
November 18, 1982
November 24, 1982
December 1, 1982
December 2, 1982
October 26, 1982

Witness
Bernard J. Jandorf
Dr. Van Murray' Sim
Bernard J. Jandorf
Dr. Marcus M. Key
Dr. Robert A. Darrow
Donald W. Falconer
Dr. Van Murray Sim
David Henry Groth
Richard R. Bates
Kent R. Irish
Katherine Diane Courtney
Charles E. Minarik
Charles E. Minarik
Charles E. Minarik
Dr. Marcus Key
Philip C. Kearney
William Upholt
Philip C. Kearney
William C. Shaw
Donald Birmingham
Donald Birmingham
Robert J. Anderson
Warren C . Shaw
Walter Edward' Sultan
Garnett R. Higginbotham
David Firestone
John L. Buckley
Sigmund R. Eckhaus
Andrew W. Anderson
Carleton G. Shead
Edward A. Metcalf
Sigmund R. Eckhaus'
David Firestone
William B. Ennis, Jr.
Joseph D. Avellino
Richard G. Horton
Frank J. Vocci
Lester L. Miller
Dr. Benjamin Harris
John F. Callahan
William W. Dorrell
William F. Barthel
Keith H. Jacobson
Merl Ringenberg
James Arthur Hebbeler
William W. Stone Jr.

w a g a a n a spinelli

certified shorthand reporters

Page

Date Taken
December 7, 1982
December 8, 1982
December 9, 1982
December 9, 1982
December 9, 1982
December 14 , 1982
December 16 , 1982
December 15 , 1982
December 15 , 1982
December 17 , 1982
December 21 , 1982

Witness
Seymour L. Friess
Robert E. Cox
'
Paul C. Warnke
Theodore C. Byerly
Harry W. Hays
Lawrence Fishbein
Dayton Klingman
Carl Gwin Baker
John S. Foster
Herbert G. Fredericks
Ralph T. Ross

January 3, 1983
January 5, 1983
January 11, 1983
January 11, 1983
January 12, 1983
January 13, 1983
January 17, 1983
January 18, 1983
January 18, 1983
January 18, 1983
January 18, 1983
January 19, 1983
January 20, 1983
January 20, 1983
January 20, 1983
January 21, 1983
January 24, 1983
January 25, 1983
January 27, 1983
January 27, 1983
February 1, 1983
February 2, 1983
February 3, 1983
February 4, 1983
February 7, 1983
February 8, 1983

Paul Aaron Possick
Henry Fischbach
Cyrus Robert Vance
John S . Leary
Lawrence M. Petrucelli
Fred I . Edwards
Herbert E. Stokinger
Joseph A. DiPaolo
Dohrman H. Byers
Douglas H.K. Lee
Boris J. Osheroff
William A. Fenner
Garth Fitzhugh
Harold Brown
Levi T . Burcham
Francis Kennedy
Thomas A. Treglia
Abram Saul Kaplan
George M. Lawton .
Eugene Bak
Nicholas S. Cox
Fred J. Delmore
Riley D. Housewright
John L. Traub
Charles E. Granito
Edward Lee Chandler

-2-

* . / :wcertified
a gshorthand
a a nreporters
d spinelli
Date Taken
February 8, 1983
February 9, 1983
February 10, 1983
February 10, 1983
February 11, 1983
February 11, 1983
February 14, 1983
February 15, 1983
February 15, 1983
February 16, 1983
February 17, 1983
February 18, 1983
February 22, 1983
February 22, 1983
February 23, 1983
February 23, 1983
February 24, 1983
February 25, 1983
February 25, 1983
March 1, 1983
(
March 1, 1983
March 2, 1983
March 2, 1983
March 3, 1983
March 8, 1983
March 10, 1983
March 10, 1983
March 16, 1983
March 17, 1983
March 17, 1983
March 22, 1983
March 22, 1983
March 23, 1983
March 23, 1983
March 24, 1983
March 25, 1983
March 25, 1983
March 28, 1983
March 31, 1983
April 1, 1983
April 7, 1983
April 7, 1983
April 7, 1983
April 8, 1983
April 8, 1983
April 12, 1983
April 13, 1983
April 14, 1983
March 30, 1983

Page

-3-

Witness
Donald Whittam
Anthony Sinclitio
Thomas R. Dashiel
Lester Boyer
*
William J. McCarville
Frank L. Bauer
Charles E. Bushey
William J. Crawford
Walter W. Melvin, Jr.
Robert S. McNamara
John H. Gerety, Jr.
R. Emmet Kelly
John S. Bush, Jr.
Lee A. DuBridge
Robert L. Andreoli
Robert W.'Morthland
James H. Gardner
George M. Lawton
Kennard A. Reynard
Alan P. Poland
Arthur J. Schlesinger
Dr. Henry Kissinger

A la n P. P o la n d

William Childs Westmoreland
John P . Frawley
Harold H. Gill
Albert E. Hayward
V.K. Rowe .
.Jack E. Burton
Robert A. Shade
Gordon A. Anderson
William H. Summerson
Benjamin Brace Holder
Melvin M. Rabstein
William T. Thompson
Jerome Wilkenfeld
Harold H. Gill
Oscar Garth Fitzhugh
Etcvl H. Blair
Vincent McRae
Edwin T. Upton
Wayland J. Hayes
George M. Lawton
George M. Lawton
Edwin T. Upton
James Henry Wills
? Harry Heiman
X3*74.i
Seymour Silver
Donald D. McCollister

w a g a a n d spinelli

certified shorthand reporters
Date Taken
April 22, 1983
April 27, 1983
April'. 28, 1983
April 28, 1983
April 29, 1983
April 29, 1983
May 2, 1983
May 2, 1983
May 2, 1983
May 2, 1983
May 3, 1983
May 4, 1983
May 4, 1983
May 5, 1983
June- 6 ,' 1983
June 3, 1983
June 6, 1983
June 13, 1983
June 14 , 198 3
June 21, 1983
June 23, 1983
June 24, 1983
June--28 , 19 83
June 29, 1983
June 29, 1983
July 1, 1983
July 6, 1983
July 6, 1983
July 11, 1983
July 11, 1983
July 11, 1983
July 12, 1983
July 13, 1983
July 14 , 1983
July 14, 1983
July 15, 1983
July 18, 1983
July 21, 1983
August 1, 1983
August 3, 1983
August 3, 1983
August 4, 1983
August 5, 1983
August 9, 1983
August 10, 1983
August 11, 1983
August 12, 1983

Page

Witness
Gordon J. MacDonald
General Maxwell Taylor
Donald F . Hornig
Charles L. Dunn
«
Ronald Joseph Kassel
Spurgeon M. Keeney, Jr.
Kenneth M. Endicott
John C. Atkinson
William Horwitz
Cecil' H. Russell
Charles P. Zorsch
William R. Udell
Umberto Saffiotti
Nathan Gordon
Gordon J. McDonald
Steve S. Szabo
Albert C. Kolbye
Warren R. Bontoyan
John C. Atkinson
Milton K. Christensen
Dr. Michael Klein
Marshall Stubbs
Robert M. Gastineau
E. Ross Hart
Harold N. McFarland
Ian Alastair Mitchell
Dr. Douglas Lindsey
Daniel W. Sweet
Herschel E. Griffin
William F. Barthel
K. Diane Courtney
Harold J. Magnuson
William D. McElroy
General James A. Hebbeler
Joseph F. Coates
Peter S. Bing
William M. Creasy
John F. O'Leary
Graydon C. Essman,III
Walter Leo Zielinski, Jr.
Herbert F. York
John D. Baldeschwieler
George M. Lawton
Roswell Daniels
Umberto Saffiotti
Robert J. Heaston
Robert H. DuGuid

-4

■ certified.
w a gshorthand
a a nreporters
d spin elli

^
Page

Date Taken
August 15, 1983
August 15, 1983
August 16, 1983
August 17, 1983
August 17, 1983
August 17, 1983
August 17, 1983•
August 18, 1983
August 19, 1983
August 19, 1983
August 22, 1983
August 22, 1983
August 23, 1983
August 24, 1983
August 24,1983
August 25, 1983
August 25, 1983
August 30, 1983
August 30, 1983
August 30, 1983
August 31, 1983
August 31, 1983
September 7, 1983
September 8, 1983
September 12, 1983
September 13, 1983
September 14, 1983
September 15, 1983
September 16, 1983
September 16, 1983
September 16, 1983
October 3, 1983
October 3, 1983
October 4, 1983
October 4, 1983
October 6, 1983
October 17, 1983
October 17, 1983
October 17, 1983
October 19, 1983
October 19, 1983
October 20, 1983
October 20, 1983
October 21, 1983
October 21, 1983

Witness
David M. Cawthorne
George W. Connell
Marshall Steinberg,
John L. Buckley
Charles E. Stewart
J.G. Smeraldi
Wayne Edward
John T. Weimer
Henry L. Verhulst
Dorothy M. Ward
Dr. Arthur H. McCreesh
Paul D. Harkins
Dr. Richard D. Horton
Normand E. Olivier
Jane Lewi's
Frank J. Vocci
Verne C ’
. Fryklund, Jr.
Dr. Thomas C. Simmons
Henry N. Doyle
Eberhardt Recht’
in
Laverne A. Parks
Brunildo Antoio Herrero
Paul Doty
Frank H. Westheimer
Louis B. Arnoldi
John Angel
David Jordan
. Donald W. Norberg
William T. Thompson
Filiberto Vargas
Warren Crummett
John Wilder Tukey
Willis Hart
Donald W. Fuhlage
Francis Gene Douglas
Jerome D. Wiesner
John A. Stephens
Jack E. Peterson
Robert L. Chonoles
Frederick G. Steward
Virgil B. Robinson
William G. Kratz
Dexter B. Sharp
Jack A. Borror
Dr. Howard C. Spencer

-5-

CERTIFICATE

ce rt ify

The

undersigned,

that

on

doc ument

on

the

all

private me s s en ge r
copies

were

Mag is tr a te

15th

those

OF

SERVICE

Edward
day

of

F.

Hayes,

III,

does

March,

he did

serve

the

shown

on

the

service with

the

following

de livered
Scheindlin,

p e rs o n a l l y
before

by

attached

hand

the hour

service

exceptions;

to Judge

here by
enc los ed
list

by

Ch a m b e r s

Weinstein

and

Rivkin, Leff, Sherm an & Radler
At torneys for Dow Chemical Co.
100 Garden City Plaza
Garden City, NY 11530

T ow nl ey & Updike
At torneys for Mo nsanto
405 Le xington Avenue
New York, NY 10017

Co.

Cadwalader, W i ck e r s h a m & Taft
A tt or ne ys for Diamond Shamrock
One Wall Street
Mew York, NY
10005
Arthur, Dry & Kalish
A tt or ne ys for Uniroyal, Inc.
1230 Avenue of the Americas
New York, NY 10020
Shea & Gould
Att or ney s for Uniroyal,
330 Madis on Avenue
Mew York, NY 10017

Inc.

Clark, Ga gliardi & Miller
Atto rn eys for T&H Agriculture
99 C ourt Street
White Plains, NY
10501
Budd, Larner, Kent, Gross,
Picillio Sc Rosenthal
A tt or ne ys for Th om pso n Chemical
3?
- ■ • ::
• ’

, • • -

V •-

. ,i. • ’ 1 '

! 7

*

;I v i

I".
’■
r'-.ment of Justi ce
Room 9 0 4D
Safeway Building
Wa shi ng to n, DC
25030
Kelley, Drye & Warren
At t o r ne y s for Hercules,
101 Park Avenue
New York, NY
10173

Inc.

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

-------------------------------------------------------------------- X
In re:
"AGENT ORANGE"

Product Liability Litigation
-------------------------------- X

SUPPLEMENT TO PLAINTIFFS' EXPERT
WITNESSES’ EXPANDED SUMMARIES IN
ACCORDANCE WITH F.R.C.P. 26(b) (4) (A) (i)
AND IN ACCORDANCE WITH MAGISTRATE'S
RULINGS OF FEBRUARY 29, 1984_____

PLAINTIFFS' MANAGEMENT COMMITTEE

By/’ A r

U

J

fU s K jJ U U
»

Thomas W. Henderson, Esquire
Alison Pettiette, Esquire

A jew of iheso fondS

hie iSlijktlij biujid f[kis oddj
the Cofid/hon o f -phe cLoccLmend
<t n d dhc Copy machjne.
Pfhank tío*!

ms

DEBORAH A. BARSOTTI, Ph.D.

V.

GROUNDS FOR EACH OPINION
A.

General

Dr. Barsotti will rely upon her review of medical and scientific
literature which is cited in her Curriculum Vitae and References previously
submitted.

In addition, Dr. Barsotti's educational and personal experience

are set forth in her Curriculum Vitae.
Dr. Barsotti became involved in research with the Halogenated
Aromatic Hydrocarbons (HAH's) in 1973 as a graduate student at the
University of Wisconsin.

After the completion of her Ph.D. in 1980, Dr.

Barsotti continued with the projects at the University of Wisconsin until
her leaving to accept a position of Assistant Professor in Toxicology at
the Philadelphia College of Pharmacy and Science.
During her tenure at the University of Wisconsin, she was involved
with (1) preparation of experimental protocols; (2) the establishment of
the clinical and reproductive test parameters; (3) the day to day operation
of the Resus monkey colony including sample acquisition and testing,
animal husbandry and autopsy procedures and data analyses of Resus monkeys
chronically exposed to HAH's as well as their control.

This work has

culminated in numerous publications as presented in Dr. Barsotti's Curriculum
Vitae.

In addition, she has been invited to speak or present her work in

various atmospheres including community meetings and scientific symposia.
The specific chemical toxic compounds that she has worked with are
polychlorinated biphenyls (Aroclors 1248 and 1016 products), the polybrominated
biphenyls (Fire Master product), and hexa and tetrachlorinated dibenzo-para

dioxins (HCDD's and TCDD's).
Since Dr. Barsotti's acceptance at her new position in January
of 1983, she has continued to analyze the data from the studies of
Wisconsin for publication purposes.

In addition, Dr. Barsotti has

biological samples from these studies which are to undergo further analyses.
Furthermore, Dr. Barsotti has submitted a National Institute of Health
(NIH) graph application to continue research on HAH's.

B.

Specific

In addition to all references previously listed in Dr. Barsotti's
References and Curriculum Vitae, the following references regarding dioxins
and toxins, particularly TCDD, support Dr. Barsotti's Opinion IV A:
a)

Poland and Knutson,1982.

b)

Allen, et al. 1977.

c)

Allen, et al. 1979.

B.

4.

The statement "Recent advances in detection methodology"

is hereby deleted.

Additional specific references in support of Opinion

IV D include the following:
a)

Nature, Vol. 283, p. 772, 1979.

B.

6.

With respect to Opinion IV F, the underlying premise of

animal toxicity testing is that the effects produced by the compound in
laboratory animals are applicable to man:
a)

Casarette and Doull's Text Book: Toxicology,
The Basic Science of Poisons, 1980.

b)

Principles of Animal Extrapolation, Edward J.
Calabresi, University of Public Health, Amhurst,
Mass. 1983, published John Wiley & Sons.

In the case of HAH's, including TCDD, similarities exist in
the clinical and reproductive symptoms observed in Resus monkeys and
that reported in man:
a)

Barsotti, et al. 1976.

b)

Barsotti, 1980.

c)

Schanz, et al. 1970.

d)

Kuratsune, et al. 1972.

e)

Koshimura, 1974.

f)

EPA, 1979.

g)

Bogen, 1979.

In addition, symptoms in both species appear to be latent or
persistent after TCDD exposure has ceased:
a)

Barsotti personal research.

b)

Oliver, 1975.

c)

Pazberoba, et al. 1981.

References:

J.R. Allen, J.P. Van Miller and D.A. Barsotti, Toxicol.
Appl. Pharmacol., 47, 179, 1979.
G. Bogen, J. Amer. Ed. Assoc., 242, 2391, 1979.
EPA Report, p. 78, February 28, 1979.
Kuratsune, M . , Yoshimura, T., Matsudaka, J., Yamaguchi,
A., Environ. Health Perspec., 1, 119, 1972.
Nature, Vol. 282, p. 772, 1979.
R.M. Oliver, Brit. J. Indust. Med., 32, 49, 1975.
Yoshimura, T., Fukuoka, Acta Medica, 65, 74, 1974.

-3-

1375rr>un

ARTHUR W. GALSTON, Ph.D.

II.

SUMMARY OF TESTIMONY

Dr. Galston personally observed the devastation of the Vietnamese
countryside on four separate occasions between 1971 and 1982 and will
describe those observations by way of pictorial evidence he has available
to him, including his own slides of the defoliation of the countryside
of Vietnam.

More specifically, Dr. Galston visited South Vietnam during

the year 1975 for approximately two weeks.

He later visited South Vietnam

to attend the Ho Chi Minh Symposium in 1983, which lasted one week.
However, Dr. Galston remained in Vietnam for an additional week and made
several visits to the Ma Da Forest as well as the surrounding countryside
in order to evaluate the permanent defoliation and destruction of the
Vietnamese countryside more than ten years after the war in Vietnam had
ended.

In addition, Dr. Galston will discuss the manufacturing processes

of 2,4,5-T and 2,4-D and the necessity of developing further refinements
on the processes used by industry in order to significantly reduce the
imminent dangers to our society from exposure to dioxins and if these
manufacturing processes cannot be so refined to eliminate the manufacturing
of these chemicals.V
.

V.

GROUNDS FOR EACH OPINION
A.

General

The bases f o r th e f a c t s and o p in io n s to which D r. G a ls to n w i l l
t e s t i f y in c lu d e a re v ie w o f the a p p lic a b le m e d ic a l and s c i e n t i f i c

lite ra tu r e

which is a tta c h e d to the Expanded Summary (R e fe re n c e s ) p re v io u s ly su b m itted

to the Court, as well as all articles and publications cited in Dr.
Galston's Curriculum Vitae which has been previously submitted to the
Court and which will be supplemented below as to any citations then "in
press" (relating to IV (1), (2), (3), (4) and (5)); his educational
and professional background specifically include his work experience
at E.I. Dupont de Nemours, with the individual manufacturing processes,
and forty years of experience with plant growth substances.

See

Curriculum Vitae and publications previously attached to Expanded Summary
for experience and educational background.

In support of Dr. Galston's

Opinions IV (1), (2), (3), (4) and (5) in addition to all references
previously listed in Dr. Galston's References and Curriculum Vitae, Dr.
Galston specifically makes reference to the following citations in
support of his five specific opinions:
a)

Baughman, R. & M. Meselson, 1973.

b)

Isensee, et al. 1971.

c)

Kearney, et al. 1972.

d)

Lang, A. ed. 1974.

e)

Leng, M.L., 1972.

f)

Meselson, M . , et al. 1978 (Arlington, VA)

g)

Meselson, M . , et al. 1972.

h)

Mrak, 1969.

i)

Shadoff, et al. 1979.

j)

Tung, T.T., et al. 1973.

k)

Westing, A.H., 1973.

l)

Whiteside, T., 1977.

m)

Galston, Green Wisdom, Basic Books, Inc., 1981.

n)

Galston, 1980. Herbicides in Academic American
Encyclopedia, Arete Publishing Co., Inc., Princeton, NJ.
- 2 -

_ ^ r.«^

o)

Galston, 1979; Herbicides: A Mixed Blessing,
BioScience 29: 85-90.

p)

Galston, 1979, Plant, People, Politics; BioScience
20-7: 405-410 illus.

q)

Ho Chi Minh Symposium: submitted article which is
being sent and will be produced for the defendants.

In addition, Dr. Galston will rely upon his work in connection with the
Ho Chi Minh Symposium (which work, while currently in press, will be
provided to the defendants, at least the contributions of Dr. Galston
which he has recently obtained to "proof") ; his knowledge as to TCDD
transmission to humans through the food chain by his review of significant
scientific and medical literature (additional references and articles
are attached and incorporated 'by reference to the Expanded Summary and
listed under IV entitled "Substance of Opinion".)

Further, references

attached to the previously submitted Summary are reurged at this time,
as well as all articles, publications, and presentations of Dr. Galston
which are listed in Dr. Galston's Curriculum Vitae.

B.

S p e c ific

In a d d itio n to th e g e n e ra l substance o f o p in io n s l i s t e d

under IV ,

Dr. Galston's research has involved the studies of chemical and physical
plant growth regulatory systems.

These include (a) auxins (related to

herbicidal compounds); (b) gibberellins; and (c) polyamines.

Physical

factors included in his research include (a) red light (perceived by
phytocromes); (b) blue light (perceived by flavoproteins).

He has also

studied growth and differentiation in tissue cultures including regeneration
from single cells and protoplasts.

In his auxin research (related to

herbicides), more specifically Dr. Galston has studied the compounds
and 2,4,5-T and related phenols and their effect on the activity of plant
-3-

LENNART HARDELL, M.D., Ph.D.

Dr. H a r d e ll's p erso n a l exp erien ce i s s e t fo r th in " I.
Q u a lific a tio n s ". He has seen and trea ted numerous cancer p a tie n ts ,
and in p a r tic u la r , has seen and trea ted approxim ately 10-15 c a se s o f
s o f t tis s u e sarcoma per year s in c e 1976.
Dr. H ard ell has com pleted one a d d itio n a l e p id e m io lo g ic a l study
which in v e s tig a te s th e r e la tio n s h ip o f phenoxy h e r b ic id e s and liv e r can cer.
Dr. H ardell w ill forward th is im m e d ia te ly .^
Dr. H ard ell w ill forward the m edical record s ^ o f the b a sa l
c e l l carcinom a p a tie n t re fe rr e d to in h is Summary, i f p erm itted to do so
under Swedish law .
Dr. H ard ell w ill forward the co p ies o f the u n d erlyin g data ^
which formed the b a is s of h is v a rio u s ep id em io lo g ica l s tu d ie s .

1/

C opies w ill be su p p lied to co u n sel upon r e c e ip t.

MAUREEN C. HATCH, Ph.D.

II.

SUBJECT MATTER
Pursuant to order o f M a g istra te S c h e in d lin , Dr. Hatch w ill t e s t i f y

a t len g th to the data c o lle c te d in Vietnam regard in g untoward pregnancy
outcom es. The data c o lle c te d in Vietnam were provided to Dr. Hatch fo r her
review a t the Ho Chi Minh C ity Symposium. She w ill provid e th e u n d erlyin g
V ietnam ese s tu d ie s which are cu r r e n tly u n a v a ila b le to th e d efen d a n ts, and
th is w ill be in corp orated h erein and a tta ch ed to t h is Supplement fo r a l l
p u rp o ses.

V.

GROUNDS FOR EACH OPINION
A. G eneral
Dr. H atch's review o f a p p lic a b le m ed ical and s c i e n t i f i c lit e r a t u r e

has been attach ed and in corp orated to Dr. H atch 's Expanded Summary and i t
e n t a ils a l l of Dr. H atch's own a r t ic le s which are c ite d in her curriculum
v it a e p r e v io u sly subm itted, as w e ll as a p p lic a b le s c i e n t i f i c m ed ical
lit e r a t u r e by o th ers which is lik e w is e in clu d ed in Dr. H atch 's curriculum
v ita e ; atten d an ce and/or p a r tic ip a tio n a t v a r io u s sem inars (p le a se se e the
curriculum v it a e which was p r e v io u sly subm itted w ith Dr. H atch 's summary,
th ese in clu d e her attendance and/or p a r tic ip a tio n a t v a rio u s sem inars
in c lu d in g her p r e se n ta tio n s o f p a p e r s). Dr. Hatch has a tta ch ed c o p ie s o f
her v a r io u s p r e se n ta tio n s at co n feren ces to th e Supplem ent. A lthough th e se
papers were not p u b lish ed , Dr. Hatch p resen ted th e se papers a t th e v a rio u s
sem inars lis t e d in the Addendum and curriculum v it a e p r e v io u sly su b m itted .

Dr. Hatch w ill r e ly on a l l o f h er p u b lish ed and nonpublished a r t ic le s and
p r e se n ta tio n s.
B. S p e c ific
1. Dr. Hatch has a tta ch ed a copy o f Dr. John C o n sta b le's and
Dr. Maureen H atch's a r t ic le which i s re fe rr e d to and which w i l l be r e lie d
upon s p e c if ic a lly by Dr. Hatch as to t h is o p in io n .

In a d d itio n , Dr. Hatch

has a tta ch ed the data p resen ted by the V ietnam ese in v e s tig a to r s and review ed
by Dr. Hatch a t the Ho Chi Minh Symposium in 1983.
2 (2 ). As to the o p in io n and the fa c tu a l b a s is fo r the op in ion
as l i s t e d in IV ( b ) , Dr. Hptch has l i s t e d s p e c if ic a lly the a r t ic le s which
she w i l l use to t e s t i f y as to the o p in io n s. Dr. Hatch has req u ested the
a r t ic le from P eterson which she heard Dr. P eterso n p resen t a t a s c i e n t i f i c
co n feren ce. However, h is m anuscript i s not prepared a t t h is tim e and she
w ill supplem ent th is answer w ith a copy o f the m anuscript which she has
alrea d y req u ested from Dr. P eterson w ith in two w eeks.
R eferen ces C ited
As fa r as the r e fe r e n c e s c it e d , a l l a r t ic le s which are in p r e ss,
in c lu d in g the one from C o n sta b le, J . and M. H atch, e d ite d by W estin g, is
atta ch ed to th is supplem ental summary. As p r e v io u sly d isc u sse d , the
r e fe re n ce to R. P eterso n , Hormonal changes and "w asting" observed in
m o d era tely -h ig h -d o se anim al exp erim en ts, p resen ted a t the Symposium on
P u b lic H ealth R isks o f the D io x in s, R o c k e fe lle r U n iv e r s ity , O ctober 1 9 -2 0 ,
1983, t h is m anuscript i s b ein g ob tain ed from Dr. P eterso n and w ill be
forw arded to a l l p a r tie s w ith in th e n ext two w eeks. At th is tim e Dr. Hatch
does n ot have a copy o f t h is a r t i c l e but has m erely heard the p r e se n ta tio n .

-2-

Curriculum Vitae

Dr. Hatch w i l l r e ly on a l l o f her a r t ic le s which she has lis t e d
in h er curriculum v it a e , both p u b lish ed and n on p u b lish ed , and she has
a tta ch ed fo r a l l p a r t ie s ' con ven ien ce a copy o f p r e se n ta tio n s which have
been reduced to w r itin g which she p resen ted a t v a rio u s s c i e n t i f i c co n feren ces
and sem inars.

In a d d itio n , Dr. Hatch w ill r e ly on one or more o f her a r t ic le s

which are c ite d in her Addendum and her curriculum v ita e fo r the purposes o f
her t r i a l testim on y.

-3-

ALASTAIR W.M. HAY, Ph.D.

V.

GROUNDS FOR EACH OPINION

A. G eneral
Dr. Hay l i s t s as a g en era l ground fo r h is op in io n atten d an ce and
p a r tic ip a tio n in v a rio u s sym posia and s c i e n t i f i c workshops which are l i s t e d
s p e c if ic a lly in h is curriculum v it a e a tta ch ed to h is Expanded Summary and
s p e c if ic a lly which l i s t s the Ho Chi Minh Symposium he atten d ed in Vietnam
in 1983, and the D ioxin C onference he atten d ed in C in c in n a ti, Ohio in August
and September o f 1983 sponsored by the American Chem ical S o c ie ty , which
p roceed in gs w ill be summarized in an a r t ic le to be p u b lish ed by the American
Chemical S o c ie ty and which a r t ic le i s bein g se n t from England and w i l l be
atta ch ed as a supplem ent to th is Summary. Review o f v a rio u s documents o f
c e r ta in d efen d a n ts, which documents were review ed by Dr. Hay in the
p rep aration and w r itin g o f The Chemical Scythe and are in clu d ed and documented
in h is b ib lio g ra p h y to th a t book, p u b lish ed by Plenum P ress in 1982.
In a d d itio n , Dr. Hay has been provid ed documents from the v a rio u s
d efen d an ts which the defen d an ts have produced fo r the p l a i n t i f f s and which
Dr. Hay w ill use and review p rio r to g iv in g h is d e p o sitio n in th is ca se;
p erso n a l research - Dr. Hay has had e ig h t y ea rs o f p erso n a l resea rch on
2 ,4 ,5 -T , 2,4-D and th e ir contam inant, d io x in s .

He has p e r so n a lly made two

f ie ld tr ip s to S eveso, I ta ly ; two f ie ld tr ip s to Vietnam , in clu d in g h is
atten d an ce a t the Ho Chi Minh Symposium, and an a d d itio n a l tr ip to ob serve
the lon g-term e f f e c t s of d e fo lia tio n in V ietnam . He has a ls o p e r so n a lly
research ed h is book, The Chemical S c y th e , and he has fu rth er p a r tic ip a te d in
s c i e n t i f i c s tu d ie s in Great B r ita in on the m u ta g en icity o f d io x in and 2 ,4 ,5 -T
as w e ll as oth er chem ical h e r b ic id e s in co n ju n ctio n w ith th e I n te r io r Chem ical

Indu stry (IC I) Company in Great B r ita in . With th e ir p erm issio n , he has
p u b lish ed h is fin d in g s and th ese are p u b lish ed in Chapter 2 e n t it le d
"Toxicology" o f The Chemical S cy th e, L essons o f 2 ,4 ,5 -T and D io x in , by
A la s ta ir Hay, p u b lish ed by Plenum P ress in 1982, New York. More d e ta ile d
chem ical s tu d ie s which Dr. Hay has p a r tic ip a te d in w ill be p u b lish ed in
an a r t ic le produced by the American Chem ical S o c ie ty from a con feren ce
which was h eld in A ugust-Septem ber o f 1983, P roceeding C onferences on D io x in .
A copy o f Dr. H ay's own a r t ic le i s c u rren tly in p ress and i s b ein g forwarded
to p l a i n t i f f s to be d is tr ib u te d to a l l p a r tie s in in t e r e s t as a supplem ent
to th is Summary a t th is tim e.
In a d d itio n , Dr. H ay's curriculum v it a e l i s t s h is ed u cation
background and e x p e r ie n c e , which form the b a ses of h is fa c ts and o p in io n s.
He has in a d d itio n review ed the cu rren t s c i e n t i f i c and m ed ical lit e r a t u r e
which has been c ite d s p e c if ic a lly in th e b ib lio g ra p h y a tta ch ed to The
Chemical S cy th e. The Chemical Scythe w ill be r e lie d upon by Dr. Hay, as
w ill the a r t ic le s and p u b lic a tio n s in Dr. Hay' s curriculum v it a e a tta ch ed
to the Expanded Summary p r e v io u sly f ile d .
B. S p e c ific
Dr. Hay w i l l t e s t i f y to th e grounds which support th e above in clu d in g
h is knowledge o f th e spraying o f A gent Orange, e s p e c ia lly i t s e f f e c t on the
V ietnam ese co u n try sid e which knowledge he has ob tain ed by c a r e fu lly rev iew in g
the American A sso c ia tio n fo r Advancement o f S cien ce s tu d ie s conducted by
P ro fesso r Matthew M eselson in 1970, and the N a tio n a l Academy o f S cien ce
rep o rt conducted by th e Department o f D efen se in 1974 and a review o f th e
p e r tin e n t s c i e n t i f i c and m edical lit e r a t u r e d e sc r ib in g the sp rayin g a c t i v i t i e s
of Agent Orange in Vietnam which b ib lio g ra p h y i s l i s t e d and c ite d in The
Chemical S c y th e , su p ra, and fu rth er h is own p u b lic a tio n s as a tta ch ed to the
curriculum v it a e p r e v io u sly su b m itted .
-2-

In a d d itio n , Dr. H ay's own p erso n a l ob serv a tio n o f th e V ietnam ese
co u n try sid e on h is two tr ip s to Vietnam fo r th at s p e c if ic purpose and h is
atten d an ce a t th e Ho Chi Minh Symposium in 1983; the purpose and the
h is t o r ic a l tr a c in g o f the anim al s tu d ie s by Dr. H ay's review o f the m edical
and s c i e n t i f i c lit e r a t u r e on anim al s tu d ie s are d e ta ile d in Dr. H ay's book,
The Chemical S cy th e; Dr. H ay's review o f p e r tin e n t s c i e n t i f i c and m edical
lit e r a t u r e fo r h is research in p rep aration o f th a t book, and a ls o review
o f the m edical and s c i e n t i f i c lit e r a t u r e , in clu d in g the new Ranch Hand Study
r e c e n tly r e le a se d by the U .S. A ir F orce, which has been su p p lied to Dr. Hay
by th e p la in t if f s ; h is t o r ic a l tr a c in g o f the human data in clu d in g the
in d u s tr ia l a c c id e n ts sin c e 1974, Hay, A. The Chemical S cy th e, Plenum, New
York, pp. 9 5-146. A ll r e fe re n ce s to s p e c if ic documents in clu d in g the EPA
D ioxin document which has been su p p lied to the defendants in resp on se to
the g u id e lin e s provided fo r the p l a i n t i f f s ' government ca u sa tio n and in
p rep aration fo r the d e p o sitio n s o f the p l a i n t i f f s ' government ca u sa tio n
w itn e sse s and the ex a ct t i t l e s o f th o se four documents are as fo llo w s:
1.

EPA, R esearch and D evelopm ent, H ealth A ssessm ent
Document on D ioxin fo r the O ffic e s o f A ir Q u a lity ,
P lanning and Standards, prepared by the Environm ental
C r ite r ia and A ssessm ent O ffic e , C in c in n a ti, Ohio
45248 (J u ly , 1983).-

2. EPA, R esearch and D evelopm ent, H ealth and Environm ental
E f f e c t s , P r o file fo r : T etra , Penta and H exachlorodibenzop -d io x in s , fo r the O ffic e o f S o lid Waste and Emergency
R esponse, by the Environm ental C r ite r ia and A ssessm ent
O ffic e , C in c in n a ti, Ohio 45248 (June, 1983).
3. EPA, Research and D evelopm ent, Ambient Water Q u a lity
C r ite r ia fo r 2 , 3 , 7,8-TCDD, prepared fo r O ffic e o f Water
R eg u la tio n s and Stan d ard s, by the Environm ental C r ite r ia
and A ssessm ent O ffic e , C in c in n a ti, Ohio 45248 (J u ly , 1 9 8 3 ).
4 . EPA, R esearch and D evelopm ent, D io x in , In d u str ia l
Environm ental R esearch, C in c in n a ti, Ohio (1 9 7 8 ).

ijv Q.7
«>■ 1
-3-

A d d itio n a l Papers and P a r tic ip a tio n in
V arious Symposia and S c ie n t if ic C onferences
Dr. Hay i s sending a l l w r itte n docum ents, w hether p u b lish ed or
n onpu blished, to supplem ent t h is Summary, in c lu d in g N os. 2 ,3 ,5 and 7, and
th ese w ill be a tta ch ed and in corp orated by r e fe r e n c e to t h is Supplem ental
Summary.

-4-

RONALD H. KERMAN, Ph.D.

V.

GROUNDS FOR EACH OPINION

A. G eneral
Dr. Kerman has been doing a study in H ouston, Texas in con n ection
w ith h is work a t the U n iv e r sity o f Texas M edical S ch ool, H ouston, T exas,
w ith a study known as the Texas Agent Orange Study, which has review ed the
m ed ical h is t o r ie s and record s and done t e s t in g on Vietnam v e te r a n s who
are r e s id e n ts o f Texas and who have gone to the VA H o sp ita l fo r treatm en t.
At t h is tim e, Dr. Kerman i s unable to send h is u n d erlyin g data s in c e the
d ata has been given to th e computer fo r a n a ly s is and fo r co n firm a tio n .
The u n d erlyin g data and the fin a l summary and r e s u lt s should be a v a ila b le
w ith in two weeks and w ill be provided im m ediately to a l l p a r tie s o f in t e r e s t
and to the Court j u s t as soon as p l a i n t i f f s r e c e iv e sa id in form ation from
Dr. Kerman.

MARVIN S. LEGATOR, Ph.D.

V.

GROUNDS FOR EACH OPINION

A. G eneral
Dr. L eg a to r's tr a in in g and p r o fe s s io n a l ex p erien ces have been
in th e g en era l f ie ld s o f to x ic o lo g y w ith major em phasis in g e n e tic
to x ic o lo g y .

He has prepared, o ffe r e d and taught cou rses fo r both m edical

stu d e n ts and graduate stu d en ts in the areas o f g e n e tic rep ro d u ctiv e m utation
and to x ic o lo g y . H is cu rren t resea rch among oth er areas has to do w ith
the e f f e c t s o f ch em icals as they a f f e c t sperm; s p e c if ic a lly , d e te c tin g a
n o n -d isju n c tio n error in sperm which produces an in c r e a se in the number
o f Y b o d ies by flu o r e sc e n t s ta in in g .

He i s e s p e c ia lly in te r e s te d in the

area o f male m ediated e f f e c t s and in th is regard he and h is c o lle a g u e s at
the U n iv e r sity o f Texas M edical Branch have been e v a lu a tin g the e f f e c t s of
ch em ica ls in rod en ts lo o k in g fo r adverse h e a lth outcom es and s p e c if ic a lly
b e h a v io r a l an om alies. They have r e c e n tly p u b lish ed a s e r ie s o f a r t ic le s
regard in g b eh a v io ra l anom alies a fte r a d m in isterin g s e le c te d ch em icals to
th e m ales and e v a lu a tin g the F -l progeny. A d d itio n a lly , th ey are a lso
w orking on the e f f e c t o f ch em icals a fte r in u tero exposure o f an im als,
s p e c if ic a lly they are showing the typ es and frequency o f chromosomal anom alies
to th e fe tu s and pregnant fem ale.
Dr. L egator th erefo re b e lie v e s th a t he has ra th er broad exp erien ce
in th e area o f to x ic o lo g y , g e n e tic to x ic o lo g y , rep ro d u ctiv e e f f e c t s , te r a to lo g y
and m ale m ediated e f f e c t s of ch em ica ls.
I t should be empahsized th a t he has been in v o lv ed in se v e r a l
ex p ert com m ittes having to do w ith the e f f e c t s o f d io x in -in d u ced adverse
h e a lth hazards in clu d in g rep ro d u ctiv e and g e n e tic e f f e c t s , a l l o f which are

noted on h is curriculum v ita e p r e v io u sly su p p lie d .

He w ill review and

r e ly upon a l l of the a v a ila b le m ed ical record s fo r both P l a i n t i f f Jordan
and P la in t if f Ryan.
In a d d itio n , Dr. L egator may r e ly upon the fo llo w in g r e fe r e n c e s:

Bioaccumulation

Matsumura, F. and H.J. Benezet.
1973. Studies on the b io ac cur ul at i o n and microbial degeneration o f 2 , 3 , 7 , 8 - t e t r a c h l o r o d i b e n z o - p d i o x i n . Environ. Health Perspect. 5: 253.

C a rcin o g en icity
Gerry, D.L. et a l . 1972. Studies wi th ch l o ri n a t e d dibenzo-pd i o x i n s , pGlybror.:ir.3ted biphenyls, and po ly c h lo ri n a te d biphenyls in
a t'.vo-stacie system o f mouse skin tumorigenes is :■ potent a n t i c a r c i n o Genic e f f e c t s .
Ar.r:. N.Y. Acad. Sci. 320: 405.
DiGiovanni, J . , A. V i a j e , D.L. Berr y, T.J. Slaaa'and M.R. Ouchau.
1977.
T u m o r - i n i t i a t i n g a b i l i t y o f 2 , 3 , 7 ,8- tet r a ch lo rn d ib e n zo -p d i o x i n fTCDD) and Arcchlor 1254 in the two-stage system o f mouse
skin carcinogenesis. B u l l . Environ. Contam. Tox icol. 18: 552.
DiGiovanni, J . , O.L. r<e'*ry M.R. Juchau and T.J. Slaqa.
1979b.
2 , 3 . 7 , 5 - T e t n c h ] o r e d i terzo p - d i o x i n : potent antic arcin oge nic act1
v i t y in LD-1 mice. Biochem Biophvs. Res. Comm. 85: 577.
P i t o t , H.C., T. Goldsworthy, H.A. Campbell and A.' Poland. 1980.
Q ua nt ita tiv e evaluation o f the promotion by 2,3,7 , 8 - t e t r a c h l orod i b e n z : - p - d i o x i n of hepatocarcinogenesis from diet*' ¡nitrosamine
Can. Res. 40: 3516-3620.
Toth, K. , S. Somfai-Re 11e , J. Sugar and J. Bence. 1979. Carcino­
g e n i c i t y of herbicide 2 , 4 , 5 - t r ich 1oro-phenoxyethanol- c o n t a i n i ng
d i o x i n and of pure d i o x in in Swiss mice. Nature 279: 548.

*7 ^

-2 -

Enzyme Induction

uiG io va rn i, J . , D.L, Derry, T.J. Slaqa, A.H. Jones and M.R. Juchau.
197nd .
Effects of pretreatment w i th TCDD cn the capacity o f hepatic
and excraheoatic mouse tissu e s to convert prncarcinogens to mutagens
f o r 5. t yphirm.T'ion auxotrophs. To x ic o l. Ape 1. Pharmacol. 50: 229.

G eneral T oxicology
Grieo, J.B. ana F. DeMatteis.
1973. Effec ts o f 2 , 3 , 7 , 8 - t e t r a c h l o r o diherizn-p-dioxin on clru'" metabolism and hepatic microsomes o f ra ts
and mice. Environ. Health Perspect. 5: 211.
Jones, G. and J.E. Grieg.
1975. Pathological changes in the l i v e r
of mice given ?. , 3 , 7 , 8 - te t r a c h l orodi benzo-p-dioxin. Experientia
31(11): 1315-1317.
McConnell, E.E., J.A. Moore, J.K. Haseman and M.W. H a rr i s .
1978b.
The comparative t o x i c i t y o f c h l o r i n a t e d dibenzo-p-dioxins i n mice
and guinea pigs. T o xi col . Appl. Pharmacol. 44: 335.

G en etics
K o u r i , R.E. and ...W. Hebert.
1977. Genetic re g u l a t i o n o f suscep­
t i b i l i t y to p o l y c y c l i c hydrocarbon-induced tumors in the mouse.
_In: Proc. Symp. Origins o f Human Cancer. Cold Spring Harbor, N.Y.

Mechanisms of A ction
Meal, R.A., P.W. Beatty and T.A. Gasiewicz. 1979. Studies o f the
mechanisms of t o x i c i t y o f 2 , 3 , 7 , 8 - t e t r a c h l o r o d i b e n z o - p - d i o x i n (TC7').
Ann. M.Y. Acad. Sci. 320: 204.

M etabolism
Chinbra, R.S. et a i .
1974. S ele cti on o f inducers as an importance
factor- in c h a r a c te r i z i n g genetic d if fe re n c e s to i nd uct ion or ary l
hydrocarbon hydroxyl as* i n s t r a i n s o f mice. L i f e Sci. 15: 123.
: ^3*7^0

-3-

5

M etabolism (C ont'd)
Guenther, T.M., J.M. Fysh and G.W. Hebert.
1979. 2 , 3 , 7 ,8 - T e t r a chl orc.ii benzo-p-o : oxi n: covalent binding o f rea ctive metabolic
intermediates p r i n c i p a l l y to p r o te i n in v i t r o . Pharmacology (19) 1 :

1l. -2 2 .

Lu ci er, G.W. e t a l .
microsomal enzymes.

1973. TCDO-induced changes in r a t l i v e r
Environ. Health Perspect. 5: 199.

K o u r i , .R. 1976. Relationship between le v e ls o f aryl hydrocarbon
hydroxylase a c t i v i t y and s u s c e p t i b i l i t y to 3-methylchoianthrene and
benzo(a)-pyrene-induced cancers in inbred s t r a i n s o f mice. In:
R.J. Fr e u d f' th a l and P.W. Jones (e d s . ) , Polynuclear aromatic
hydrocarbon:: chemistry, metabolism and carcinogenesis. V o l . 1.
Raven Press, H.Y. p. 139.
Poland, A.P. and E. Glover. 1973a. Chlorinated d ib e n z o -p - d i o x i n s :
potent inducers o f u- Am in ol ev u li ni c acid synthetase and aryl
hydrocarbon hyaroxylase.
II.
A study o f the s tr u c tu r e a c t i v i t y
r e l a t i o n s h i p . Molecular Pharmacol. 9: 736.
Poland, A.P. and E. Glover.
1973b. 2,3 ,7 ,8 -T e tra chl or o di be nz o- pd i o x i n : a potent inducer o f u- Aminole vu linic acid synthetase.
Science 179: 476.
Poland, A.P. and E. Glover.
1974. Comparison of 2 , 3 , 7 , 8 - t e t r a chlor od iben zo -p- diox in a potent inducer of ar yl hydrocarbon
hydroxylase w it h 3-methylcholanthrene. Mol. Pharmacol. 10: 349.
Poland, A.P. and E. Glover.
1979. An estimate o f the maximum in_
vivo covalent binding o f 2 , 3 , 7 , 8 - t e t r a c h l o r o d i b e n z o - p - d i o x i n to r a t
T lv e r p r o t e i n , ribosomal RNA, and DMA. Cancer Res. 39: 3341.
Poland, A.P. and A. Kende. 1976. 2 , 3 , 7 , 8 - t e t r a c h lo r o d i b e n z o - p d i o x i n : environmental contaminant and molecular probe. Fed. Proc.
35: 2404.
Poland, A.P., D. Smith, G. Metier and P. Possick. 1971. A health
survey o f workers in a 2,4-D and 2,4,5-T p1a. t. Arch. Environ.
Health 22: 316.

Poland, A.P. et a l .
1974. Genetic expression o f ar yl hydrocarbon
hydroxylase a c t i v i t y indu ction o f mono-oxygenase a c t i v i t i e s and
cvtochrome P-l-450 formation by 2,3,7,8-TCDD in mice g e n e t i c a l l y .
Jour. B i o l . Chem. 249: 5599.

-4 -

Mutagenicity

( i r « c /\ S. and F.S. Moreland. 19“ 5. Cytogenetic evaluation o f several
dio xins in (.hr; r a t . T o x i c o l . -Appi. Pharmacol. 33: 161.
Hussain, f . , L. Ehrenberg, G. Lo fro th and T. G e j v a l l.
1972.
genic e f f e c t s o f TCDD on b a c t e r i a l systems. Ambio. 1: 32.

Muta­

S e i l e r , J.P. 1973. A survey on the mutagenicity o f various p e s t i ­
cides. Experientia 20: 622.

Pharm acokenetics and D is tr ib u tio n
A l l e n , J . R . , D.A. B s r s o t t i , -J.P. Van M i l l e r , L.J. Abrahanson and
J . J . Laucri. 1977 . Morphological changes in monkeys consuming a
d i e t containing low levels o f TCDD. Food Cosrnet. To xicol. 15: 401.

T e r a to g e n ic ity
Berry, D.I.. et a l .
1376. Transplacental induction o f carcinogen
h y d r n x i y l a f ing systems with 2,3,7 , 8 - t e t r a c h l o r c d i b e n z o - p - d i o x n .
Toxicol. Appl. Fi’ -.rrrv’. c o l . 36: 569.
i-hera, K.S. and J.A. Roddick. 1373. P c ly cM or o di bs n zo- p -d io xi n s:
prenatal e f f e c t s and in» dominant le t h a l t e s t in Wistar r a t s .
In:
E.D. B l a i r ( e d . ) , Chi r.rcd'-cmns - o r i g i n s ¿mi fate. Adv. Chem. Ser. ,
No. 120. Am. Chem. See., Washington, D.C. p. 70.
Moore, J . A . , B.M. Gupta, J.G. Z i n k ! , J.G. Vos. 1973. Postnatal
e f f e c t s o f maternal
-nesure to. 2 , 3 , 7 , 8 - te t r a c h l o r o d i b e n z o - p - d i o x i n
(TCDD). Environ. He. tf Perspect. 5: 81.
Smith, F . A . , B.A. Schwetz and K.D. Nitschke.
1975. T e r a to o e n i c i ty
o f TCDD in CF-1 mice. To xi col . Appl. Pharmacol. 38: 517.
Sparschu, G.L., F.L. Dunn and V.K. Rowe. 1971. Study o f the t e r a ­
t o g e n i c i t y of TCDD in the r a t . Food Cosrnet. To xi col . 9: 405.

C ourtney, K .D ., D.W. G aylor, M.D. Hogan and H.L. F a lk , 1979
T era to g en ic e v a lu a tio n o f 2 ,4 ,5 -T , S cien ce 168: 864.
-5-

137 V

ALAN SCOTT LEVIN, M.D.

II.

SUBJECT MATTER
Dr. L evin w i l l d is c u s s c lin ic a lly , u ses o f the ep id em io lo g ic

approach, i . e . c lin ic a l ep id em io lo g y . Dr. L e v in 's a r t ic le w hich has been
p r e v io u sly subm itted and th e paragraphs which d escrib e the harm ful e f f e c t s
th a t 2,4-D and 2,3,7,8-T C D D , as w e ll as o th er d io x in s , have on th e immune
system w ith referen ce to (1) r e p r e se n ta tiv e c la s s p l a i n t i f f s whom Dr. Levin
has te s te d ; (2) n o n -r e p r e se n ta tiv e c la s s p l a i n t i f f s or Vietnam v e te r a n s; and
(3) o th e r s. Dr. L evin has perform ed c l i n i c a l s tu d ie s on th e se th ree gen eral
c a te g o r ie s of people w ith in h is own p r a c tic e and the u n d erlyin g data which
w i l l form the b a s is o f th ese o p in io n s are atta ch ed and in corp orated h e r e in .

IV.

SUBSTANCE OF OPINIONS
C.

Dr. L evin w i l l u se th e c l i n i c a l data which he has provided in

resp on se to th is supplem ent to h is Expanded Summary to form h is o p in io n s
r e la te d to the ca u sa l r e la tio n s h ip o f th e v a rio u s Agent O r a n g e /d io x in -r e la te d
a d verse h ea lth e f f e c t s upon the in d iv id u a l r e p r e se n ta tiv e c la s s p l a i n t i f f s
th em selves whom he has in d iv id u a lly te s te d .

These documents are a tta ch ed

to t h is supplem ent.

V.

GROUNDS FOR EACH OPINION
A. G eneral
The b a s is fo r such f a c t s and o p in io n s exp ressed h e r e in by Dr. L evin

in c lu d e h is review o f the m ed ical and s c i e n t i f i c lit e r a t u r e , s p e c if ic a lly

137S8

3

th ose documents which Dr. L evin has a tta ch ed to h is curriculum v ita e
Addendum and the b ib lio g ra p h y a tta ch ed to Dr. L e v in 's a r t i c l e , which was
p r e v io u sly subm itted; h is p erso n a l resea rch and c l i n i c a l e x p erien ces as
o u tlin e d under I I above and IV above, which c lin ic a l data i s atta ch ed and
in corp orated h erein fo r a l l purp oses; and h is p erson al knowledge o f the
d e f o lia t io n o f Vietnam ; and h is review o f a l l p e r tin e n t m ed ical data o f
the r e p r e se n ta tiv e p l a i n t i f f s , p a r tic u la r ly w ith r e sp e c t to o p in io n IV C.
In th is regard, Dr. L evin w i l l have review ed a l l m edical reco rd s and data
o f th e r e p r e se n ta tiv e p l a i n t i f f s which has been subm itted to th e d efen d an ts
and which Dr. L evin has review ed p r io r to g iv in g h is d e p o sitio n testim o n y .

Curriculum V ita e - B ib liograp h y R eferen ces
The r e fe re n ce to E sp o sito , N .P ., T.O. T iernan and F .E . Dryden,
1980, D io x in s, prepared fo r I n d u s tr ia l P o llu tio n C ontrol D iv is io n , U .S.
EPA, C in c in n a ti, O hio, C ontract N os. 6 8 -0 3 -2 5 7 7 , 6 8 -0 3 -2 6 5 9 , and 68-0 3 -2 5 7 9 ,
EPA 6 0 0 /2 -8 0 -1 9 7 , i s the f u l l th e c i t e on the E sp o sito document referred
to be Dr. L evin.
D.r. L e v in 's f u l l r e fe r e n c e s and any m a te r ia ls he w i l l use which
are not p u b lish ed are atta ch ed h ereto and in corp orated h erein fo r a l l
p u rp oses. A summary o f h is fin d in g s on the in d iv id u a l r e p r e se n ta tiv e c la s s
p l a i n t i f f s w i l l be fu rn ish ed and attach ed to t h is supplem ent, as w e ll as
h is u n d erlyin g c l i n i c a l d ata fo r such o p in io n s.

-2-

PETER ORRIS, M.D.

I.

QUALIFICATIONS
Dr. O rris' testim on y w ill be g iv en as a p r iv a te c it iz e n and n ot

as a NIOSH M edical O ffic e r . F u rth er, the research he i s cu r r e n tly in v o lv ed
w ith irt S t. L ouis concerns truck d r iv e r s p o t e n t ia lly exposed a t tru ck in g
term in als in S t. L o u is, not Times Beach. T h is work w ill be ex p la in ed in
d e t a il below .

V.

GROUNDS FOR EACH OPINION
A. G eneral
The p r o je c ts which are d escrib ed below are s t i l l pending and w ill

not serve as a b a s is fo r Dr. O rris' o p in io n s.
Dr. O rris' research a c t i v i t i e s in clu d e look in g in a q u a lita tiv e
manner at the v etera n s th at he has seen a t Cook County H o sp ita l sea rch in g
fo r p h y sic a l in d ic e s th at would in d ic a te d egree o f exp osu re. He has not
done th is in a sy stem a tized approach y e t , but i t i s bein g co n sid ered .
Through the D iv is io n o f O ccupational M edicine a t Cook County
H o sp ita l, he i s coop eratin g w ith L ocal 600 o f the In te r n a tio n a l Brotherhood
o f Team sters and the C entral S ta te s ' P ension Fund o f the T eam sters' Union
to review the m orbidity exp erien ced between 1976 and 1983 of team sters
p o te n tia lly exposed to d io x in in 1972 during th e ir employment’ in and around
th ree trucking term in a ls in S t. L o u is, M isso u ri. These term in a ls were
sprayed dm 1972 w ith an o i l co n ta in in g d io x in s in an e f f o r t to reduce d u st.
He w ill be u t iliz in g the h e a lth in su ran ce cla im s f ile d w ith the C en tral
S ta te s ' Teamster Fund fo r th is group o f team sters and comparing i t

a s u ita b le c o n tr o l group o f tea m sters not so exposed.
A gain, through the D iv is io n o f O ccupational M edicine a t Cook
County H o sp ita l, he i s coo p era tin g w ith the W isconsin V eterans A d m in istration
and the Woods VA H o sp ita l in M ilwaukee, W iscon sin , as w e ll as se v e r a l
V eterans A sso c ia tio n s in W isconsin to ev a lu a te th e p o s s ib ilit y o f u t iliz in g
tw in p a ir s in an in v e s tig a tio n o f Agent Orange exp osu re. These approxim ately
61 tw in p a ir s had one member in Vietnam and th e o th er member n ot serv in g
in Vietnam . The i n i t i a l sta g e o f th is study i s the d is tr ib u tio n to th ese
tw in p a ir s o f a q u e stio n n a ire prepared a t the D iv isio n o f O ccupational
M edicine. T his q u e stio n n a ire attem p ts to a s s e s s w hether a h is to r y o f
exposure to Agent Orange can be acquired in th is manner. I t a ls o i s an
attem pt to see w hether th ere are enough tw in p a ir s in which one member
has a c le a r h is to r y o f exposure to Agent Orange and th e o th er member has
no s ig n if ic a n t confounding exposures in order to determ ine w hether i t i s
f e a s ib le to proceed w ith more in depth h e a lth h is t o r ie s and p h y sic a l
e v a lu a tio n s. To r e s t a t e , th is q u estio n n a ire i s d esign ed to a s s e s s w hether
an exposure h is to r y can be i l l i c i t e d and a d if f e r e n t ia l exposure ex p erien ce
determ ined fo r th ese tw in p a ir s .
i s cu r r e n tly b ein g se n t o u t.

T his q u estio n n a ire has been prepared and

I t w i l l go on ly to th e S ta te o f W iscon sin .

In the N a tio n a l I n s t it u t e fo r O ccupational S a fe ty and H ea lth ,
he has been in v o lv ed in resea rch in to exposures o f f ir e f ig h t e r s and o th ers
in v o lv ed in transform er e le c t r ic a l f i r e s .

These f ir e s have engended a

p o s s ib le exposure to d io x in s through the fa c t th a t th e tran sform ers are
bathed in o i l s c o n ta in in g p o ly c h lo r in a te d b ip h en o ls and c h lo r in a te d b en zen es.
When th ese su b sta n ces are burned above 5 0 0 °, th ey may produce fu ran s and
d io x in s . NIOSH (H azards and T ech n ical E v a lu a tio n s Branch fo r w hich Dr.
O rris works) has look ed a t many o f th e se f ir e s in v a r io u s area s o f the
cou n try. He has been in v o lv ed in S t. P a u l, M innesota and C hicago, I l l i n o i s .
-2-

'

These as y e t are not p u b lish ed .
When e v a lu a tin g p a tie n ts fo r p o s s ib le TCDD in to x ic a tio n , Dr.
O rris u ses c e r ta in in d ic e s in attem p tin g to reach a d ia g n o s is . A l i s t
o f th e se elem ents i s a tta ch ed .
B. S p e c ific
Acne - The V eterans A d m in istration review e n t it le d "Review
of th e L ite r a tu r e on H erb icid es In clu d in g Phenoxy H erb icid es and A sso cia ted
D io x in s, V ol. 1 , prepared by JRB A sso c ia te s fo r the V eterans A d m in istration
under C ontract No. V101(93) P -823, dated O ctober, 1981. A d d itio n a lly ,
" E sp osito" , which i s th e EPA p u b lic a tio n e n t it le d "D ioxins" EPA 6 0 0 /2 -8 0 -1 9 7 ,
November, 1980 by E sp o sito , Tiernan and Dryden.
A rch ives o f Environm ental H ealth ; "The Development and P rogn osis
o f Chronic I n to x ic a tio n by T etra ch lo ro d ib en zo -p -d io x in in Men" by Jana
P azderova-V ejlupkova, M .D., e t a l . , V ol. 36, No. 1, January-February, 1981.
B r itis h Journal o f In d u str ia l M ed icin e, "T etrachlorodibenzo D ioxin :
A Survey o f S u b jects Ten Years A fter Exposure" by G. May in V ol. 39, pp.
128-135, 1982.
Journal o f O ccupational M edicine, " M ortality E xperienced o f
Employees Exposed to 2 ,3 ,7 , 8 -te tr a c h lo r o d ib e n z o -p -d io x in (TCDD)" by
Ralph R. Cook, e t a l . , V ol. 22, No. 8 , A ugust, 1980.
Journal of O ccupational M edicine, "The M o rta lity E xperienced o f
Workers Exposed to T etrach lorod ib en zo D ioxin in a T rich lorop h en ol P rocess
A ccident" by Ju d ith A. Zach and Raymond R. Suskind, in V ol. 22, Nol 1,
January, 1980.
"Environm ental C hloracne Update and O verview", James S. T aylor,
Annals of the New York Academy o f S c ie n c e , 1979. (Volume unknown)
i O6 »
-3-

Liver Effects

- Veterans' Administration review and the

E sp o sito EPA document, as w e ll as:
"H alógenated B ip h en y ls, T erp h en yls, N ap th alen es, D ib en zod ioxin s
and R elated Products" e d ite d by Renata D. Kimbrough, p u b lish ed 1980,
E lsev ier/N o rth H olland B iom edical P r e ss, 1980, Amsterdam, New York and
O xford.
"Chemical Porphyria in Man", e d ite d by S tr ik , J.J.T .W .A . and
Koeman, J .H ., a ls o E lseiv er/N o rth H olland B iom edical P r e ss, 1979, Amsterdam,
New York and O xford.
"D ioxin, T o x ic o lo g ic and Chemical A sp ects" , e d ite d by C a tta b en i,
F lam in io, C a v a lla ro , A ldo, G a lli and G iovanni, p u b lish ed by SP M edical
and S c ie n t if ic Books, New York, London, 1978.
"C hlorinated d io x in s and R elated Compounds: Impact on the
Environment" P roceed in gs of a Workshop h eld a t I n s t it u t o S u p eriore
D is a n ita , Rome, I t a ly , 22-24 O ctober, 1980, e d ite d by 0 . H u tzin ger, R.W.
F rey, E. Marian and F. P o c c h ia r i, p u b lish ed by Permagon P r e ss, 1982.
"The Developm ent and P rogn osis o f Chronic I n to x ic a tio n by
T etra ch lo ro d ib en zo -p -d io x in in Men" by P azderova-V ejlupkova; A rch ives
o f Environm ental H ealth , 1981.
"H epatic Porphyria Induced by 2 ,3 ,7 , 8 -te tr a c h lo r o d ib e n z o -p -d io x in
in the Mouse" by J.A . G o ld ste in , e t a l. in R esearch Communications in
Chem ical Pathology and Pharm acology, V oi. 6 , No. 3 , November, 1973.
P ersonal communication from Dr. J.J.T .W .A . S tr ik con cern in g
p a tie n ts seen a t Cook County H o sp ita l, S e c tio n o f O ccupational M ed icin e,
on J u ly 17, 1981 (attach ed h e r e to ).
T oxicology and A pplied Pharm acology, V o i. 57, No. 2 , pp. 156-163,
C an ton i, L ., M. Salmona and M. R iz z a r d in i " P orp h yrin agen tic E ffe c t o f
C hronic Treatm ent w ith 2 ,3 ,7 ,8 te tr a c h lo r o d ib e n z o -p -d io x in in Female R ats,

Dose Effect Relationship Following Urinary Escretion of Porphyrins.

P erip h era l Neuropathy - Here as w e ll, the VA rev iew , page 6 -2 6 ,7
and E sp o sito , th e EPA book, p. 214.
P azderova-V ejlupkova, "The Developm ent and P ro g n o sis o f Chronic
I n to x ic a tio n by T etra ch lo ro d ib en zo -p a ra -d io x in in Men" from the A rch ives
of In te r n a l M edicine, February, 1981.
"Human H ealth E ffe c ts from A c c id e n ta l R elea se o f T etra ch lo ro d ib en zo p -d io x in TCDD a t S eveso, Ita ly " ; Franceso P o c c h ia r i, V itto r io S ila n o , and
A lfred o Z am oieri, 1979, Annals o f New York Academy o f S cien ce (Volume unknown).
N eu ro p sy ch ia trie D isord er
Archives of Environmental Health from Czechoslovakia; "The
Development and Prognosis of Chronic Intoxication by Tetrachlorodibenzopara-dioxin in Men".

S o ft T issu e. Sarcomas It

S o ft T issu e Sarcomas and Exposure to Chem ical Su b stan ces: A

Case R eferen ce Study" by M. E rik sso n , L. H a r d e ll, N.O. B erg, T. M oller and
0 . A xelson , B r itis h Journal o f I n d u s tr ia l M ed icin e, V ol. 38, pp. 2 7 -3 3 ,
1981.
"Case C ontrol Study: S o ft T issu e Sarcomas and Exposure to
Phenoxy A c e tic A cids and C h lorop h en ols; L. H a rd ell and A. Sandstrom ,
B r itis h Journal o f C ancer, V ol. 39, p. 711 fo llo w in g 1979.
" R elation o f S o ft T issu e Sarcoma, M alignant Lymphoma and Colon
Cancer to Phenoxy A cids and C hlorophenols and O ther Agents" by Lennart
H a rd ell, Scandanavian Journal o f Work and E nvironm ental H ea lth , V ol. 7,
pp. 119-130, 1981.
-5-

*

L etter in the Journal o f American M edical A s s o c ia tio n , June 17,
1983, V ol. 249, No. 23; "D ioxin Exposure and Sarcoma" by M arilyn A.
F in g erh u t, P h .D ., W illiam E. H alp erin , M.D. M.P.H.
Lymphoma
H a rd ell, L ., E rik sson , M ., Lennerp Lungren, E ., ''M alignant Lymphoma
and Exposure to Chem ical S u b stan ces, E s p e c ia lly O rganic S o lv en ts and
C hlorophenols and Phenoxy A cids: A Case C ontrol Study" B r itis h Journal o f
Cancer, V ol. 43, pp. 169-176, 198.1.
G a stric Carcinoma
" M ortality Study o f Persons Exposed to D ioxin in a T rich lorop h en ol
P ro cess Accident" th at occurred in the BASF AG on November 17, 1953;
A.M. T h ie ss, and R. F ren tzel-B ey en e and R. Link; American Journal o f
I n d u s tr ia l M edicine, V ol. 3 , pp. 1 79-189, 1982.
C on gen ital D e fe c ts in the O ffsp rin g s
o f P ersons Exposed to D ioxin _________
In the D ioxin E sp o sito Book and the review o f the lit e r a t u r e from
the V eterans A d m in istra tio n , as w e ll as a r t ic le s by Dr. Ton That Tung,
e n t it le d "The M u tagen icity o f D ioxin and i t s A ffe c ts on R eproduction Among
Exposed War V eterans" (no d a te ).
" E ffe ts D e l'u t ilis a t io n M assive Et C ontinue De D e fo lia n ts Sur
L apopu lation C iv ile " , Tung, T .T ., unpu blished work r e le a s e s by th e auth ors
in Hanoi in Ju ly 20, 1969; A d d itio n a lly , Le Problème Des E ffe ts M utagenes
Sur La Second G eneration Apres L 'E x p o sitio n Aux H erb icid es" , 1979, and
a tr a n s la tio n by J . D avidson.
5

-6-

M etabolism o f TCDD
Kimbrough’s book: H alogenated B ip h en y ls, T erp h en yls, N ap th alen es,
D ib en zod ioxin s and R elated P roducts" .
The VA study and E s p o s ito 's work.
L ip id A bnorm alities
VA review and E sp o sito
Increased Breaks and Gaps in Other Chromosomal
A b n o rm a lities._______________________________________
R eference to E sp o sito , p. 229.

-7-

Dr. P eter O rris
S e c tio n o f O ccupational
M edicine
Cook County H o sp ita l
1835 V/. H arrison S tr e e t
C hicago, HI. 60612
USA

Your reference
Your letter of
Our reference 737/81 JH/MV
Date 17 July 1981
Enclosure(s) se v .

Subject

Dear Dr. O r r is,
I a p p recia te i t very much to be co n ta cted on in te r p r e ta tio n o f
u rin a ry porphyrin p a tte r n s . In your appendix you m entioned normal
v a lu e s o f co p ro - and uroporphyrin w ith in th e mg range. I th in k
t h is have to be |jg. Looking to your data I lik e to make th e fo llo w in g
rem arks:
P a tie n t no

T o ta l porphyrins
(our normal range: 0-2C0 yg)

COPRO/URO r a tio
> a,3 .5 -4 .0

in crea sed
in crea sed
normal
in c r e a se d
normal
normal
normal

d ecreased
decreased
decreased
normal
d ecreased
d ecreased
d ecreased

1
2

5
g

10

13
14

Im portant would be to d eterm ine tha u rin ary porp h yrin s se p a r a te ly e .g .
uroporphyrin , h e p ta c a r b o x v lic , h e x a c a r b o x y lic , p e n ta c a r b o x y lic - and
coproporphyrin to e s t a b lis h any in c r ease in the u ro- and heptacarb oxyl i c
p orp h yrin . Th ese two oorp h vrin s are in d ic a t iv e fo r liverdam age caused
by porphyrinocrenic ch em ica ls . A sm a ll in c r e a se means a f i r s t in d ic a tio n
n o t a r e a l d is e a s e s t a t e . T h erefore I hope you may have th e p o s s ib ilit y
to a s s e s s th e porphyrin p a tte r n . Because th e r e a ls o m ight be a p o s s ib ilit y
o f g e n e t ic a lly determ ined p o rp h y ria , a fa m ily anamnese cou ld be im portant
to o . E n closed you w i l l fin d some r e p r in ts . One. i s o f s p e c ia l valu e to
you. I t i s on Vietnam v e te r a n s from. A u str a lia s u ffe r in g m ental d is e a s e.
In co o p era tio n w ith the m ed ical d o cto r we s t iir t rese a r c h on brain e f f e c t s .
Maybe you can comment on t h is su b ject?
Kind regards,

Dr.

A. S trik
n
i

Africnliursl 'Jriiversity/biOiCcii.'îioii/Dc Drcijcn 12/6703 BC VV-.ipinmsen/The Neclicdumls/Tel. (03370) 32137

June 3, 1981

Dr. J.J.T.W.A. Strick
Department of Toxicology
Agriculture University
Wageningen, Netherlands
Dear Dr. Strick:
I have taken the liberty of writing you today concerning
your work on Chronic Hepatic Porphyria and its relationship
with chlorinated polycvclics. During the past year, we have
seen a number of Viet Nam. veterans here at the Section of
Occupational Medicine at Cook County Hospital., Cook County
Hospital is a large public hospital situated in Chicago v/ith
3.400 beds and 750,000 out-patient visits a year. The Section
of Occupational Medicine provides Occupational Consultative
Services to patients in the hospital and on an Out-patient
bases. Additionally, we have a joir.t Internal/Occupational
Medicine Residency Training program that is currently affiliat
with Northwestern University Medical School.
The- Viet Nam veterans that we have seen over the past yea
have ccma to us v/ith multiple systemic complaints that, they
believe have been caused by their e x p o s u r e to 2,3, 7, 8 tetra
chlcro-dibenzo-parn-dioxin,as an impurity in the Herbicide
Agent Orange.
In the process of researching the literature
concerning these toxic exposures, we discovered your book
"Chemical Prophyria in Man" published in 1979, and your art.icl
in the Annals of the New York /Ic.aderr.y cf Sciences, Volume 2 30,
June, 1979. On the basis of this information and discussion
with others in the field, we decided to secure 24-hour urinary
quantitative porphyrins on some of these patients. Cur
laboratory could only supply us with values for uro-porphyrins
and copro-porphyrins. The results are listed in Appendix I.
This, of course, is a small cohort, that is self selected
whose exposure is not documented, and whose other exposures
are uncontrolled.
Despite' this we found these results interas
but wonder what is the range within the normal population.
Further, we were unclear as to how’ much weight can be placed
upon abnormal rations with normal quantitative results. We
would be interested in your comments on this situation. And
further, if you could direct us to the publishing house in the

Dr. J.J.T.W.A. Gtrick
Department of Toxicology
Agriculture University
Wageningen, Netherlands

United States that carries your book, "Chemical Porphyria
in Man", we should liJ:e to order a copy. Thank you very
much for your consideration of this matter. t'Je are looking
forward to your thoughts.
Sincerely

Peter Orris, M.D., M.P.H.
Attending Physician
Section of Occupational
Medicine
Cook County Hospital

-'IT 1
! J , -i ' 1 ! 1‘ 1t,H 1 PORPHYRINS

/ URO.

SYMPTOMS
__________ ______

A rth a lg i a
jc'-ALA » ?:.ko
161/
Mya1g 1a
¡Forpho = 0 .3
. Genre - lu i
.85 = .8 7 Ma1a i sc
Pa r e s t has ia
¡'irò
- 135
j
A r th s1g i a
Bk,
:Copro = G^i
Uro
= 185
' 5 k = 1.55 Mya l g i 0
M alai se
;
P a rcsth es i a
:
--------— .------- -------------- ------------------------------ 1---------------------------- 1
Copro - i 2 S
j 123,
A r th a lg la
. ' ,Uro
= 38
I '3 3 = 3 .6 Mya1g i a
Ma1a i se
S'
IJ
P a r e sth e sia
_____
jDALA » 1 . SO
;PEG » 0 .4
Mya1g i a
7 6 /1 3 = 4 .2 Ma1a i se
, .Copro " / 6
|Uro 15 1C
P a r c sth e s ia
/JALA = 2 .7 0
vorpho = 0 . 3
' 'Cvpro
hrj
,;!rn •- 17
:/ala‘ "~~* 6 “. 3*1
r l'G — 0 .5
.Copro = SO
.Uro = 7
CALA = 4 .7 7
j’CG = 0 .8
’C ooro = 27
)Jro
= 2
<
PALA » 3-Ó0
P3G = 0 .7
Copro = l4 i
Uro = 3
i1
j
,|
’ !.

!
'i .
!
1 ..

4 6 /1 7

« 2 .7

8 0 /7

=

2 7 /2

lA l/S

Ar th o 1g i a
Mya1g i a
P ares th es i a

V

ALCOHOL
CONSUMPTION

OTHER CLINICAL ABNORMALITIES

memory lo s s
h’/O paranoid s c h iz .O
d ec r e a se lib id o
HGP
CO
rash d ev elo p ed a f t e r exp.
CO

3+

memory lo s s

-

in c r e a se chromosomal damage
h o s p ita l fo r mental h e a lth
in fe r tility
p o ly c y s t ic kidney £ t e s t i e s

2+

a n x ie ty
n au sea, vom iting
p o ly c y s t ic kid n eys
rash

0
—

1+

''^ X * 1

d e c r e a se lib id o
tempernon to 1 , nervous
sk in pa in c r a c k lin g , in crea se pigm ent

11.4 Art h a !g ia
Mya 1g i a
Pares th es i a

0

unable to have c h ild r e n
vorni tin g
rash

=

Ar th a 1g i a
13.5 M alai se

0

S.O .B . (h’/0 T/B) c y s t ic sk in le s io n s
D ecrease memory d ecrea se h ea rin g £
rash ( t ’n i gh) turn i t i s

=

Ma1a i sc
1 7 -6 P a r e sth c s ia

0

rash
a ta x ia
d e c r e a se memory

X 2 y r s.

. . ...

OHANTIATIVr
r Ol.f’ iIYÍ'. I HS

DALA = 3 . 3 O
PL'G = 0 . 2
Copro
Uro = 30

ALCOHOL

corno/

u;;c.

SYMPTOMS

0

Mo 1U i s e
P a resth es i 0

3+

in c r e a se SG0T
L iver scan - parenchyma terns D isc
rash

» k.7

A n Î1. 11<1 i a
1*01 e s lh e s t a
Molai sc
Mya 1 g 1a

H-

DALA = 6 .0 0
PBG = 0 .6
Ccpro = 1¿3
U ro.= hC

ihS/kO = 3 .7

A rth aly i a
M yalgia
Ha la i se
P a resth es i a

3+
157':;
s in c e 0

DALA = 4 . 5 0
PDG = 0 .6
Copre = 101
Uro = 50

101/50

Ma 1a i se

0

lower back pain hem aturia
d ecrea se lib id o d ecrea se memory
c o n g e n ita l d e fe c ts in c h ild .

P a r e sth e sia

1+

s e iz u r e d iso r d e r s d ep ressio n
p e r s o n a l¡ ty <:r.ange a n x ie ty
memory lo s s rash (s c r o ta !)
headaches
w eight lo s s

=

375/30

12.6

o\
II
\j->

II

Copro

Uro = 51

DAI A
-'i. 1
I’liG = O . 3
Copro - -52
Uro = 1 1

13-

OTHER CLIMI CAL ASÜORNALIT!LS

a n x ie ty
photophobia
d e p r e ssi on
i nscr.n i a
rash
d ecrea se lib id o

DALA = 5 .5 0
r - r c =• 11 . 1

12.

CONSUMPTION

13781

PATICHT
KC.

3^/51

52/11

=

.66

= 2.0

DALA = 11.30
PDG = 1 . 2
104/37 = 1 .1 9
Ccpro = 1QA
/
Uro = 87
U1.«_t i in rnrj/24 h r.
¡Horma 1 : 0 -7 .0 0 )
Por;
i 1 i r.cejen in n g / 2 -l hr . (Honro 1 :o,9. " -!i. )
C epreporphyrin in rr.g/2 k h r . (l.’or.T.ol :
U roporphyrin in ii.fi/?h lir. ( 1¡o rir.n I : 0 -'i 0 )

14.

Art ha 1g i a
Îiya ! pi a
Ma le ! s e
P a r e sth e si a

lief*
i nil
sk in rash
headaches

i!e-: 1 r.V.e ì 11. 1ill i
anx i e i.y
fo ca l p ro !, g lor cru
1onechr ?t i s

d ep ress ion
H/0 drug O.B. 1S&3
tem poral heí^caches
(sev era 1/w eek)

-

OO
o1
«-r\

FJ’Tr'’.......... r' ~ " ' ï S DH L’UTILISATION MASSIVE ET CONTINUE DE
DEFOLIANTS SUR LA POPULATION CIVILE
(ETUDE

LIMINAIRE)

(TON THAT TUNG, TRINK KIM ANN, BACH QUOC TUYEN, DAO XUAN TRA, NGUYEN XUAN HUYEN
(HANOI)
Chargés par l ’A sso c ia tio n G énérale des M édecins de la République Dém ocratique du
Vietnam d ’enquêter sur le s e f f e t s c lin iq u e s de l ’e n p lo i d ’h e r b ic id e s e t de
d é fo lia n ts sur la p op u lation c i v i l e , nous avons é tu d ié un groupe d ’h a b ita n ts
du Sud Vietnam en exode dans le Nord . De c e t t e lim in a ir e , sem blent se dégager
c e r ta in s f a i t s d ’une g r a v ité p a r tic u liè r e : 1 ’u t i l i s a t i o n m assive e t p rolon gée
d ’h e r b ic id e s e t de d é fo lia n ts peut amener des a lté r a tio n s chromosomiques sur
la p o p u la tio n v iv a n t dans le s zones d ’épandage, e t peut même provoquer des aber­
r a tio n s chromosomiques avec m alform ations c o n g é n ita le s .
Ht ERIEL D’ETUDE ET METHODES D’EXAMEN*1
Sur un to t a l de 903 personnes com posées d ’h a b ita n ts du Sud Vietnam en exode au
Nord e t groupés dans le s h ôp itaux ou dans le s ce n tr e s d ’héb.' rgement de H anoi,
nous avons pu is o le r un lo t de 179 personnes qui ont vécu sur le s lie u x
d ’ épandage de 2 m ois â 5 ans ou qui ont é té d irectem en t v ic tim e s de l ’épandage,
se r é p a r tis s e n t on :
- 90 hcim es a d u lte s
- 19 femmes a d u lte s dent 4 mères
- 70 en fa n ts en tre 6 e t 14 ans
179
L’ in te r r o g a to ir e c o n s is te à r e c u e illir le tém oignage v is u e l d ’un épandage
par a v io n , à év a lu er le nombre d ’épandages sur la ré g io n , à p r é c is e r le s
prem iers sig n e s c lin iq u e s ob servés par le s m alades sur eux-mêmes e t à estim er
le s d égâts cau sés aux hommes e t aux animaux. Puis on procède à l ’examen
g én éra l de ces personnes le q u e l e s t p a r fo is s u iv i d ’un examen s p é c ia lis é (examen
o c u la ir e , n eu ro lo g iq u e, p éd ia triq u e ou g é n é tiq u e ).
3 icn entendu, avant d ’ê tr e in te r r o g é e s, to u te s ces personnes ont su b i au p r éa la b le
un examen psychosom atique.
RESULTATS DE L’ENQUETE
On peut d is tin g u e r :
1 . un ta b lea u clin iq u e, des prem ières heures
2 . des e f f e t s secon d aires
1• Tableau c lin iq u e des prem ières heures
Dès que la b ro u illa rd chim ique tombe sur le p aysage, le — lad e éprouve des
p icotem en ts dans le s yeux avec larm oiem ents e t rh in orrh ée iu te iise s ; une âpre
edeur de ch lo re ou de DDT le s a i s i t à la g o rg e, pendant qu’une fo r te se n sa tio n
de c h a le u r , sem blable à c e lle du piment monte aux n a r in e s. Le p a tie n t étern u e
sans c e s s e ,s e met à vom ir, to u t en se p la ig n a n t de cép h alée e t d ’a sth é n ie in te n ­
se : c e t t e d ern ière se n sa tio n r e v ie n t tr è s souvent dans le s in te r r o g a to ir e s .
Tous ces symptômes commencent à s'am ender après 24 h eu res, n a is ce n 'e s t s e u le ­
ment qu’après 3 à 4 jo u rs que le malade époouve une se n sa tio n do m ie u x -ê tr e .
D 'a u tres m alades accu sen t un gonflem ent oedémateux des p a u p ières, des v e r t ig e s ,
des se n sa tio n s de brû lu re sur la peau avec p h ly ctèn c.
_____ ______

2
V o ic i le tab leau des symptômes :
TABLEAU I
^m ptônos a ccu sés par le s
m alades au moment de l'ép an d age

M alades se p laign an t
de ces symptômes

Pourcentage

S en sa tio n de ch a leu r, dans le n ez,
rh in o rrh ée, éternuem ent

163

91%

V om issem en ts,p a rfo is avec d ia rrh ée

.1 3 0

73%

S en sa tio n de brû lu re aux yeux,
larm oiem ents p a r fo is avec oedème :
des--paupières

130

737.

C éphalée, a sth é n ie

125

70%

S en sa tio n de b rû lu re sur la peau,
avec p a r fo is érythèm e •rp h ly .-ttn e:

73

Al %

T achycardie avec p a r fo is v e r tig e
usyncope

68

38 %

En somme , le s prem iers sig n e s c lin iq u e s son t c o n s titu e s par des sig n e s
ocu lo-n asau x s u iv is de cép h a lée , de vom issem ents accompagnés d'une se n sa tio n
de m a la ise , d 'a sth é n ie in te n se la q u e lle peut se p rolon ger pendant 3 ou A mois
avec des larm oiem ents c o n tin u e ls . C ette a sth é n ie peut r e s te r comme sig n e
dominant dans le s m ois qui su iv e n t l'a g r e s s io n .
2. E ffe ts seco n d a ires
Les e f f e t s se c o n d a ir e s 'se groùpent en 3 syndromes :
a) un syndrome d 'a sth é n ie prolongée
B) un syndrome o c u la ir e
c) un syndrome g én étiq u e

13733

a)
syndrome d 'a sth é n ie p rolon gée : 31 sur 109 a d u lte s , c ' e s t à d ira
29,A5% des personnes se p la ig n e n t d 'a sth é n ie g é n é r a lis é e r c e r ta in e s se son t
c o n fin é e s au l i t pendant 2 à 3 m o is, m ais r e s te n t a p r è s, in ca p a b les d'un
e f f o r t d u ra b le. A c e t t e a s th é n ie , s ’a jo u te n t de l'in so m n ie , de la c é p h a lé e ,
de l'im p u issa n ce s e x u e lle souvent e t des tr o u b le s de- la m en stru ation chez la
femme.
Une forme a ttén u ée de c e tte a s th é n ie , c ’e s t l'a s th é n ie v is u e lle qui a ffe c te
81,3% d«~ -.-i;t:.r.?.ü de l'ép a n d a g e. L 'épreuve de la le c tu r e e s t tr è s in té r e s s a n te .
Au d éb u t, la le c tu r e sem ble a i s é e , r a p i d e m e n t le p a tie n t se p la in t de v o ir
flo u p u is de fa tig u e dans le s yeux : i l abandonne a u s s itô t la le c t u r e . Sur
A3 personnes qui su b isse n t c e t t e épreu ve, 23 lis e n t en m oins de 5 m in u tes, 9
ju sq u 'à 15 m in u tes, 7 seulem ent a r r iv e n t ju sq u 'à 30 m in u tes. Lorsque la fa tig u e
o c u la ir e s u r v ie n t, le s le t t r e s s 'é la r g is s e n t , le s lig n e s se su p erp osen t :
s i le p a tie n t p e r s is te dans se s e f f o r t s , des larm oiem ents, de la te n sio n dans la
le s yeux e t de la cép h alée a p p a r a isse n t. Un repos de 5 à 10 m inutes lu i permet
de co n tin u er la le c tu r e , tou jou rs dans le s memes lim it e s .
Dans sa forme la p lu s grave., e l l e prend le -ta b le a u c lin iq u e d 'une v é r ita b le mala­
d ie d'A ddison : l'exam en c lin iq u e ne r é v è le absolum ent r ie n , s i ce n 'e s t une
extrêm e adynam ie. S e u l, l'exam en des.chrom osom es a perm is de l'a t t r ib u e r à une
grave ir o x ic a tio n par le s d é f o lia n t s .

O bservation 1

A sth én ie profonde sur une n aïad e ayant vécu 3 ans dans une
zone d'épûndage : anom alies marquées des chronosoncs à la
c u ltu r e des le u c o c y te s .

TRAN THI T R ... 47 a n s, so ig n ée â l'H ô p ita l E pour n eu ra sth én ie profonde.
A n técédents : r ie n à s ig n a le r **t p o in t de vue f a m ilia l, n a is a séjou rn é do
1966 à 1968 dans une rég io n qui a é té soum ise à des épandages q u o tid ie n s de
d é fo lia n ts ; de p lu s, e l l e a é té 3 f o i s gravem ent in to x iq u é e par des gaz (CS
probablem ent) a lo r s qu’e l l e s ' é t a i t r é fu g ié e dans un ab ri so u terra in pour
échapper arx o p éra tio n s de r a tis s a g e .
Paludism e ch ron iq u e.
A l'exam en , é ta t extrêmement, adynamique r. la malade p a rle peu, à v o ix b a sse ,
sc s mouvements son t le n t s , e l l e r e s te d ep u is de lon gs m ois couchée sur son
l i t . E lle répond c la ir e n e n t e t exactem ent aux q u e stio n s.
T ension a r t é r ie lle : 110/80 ; pouls : 8 0 /n ; r e s p ir a tio n : 25/m
Rien â ’ .‘ g n a ler à l'ex a n en du coeu r, des poumons e t de l'abdom en.
La malade remue tr è s peu le s membres du c ô té d r o it ,n a is pas d 'a tr o p h ie
m u scu la ire. R éflex es : normaux. Examen du systèm e nerveux : str ic te m en t n é g a tif.
Examens de la b o r a to ir e :
Dosage d e s _17 -c é to s té r o id e s : 4,31 n g/24 heures (2 0 /2 /7 0 )
Urée sanguine : 0 ,4 0 g/L
N.G. : 3 .8 0 0 .0 0 0 GU, 7000 G B
Hémoglobine : 70 %
F .L . n eu tre
59
eo sin o
3
lympho
36
mono
2
Bordet Wassermann : n é g a tif
C ulture des le u c o c y te s (72 h) î taux d 'a n o n a lie s chromosomiques 7,6% (par rapport
au taux 1,14% des tém oin s).
b) syndrome o c u la ir e : nous avons ob servé le s lé s io n s su iv a n te s :
- ' o th en ic v is u e lle ' (v id e supra)
- d im in u tion de l'a c u it é v is u e lle : l'a c u it é v is u e lle e s t a b a issé e aud esso u s de 10/10 chez 31 m alades sur 60 exam inés, (78,4%) a lo r s que le groupe
tém oin des sudvietnam iens ne p résen te que 26,4% de personnes dont l'a c u it é
v is u e lle e s t au -d essou s de la norm ale.
- lé s io n s o c u la ir e s : l'ex a n en de la cornée au b io n icro sco p e a r é v é lé des
lé s io n s c i c a t r i c i e l l e s de la cornée dans une tr è s g r o sse p ro p o rtio n : 24,6%
d es yeux exam inés de 65 p erson n es. On a d é te c té :
- d e s c ic a t r ic e s s u p e r f ic ie lle s dans la rég io n lin b iq u o , su rto u t dans le s secteu rs
in fé r ie u r s e t la téra u x d a la cornée (10 ca s)
- des c ic a t r ic e s sur la zone c e n tr a le de la cornée (10 ca s)
- 7 4 jeu d o -p tery g io n s
' 13784
- I e c t a s ie de la cornée
• L'exam er ophtalm ologique a perm is de d écou vrir le s a sp e c ts su iv a n ts :
- n é v r ite op tiq u e .................................................................................. 1 cas
- n é v r ite op tiq u e ré tr o b u lb a ir e ......................... ................... ..1 cas
- c a ta r a c te ................................................................................................. 2 cas
- o p a c ific a tio n de l'hum eur v it r é e ........................................ .2 cas

c) s yndroir.g g é n é tiq u e .
I l c o n s is te en :
1 / a lté r a tio n s chroncsoniquos chez 1 .-.
2 / m alform ations c o n g é n ita le s revêt"...:
tr is o n ie 21
3 / n a lfo rm a tio n s c o n g é n ita le s r u l t i p i .
chromosomiques m u ltip le s.

^

pravenent a t t e in t s
...:-.au, pratiquem ent la
c e lle s avec a lté r a tio n s

1 / A lté r a tio n s chronosoriciues ch cc
: gravement a t t e in t s
V o ici l'o b s e r v a tio n prem ière qui nous .. ..... : la v o ie des a lté r a tio n s chromo
soniqu es : sur une f i l l e t t e née avec ces
:1e m a tio n s m u ltip le s ( v . i .
o b serv a tio n 4)non ra tta c h a b lc s à aucur.
ru, la c u ltu r e des le u c o c y te s nou
a r é v é lé n i p o ly p lo ïd ie , n i aneuploïd : .. r..-;:
a lt é r a tio n s chromosomiques
tr è s g ra v es, qu'on retrouve d 'a ille u r '
.. c u ltu re des le u c o c y te s de la m ère.
Nous avens a lo r s r e c u e illi le sang de .
. ersen n es :
- un lo t de 6 personnes a t t e in t e s d \
ant vécu de 2 à 3 ans dans le s
zones d’ épandage pour conparer le u r s
. j à ceux de 2 a u tres lo t s ;
- un lo t de 5 n ord vietn an ien s norme
- un l o t de 5 su d vietn an ien s normaux
Ces 16 personnes ont é té é tu d ié e s soi:;; : :
: ..u p o in t de vue des an técéd en ts
hém atolcgique , m étab oliq u e, médicament
:: rccn tp en clo g iq u e , pour ex clu re
to u te a u tre cause d ’a lté r a tio n chromes
.
V o ic i le com pte-rendu g én éra l de la rcc.
j anom alies chromosomiques :
M éthodes d ’examen :
La c u ltu r e du sang p érip h ériq u e a é té : .
. r. la m icrotech n iq u e de L ejeu n e.
In cu b ation : 72 h à 37° C. B locage des
::.étaphasc avec de la
C o lch icin e à 0,04%. Les m ito ses ont é té :
. ;::i:ccs du p e t it g ro ssissem en t
(x 10 0 ). Toute an on alic e s t rep érée e t
par deux s p é c i a l i s t e s . Les
anom alies so n t comptées e t p h otograp h ié: ' cour. immersion (x 1000). Les étu d es
caryotyp iq u es ont é té f a it e s sur document::; p h otograph iques. Pour chaque m alade,
donc le d ia g n o stic e s t com plètem ent c a c h é , c:-. : compté 100 m ito se s e t an a ly sé
300 c e l l u l e s . 1600 c e llu le s des tém oins . : -i a n a ly sé e s.
Les caryotyp es son t d r e ssé s su iv a n t la
1.. .;: ion de Denver (I 9 6 0 ). Les
anom alies son t c la s s é e s en anom alies chro cu ti J 1 ..eues e t an om alies chrom osom iques.
Sont com ptées a u ssi corne ca ssu r e s chrc:v :... i :
le s im ages en r in g , le s
d ic e n tr iq u e s , le s fragm ents e t le s tran s i c c . o r s . Les an om alies ; r in g ,
éch an ge, tr a n slo c a tio n sont m u ltip lié e s par deux. Mous ne m entionnons pas le s
anom alies su sp ectes comme le s fu sio n s télcm éricpuos ou le s im ages non
id e n t i f i a b l e s .
R é su lta ts
V o ic i le s r é s u lta ts : sur 1100 c e llu le s î . so: - : des tém oin s, nous relev o n s un
taux d ’ anom alies de 1,14 pour 100 c e l l u l e ; ; peur 1500 c e llu le s des tém oins,
i l n 'e x is t e aucune cassu re chromosomique et set; 1m en t 0 ,4 pour 100 c e llu le s de
ca ssu r e s chrom atidiennos ; rcur 1600 c e llu le s des v ic tim e s de l'ép a n d a g e, nous
comptons un taux d ’anom alies do 5 ,8 8 pour 100 c e l lu le s . La d iffé r e n c e du taux
d 'an om alies chez le s témoins e t chez le s v ictim es des épandages a é té trouvée
tr è s s ig n if ic a t iv e , t ^ 2,33 avec p ( 0 , 0 l
.
1
( c f . tab leau I I )
I à î 00
2 ) anom alies chromosomiques du type scr..--.u avec m alform ations c o n g é n ita le s
Les anom alies chromosomiques r e lè v e n t du type connu sous le nom de T risom ie 21.
En p lu s de c e t t e tr is o n ie , i l e x is t e encore des a lté r a tio n s s tr u c tu r a le s a t t e i ­
gnant le tau x de 1 1 , 66 % pour la prem ière o b serv a tio n e t de 19% pour la 2 ëme
o b se r v a tio n . P n m i ces a lt é r a t io n s , la ca ssu re chromosomique a é té de 3 ,3 3 pour
100 c e llu le s dans le s 2 c a s, ce qui e s t , comme nous le sa v o n s, un sig n e tr è s
sûr d 'a lté r a tio n s chromosomiques d 'ap rès D ubinin (1) (1 9 6 2 ), Bender e t Gooch (2 )
il 962V Won<* An Oyi nr Chou Shint? T îtict f'ï'* f i n c

i
Examen neuropsychinus : (3 Novembre 1970) par le Dr DANG DINH HUAM.
Retard de cr o issa n c e (81 en à 34 n o i s ) . M alform ations du m a ssif c r a n io -fa c ia l :
crâne é la r g i en a r r iè r e , b o sses p a r ié ta le s p roém inentes, fo n ta n e lle bregm atique
en core e x is ta n te 3 ',/> m ois.
Bras e t d o ig ts rela tiv em en t c o u r ts , su rto u t le 5èma d o ig t des deux c ô t é s .
H ypotonie m usculaire tr è s prononcée : peut toucher sa t ê t e avec se s p ie d s . L a x ité
exagérée des a r tic u la tio n s : on peut éten d ra le s p ied s ju sq u 'à fa ir e toucher
la c r ê te t ib ia le avec le s o r t e i l s . Strabism e in tern e à gauche. Mouvements
nystagm oïdes h orizon tau x v ers la d r o it e . île peut marcher se u le : f a i t des pas en
h o r iz o n ta l en s'appuyant le long du l i t .
Au p o in t de vue p sychiqu e : retard g é n é r a l, degré prononcé d 'o lig c p h r é n ie .
E xécute avec le n te u r c e r ta in s ord res sim p les e t h a b itu e ls . : o u v rir la bouche,
t ir e r la langue, le v e r le s b ra s, e t c . . . m ais no peut ex écu ter un ordre p lu s
com pliqué oomne tendre un o b je t à sa m ère. Tendance aux mouvements d 'im ita tio n
e t à la p e r sé v é r a tio n . F a cu lté de langage extrêmement lim it é e .
C ulture des lym phocytes (Dr BACH ÇUOC TUYEM) : triso m ie 21. A lté r a tio n s
chromosomiques : 192 ( c f . tab leau I I I )
3) M alform ations c o n g é n ita le s m u ltip le s avec a lté r a tio n s chromosomiques
sur l'e n fa n t e t sur la mère
L 'o b serv a tio n su iv a n te e s t extrêm em ent in té r e s s a n te : une f i l l e t t e âgée de
17 m ois e s t p orteuse de n a ïfo rm a tien s m u ltip le s : b o sses fr o n ta le s a ccen tu ées
m éplat o c c ip it a l, r é tr é c isse m e n t b ila t é r a l des canaux lacrym o-nasaux , pouce en
s p a tu le , p ied v a lg u s, o r t e il surnum éraire e t en sy n d a c ty lic avec le 5ène o r t e i l
gau ch e. La c u ltu r e d es le u c o c y te s nous a r é v é lé des a lté r a tio n s str u c tu r a le s
im portantes qu'on retro u v e sur 1 a m ère, m ais non sur le fr è r e e t la soeu r de
l'e n fa n t qui son t nés avant l'ép an d age e t e t qui ont tou jou rs vécu lo in de
c e t t e zone.
V IJ3C L V u L I L U

. «
•
• .
. <
.
•
===*====»===*=*^ « .M. alform
ations
m u_ ltip
le s e t anom alies
chromosomiques
L 'en fa n t HOANG THI H . .. , de sex e fém in in e t âgée de 17 m ois, a é té exam inée
le 20 Octobre 1970 pour déform ations m u ltip le s : b o sses fr o n ta le s ex a g é r é e s,
m éplat o c c ip it a l, m alform ation des p a v illo n s ; aux 2 p ou ces, la 2 ème phalange
e s t a p la tie en s p a tu le , le s p ied s so n t en v a lg u s avec des o r t e i l s r ela tiv em en t
lo n g s, le 2ème o r t e il éco u rté e t le 5ène o r t e il gauche é p a is s i e t b if id e .
L 'a p p a r itio n d'une d a c r y o c y stito suppurée 15 jo u rs e t 3 m ois après la
n a issa n ce a perm is de' d éco u v rir encore un r é tr éc isse m e n t c o n g é n ita l b ila t é r a l
des canaux lacrym o-nasaux.
A n técédents : La mère âgée de 33 ans e s t m ariée jeune ?. 19 ans: e l l e a eu ,
a v a n t, 2 en fa n ts normaux e t b ien p o rta n ts : un garçon a ctu ellem en t âgé de
15 ans e t une f i l l e âgée de 17 a n s. E lle n vécu pendant un an dans une zone
fr o n tiè r e de la p rovin ce de QUANG TRI (au nord de CAM LO) : c e t t e région a é té
soum ise tou t d’abord à un épandage sporadique de d é f o lia n t s , une f o is tous le s
deux m ois en v iro n , m ais dès la seconde m o itié de l'a n n é e , l'ép fn d a g c s ' e s t
in t e n s if ié au rythme de I à 3 épandages par jo u r . E lle a e tc d irectem en t a t t e in t e
par l'ép an d age deux f o i s , avec la s symptômes d 'ir r it a t io n o c u lo -n a sa le déjà
s ig n a lé s ; e l l e a n o té même la p erte d'une p a r tie de sa ch ev elu re après chaque
a t t e in t e . E lle b u v a it de l'e a u de sou rce de la rég io n durant to u te l'a n n é e .
E lle n 'a pas eu de ru b éole au cours de sa 3ème g r o s s e s s e .
^

13786

D erm atoglyphes : r ie n d'anorm al
m d io g ra p h ic du pied gauche (Dr HOANG SU) : 6 ème o r t e i l surnum éraire e t en
sy n d a c ty lie avec le 5èmc.
Examen neu rologiq u e (Dr NGUYEN ÇUOC ANH) : à 17 m o is, le retard du développem ent
psychom oteur e s t c o n sid é r a b le . Léger p t o s is . L in it a t io n .du regard v ers le haut
avec tendance à l'a s p e c t d it on "coucher de s o l e i l " .

5

O bservation 2 : M icro cép h a lie avec é ta t d écérébrë at triso m ie 21

• naasascttassa

L 'en fan t NGUYEN THI T . .. de sexe fém in in , âgé de 10 m ois, p résen te une
n ic r c c é p h a lic a v ec, d ep u is sa n a issa n ce dos a ccès de con tractu re en e x te n s io n .
pendant 2 n o is , do Mars 1969 à Mai 1969 dans une région montagneuse de la
province de Cuang Tri-Thua T hicn qui a é té soum ise à des épandages q u o tid ie n s
par l'a v ia t io n a m érica in e. Un m atin , à 9 h eu res, e l l e fu t le tén o in d'un
épandage d ir e c t sur sa r é g io n . Au moment où un b r o u illa r d blanc tom bait sur
le s a rb res, e l l e r e s s e n t it des ir r it a t io n s dans le s yeux e t dans le n e z , avec
des larm oiem ents e t rh in orrh ée in te n se s : e l l e se m it à vomir e t r e s s e n t it une
v iv e la s s itu d e . Ces symptômes dim inuèrent dans la so ir é e e t e l l e se trouva b ien
p ortan te 3 à A jo u rs a p rès. La région où e l l e h a b ita it a v a it é té d éjà soum ise à
un épendage in t e n s if d ep u is 3 à 4 c o is , m ais à p a r tir de ce m a tin -là , l'ép an d age
d ev in t jo u r n a lie r . E lla se s e r v a it de l ’eau de la source qui é t a it p rès de sa
m aison, m ais ne to u c h a it pas aux tu b e r c u le s de la r ég io n .
En Mai 1969, e l l e s 'e n f u it au Nord Vietnam e t le 9 Décembre 1969, accoucha <
avant .terme d'une en fa n t p esan t 2,300 kg à la n a issa n c e .
A l'exam en, l'e n fa n t de saxe fém in in âgée do 10 mois p résen te une m icro cép h a lie
ty p iq u e, un fro n t cou rt a t des o r e ille s im p lan tées norm alem ent, n a is avec une
conque h yp ertrop h iée e t un con d u it a u d it if ex tern e p lu tô t la r g e . Main gauche :
p li palm aire tra n sv erse u n iq u e, b o u cles d ig it a le s norm ales, tr ir a d iu s a x ia l
en p o s itio n t' sur le s deux mains (in te r m é d ia ir e en tre le cen tre de la main e t la
p o s itio n T );
Examen neurologiq u e (25 Octobre 1970) par le Dr NGUYEN QUOC AN1I. M icrocép h alie
m a n ife ste . A ttitu d e de d écéréb ra tio n : o p isto th o n o s, e x te n sio n des 4 membres,
membres in fé r ie u r s en c ise a u x . A c tiv ité spontanée e t r é a c t iv it é presque n u lle s .
V ie uniquement v é g é ta tiv e , d 'a ille u r s mal a ssu rée : r e sp ir a tio n bruyante avec
tir a g e s u s -s te r n a l. Pas do sig n e s typ iq u es do la m aladie de Dcwn.
Q iltu re des le u c o c y te s (Dr BACH QUOC TUYEN) pendant 72 heures su iv a n t la technique
de L ejeune. T risom ie 21 c a r a c té r is tiq u e avec mosaïque 46,47 prédominance 4 7 .
A nom alies chromosomiques : 11,66% das c e llu le s
O===”
bservation
«■ -=*=” I «I I

( c f . tab leau I I I )

T risom ie 21 typique chez une en fan ^t de 3 ans nee dans ,ta
zone d'éeantîage
L 'en fa n t HOANG THI TKU T H ... 3 ans a é té exam inée par nous le 2 Novembre 1970 :
son p r o f il e s t typ iq u e d'une tr iso m ie 21 (ép ica n th u s b ila t é r a l, écartem ent des
yeu x, écrasem ent de la ra cin e du n ez, bouche e n tr 'o u v e r te en V in v e r sé , langue
en s a i l l i e hors de la b o u ch e).
Père né en 1922, mère, en 1930 : le père e s t l'a in é d'une lig n é e de 5 garçons e t
4 f i l l e s , la a ère e s t aa soeur c a d e tte d'une lig n é e de 2 f i l l e s .
Pas d 'a lte r a tio n s dans le s d crm atcglyp h es, sau f un p li palm aire tra n sv erse unique
à gauche avec le tr ir a d iu s a x ia l en t 1 ; le s b o u cles d ig it a le s sen t n orm ales.
L'examen r é v è le une la x itd lig a m en ta ire avec h yp oton ie-m u scu laire tr è 3 marquée
aux membres. P.etard psychom oteur im portant. P honation d é fe c tu e u se .
L'anamnèse r é v è le que le s p aren ts ont vécu dans une .zone de la p rovin ce de
OUAîTG NAM de 1964 à 1970. C ette rég io n a é té soum ise à das épandages co n tin u s
de d é fo lia n ts presque q u o tid ie n s , de 1966 à 1970 : p erson n ellem en t, e l l e n 'a pas
accu sé de syndrome c c u la -n a sa l par attaq u e d ir e c t e , m ais e l l e s ' e s t n o u rrie de
tu b ercu les d é te r r é s ap rès chaqua épandage e t même de r iz a t t e in t par l e s d éfo ­
lia n t s pendant une p ério d e a sse z longue : 4 a n s. L 'en fan t e s t née dans c e t t e zone
le 7 Décembre 1967.

/

C ulture das leu c o c y te s (Dr BACH QUOC TUYEN) Nombreuses anom alies
chromosomiques : 13 % ( c f . Tableau I I I )
La cu ltu re des le u c o c y te s de la mère r é v è le le s mêmes a lt é r a tio n s chromoso­
miques : 7,33% ( c f . Tableau III)
Le caryotype d". fr è r e e t de la soeu r de c c ttc en fa n t, nés avant l'ép andage
e t v iv a n t lo in de la zone d'épandage e s t absolum ent norm al.
DISCUSSION
Nous avons à rc'an d re à ces 4 q u e stio n s :
1. Le 3 d é fo lia n ts an l'e s p è c e le 2 , 4 , 5~T p e u v a n t-ils provoquer des lé s io n s
o c u la ir e s ?
2 . ^.es d é fo lia n ts p e u v e n t-ils provoquer un syndrome d 'a s th é n ie prolon gée ?

3 . Les d é fo lia n ts p e u v e n t-ils provoquer des anom alies c o n g é n ita le s ?
4 . Les ■’ -fo lia n ts p e u v e n t-ils :-o v o q u cr des a lté r a tio n s chromosomiques ?
DEFOLIANTS ET LESIONS OCULAIRES
C liniquem ent le s lé s io n s du segment a n té r ie u r <^e l'o e -il ( lé s io n s cern een n es)
so n t c o n sta té e s sur la s personnes exam inées dnns une p rop ortion anormalement
é le v é e ; to u tes ce s d e rn ières ont sig n a lé la tableau ccu lo -nasal des prem ières
h eures de l 'cp an d age. C.-mna ces lé s io n s p a r a isse n t ê tr e dues aux g o u tta le tta s
da d é fo lia n ts condensées sur la c o n jo n c tiv e e t la co rn éa , nous avons procédé
aux i n s t i l l ■ tie n s o c u la ir e s sur le s animaux. E xpérim entalem ent, sur l ' o e i l des
la p in s , l'u n da nous (4) a rep ro d u it la s lé s io n s c lin iq u e s o b serv ées sur
l'homme, par i n s t i l l o t i ' a s de S a lo st (’KHange de 2,4-D e t de 2 ,4 ,5 -T ) e t
de Tordon 22 K (4 , amine 3 ,5 ,6 a cid e p ic o lin ic u e ) :
a) le S e le s t provoque sur la cornée e t la co n jo n ctiv e des b rû lu res du 2 èmc
e t du 3èmc degré qui peuvent g u é r ir : n a is e l l e s peuvent a u ssi provoquer des
b rû lu res du 3ème e t du 4èma degré ( c la s s if ic a t io n de P c lia k ) a v e c , comme
conséquences des o p a c ific a tio n s de 1 a. co rn ée, des p e r fo r a tio n s corncennes ou
d es a tro p h ies o c u la ir e s .
b) Le Tordon 22 X provoque sur la cornéa e t la c o n jo n c tiv e du la p in des
b rû lu res du 2ème e t du 3ène degré de moindre g r a v ité mais sur une p lu s
la rg e é ten d u e.
DEFOLIANTS ET SYNDROME ASTHENIQUE
Ce syndrome asth én iq u e b iza rre s i prolongé qui nous a ta n t in t r ig u é s , p e u t - il
ê tr e a ttr ib u é à l'u sa g e da d é fo lia n ts ?
R appelons d'abord que c e tte a sth é n ie a é té s ig n a lé e sur le s tr a v a ille u r s des
u sin e s fab riq u an t le 2 ,4 ,5 -T (5) . Vers 1960, la Compagnie Dow a é t é o b lig é e de
ferm er se s su c c u r sa le s à M ichigan parce que 60 o u v riers c o n t a c t è r e n t une m aladie
c a r a c té r is é e par des éru p tio n s cu ta n ées e t des désord res du systèm e nerveux
c e n tr a l : fa tig u e chron iq u e, la s s itu d e et d é p r e ssio n . Les o u v r ie r s d'une autre
Compagnie ?1 New J ersey p résen tèren t le s marnas symptômes, m ais c e t t e a sth én ia
s 'o b s e r v a it encore chez qu?Iques-uns 6 ans a p r è s. Depuis I960, le s m édecins de
la RFA ont s ig n a lé la même m aladie chez des o u v riers tr a v a illa n t le 2 ,4 ,5 T
avec a t t e in t e du f o ie , d ésord res mentaux e t nerveux, d é p r o ssi* n ,p e r te du poids
e t de l'a o p c t it e t im puissance s e x u e lle .
Rappelons encore que la dose lé t h a le LD50 ?.at (dose en k g /p o id s cap ab le de tuer
la m o itié des r a ts d 'ex p érim en ta tio n ) e s t d 'en v iro n 400 mg pour le 2 ,4 ,5 -T . -t ot*
D 'après D r ill e t H iratzlca ( 6 ) (1 9 5 3 ), l'a b so r p tio n de fo r te s d oses de œ
-1.0 1
p ro d u it provoque chez le ch ien des lé s io n s m u sc u la ir e s.

L'ous 7 'm s con clu re : p lu t T t qu'une :
le n to de l ’or ran i s me par l ' afc serre ion ■
2 ,4 ,5 -T prévenant :s ip --1adages c c n tir u
Chez de c o is m alades, or. peut d é te c te r
retro u v er la m aladie ca u sa le : ce sont
c u ltu r e des le u c o c y te s C cf. ta b le \ 11).
DâFOLIAHTS ET A.CFDT5 TPXATCUr.tTb.E
I) 2 ,4 .5 - T ET ?Z0XIV,?.F
Les d é fo lia n ts e t h e r b ic id e s u t i l i s é s
l ’a tte n tio n du r .ide r a d ic a l e s t attire--Spandu, d ’ après Jacicie V crro tt (7) au p.<,
moins sur 5 m illio n s d 'a c r e s en 9 ans.
Le 2 ,4 ,5 -T ou ¿•■ '.de a c é tiq u e 2 ,A ,5 -c r ic !
auquel i l e s t tr è s souvent a s s o c ié par e
p lu p art du temps., cos deux p ro d u its se l
base le p é tr o le ou l ’h u ile D ie s e l. Les
partîtes a c tiv e s de. 1 ' avent-nvanpo u t i l l :
Le prem ier rapport connu sur la s e f f e t s ;
B io n c tic s Recenrch L a b cro tcries ( 3 ) . "
Le 7 ,4 ,5 - 1 e s !i dennv. f° .r \ n . v o i_ o r a l e a
.tW•t Ii' 1 . 1 V<“* >??"’*
>IU\ i’• < ?
1 ! ? i? /k s ••,• f»M '•••V
au x s o u r i s I?L*Ó Cîl*? fîOCOS C.-~ 21 1?* , 't £ |

qu'aux h yb rid es RLÓAF à 1°. de su do 112 n:.
in j e c t io n s . L’a d m in istra tio n '’a la drop
dans la plu p art des cas (du tir ’.- jou r ar
9 jo u r s , dans eue lo u es ces (du éèmx au 1:
au i 4i;m»c jou r) dans en c a s . La ’T-’.r. ^ev.speur la v o ie ó r a la , •
' la ' . c l .

-ie n m a ssiv e, une in to x ic a tio n
de b o isso n con ten an t le
e n tra în er une a sth é n ie p ro lo n g ée.
: stig m a te perm ettant de
.tâ tio n s c h r or.o s otr.iq ue s à la

î-’-V iecn rr so n t v a r ié s : mais
t t ic u lio r sur le 2 ,4 ,5 -T qui a é té
>ù m illio n s de liv r e s au
...::yde ce d if f é r e n c ie du 2 ,4-D
de ch lo re su p p lém entaire : la
dans des fou ••juins ayant pour
2 ,4 -0 e t du 2 ,4 ,5 -T sen t le s
r du 2 ,4 ,5 -T e s t c e lu i de
s r é s u lt a t s :
s ?T,6 aux ¿ o ses de 4 6 ,6 e t
':<ç ; i l a é té a u ssi ne! ni n i s t ré
ut aux AKA s o u r is . de même
la v o ie so u s-cu ta .née, en
e ffe c tu é e pendant 3 jou rs
. ur de La p o stâ tic r .) • pendant
; «s
I; : 5 jo u rs (du IQèno
u t i l i s e comme v é h ic u le le DMSO :

A l'e x c e p tio n de la dose la p lu s l a s s a ( 7 ! ; :
cu tan ée) to u te s le s a u tr e s dose;,- que l l e
une in c id e n c e l l -r 'C- d-; fo e tu s que m aux,
e s t tr è s fréquente., 7i la dose d.a ! 1S m.a/k
f a ib le s . La tau:: d ’ eppcvi cion des r e in s h;,
f a i t e p eu rles scucnes AKl e t le s so u r is 3 :
La m o r ta lité fc o tr .le e s t nu on e n té e '.ans i.
pendant 3 à 9 jo u rs ,_•• -'!
la so u r is
une dose p lu s fa ib le (AC; 4 nq/hg par v o ie e. .
c u ta n é e ).
Une étude s im ila ir e a é té f a it e sur le ra t !..
des d oses do. 2 1 ,5 e t 4 6 ,4 mç/kg en suspens'
par la v o ie o v a le , du 6êmc jou r au 1 5èm jeu.:
taux e x c e s s if b', m o r ta lité
r.tnl-e ut une i:.
le s su r v iv a n ts. F a it d icn e oc reiaarnue, uv.
avec la p lu s co u rte durée d es in j e c t io n s ,
t r o is f o is p lu s grande chez le s .îimnux d

•; aux so u r is 3L6 par v o ie cou s: i n v o ie u t i l i s é e , o r t provoqué
--.ion d'u n e d iv is io n p a la tin e
e l l e e s t ..■ .ulle à ¿es d oses p lu s
e s t a u s s i é le v é , ex cep tio n
ait 4 6 ,4 mq/kg par v o ie o r a le .
. groupes recev a n t I 13 mg/kq
avant c e t t e meme d o se , mais
et 2 ! ,5 mg/kg pe.r v o ie so u s-

Comme le 2 ,4 ,5 - 1 e s t m élangé à des impureté;:
ces d e r n iè r e s . 4 La C onférence EDA (24 Tév;-..
dose de d io x in e s de 9 ,! /'- g /k g /jo u r , sur les
f o e t a le a é té de 82% e t le s ano »¡•nl i cr­ í r **1
1 ’ in c id e n c e dus anom alies a ê té de 5« (9) .

a le s d io x in e s , on a é tu d ié a u s s i
70) on a trou ve qu 'avec 1
t e r 3 a a g e s t a t io n , la m o r ta lité
32"? A la dose de 0 ,5 j<- g /k g ,

D’aucre p a r t, avec le " ,4 ,5 T p u r if ié , ce t r
sur la so u r is éw ir.s-'.Jecstcr e t sur ’ e h ans'.FDA S tu d io s.

téra to g èn es on t é té confirm es
r le s MIEKiî S tu d io s e t le s

r; ruche Spraguo-D aw ley. Avec
-r. 50% de m ie l, e t a d m in istrées
la g e s t a t io n , on a observé un
te « le v é e de truilfcncp.fcinns chez
' es f a ib le d ose (4 ,6 mg/kg) e t
j;:cc des fo e tu s anormaux a é té
■ ace. que chez le s tém oins.

13789

II) VOIE DE CONTAMINATION ET DOS!' l’INT!'..'

Far q u e lle v o ie a pu se fa ir e la ccntamii-.
q u e lle dose le s e f f e t s téra to g èn es pouver. .
I l ne sem ble pas que ce
s o it
par m
v o ie r e s p ir a to ir e ) ; i l sem ble p lu tô t que
par le s épandages co n tin u s qui s o it lcvêhi.
D 'autre p a r t, i l fau t s ig n a le r que le 2 ,4 ,
un c e r ta in temps : M ille r e t Bar*g (11) af :
par a cre, i l peut p e r s is te r pendant 4 à
de 6 m o is.

'.MOCENE

a la femme p esta n te e t à
..lif e s t e r ?
.j d ir e c te (v o ie la cry m o -n a sa le,
l ’eau des sou rces p o llu é e
■ .le l'in t o x ic a t io n .
-.•ut p e r s is te r dans le s o l pendant
. qu'à la dose de 0 ,2 5 à 8 liv r a s
j ; De Rese (12) donne un maximum

d oses em ployées par acre au
W hitesidc (13) a c a lc u lé qu'en tenant ccm;
Vietnam , une vietnam ienne de 40 kg buvant . .c e s d'eau contam inée, absorbe
120 mg de 2 ,4 ,5 -T par jou r s o it 3 mg par k.
:>oids. Avec le 2 ,4 ,5 -T p o llu é de
d io x in e s , ce qui e s t la r è g le , le taux de
lu es absorbées e s t de 1 /1 0 de
microgramme par jo u r .
Une t e l l - dose p e u t - e lle ê tr e téra to g èn e ?
. a i t qu’i l e s t d i f f i c i l e de
d 'ex p érim en ta tio n à 1 'homme,
tra n sp o ser le s d oses ob serv ées chez le s a;
orm is de comparer la s e n s i b i l i t é
Heureusement l'e x p é r ie n c e de la thalidcm id.
de la race humaine ?. c o llé des animaux. Av
. th alid om id c, la dose téra to g èn e
la plus b asse a é té estim ée à 0 ,5 m q/Kg/jc.. . our la même a c tio n , c e t t e d ose a
é té estim ée à :
30 mg chez la so u ris
50 mg chez le rat
100 mg chez le chien
350 mg chez le ham ster
..ter) (14)
On peut donc dire" que la femme e s t s e n s ih i
.'- .f f a t téra to g èn e :
60 f o is p lu s que la s.
100 f o is p lu s que le t
200 f o is p lu s que le
700 f o is p lu s que lu : ... r
En supposant que la femme s o it a u ssi sa n si.
2 ,4 ,5 -T qu'à la ThalidomJdc
(ce qui e s t tr è s p o s s ib le ) , on peut chercha. .. c a lc u le r la dose minimal-:
téra to g èn e chez la femme sachant que c e lle -.: i r.t s e n s ib le à c e t e f f e t 100
f e i s p lu s que le rat : en nous rep ortan t r.:..: e x p érien ces sur le rat ce la
souche Sprague-D ovlcy, la dosa téra to g èn e I ; . js fa ib le é ta n t de 4 ,6 n g /k g , la
dose m inim ale téra to g èn e chez 1-a femme sera : ., . a l'o r d r e de 4 ,6 _ ....,
„
Toô = ° ’vVf6 mR'kR-

D’ après W h itesid c, la dose absorbée par une
tnamicnne do 40 kg e , bov.ant
de l'e a u p o llu é e e s t de 3 m g/kg, c 'e s t à d. : f o is su p érieu re à la dose présumée
té r a to g è n e . S i le s épandages so n t quotidien. -r une r é g io n , le s chances pour
une jeu n e femme p esta n te de co n cev o ir un ,t\-. _ ..; anormal or.t extrêmement f o r t e s .
Supposons m aintenant que l ' e f f e t tératogèn e s o it du aux d io x in e s : comme la femme
d o it en absorber par jeu r I /1 0 de micrcgram:-..: par l'e a u p o llu é e (W h ito sid e);
ce médicament s'a ccu m u lera it dans 1 'organism e comme tous le s hydrccarbones c h lo r in é s ‘ e t f i n i r a i t par a tte in d r e le s e u il téra to g èn e ; e t comme le s épandages
so n t q u o tid ie n s , le s chances pour e l l e de co n cev o ir un en fa n t anormal sen t
égalem ent tr è s f o r t e s .
Donc pour que la dose de d r fe lia n t s o it térv.-..-,èn c, i l fa u t q u 'e lle a tte ig n e un
s e u il qui n'-a pu ê tr e p r é c isé comme avec la
'.iidom ide, m ais ce s e u il peut
ê tr e fra n ch i :
a) s o it par s e n s i b i l i t é marquée de l'o rg a n ism e humain au 2 ,4 ,5 -T ou -aux
d io x in e s
b) s o it par u t i l i s a t i o n de dose m assive
13*7^0
c) s o it par accum ulation dans l 'organism e:.
°

I I I ) VALEUR DES EXPERIENCES ANIMALES I. ' LES TESTS TE3AT0GENESUne iiss p lu s g ro sses d i f f i c u l t é s d'apprd.:. ;cn résid u dans la s e n s i b i l i t é
v a r ia b le d'une esp èce à l'a u tr e v is à vi_. -n médicament téra to g èn e : par
exem ple, la thnlidcr*ido dangereuse peur ' . 1 :pin ne provoque aucune m alform ation
chez le r a t. Néanmoins, s i I'expérim enta:
e s t p o s it iv e sur p lu sie u r s
e sp è c e s, au moins sur t r o is , ilf a u t lu i
dur une axtrên e a tte n tio n ,
su rto u t s i ces esp èces se n t des rongeur.-: , :■ on s a it q u 'il n 'o x is te pas de
d iffé r e n c e s fondam entales en tre le s réacL . ..s de l'em bryon humain e t c e lu i
des rongeurs (1 5 ).
IV) ACTION FOETICIDE CHEZ LA FEMME
I c i, l'é p r e u v e c lin iq u e peut ê tr e d ô c isiv ,. . - e a pu r e le v e r :
1 ) une a c tio n ab ortive : d e l ' in te r r r .r a tc i: vos v ic tim e s de 1 ' épandage, nous
r a t t ir e r l'a t t e n t io n m éd icale sur
avens dégage ries f a it s a ssez tro u b la n ts ;
la s u s c e p t ib ilit é du m a té r ie l gén étiq u e I... .Ai aux d é fo lia n ts :
a /- après le s épandages dans le s jou rs c . ai v e n t, i l y a nu un nombre an om al
; d i s t r ic t s du LONG DIEU e t
d'avortem ents humains : par exem ple, dans
d ’AN TRACH (5èmo zo n e ), sur 73 femmes ayc.;. r.an ifosté des sig n e s d 'a t t e in t e o c u lo n c s a le , i l y a eu 22 avortem ents (.'panda:: _ i mois de Mai 1966).

b / on a observé a u ssi des avortem ents
:s animaux dom estiques :
- dans lu d is t r i c t d'AN UCVIA (5èine z.
après l 'épandage (Mars 1966)
7 vaches ont avorté (<lans ce même des troc.-: . a s ig n a lé a u ssi que truites
le s p ou les après l ' épandage ont c e ssé de ;
u)
- dans le s d is t r ic t s de LONG DIKK et r! AU TRACH, après l'épancîage du mois
de Mai 1966, 63 b u fflo n n es e t 92 tr u ie s ou a v o r té .
2 ) une fréquence accrue des avortem ents r.è: : i ras : dans le s zones d*épandage, .

i l a é té sig n a lé une fréquence anormale d' . zzenents m o la ires . Ce f a i t
d o it nous in q u ié te r s i l'o n so. r a p p e lle qiu Lu p la cen ta de t r ip lo ïd ie montre
même m acroscopiquem ent, dans la m a jo rité d u as, un a sp ect v é s ic u la ir e ,
su b n Ô lairc, in té r e ssa n t une p a r tie eu la z: i i té des v i l l o s i t é s (T h ilip p e
e t Boue) (1 6 ). Une a b erra tio n chromcsomiqu par in g e s tio n de 2,A ,5-T au
début de la g e s ta tio n reu t ê tr e à 1 1c r ig i du ces avr.rtem.onts m ô la ir e s.

DEFOLIANTS ET TRISOMIE 21*12
Nous avons observé deux cas de triso m ie 21 sur 2 sudvietna.m ienrr s ayant vécu
dans le'-.zo n es d'épandage : l ’une d 'e lle s a même a.ccusé des sig n e s immédiats
d 'a g r e ssio n o cu lo -n n sa le à la s u ite de l'u n Je ces épandages.
On s a it que la T risom ie 21 e s t la conséquence d'une erreu r dans la sép a ra tio n
des chromosomes hom ologues, erreu r qui a é té a ttr ib u é e au v ie illis s e m e n t m ater­
n e l. Mais c e tte triso m ie peut se v o ir a u ssi dans le s s u it e s de r a d ia tio n ou
de p r ise de médicaments toxiq u es e t l'o n s a it nue le p rod u it n o c if peut a g ir
sur 1 'organegénèse en tre la 2èmo e t la 7ème sersoine de la g e s ta tio n .
V o ic i le s anom alies que nous avons c o n sta té e s sur l'exam en de n o s ■ trisom iq u es :
1 ) la jeu n esse de la. mère dans le 1er cas : on s a it que la tr iso m ie 21 sur­
v ie n t su rto u t chez le s d e r n ie r s-n é s d'une fa m ille nom breuse, par conséquent
le p lu s souvent chez la mère â g ée. D 'après C arter (17) e t Penrose ( ! £ ) , Turpin
e t Lejeune (19) c e u x -c i estim en t qu'avant 1 T.ae de 30 a n s, le risq u e e s t de ‘ ‘-rr1 ' ordre de 1/2000 ; ?. 35 ans, i l s 'é lè v e , à A/ioOO pour a tte in d r e une valeu r
de l'o r d r e de 2% p assé l'â g e de A5 ans. Les Jeux mères de nos trisom iq u es ont
resp ectiv em en t, au moment de la n a issa n ce de Leur en fa n t :22 ans (Ob
e t 37 ans (O bservation 3 ) .
2) La triso m ie 21 dans le prem ier cas n 'e s t pas pure : a l i e e s t encore.
.a sso ciée à une m icrocép h alie •

3) Lea 2 triso m iq u es ne p résen ten t nucu a Ité r é e ion des dornatop.lyphes sur
le s d o ig ts ; s e u l, le r l i palm aire transv je unique a é té co. s ta té su r i 'une
dus m ains, dans la s '¡eux c a s .
4) la trop grande fréquence de c e t t e trisu m iu sur une s i faible* p o p u la tio n
de m ères. On s a it que la tr is o n ia 21 su r v ie n t avec une fréquence s itu é e en tre
1/600 e t 1/700 n a issa n c e s, a lo r s que sur .notre fa ib le l o t , e l l e a é té de
2/4 n a issa n c e s.
5) e n fin , ce qui permet .'.'affirm er que ces tr iso m ie s 21 r e lè v e n t d'une in to ­
x ic a tio n m édicam enteuse, c 'c s t qu'a c ô té de c o tte tr is o m ie , nous avons
r e le v é des anom alies chromosomiques s tr u c tu r a le s d ’une haute g r a v ité :
- chez la prem ière e n fa n t, i l y •’ 3 ,3 3 /ICO c e llu le s de ca ssu r e s chrom osom iques.
- chez la seconde e n fa n t, i l y a 3,33/lG O c e llu le s de c a ssu res chromosomiques
C 'e st à d ir e près de 6 f o is de p lu s que crhea le s su r v iv a n ts d'H iroshim a
(0 ,5 5 /1 0 0 c e llu le s de en ssu re i hromosi-aiique, d 'a p rès Jlloon e t Al (2 0 ).
DEFOLIANTS ET AUTRES 'lALFQRldATTONE CONGENITALES
L 'o b serv a tio n 4 r é v è le l'e x is t e n c e de m u ltip le s anom alies (crâ n e, canal
lacrym al, membres) sur une en fan t a s s o c ié e à des a n c n a lie s str u c tu r a le s dos
chromosomes qu'on retrouve d 'a ille u r s sur la mère (13% chez l'e n fa n t e t 7,33%
chez la mère) • C eci nous penr.ee de supposer nue la mère e t l'e n fa n t probablem ent
ont é té soum ises à de m u ltip le s a g r e ssio n s par des su b sta n ces chim iques au
moment de la g e s ta tio n , l'em bryon s 'é t a n t r é v é lé comme p lu s s e n s ib le que
l ’a d u lte aux a lté r a tio n s chrom osom iques.
DEFOLIANTS ET ALTERATIONS CHROMOSOMIQUES123
On s a it que la s su b stan ces chim iques peuvent provoquer d e sa b e r r a tie n s chromosomi­
q u es. D arlinqtor. e t K eller (21) (¡9 4 7 ) o n t, le s prem iers d é c r it le s a lté r a tio n s
chromosomiques provoquées par le s m outardes à l'a z o t e sur T rn riescan tia, ce qui
o u v r it la v o ie aux étu d es sur le s a lt é r a tio n s chromosom.ioues provoquées par le s
médicam ents an tica n céreu x (2 2 ,2 3 ,2 4 ) e t par le s su b sta n ces chim iques dont la
l i s t e a é té étn '-l.ie par F tahl e t L uciani (25) . P uis ce fu t la tranéclie de
la th alid em id e e t le s r é v é la tio n s sur Le LSD 25 ( 2 6 ,2 7 ,2 9 ).
Nous croyons que nous soi-m.es le s prem iers à s ig n a le r le s a b erra tio n s chronosoniqu'
par la s d.:f c i l :a ts .
Nous pouvons s o u te n ir que l'a lt é r a t io n des chromosomes a jo u é un r ô le n é fa ste
au cours de la g e s ta tio n :
1 ) ce son t le s a lté r a tio n s chromosomiques qui ont é té resp o n sa b les des a v orte­
ments m u ltip le s chez la femme e t l ’anim al, d 'a p rès lu s travaux do Carr (2 9 ),
r e p r is récemment par le s au te • ? fr a n ç a is (Boue e t doué) (3 0 1 , P h ilip p e e t Boue
(1 6 ), Roux (3 1 ).
2 ) ce so n t le s a lté r a tio n s chromosomiques de l'cnb.ryon au début de son develop
pensent qui ont créé le s anom alies c o n g é n ita le s , du type rap p orté dans
l'o b s e r v a tio n 4.

3) Les d é -a lin n ts (du type 2 , 4 , 5-T) ou d io x in e s ) sont in d u cteu rsà la f o is
d 'a lt e r a t io n s chromosomiques e t de té r a to g é n è se , e t ces f a i t s ont é té amplement
w g* sm
prouvés par l'e x p é r im e n ta tio n e t nos o b se r v a tio n s c lin iq u e s .
0w

Ouol sera l'a v e n ir d'une p op u la tion dent la v ie a é té remani éc par de t e ls
b ou leversem en ts é c o lo g iq u e s, qui n'oparm ent cerne n as, to u t c nmme dans la
guerre atom ique, le patrim oine ehrcm cscniuue humain ? T.;- r nn r »•r

n t* t* i *-»t » 1

3
- i: -

..

le s leu cém ies e t 1 ■2s nîonstruosLto s (13) sero n t certain em en t le s d en iers
le s p lu s graves à -. ai: •'•••>. A l'h e u r e a c t u e lle , par 1 ' a lté r a tio n de leu rs
chrcm csom es. i l e x is ta daux populations .t.«i so n h len t p artager le meme so r t
tragiq u e : la p o p u la tio n su rv iv a n te d''Hiroshim a e t de Nagasaki e t le s
v ic tim e s des aor.es d'épandnp.e de d é fo lia n ts nu Sud-Vietnam .
En c o n c lu sio n ,
l ' u t i l i s a t i o n m assive e t p rolongée des d é f o lia n t s , en dehors des lé s io n s
o c u la ir e s perm anentes peut amener des a it é r a t ie n s chromosomiques de to u te une
p o p u la tio n o b lig é e de s'a c c r o c h e r au s o l a n c e s tr a l, e t ccs a lté r a tio n s
peuvent provoquer dans sa. descendance des m alform ations c o n g é n ita le s dont
l'im p o rta n ce r e s te à p r é c is e r .
Dana l ’h is t o ir e abom inable des g u e r r e s » n 'a -t-o n *11j am ais vu so r t a u s s i inhumain
réserv e aux su rv iv a n ts sin o n avec la gu erre atom ique ?
P UFERFMCE5
(1) DUBININ HP l z d An. CCCS 1962, i. : 39
(2) BENDER MA a t GGOCH PC, P roc. n a t. .Va. S ci (U S), 1962, 48 : 522
(3) HONG AN CHI e t CHOU SHING TING, A cc. B io l. cxn . S in ic a , 1964, 9 : 178
(4) DAO XUAN TRA . é s ’ons o c u la ir e s ex p érim en ta les avec le S e le s t e t le Tordon
22 K, T ra v a il non p u b lié , P ro to co le S annexé au rapport.
(5) WHITESIDE T. D e fo lia tio n , In ta x t P u b lish er NY 1970 p. 48
( 6 ) DRILL e t HIRATZKA, c it é s par GKUMMFR G. D ésherbants au Vietnam ; VN-Auss.
b . A fr. A s ia t. S o lid a r . b e r lin , I960, p. 55
(7) J a ck ie VEP.RETT, In E ffe c ts o f 2 ,4 ,5 -T on "an and t!ie Environm ent, US Senate
9 1 st C ongress, W ashington 1970. p. 104
( 8 ) RI0NETIC3 RE. LAP. in ouv. c i t é p. 407
(9) FDA, tr a v a il non p u b lié
(10) SPARSCUU C-L, DUNM FL, e t HOUE VK (Dow Chemical C°) , Soc. of T c x ic c lc g y
9th Ann. M eet. A tla n ta , G eorgia 1 7 /3 /1 9 7 0
(11) .MILLER MW e t 3ERG GC, Current R esearch in P e r siste n c e of U erb icid .es,
ch. Thomas P u b lish e r s, 1969
(12) DE ROSE KR B ot. Gaz. 1946. 107 : 533
(13) WHITESIDE T. ouv. cité p. 407

(14) FALTER, c it é par EPSTEIN 3. E ffe c ts of 2 ,4 ,5 -T ouv. c it e p. 406
(15) TUCHMANN DUPLESSIS F . B u ll. Fed. S oc. Gyn. O bst. 1968, 20 : 9
(16) Fui lip p e F., e t HOUE J .E . P resse né J . 1970, 78 : 641
(17) CARTER CO e t EVANS FA Lancet 1961 11 : 783
(18) PENROSE LS Hunan Chromosomal a b n o r m a litie s, S ta p p les P r e ss, London 1961
p . I 16
Cï 9) TURPIN R. e t LEJEUNE J . Les chromosomes hum ains, G a u th ie r -V illa r s , P aris
1955. p. 93
(20) BLOOM AD e t A l. Lancet 1967 II : 802
(21) DARLINGTON et FELLER PC H ered ity , 1947, 1 : 187
(22) CCNF.M PE e t LANSKY GS, B r it. Med. J . 1961, 2 • 1055
(22) BELL S . e t WOLFE S. Proc. N at. A a d . S ci (US) 1964 : 51, 195
(24) BELL S . et 1.1. Blond, 1966, 27 : 771
(25) STAHL A. e t LUCIANI JM N ile Revue Erse d 'H ém a to lo g ie. 1970, 10 : 17.8
(26) C C E 'jm e t A l. S cien ce (NY) 1967 , 155 : 1417
(27) I.'.diN S. e t EGGZCUE J . S cien ce (NY) 1987, 157 : 313
(23) Hans ZELLWEGER e t A l. L an cet, 1967, II : 1066
(29) CARR DH An. J . O bst. Gyn. 1567, 97 : 233
(30) BOUE JG e t BOUE A. P ressa Méd. 1970, 73 : 635
(31) ROUX Ch. P resse méd. 1970, 78 : 647
13793

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EPANDAGE DE 2,4,5 - T

AU SUD VIETNAM

PROTOCOLE D'EXAMEN CHIMIQUE

essssssssxasassssssssssssâaa

Le 15 J u i l l e t 1969 à 9 heures du m atin, t r o is avion s C 123 ont répandu
des to x iq u es ch in iq u es sur la p a r tie o c c id e n ta le , du d i s t r i c t de
HUONG THUY, Province de. THUA THIEN.
Les p ro d u its to x iq u es ont d é tr u it 300 h e c ta r e s de te r r e s c u ltiv é e s
(c é r é a le s , légum es, arbres f r u it ie r s . . . )
Près de 100 personnes ont é té in to x iq u é e s avec le s tyr-ptômes : c é p h a lé e ,
f i è v r e , vom issem ents. . .
- le s p ro d u its to x iq u e s, de co u leu r brune p â le , tombent en fin e s g o u c tr le t
te s e t recouvrent en tièrem en t le s f e u i l l e s e t la su r fa c e do la terre
- nous avons p r é le v é sur le s f e u i l l e s ces g o u t t e le t t e s
a n a ly tiq u es
D ivers e s s a is chim iques ont é té e ffe c tu é s :

à ’ des fin s

I . avec le r é a c t if au bromure m orcurique (I!)<Br2) : r é s u lta t n é e a tif (
2 . avec le r é a c t if à l'a c id e chrom otropique on m ilie u su lfu r iq u e : r é s u lta t
p o s i t i f (a p p a ritio n d'une c o lo r a tio n rose v i o l e t t e ) .
3 . avec le r é a c t if au Rhodamine P : r é s u lta t p o s i t i f (a p p a r itio n d'une
c o lo r a tio n r o u g e ).
4 . par chrom atoeraphie sur couches m inces :
- sur couche de s ilic a .ç e l G
- avec le systèm e de s o lv a n ts : cl lc r o fo r n e , a cid e a cétiq u e (dans le
raoport 1 9 : ! )
- Ion aubntancos
réferen ce : n. lutyL e s te r du 2,4 D
n . b u ty l e s t e r du 2 ,4 ,5 T
- r é v é la te u r : vapeur d ’ iode
RESULTATS
- a p p a ritio n de ta ch es v io le t t e s
- le s é c h a n tillo n s e t le s su b stan ces de r é féren ce ont le mène Rf
(rapport fr o n ta l)
CONCLUSIONS
Nous basant sur l'a c t io n n o civ e snr le s arbres c u lt iv é s , e t sur le s
r é s u lta ts des examens de la b o r a to ir e , nous con clu on s qee le s p ro d u its
chim iques répandus par le s avion s am éricain s sur HUONG THUY so n t le s
e s t e r s n. b u ty lin iq u e s du 2 ,4 D e t du 2 ,4 ,5 T.

20 J u i l l e t J 969
L 'ex p ert ch im iste resp o n sa b le,
HUYNH VAN BA

HISTORY

C h a r a c te r is tic
D e f in it iv e H isto r y o f exp osu re to a known q u a n tity o f TCDD
D e fin ite H isto ry o f exp osu re to a su b sta n ce c o n ta in in g TCDD
but q u a n tity unknown.
D e fin ite H isto ry o f exposure to a su b sta n ce p o s s ib ly c o n ta in ­
in g con tam in a tion .
H isto ry o f p o s s ib le exposure to a su b sta n ce w ith TCDD p r e se n t.
CLIBICAL
Acne b egin n in g w ith in th r e e months o f exp osu re and no p r io r
h is to r y o f acn e.
Acne b egin n in g w ith in s i x months o f exp osu re and no p rio r
h is to r y o f acn e.
Acne b egin n in g w ith in s ix months o f exp osu re w ith a p rio r
h is to r y o f acne w ith in th e la s t ten y e a r s.
H e p a titis o ccu rrin g w ith in th ree m onths o f exposure w ith ou t
o th er p rob ab le e t io lo g y .
P orphyria C utania Tarda o ccu rrin g w ith in th ree months o f
exp osure w ith o u t o th er probable e t io lo g y .
C hronic h e p a tic porphyria o ccu rrin g w ith in th ree months o f
exposure w ith o u t o th er probable e t io lo g y .
P e rip h era l neuropathy occu rrin g w ith in th r e e months o f
exposure w ith o u t o th er probable e t io lo g y .
A cute n e u r o p sy c h ia tr ie d iso r d e r w ith in 30 days o f exp osu re.
S o ft t is s u e sarcoma
Lymphoma
G a str ic carcinom a
Cancer o f any organ system in th e a b sen ce o f s ig n if ic a n t
confounding c a r c io n g e n ic r is k fa c t o r s .
M u ltip le spontaneou s a b o r tio n s in fem ale exposed
C o n g en ita l d e fe c ts in m u ltip le o ffs p r in g s o f m ale or fem ale
exposed w ith o u t o th e r p robable e t io lo g y or chromosomal
ab n orm ality.
t

Characteristic

M u ltip le spontaneous a b o r tio n s in fem ale p artn er o f mala
exp osed .
High l e v e ls o f TCED found in Fat or B lood.
Abnormal nerve con d u ction v e l o c i t i e s w ith in th ree months
o f exp osu re w ith o u t o th er p rob ab le e t io lo g y .
E lev a ted l i v e r enzymes w ith in th r e e months o f exposure
w ith o u t o th e r probable e tio lo g y .
E lev a ted serirn c h o le s te r o l or T r ig ly c e r id e s w ith in th ree
months o f exposure w ith o u t o th er p rob ab le e t io lo g y .
E lev a ted u rin e U roporphyrin w ith in th ree months o f exposure
w ith o u t o th er probable e t io lo g y .
Abnormal com p osition o f u rin ary p orp h yrin s w ith in th ree
months o f exposure w ith o u t o th er p rob ab le e t io lo g y .
In crea sed frequency o f breaks and gaps on chromosomal
a n a ly s is .

MARVIN A. SCHNEIDERMAN, Ph.D.

As a fu rth er supplem ent to Dr. Schneiderm an's Summary o f
testim o n y , and by way o f fu r th e r d e s c r ip tio n o f h is su b je c t m a tter,
su b stan ce o f op in ion and b a ses fo r th o se o p in io n s, P l a i n t i f f s s t a t e as
fo llo w s:
The m u lti-s ta g e model o f cancer d e r iv e s from a s was stim u la ted
by th e o b serv a tio n in humans th a t cancer in c id e n c e (and m o r ta lity ) r a te s
in c r e a se very r a p id ly w ith a g e.

O v e r a ll, in a b a s ic a lly s ta b le s it u a t io n ,

w ith no im portant changes in exposure (e ith e r in c r e a se s or d ec r e a se s) the
r a te s fo r (many) a d u lt can cers in c r e a se w ith about the fo u rth to s ix th power
o f age. Arm itage and D o ll in 1961 (P. Arm itage and R. D o ll, S to c h a sic Models
fo r C a rcin o g en esis in P roceed in gs o f th e 4th B erk eley Symposium on
M athem atical S t a t i s t i c s and P r o b a b ility , Ed. J . Neyman, V o l. 4 , pp. 1 9 -3 8 ,
U n iv e r sity o f C a lifo r n ia P r e ss, B erk eley , 1961 la id out t h is con cep t in a
m athem atical form . T heir m athem atics i s an ex p r e ssio n o f th e con cep t th a t
a s in g le c e l l becomes m alignant a f t e r i t has gone through some f i n i t e number,
say j . , h e r ita b le ch an ges, or s t e p s , the p r o b a b ility o f each ste p b ein g
r e la te d to a "background" e f f e c t (some o f w hich cou ld c le a r ly be a g e n e tic
p r e d is p o s itio n ) p lu s an e f f e c t co n trib u ted by exposure to some exogenous a g en t,
i . e . some e x te r n a l chem ical or p h y sic a l a g e n t.

In th e ir fo rm u la tio n they

re c o g n iz e th a t n ot a l l sta g e s or ste p s need be a ffe c te d by th e e x te r n a l
fa c to r or a g en t.
The m athem atical statem en t o f the p ro cess ta k es th e form
(a .l + b i.d )
where P = p r o b a b ility o f cancer
e = th e n ature c o n sta n t, b ase o f th e
n a tu ra l lo g a rith m s

5

e = Che n atu re c o n sta n t, base o f the
n a tu ra l logarith m s
j = number o f ste p s or sta g e s
i = the i 1-*1 sta g e among th e j
a^=* background e f f e c t a t th e i 1"*1 sta g e

a^> 0

b^= dose e f f e c t a t the i c^ sta g e

b^i 0

d = dose

M u ltip ly in g out th e product term in t h is equator g iv e s :
Q = aQ + q^d + ^2^

2

+ ^3^

3

+ •••

The q^ now are th e r e s u lt s o f th e ap p rop riate p r o d ic ts o f th e a^ and b^
(some o f the b^ could equal z e r o ) .

i s the product o f th e a^

The term e - Q
can be w r itte n in an "expanded" form as
2
3
4
i - Qy + 3____31
+
S_
2!
3!
4! . . .
where N! = N (N -i)(N -2 ) . . .1
w r itin g t h is term t h is way le a d s to
2
P = 1 - (1 1 Q +
+ . . .)
2
3
= Q4 £ + L .
^ 2!
3!
2
2
(a 0 + ci1d + q2d + • • •) - (a Q- qxd + q2d +
21
Where the d o se , d , i s r e la t iv e ly sm a ll,

13799
-2 -

The h ig h er d egree term s used are even sm a ller in com parison w ith
d ( i . e . the s o -c a lle d lin e a r term q^d dom inates) le a v in g , as a
f i r s t approxim ation a t low d oses o f d
p = ao + q][d,
which i s
The g en era l form fo r the s o -c a lle d " lin e a r , n o -th resh o ld " dose
resp on se cu rve.
Further developm ents o f th e m u lti-s ta g e model have led to a t
le a s t f iv e a d d itio n a l con cep ts:
1.

In e x tr a p o la tin g from anim al r e s u lt s to p o s s ib le d is e a s e
in cid en ce in humans a s a fe ty -fa c to r i s som etim es
introduced by u sin g the upper 95% co n fid en ce lim it
on the estim a te fo r q^ ( t h is i s u s u a lly la b e lle d q^ ) .
Under th o se circu m stan ces in which th e lin e a r term
(q^ above) does not dom inate, so th a t th e p r o b a b ility
eq u ation may be o f the form

P = a Q + q^d + q2d 2 + . . .

i t has been shown th at the upper co n fid en ce lim it form
fo r th is curve n o n e th e le ss u su a lly ta k es a lin e a r form ,
i.e .
P = a o + q^1.* d .
However, the more intended form o f the eq u ation can be
used fo r e x tr a p o la tio n .
2. The sta g e a t which a carcin ogen a f f e c t s th e c e l l (or the
ca rcin o g en ic p ro cess) m o d ifies the tim e cou rse o f the
appearance o f the cancer in the a ffe c te d p o p u la tio n .
Both the le v e l and d u ration o f exposure are o f consequence.
For person s whose exposure has ended, Brown and Chu
(Brown, C.C. and K.C. Chu, Approaches to E p id em iologic
A n a ly sis o f P ro sp ectiv e and R e tr o sp e c tiv e S tu d ie s:
Example o f Lung Cancer and Exposure to A rsen ic in
Environm ental E pidem iology: R isk A ssessm en t,
P roceed in gs o f a SIMS C on feren ce, Siam I n s t it u t e fo r
M athem atics in S o c ie ty ) have shown th a t by lo o k in g at
both r e la t iv e r is k s , and a b so lu te e x c e ss r is k s fo r a
s u b s ta n tia l p op u la tion whose exp osu res have ceased i t
should be p o s s ib le to determ ine w hether d io x in behaves
-3 -

13800

in humans as an ea rly sta g e or as a la t e sta g e carcin ogen
— or perhaps as b oth , as the anim al data seem to im p ly.
A sh o rt " la te n t period" (tim e from f i r s t exposure to the
carcin ogen to the appearance o f th e d is e a s e ) could in d ic a te
e ith e r a very p oten t ca rcin o g en , or a carcin ogen a c tin g
as a la t e sta g e in th e p ro cess (o r , o f co u rse, b o th ).
The appearance o f cancer in r e la t iv e ly young persons i s
c o n s is te n t w ith a sh o rt la t e n t p e r io d .
Immunologic E ffe c ts - and p o s s ib le consequences
Joseph K. P rin ce (Chapter 5 , Im m uno-toxicology and Chem ical
C a rcin o g en esis in : Environm ental T ox ico lo g y P r in c ip le s and P r a c tic e s ,
S. Somani, and F. Cavendar, e d ., C harles C. Thomas, S p r in g fie ld , 111.
(1981) has w r itte n th a t "TCDD has th e c a p a b ility o f cau sin g im m unosuppression
. . ." (fo llo w in g the dosing o f n u rsin g fe m a le s ). As support o f the
im m unotoxicity o f d io x in he c i t e s th e work o f F a ith and L u ster
(" I n v e s tig a tio n s on the e f f e c t s o f 2 , 4 ,7 ,8 te tr a c h lo r o d ib e n z o d io x in
(TCDD) on param eters o f v a rio u s immune fu n c tio n s , A nnals, N.Y. Acad.
S c i. 1 9 7 9 ). P rin ce a ls o c it e s s e v e r a l o th er au th ors and th e ir s tu d ie s
on the e f f e c t s o f TCDD on immune fu n c tio n .
What i s o f s u b s ta n tia l consequence w ith r e sp e c t to p o s s ib le im m unologic
e f f e c t s in person s exposed to TCDD (Moody, e t a l . , 1984 "The C hronic H ealth
E ffe c ts o f O ccupational Exposure to D io x in : Unanswered Q u estio n s, Am. Jour,
o f In d u s tr ia l Med. 5: 157-160, c i t e s e v e r a l " sc a tte r ed rep orts" l i s t i n g a
range o f to x ic resp o n ses in workers in c lu d in g "immunologic a lte r a tio n s " )
i s the rep orted in c r e a se s in cancer in p erson s who were immune su p p ressed
as p art o f v a r io u s m edical trea tm en ts.

Irv in g Penn, d e r iv in g h is data

from a r e g is tr y o f p a tie n ts on im m unosuppressive therapy (Penn, I . , 1979,
Cancer A sso cia ted w ith im m unosuppression. Sec F CRC Handbook: s e r ie s
in c l i n i c a l la b o ra to ry s c ie n c e , C lev ela n d , CRC p u b lish in g C o ., se e a ls o
H oover, R. and V .F . Fraum ini, J r . (1973) R isk o f Cancer in R enal T ransplan t
-4-

Cancer p a t ie n t s , Lancet 2: 55-57) rep orted e x c e ssiv e in cid en ce o f
reticu lu m c e l l sarcom as, K a p o si's sarcom a, and oth er lymphomas and
leu k em ias.

In a d d itio n , an e x c e ss in sk in cancer was a ls o rep o rted .

R ecent rep o rts o f in c r e a se s in K a p o si's sarcoma in person s w ith
A cquired Immune D e fic ie n ty Symdrome (AIDS) (H.W. J a ffe e , Keewhau C hoi,
e t a l. (1 9 8 3 ), N a tio n a l C ase-C ontrol Study o f K ap osi's Sarcoma and
P n eu m ocystites C a r in ii Pneumonia in Homosexual Men: P art 1
E p id em io lo g ica l R e su lts. A nnals o f E xtern al M edicine 199 //2, pp. 145151) has r e a c tiv a te d concern about th e a lt e r a tio n o f immune fu n ctio n
and th e developm ent o f unusual forms o f can cer. The p relim in ary rep ort
by the A ir Force on the "Ranch Hand" study rep o rts both e x c e s s iv e nonm ela n o tic sk in can cers (not a d ju sted fo r su n lig h t exposure) and "no
group d iffe r e n c e s (in immune fu n c tio n s) . . . a fte r adjustm ent" fo r
age and smoking h a b its . However, th is statem en t i s e s s e n t ia lly negated
in th e te x t o f th e rep ort (page i i i ) where i t s ta te s "The assessm en t o f
th e immune system by la b o ra to ry te s t in g was compromised by e x c e s s iv e
t e s t v a r ia b ilit y ."

A d is c u s s io n then fo llo w s th a t m entions the

unexpected fin d in g o f age and smoking e f f e c t s — and adjustm ents fo r th e se .
S t a t i s t i c s on Cancer in Humans
Two s e t s o f s t a t i s t i c s on cancer in humans are o f conseq u en ce. The
N a tio n a l Cancer I n s t it u t e has p u b lish ed data from i t s own in cid en ce
c o lle c t io n system (SEER, S u r v e illa n c e , E pidem iology and End R e su lts) and
from the m o r ta lity data c o lle c te d by the N a tio n a l C enter fo r H ealth
S ta tis tic s .

Many o f th e se d ata are assem bled in NCI Monograph 57

" S u r v e illa n c e , E pidem iology, End R e su lts: In cid en ce and M o r ta lity Data:
197 3 -7 7 , NIH P u b lic a tio n No. 81-2330 US DHHS, NIH, NCI, B eth esd a, Maryland)
P a r tic u la r ly p e r tin e n t are T able 10 B (p . 6 8 ) "Number o f M alignant and In
S eta c a se s diagnosed 1973-77 as prim ary s i t e , age group, and median a g e,

a l l r a c e s, m ales, a l l areas (in c lu d in g Puerto R ic o ), Table 10 E which
g iv e s in cid en ce r a te s per 100,000 by f iv e year age groups, Table 10 H
which corresponds to T able 10 E, re p o r tin g death r a te s , ra th er than
in cid en ce c a se s. Monograph 57 a ls o g iv e s data se p a r a te ly by w h ites and
n o n -w h ites, m ales and fem a les.
Because sk in can cers (o th er than melanomas) are in ad eq u ately rep orted
through the u sual channels fo r which data on o th er can cers are rep o rted ,
th e N a tio n a l Cancer I n s t it u t e has undertaken s p e c ia l sam pling s tu d ie s o f
sk in can cer. A (p relim in ary) rep o rt on the " in cid en ces o f non-melanoma
sk in Cancer in the Unitfed S ta te s , 1977-78" (S c o tto , J . , F ea rs, T ., e t a l .)
w as p u b lish ed in 1980 as DHEW p u b lic a tio n No (NIH) 80-2154, and covered
8 geographic a r e a s, ranging from M in n ea p o lis-S t. Paul in the North to

New M exico in the Southw est.
An attem pt i s made in t h is rep o rt to account fo r the s u n lig h t e f f e c t
(in w h ite s) by r e la tin g a g e-a d ju sted r a te s to an index o f u lt r a - v io le t B
r a d ia tio n le v e ls (which were about tw ice as high in New M exico as in
M in n ea p o lis.) The age ad ju sted r a te s in M inneapolis were somewhat more
than h a lf th o se in New M exico. H ig h est r a te s were rep orted in New O rleans
and A tla n ta , and lo w est r a te s in D e tr o it.

The c o r r e la tio n betw een UV-B

and sk in cancer r a te s i s q u ite good— but not a b so lu te ly 1 to 1 . Age a d ju st­
ment i s e s s e n t ia l, because r a te s r i s e very ra p id ly w ith a g e. For exam ple,
the " a ll areas" ra te fo r w h ite men ages 35-44 were 156.8 per 100,000
compared to a r a te o f 1971.9 per 100,000 fo r w h ite men aged 7 5 -8 4 , a 12
fo ld d iffe r e n c e .
D ioxin a s a H ighly P oten t C arcinogen
The Environm ental P r o te c tio n A gen cy's C a rcin o g en esis A ssessm ent Group
as p art o f i t s review o f m a te r ia ls su sp ected o f b ein g p o s s ib le human
ca r c in o g e n s, has review ed and ta b u la ted th e data on 54 m a te r ia ls .

Potency was defined in two ways, first, as the (linear) slope of the

dose resp on se curve (q^ , upper 95% co n fid en ce lim it ) in u n its o f
m illig ra m s per kilogram per day, and secon d , in u n its o f m illim o d es per
kilogram per day - th e l a t t e r b ein g an attem pt to tak e in to account
the d iffe r e n t m olecular w eig h ts o f th e d if f e r e n t m a te r ia ls exam ined.
Among th ese 54 m a te r ia ls , the ch em ical id e n t if ie d by EPA as te tr a c h lo r o d io x in had a slo p e (in m g/kg/day) o f 4.25x10"*. The n ex t h ig h e s t slo p e
recorded (about l/7 t h as ste e p ) was fo r h exach lorod ib en zo d io x in ,
5 .7 x l0 4 . On c o n tr a s t, th e slo p e fo r a fla to x in B^, con sid ered by some
persons to be the most c a rcio n g en ic o f the non man-made m a te r ia ls was
3
2.9x10 , approxim ately 1 4 0 -fo ld l e s s steep than TCDD. A nother h ig h ly
3
p o ten t m a teria l by t h is c ir te r io n was b is(c h lo r o m e th y e )e th e r , 9 .3x10 .
Benzene (based on human d ata) i s rep orted to have a slo p e o f 5 .2 x 1 0

-2 ,

making TCDD 10 m illio n tim es more p o te n t.
On a m olar b a s is , th e se same m a te r ia ls had th e fo llo w in g "potency"
v a lu e s in Mm/kg/day
TCDD
H( 6 )CDD
A fla to x in B^

1 X 10
2 X 10
9 X 10

BisCME
Benzene

1 X 10

4

Other h ig h ly c a rcin o g en ic m a te r ia ls on a m olar b a s is were
A ld rin
B e n z id in e
D ie ld r in
D ie th y in itr o sa u r in e
N -N itroso-N
e th y l urea
N -n itroso-N
m ethyl urea

4 x 103
4 x io 4
1 X io 4
4 x 103
4 x 103
3 x 104
-7 -

1380

Cancer bio-assays of TCDD

At le a s t a h a lf dozen lo n g -term la b o ra to ry s tu d ie s have been
conducted to ev a lu a te the c a rcio n g en ic p o te n tia l o f TCDD. Among the
f i r s t was a r e la t iv e ly sm all stu d y by Van M ille r (Van M ille r , J .T ., J .J .
L a lic h , J .R . A llen (1977) In creased in cid en ce o f neoplasm s in r a ts exposed
to low le v e ls o f 2 , 4 , 7 ,8 te tr a c h lo r o d ib e n z o -p -d io x in . Chemosphere 6 (9 , 10)
pp. 537-544, and 6 2 5 -6 3 2 ).

2 £b

Dead by
Week 95

Number o f
male r a ts
With tumors

0 (c o n tr o ls )
0 .0 0 1

0
.0 0 1

6 /1 0
2 /1 0

0
0

0.003

.005
.05
.5

4 /1 0
4 /1 0
5 /1 0
*
*
A
*

5
3
4 •
4
7

Dose o f TCDD
in d ie t
m g/kg/week

0 .0 1
0 .1

0 .4
2 .4
240
500

1 .0

5 .0
500
1000

* a l l d ied w ith in 4 weeks

The tumors in clu d ed a w ide range in v o lv in g th e t e s t e s , th e l i v e r , sk in ,
k id n ey , m u scles, b r a in , e t c .
Richard Kociba o f Dow conducted a la r g e r stu d y , a ls o in r a t s , and in
both se x e s which was su b je c t to la t e r d e ta ile d review o f th e p ath ology
(K ociba, R .J ., D.G. K eyes, and J .E . B eyer, 1978, R e su lts o f a two year
ch ro n ic t o x ic it y a cid o n c o g e n ic ity study o f 2 , 4 , 7 ,8 te tr a c h lo r o d ib e n z o -p d io x in in r a t s , T o x ico lo g y and A pplied Pharm acology 4 6 (2 ), 2 7 9 -3 0 3 . See
a ls o a more expanded rep o rt in the A nnals o f th e New York Academy of
-8-

13805

Science 320: 379-404).

The r e s u lt s o f the Kociba study in male anim als are:
Dose
(m g/kg/day)

Number o f anim als w ith tumors

0 (c o n tr o ls)
0 .0 0 1
0 .0 1
0 .1

Tongue

Hard P a la te

0/76
1/49
1 /5 0
3/42

0/51
1/34
0/27
4/3 0

(6 /3 0 Sq u ire)

fem ale anim als
Dose

t

Anim als w ith tumors

Lung
Squamous C e ll
Carcinomas

L iver
(H e p a to c e llu la r
carcinom as)

L iver
HC & hyper­
p la s t ic nodules

Hard
P a la te

C ontrols

1 /8 6

9/86 (1 6 /8 6 -)

1/5 4 (0 /5 4 S)

0 /8 6

0 .0 0 1
(22 ppt)

0/5 0

3/5 0 (8 /5 0 S)

0 /3 0

0/5 0

0 .0 1
(220 ppt)

2/50

18/50 (2 7 /5 0 S) 1/27

0/5 0

0 .1
( 2 .2 ppb)

11/49

34/98 (3 3 /4 7 S) 5/2 4

7/49 (8 /4 7 S)

There was l i t t l e d iffe r e n c e , excep t fo r the c la s s if ic a t io n o f
h y p e r p la stic liv e r n od u les between Squire and K ociba.
The N ation al T oxicology Progran (NCI) com m issioned a study o f TCDD in
r a ts and m ice which was ca rried out by the I l l i n o i s I n s t it u t e o f T echnology.
The chem ical was ad m in istered by stomach tube (g a v a g e ).
These are the rep ort r e s u lt s in male r a ts:

138 GB
-9-

¿T A ' -

Dose
mg/kg/wk

Type o f tumor (in c lu d in g h y p e r p la stic
n o d u le s, and adenomas)
L iv er

A drenal
C ortex

Thyroid
Adenomas

■ •/Adenomas and
Carcinomas

3/7 5

0 /74

6 /7 2

1/6 9

1 /69

0 .0 1

1 /5 0

0 /5 0

9 /5 0

5/48

5 /48

0 .0 5

3 /5 0

0 /5 0

12/49

6/5 0

8 /5 0

0 .5

7/5 0

3 /50

9/4 9

8 /5 0

11/50

Subcutaneous
t is s u e f ib r o s is
C ontrol
(v e h ic le )

In fem ale r a t s , s ig n if ic a n t in c r e a se s in tumor in cid en ce was found
(com paring c o n tr o ls w ith th e high dose anim als in subcutaneous t is s u e fib r o ­
sarcom as, liv e r (n e o p la s tic nodules above and a ls o n e o p la s tic n od u les p lu s
carcionm as( and ad ren al c o r t ic a l adenomas. P itu ita r y adenomas were in crea sed
fo r a l l d o se s, and t h is in c r e a se was s t a t i s t i c a l l y s ig n if ic a n t fo r th e low
dose group (1 /6 6 v s 5 /4 7 ).
Among th e m ice (B6C3F1) th ere was a s ig n if ic a n t e x c e ss o f liv e r
carcinom as among th e m ales when the h igh dose anim als were co n tr a ste d w ith
the c o n tr o ls . Among th e fem a les, th ere were s t a t i s t i c a l l y s ig n if ic a n t
e x c e sse s in subcutaneous t is s u e fib ro sa rco m a s, lymphomas (and leukem ias
and lymphomas combined) o f th e h em a to p o ietic system , liv e r neoplasm s (in
t o t a l) and f o lle c u la r c e l l adenomas o f th e th y r o id .
S ev era l sk in p a in tin g s tu d ie s were a ls o conducted on m ice, one under
co n tr a c t to th e NTP (NCI) a t th e I l l i n o i s I n s t it u t e o f T echnology. There
was an in c r e a se o f 3 to 6 fo ld in fib rosarcom as o f th e in tigu m en tary system
o f both m ales and fe m a le s.

In fem a les th e se in c r e a se s were s t a t i s t i c a l l y

s ig n if ic a n t fo r both TCDD ad m in istered a lo n e , and a ls o fo llo w in g a s in g le
dose o f 50/mg o f D im eth ylb en zau th racen e. O ther sk in p a in tin g s tu d ie s

-10-

„T A '

in clu d ed work by Berry (B erry, D .L ., T .J . G laga, J . D iG iovanni, and
M.R. Juchau (1 9 7 9 ),

S tu d ies w ith c h lo r in a te d d ib e n z o -p -d io x in s,

polybrom inated b ip h e n y ls, and p o ly c h lo r in a te d b ip h en y ls in a two sta g é
system o f mouse sk in tu m o r ig e n e sis: P o ten t a n ti ca rcio n g en ic e f f e c t s ,
Ann N.Y. Acad. S c i 320: 405-415) showed th a t th e tim ing o f th e a d m in istra tio n
o f carcin o g en s could str o n g ly a f f e c t su p p ress tu m o rig en esis.
work has been rep orted by Cohen and c o lle a g u e s .

S im ila r

(Cohen, G.M ., W.M. Bracken,

R .P . I y e r , D.L. B erry, J.K . S e lk ir k , and T .J . S la g a , 1979. A n tic a r c io n g e n ic
e f f e c t s o f 2 ,3 ,7 ,8 te tr a c h lo r o d ib e n z o -p -d io x in on b en zo (a )p y ren ic and 7 ,1 2
d im eth ylb en z(a) anthracene tumor i n i t i a t i o n and i t s r e la tio n s h ip to DNA
b in d in g , Cancer R esearch 39(10) 4 0 2 7 -4 0 3 3 ).
P it o t ( P it o t , H .G ., T. G oldsw orthy and H. P oland, 1980. Prom otion
by 2 , 3 , 7 ,8 te tr a c h lo r o d ib e n z o -p -d io x in o f h ep a to ca rcin o g en esis from d ie t h y ln etro sa m in i. Cancer R esearch 40: 3616-3620) rep orted th a t in a sm all tw osta g e c a r c io n g e n e sis experim ent th a t 5 o f 7 r a ts greated w ith TCDD in
a d d itio n to DEN had h e p a to c e llu la r carcinom as in c o n tr a st to none in the
com parable c o n tr o l groups.

..

The EPA has rep orted th a t a d ose o f 1 .x 10 ^ m g/kg/day, based on
th e s tu d ie s by K ociba, th a t th e one h it and th e m u lti-sta g e model estim a ted
th a t th e r e would be an in crea sed lif e t im e r is k o f 1 .1 x Í 0 ^ w ith an
upper 95% co n fid en ce lim it o f 1 .5 x 10 —6 or 1 .6 x 10 -6 w hether based on
th e d ata from th e fem ale or m ale a n im a ls.

138G8
- l i -

a ■’<*'

-

ELLEN KOVNER SILBERGELD, Ph.D.

As a fu rth er supplem ent to Dr. S ilb e r g e ld 's Summary, P l a i n t i f f s
s t a t e a s fo llo w s:
y

TCDD and 2 ,4 ,5-T can cause male m ediated tr a n sm itta b le damage
m an ifested by b ir th d e fe c ts , m isc a r r ia g e s, and o th er untoward pregnancy
outcom es when c e r ta in circu m stan ces o ccu r. These circu m stan ces are when
th e amount o f exposure to TCDD and to 2 , 4 , 5-T , e ith e r a lo n e or to g eth er
( t h is amount b eing measured by in t e n s it y and d u ration ) i s a p p ro p ria tely
p a ired w ith th e tim ing o f th a t exposure in r e la tio n s h ip to sp erm atogen esis

'i

and the p a r tic ip a tio n o f the male in rep ro d u ctio n .
Dr. S ilb e r g e ld 's o p in io n s are in fo u r c a te g o r ie s as d e lin e a te d
in S e c tio n IV o f her Expanded Summary. O pinion IV A r e la t e s to anim al
data and anim al t o x ic it y . The grounds fo r her o p in io n are s p e c ifie d on
th e two pages o f c it a t io n s headed " S ilb e r g e ld - Animal T oxicology" and
b egin n in g w ith " B leib erg , e t a l . , 1964; A rch ives o f D erm atology, Volume 89,
p. 793" and ending w ith "Tukey, e t a l . , 1982; C e ll, Volume 3 1 , p . 275."
O pinion IV B r e la t e s to re c e p to r s and TCDD. The grounds fo r t h is
o p in io n are s p e c ifie d in th e two pages headed " S ilb e r g e ld - Receptors/TCDD"
and b egin n in g w ith "Vos, e t a l . , 1973; Environm ental H ealth P e r s p e c tiv e s ,
Volume 5 , p . 149" and ending w ith "Okey, e t a l . , 1980; Jou rn al of
B io lo g ic a l C hem istry."
O pinion IV C r e la t e s to rep ro d u ctiv e to x ic o lo g y . The grounds
fo r t h is o p in io n are s p e c ifie d on the two pages headed " S ilb e r g e ld R ep roductive T oxicology" b egin n in g w ith "Courtney, e t a l . , 1970,
k ,
T era to g en ic E v a lu a tio n o f 2 , 4 , 5-T ; S c ie n c e , Volume 168, p . 864" and
ending w ith "Lamb, e t a l . , 1981; Journal o f T o x ico lo g y and E nvironm ental

1 .3 8 u 9

H ea lth , Volume 8 , p . 825."
O pinion IV D r e la t e s to th e n eu ro to x ic e f f e c t s o f 2 ,4 -D , TCDD,
and 2 ,4 ,5 -T . The grounds fo r t h is o p in io n are s p e c if ie d on th e page
headed " S ilb e r g e ld - N eu rotoxicology" b eg in n in g w ith " B leib erg , e t a l . ,
1964; A rch ives o f D erm atology, Volume 89, p . 793" and ending w ith
P azderova, e t a l . , 1981; A rch ives o f Environm ental H ea lth , Volume 3 6 , p . 5."
In a d d itio n to th e p u b lic a tio n s l i s t e d on th e se seven p a g es,
Dr. S ilb e r g e ld 's a tten d an ce and p a r tic ip a tio n in th e e d u c a tio n a l and
s c i e n t i f i c con feren ces and sym posia l i s t e d on th e se pages have co n trib u ted
to h er knowledge and th e r e fo r e are th e b a ses o f h er o p in io n .
Her p erso n a l and p r o fe s s io n a l e x p e r ie n c e s in th e se f i e l d s are
f u lly d e lin e a te d in h er curriculum v it a e .

THEODOR D. STERLING, Ph.D .

V.

GROUNDS FOR EACH OPINION
Item s 2 through 7 are b ein g a tta ch ed to t h is supplem ent to

Dr. S t e r lin g ’s Summary fo r a l l p a r t ie s .

Item 6 , E v a lu a tio n o f Data

su b m itted by V ietnam ese in v e s tig a to r s and I n te r n a tio n a l Group o f E x p erts,
how ever, th e p o r tio n s th a t D r. S te r lin g w i l l r e ly on to form h is o p in io n s
h as been c ite d and quoted in S t e r lin g , T. and A rundal, A ., The E pidem iology
o f 2 ,4 ,5 -T from 1969 to th e p r e s e n t, Journal o f N orthw est C o a litio n fo r
A lte r n a tiv e s to P e s t ic id e s , A p r il, 1984, which a r t i c l e i s b ein g provided
w ith t h is Supplem ental Summary.
V.

B. S p e c ific
Item 1 r e fe r s to Dr. S t e r lin g 's a n a ly s is o f th e Kociba a r t i c l e .

The i l l u s t r a t i v e and d em on strative graphs which Dr. S te r lin g has prepared
fo r h is a n a ly s is o f K o cib a 's a r t i c l e are bein g a tta ch ed h ereto and
in co rp o ra ted h e r e in .

Item 2 , IARC Monographs on th e E v a lu a tio n o f th e

C arcin ogen ic R isk o f Chem ical to Humans in clu d e 15 monographs w ith th a t
t i t l e , Volumes 1 through 1 5 , and in c lu d e phenoxy h e r b ic id e s 2 ,4-D , 2 ,4 ,5 -T
and o th e r s .
V.

C. The a r t i c l e c ite d from th e In te r n a tio n a l Symposium on

H erb icid es and D e fo lia n ts in War were review ed by Dr. S te r lin g as w e ll as
o th ers in th e Ho Chi Minh C ity Symposium in 1983 and th e r e le v a n t p o r tio n s
th a t D r. S te r lin g w i l l r e ly on are c ite d in h is Arundal and S te r lin g recen t
a r t i c l e a tta ch ed to t h is Summary.

">5-

,-'r i. •
1 3.

The B is a n ti, e t a l. a r t ic le i s atta ch ed h ereto and

in corp orated h erein fo r a l l pu rp oses.
V.

C (2 ). The f i r s t two r e fe re n ce s c ite d r e fe r to th e In te r n a tio n a l

Symposium on H erb icid es prepared by V ietnam ese in v e s tig a to r s and the
r e le v a n t p o r tio n s are c ite d in Dr. S te r lin g and Dr. A ru n d al's new a r t ic le
a tta ch ed h ereto and in corp orated h erein fo r a l l p u rp oses. The th ird
r e fe r e n c e to Report to M in ister s V eterans A f f a ir s , C ase-C ontrol Study o f
C on gen ital A nom alies, p u b lish ed by th e A u str a lia n P u b lish in g S e r v ic e ,
Canberra, January, 1983, i s a two volum e, p u b lish ed document put out by
th e A u stra lia n government and a v a ila b le fo r th e d efen d an ts to o b ta in
from th e A u stra lia n governm ent. T his document in c lu d e s 300-400 pages
and i t would be too volum inous to reproduce h e r e .
V.

C. I t should be em phasized th a t in th e Expanded Summary o f

Dr. S t e r lin g , a ty p o g ra p h ica l error occurred and th e sen ten ce should read:
In a d d itio n , Dr. S te r lin g w ill t e s t i f y th a t th ere i s ample evid en ce th a t
exposure to 2 ,4 ,5 -T i s te r a to g e n ic in humans when th e mother i s exposed,
and co n v in cin g ev id en ce i s now ex ta n t . . ( i t should not read "not" e x t a n t ) .

Further R eferen ces
Item s 2 through 7 under "Further R eferen ces" are b ein g attach ed
h ereto and in corp orated h erein fo r a l l p u rp oses.
2. Dr. S t e r lin g 's a n a ly s is o f K ociba, e t a l. i s p rovid ed .
3 . The s tu d ie s c ite d b elow , th e f i r s t two o f th e item s are c ite d
in r e le v a n t p o r tio n in Arundal and S t e r lin g 's new a r t ic le which i s a tta ch ed
h ereto fo r a l l p u rp oses.
(3) A ttached h ereto fo r a ll.p u r p o s e s .

> .. ^
M r v .-TJ : :.•
4.

The u n d erlyin g data from w hich Dr. S te r lin g w i l l form h is

o p in io n s were taken from computer ta p es betw een th e y ea rs 1969 to 1975 from
th e N a tio n a l C enter fo r H ealth S t a t i s t i c s . A tru e and c o r r e ct copy o f t h is
computer tape m a te r ia l i s provided fo r a l l p a r tie s and a tta ch ed to t h is
Supplem ental Summary.

In a d d itio n , Dr. S t e r lin g 's a n a ly s is from t h is

d a ta , or a summary o f th a t a n a ly s is , w i l l be p rovid ed and supplem ented
w ith in two w eeks.

13
-3 -

filed

CLEW S OFFICE
U. S. DISTRICT COURT C.D. N.Y.
in

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

¿1

if

T IM I A.M.

X

P.M .

In Re
MDL 381
( A ll C a s e s )

AGENT ORANGE
P roduct L ia b ilit y L itig a tio n
x
PLAINTIFFS AMENDED LIST OF FACT
WITNESSES IN SUPPORT OF CLAIMS

MARCH 2 7 , 19 8 4
PL A IN T IFFS' MANAGEMENT COMMITTEE
26 C o u r t S t r e e t
B r o o k ly n , New Y ork 1 1 2 4 2
(2 1 2 ) 330 - 0 9 0 0

sisei
138

PLA IN TIFFS' AMENDED LIST OF FACT WITNESSES
IN SUPPORT OF CLAIMS
P l a i n t i f f s s u b m it th e f o l l o w i n g l i s t o f p o t e n t i a l w i t n e s s e s t o b e
c a l l e d a t t r i a l p u r s u a n t to t h e M a g i s t r a t e ' s P r e t r i a l O rd er N o.
1 8 , d a te d M arch 2 6 , 1 9 8 4 , r e s e r v i n g th e r i g h t to s u p p le m e n t t h i s
l i s t w ith a d d i t i o n a l nam es and a d d r e s s e s from tim e t o tim e a s
a d d i t i o n a l in f o r m a t io n and w i t n e s s e s a r e d i s c o v e r e d .
T h o se w i t n e s s e s d e s i g n a t e d w it h an a s t e r i c k "*" h a v e b e e n d e p o s e d
in t h e s e p r o c e e d i n g s . T h e ir a d d r e s s e s and t h e n a t u r e o f r e l e v a n t
p o r t i o n s o f t h e i r t e s t im o n y a r e a s e q u a l l y w e ll-k n o w n to t h e
d e f e n d a n t s a s t o th e p l a i n t i f f s .
T he w i t n e s s e s
fo llo w s :

not covered

by t h e

above

r e s e r v a tio n s ,

are,

as

C a r d i o l o g i s t f o r M rs. F ord
T r e a te d D anny F ord f o r
h y p e r te n s io n .

DR. THOMAS ABOUD
T o le d o C l i n i c
T o le d o , O h io
EDWARD E ADAMS
GORDON A . ANDERSON*
102 H ic k o r y L ane
N a u g a tu c k , C o n n e c t ic u t

Texas Disability Officer
and friend of Jordans'

IRENE ANTONIK

81 2 S u s s e x
A u s t i n , TX 7 8 7 4 5
ARNOLDI, LOUIS B .*
EUGENE BAK*
DONALD K. BALLMAN*
7 7 2 2 R e v e l l e D r iv e
La J o l l a , C a l i f o r n i a
DONALD BARNES

13816
1

E. D. BAUMGARTNER
R. E . BAYNARD
JEANNIE BEAVERS
F lo w e r H o s p i t a l
P e r s o n n e l D e p a r tm e n t
S y la w ia , O h io

Knows t h e h o s p i t a l and
b u s in e s s s t r a in re
D anny F ord

BILLIE MARIE BELL
4 4 0 4 B o n n ie D r iv e
F t . W o rth , TX 7 6 1 1 6

D anny J o r d a n 's m o th e r

CLOYCI G. BELL
4 4 0 4 B o n n ie D r iv e
F t . W o rth , TX 7 6 1 1 6

D anny J o r d a n 's S t e p F a th e r

BELL TELEPHONE OF PA.
1 P ark Way
P h ila d e lp h ia , P a. 19101

P erson n el record s o f
G e o r g e E w a lt

W. B . BELLS
A t t e m p t in g to l o c a t e
BING , PETER S .*
Dow E m p lo y ee
D e p o se d t w ic e

ETCYL H. BLAIR*
JOHN BLISH
A t t e m p t in g to l o c a t e
A . A . BLOCK
A tte m p tin g to l o c a t e
KANSAS C IT Y , MO.
WILLIAM BLUMENAUER
A t t e m p t in g to l o c a t e
JOSEPH L. BOLTON
A t t e m p t in g t o l o c a t e

G o v 't C o n t r a c t in g
O ffic e r P a r t ic u la r ly
r e ; H e r c u le s

JACK BORRER*
1 2 9 2 0 W e llsw o o d T r a i l
C h e s t e r f i e l d , O h io 4 4 0 2 6
AL BOTHWELL
A t t e m p t in g to l o c a t e

H igh S c h o o l f r i e n d o f
L a m b io t t e 's who w as w it h
him in V ie tn a m

13817
2

■7

JAMES E . BOWERS
A t te m p tin g to l o c a t e
S T . LO UIS, MO.
DANIEL BRAXTON
A t t e m p t in g to l o c a t e

G e o r g e E w a lt 's F o rem a n ,
1975

BOB BROWN
A t t e m p t in g to l o c a t e

S e r v e d w it h D an . J o r d a n
in V ie tn a m

BROWN, SGT.
A t t e m p t in g to l o c a t e

W ith D anny F ord in
sp rayed a r e a s

DAVE BUNIN
W ill s u p p ly a d d r e s s
w it h e x p e r t sum m ary
m a te r ia ls

E c o n o m is t

JOHN S . BUSH, J r .*
WILLIAM CALLAHAN
A t te m p tin g to l o c a t e
W est V i r g i n i a

Was w it h E w a lt in V ie tn a m

MELVIN CALVIN*
2 6 8 3 B uena V i s t a Way
B e r k e le y , C a lifo r n ia

F orm er m em ber o f PSAC
and d i r e c t o r o f Dow
C h e m ic a l r e g o v e r n m e n t
k n o w le d g e v s . D o w 's
k n o w le d g e and f a i l u r e
to w a rn .

RICHARD CASEY
A t t e m p t in g to l o c a t e
C i n c i n n a t i , O hio

T e s tim o n y fro m p o i n t o f
v ie w o f " R a n c h h a n d e r "
c o n c e r n in g f a c t s o f
s p r a y in g and d e f o l i a t i o n

ELLIS CASH

G o v ern m en t C o n t r a c t in g
o ffic e r

A t t e m p t in g to l o c a t e
EDWARD LEE CHANDLER*
EDWARD E. CHAPMAN*
6 7 4 8 N . E u c lid
G la d s t o n e , M is s o u r i
J . G. CHARLTON
ROBERT L . CHONOLES*
23 C a n n e lla D r iv e
E d is o n , New J e r s e y

138Í8
3

EMIL CHRISTOFANO*

Re H e r c u le s ' l i a b i l i t y

GEORGE F . COLLINS

D ir e c to r o f p ro cu rem en t
P r o d u c t io n , R ich m o n d , V a .
( P r o c u r e m e n t, s u p p ly and
f a i l u r e to w arn i s s u e s )

J . G. COPELAND, J r .
A t te m p tin g to l o c a t e ;
N ot y e t d ep osed

A s s t . G en . M a n a g e r , '6 4
G en . M gr. S y n t h e t i c s ,
6 5 - 7 2 (Re H e r c u le s )

DIANE COURTNEY*

G o v ern m en t e x p e r t
w i t n e s s on c a u s a t i o n

GEORGE & MARGE CRAWFAS
49 H eck R d.
K e n n e ssa w , G a.

Saw c h a n g e s in D anny F ord
C h r i s ' s B r o th e r and S i s t e r
in Law

JOHN CRAWFAS
B ea ch V a l l e y R d.
A t l a n t a , G e o r g ia

C h r is ' B r o th e r

OWEN & BETTY CRAWFIS
6 1 - 8 3 W h ite fo r d C e n te r R d.
T o le d o , O hio

M o th er and dad o f C h r is .
U sed to t a k e D anny f o r
t r e a t m e n t (6 1 3 8 ? )

ROBERT CROCKER
A t te m p tin g to l o c a t e

A m ou n ts - d o in g aw ay o f
h e r b s - h a s t a p e s to
d e t e r m in e e x p o s u r e
to V e te r a n s I I ' s

EUGENE D. CRITTENDEN, J r .*

D ir . S a le s , 6 6 -6 7
A s s t . G en . M gr. S y n t h e t i c s
6 7 -6 8
90 8 D u P on t Road
W ilm in g to n , D e l . 1 9 8 0 7

ROBERT CROCKER
A t te m p tin g to l o c a t e
WARREN CRUMMETT*
80 8 C r e s c e n t D r iv e
M id la n d , M ic h ig a n

Dow s c i e n t i s t ; e v id e n c e
c o n c e r n in g Dow l i a b i l i t y
is s u e s .

GENE CUMMINGS
A t t e m p t in g to l o c a t e

S e r v e d w it h J o r d a n in
V ie tn a m

BILL CURTIS
c / o CBS News
524 W est 5 7 th S t r e e t
New Y o r k , New Y ork 1 0 0 1 9

E v id e n c e c o n c e r n in g
e y e w itn e s s o b s e r v a tio n s
a s to t h e c o n d i t i o n
o f th e c o u n tr y o f
V ie tn a m , e x t e n t o f
r e s i d u a l d e f o l i a t i o n and

13819
4

p o s s i b l e p h o t o g r a p h ie
e x h ib its ; in v e s tig a tio n
c o n tin u e s .
THOMAS P . DALBY
A tte m p tin g to l o c a t e

G o v 't c o n t r a c t i n g
O ffic e r

S . S . DANIELS
U .S .D .A . L ia s o n NACA

L. L. DANIELSON
A tte m p tin g to l o c a t e
EDWARD DEBOLT
A t te m p tin g to l o c a t e
DIA Z, STAFF SGT.
A tte m p tin g to l o c a t e

W ith E w a lt in V ie tn a m

CHARLES DILLEY
A t te m p tin g to l o c a t e
KANSAS CITY, MO.
LINDA DIMOLA
A t te m p tin g to l o c a t e
N e s c o n s e t t , New Y ork

K e r r y R y a n 's B a b y s i t t e r

CHARLES DISHNER
M. DOJNY
OWEN DOLIN*
5 2 2 5 Sun V a l l e y D r iv e
C h a r le s t o n , W est V ir g in a
LAWRENCE E. DOTSON*
WILLIAM DUFFIELD
CHARLES L. DUNN*

C h a ir m a n , NACA; e v i d e n c e
re l i a b i l i t y is s u e s
a f f e c t i n g m any d e f e n d a n t s
in a d d i t i o n t o H e r c u l e s .

JOSEPH DUQUETTE
A t t e m p t in g to l o c a t e
R ock y P o i n t , N .Y .

On S u f f o l k C o u n ty P o l i c e
F o r c e w it h M ik e R yan

J . M. EAGAN
A t te m p tin g to l o c a t e
(S c h e d u le d to b e d e p o s e d
on M arch 3 1 , 1 9 8 4 )

5

138

JACK D . EARLY*
8 0 2 4 L a k e n h e a th Way
P o to m a c , M a ry la n d 2 0 8 5 4
WAYNE EDWARD*
PLATOON SGT. ELLY
A t t e m p t in g to l o c a t e

Was w it h E w a lt in s p r a y
areas.

DENNIS ELMORE
A t t e m p t in g t o L o c a te

G o v 't C o n t r a c t in g
O ffic e r

GEORGE W. & EUNICE EWALT
731 P en n P in e s B lv d .
Clifton

Uftlghto,

Pa.

.

P a r e n t s o f G e o r g e E w a lt
and f a m i l i a r w it h
f a m ily a i t u a t l o n

TEN EYCK
WILLIAM A . FAIRCLOUGH*
2 4 8 7 1 V ia San F e r n a n d o
M is s io n V i e j o , C a l i f o r n i a
FRED FALANA
A t t e m p t in g to l o c a t e

2692
W ith D anny F ord in s p r a y e d
areas

WILLIAM F . FALSEY*
6 7 0 6 L a k e v ie w D r iv e
L ake C i t y , M ic h ig a n
OTIS E . FANCHER
A t t e m p t in g t o l o c a t e

BIO -TEST LABS

FARMER, CAPT.
A t t e m p t in g to l o c a t e

W ith D anny F ord in s p r a y e d
areas

L. E. FAST
WILLIAM FENNER*
HERCULES, IN C .
JACKSONVILLE, ARK.
BETTY FMAYDA
1 8 9 9 R a p id s Road
H ira m , O h io

C h r is F o r d 's B u s in e s s
p a r t n e r and g o o d f r i e n d
( S e e Sm ayda)

THOMAS FORBES
M o n e s ta r y A v en u e
P h ila d e lp h ia , Pa.

F r ie n d o f G e o r g e E w a lt who
s e r v e d in sam e a r e a in
V ie tn a m

JOHN J . FORD*
15 W in te r b u r y C i r c l e
W ilm in g t o n , D e la w a r e

13821
6

KERRY & JEANETTE FORD
6 5 0 7 S e c o r e R d.
L a m b e r tv i1 1 e , M ic h ig a n

B r o th e r o f D anny F ord

RAY & ROSE FORD
1 3 4 7 8 S o u th C o u n ty L in e
H igh w ay
O tto w a L a k e , M ic h . 4 9 2 6 7

D anny F o r d 's P a r e n t s

MARGARET FORLANO
F ir s t S tr e e t
F t . D ix , N .J .

S i s t e r o f G e o r g e E w a lt

JOSEPH W. FOWLER
E /4 FRANKS
(in j a i l )

423d C om bat S u p p ly ,
w ith Lamb i o t t e in
V ie tn a m

JOHN P . FRAWLEY*

C h ie f to x i c o l o g i s t
H e r c u l e s , re many
l i a b i l i t y and
c a u s a t io n i s s u e s

H. G . FREDERICKS*
VAL K. GAERTNER
JESSE GERSHBERG
E r . D. G la d n e y
A t t e m p t in g to l o c a t e
W ith E w a lt in V ie tn a m
E a s t S t . L o u is , Mo.
A . W. GLENN
HAROLD GILL*

Dow a n a l y t i c a l c h e m is t
who a l l e g e d l y d e v e lo p e d
a n a l y t i c a l m eth o d f o r
d e t e r m in a t io n o f
2 , 3 , 7 ,8 TCDD in ' 6 4 .

CHERYL GONDEK
4 0 0 9 S h aw n ee T r a i l
F t . W o rth , TX 7 6 1 3 5

D anny J o r d a n 's s i s t e r

CHARLES E . GRANITO*
RAYMOND A . G UIDI*
420 E s s e x P la c e
M em p h is, T e n n e s s e e

13822

COLONEL HAIG
A tte m p tin g to l o c a t e

Was w it h E w a lt in s p r a y
area

WALTER D. HARRIS*
199 ALLERTON RD.
NAUGATUCK, CONN.
DAVID G. HELM*
5009 F o r e s t
K a n sa s C i t y , K a n sa s
RICHARD HICKMAN*
R o u te 4 , N o. 10 Yocum R d.
R o g e r s , A r k a n sa s

Dow g o v e r n m e n t s a l e s
M gr. r e D o w 's a t t e m p t s
to s e l l p r o d u c t s
in c l u d i n g h e r b i c i d e s
to t h e g o v e r n m e n t

JESSE HILSEN
PAUL E. HOFFMAN*
1 2 0 2 L ake S h o r e D r iv e N o r th
B a r r in g t o n , I l l i n o i s
GRAYDON HOLDEMAN*
BENJAMIN B . HOLDER*
5 2 0 3 BLOOMFIELD ST .

Dow M e d ic a l D i r e c t o r re
h e a l t h e f f e c t s in w o r k e r s ,

MIDLAND, MICH.

f a i l u r e t o w arn and la c k
o f m inim um e f f e c t l e v e l .

HARRY HOLLAND
A tte m p tin g to l o c a t e

F r ie n d o f L a m b io t t e 's

RAY HOLMES*

Dow p l a n t s u p e r v i s o r
who c o n t r a c t e d
c h lo r a c n e ; r e h e a l t h
e f f e c t s and f a i l u r e to
w arn o f Dow k n o w le d g e o f
D io x in in en d p r o d u c t s in
1964

G. HOLSING
DONALD HOLT
A t t e m p t in g t o l o c a t e

G e o r g e E w a l t ' s F orem an '8 0

VERNON HOUCK
F . GERARD & VADA HUKILL
220 W. T y le r

D anny J o r d a n ' s In -L a w s

13823
8

M agnum, O k l. 7 3 5 5 4
THOMAS R. HUNT
H e r c u le s e x - e m p lo y e e
J a c k s o n v ille , A rk an sas

RAPHAEL H. HUSTON
A tte m p tin g t o l o c a t e
PETER INFANTE
GEORGE JACKSON
A tte m p tin g to l o c a t e

G e o r g e E w a l t ' s Forem an
l a t e ' 7 0 s t o e a r l y '8 0 s

JOHN JENNINGS
A p t. B
12 L an sd ow n e A ven u e
L a n sd o w n e, P a .

H ig h S c h o o l f r i e n d o f
G e o r g e E w a lt who w as
in V ie tn a m a t sam e
tim e and k now s h i s
m e d ic a l p r o b le m s .

DAVID JORDAN*
LYNNE KELLER
208 B r a e sw o o d
A u s t i n , TX 7 8 7 0 4

F r ie n d o f D anny J o r d a n 's

R. EMMET KELLY*
665 SO. SKINNER
ST . LO UIS, MO.

M o n sa n to

VAN A . KELLY
A t t e m p t in g t o l o c a t e
P h ila d e lp h ia , Pa.

W ith E w a lt in V ie tn a m

GEORGE C. KEMPSON*
143 S o u th G ore
W e b ste r G r o v e s , M is s o u r i
Dow e m p lo y e e r e
e n v ir o n m e n t a l
p e r s is ta n c e , t o x ic it y
and l i a b i l i t y i s s u e s

EUGENE E. KENAGA*
1 2 8 1 N . W agner Road
E s s e x v i l l e , M ic h ig a n
FRANCIS KENNEDY*
WILLIAM KIDD

C lo s e s t f r ie n d s o f th e
(D an n y) F o r d s ; s h e w as
w it h C h r is w hen t h e y
fo u n d o u t t h a t D anny
F o r d 's l e g w as c a n ­
c e r o u s and how much
p a in h e w as i n . A d d r e s s
may a l s o b e 33 2 0
R om aker Road

CARL & CARLA KING
3 3 - 4 2 R om aker
T o le d o , O hio

9

13824

$ ■

#

J . M. KIRGIS
A. Y. KISTNER
A tte m p tin g t o l o c a t e
KANSAS CITY, MO.
FRANK W. KLEMAN
A tte m p tin g to l o c a t e
ST . LO UIS, MO.
GEORGE KLINE
J . KLINGMAN
PH ILIP LANDRIGAN
To b e d e p o s e d
JULES LAM
A d d r e s s t o com e

D a v id L a m b io t t e 's U n c le

MICHAEL LAMBIOTTE
A d d r e s s co m in g

B r o th e r o f D a v id
L a m b io tte

J . K. LEASURE*
R. R. N o. 2 - Box 157
M akanda, I l l i n o i s
FRANK LEMAK
To be d e p o s e d
P . R. LITTLE
HAROLD A. LLOY
E w a lt 's d a u g h t e r ' s
p s y c h o lo g is t

DR. ANNETTE LYNCH
S c h o o lh o u s e L ane
P h ila d e lp h ia , Pa.
J . R. MALLET
W. MALONEY
DAVE MANN
A tte m p tin g to l o c a t e

E m p lo y er o f L a m b io tte
b e f o r e and a f t e r
V ie tn a m

THOMAS MARKWOOD*
J e e p C o rp .
940 N . C o e . B lv d .
T o le d o , O hio

P a y r o l l R e c o r d s and l o s t
in co m e re D anny F ord

ROBERT E. MASKILL*
41 E a s t 5 3 rd S t r e e t

T-H A g r i c u l t u r e ; l i a b i l i t y
is s u e s

10

K a n sa s C i t y , M is s o u r i
RICHARD J . MARRESE*
JOHN MASON*
12 T a n n e r s D ean
L e a th e r h e a d , S u rrey
E n g la n d
L . G. MAUREY
In p r o c e s s o f l o c a t i n g
PAUL MAYFIELD
A tte m p tin g to l o c a t e
M. McCALLEY
A t te m p tin g to l o c a t e
WILLIAM J . McCARVILLE*
12 R id g e C r e s t C o u r t
C h e s t e r f i e l d , M is s o u r i
DONALD McCOLLISTER*
5 5 2 2 W h it e h a ll S t r e e t
M id la n d , M ic h ig a n
WILLIAM D. McELROY*
9 6 5 1 BLACK GOLD RD.
CALIFORNIA
JUDY McKINSEY
1 8 9 9 R a p id s Road
H ira m , O hio

B u s in e s s p a r t n e r o f C h r is
F ord and c l o s e f r i e n d
(S e e M cK im n ley)

SGT. TIMOTHY MEDDOR

s e r v e d w it h J o r d a n in
V ie tn a m

COL. BRUCE MEYERS
6 9 1 4 W. MERCER WAY
ST . LO UIS, MO.
ROY MEYERS
CHARLES E. MINARICK

D e p o se d J u l y 2 7 - 2 9 , 1 9 8 3

SHERRY MOSHER
1 8 4 3 3 5 W in c h e s t e r R d.
T o le d o , O hio

B u s in e s s ; m a n a g er
k e n n e l. S t r e s s
s t r a i n on C h r is
A d d r e s s may a l s o
W in c h e s t e r

DEBDAS MUKERJEE

G o v ern m en t e x p e r t . D e p o se d

11

o f th e
and
F ord
be 1950

13825

BOB NOBER
71 Lempa Road
H o lla n d , Pa

Was w it h E w a lt in V ie tn a m

WILLIAM R. NUMMY
71 1 W. M ead ow b rook D r iv e
M id la n d , M ic h ig a n

D e p o se d O c to b e r 2 8 , 1 9 8 3

P h o t o g r a p h ic e x h i b i t s
JACKIE OCHS
c / o GREEN MOUNTAIN POST FILMS & p e r s o n a l o b s e r v a t i o n s
& in v e s tig a tio n s
P . 0 . BOX 229
TURNER FALLS, MA.
F r ie n d o f t h e R yan s

BRIAN O'CONNOR
5 5 4 5 N e t h e r la n d A v e .
B r o n x , N .Y .
J . F . O'CONNOR

S e r v e d w it h J o r d a n in
V i etn am

SGT. THOMAS O'DONNELL
DR. OERTNER
J . E. PALLARD
FRANCIS PANNETON
L . A . PARDEE
PHIL PENN

A m ou n ts - d o in g aw ay
o f h erb s - h as ta p es
to d e t e r m in e e x p o s u r e
to V e te r a n s I I ' s

REBECCA PEPPER
6 7 1 8 S i l v e r m i n e D r iv e
#1004
A u s t i n , TX 7 8 7 3 6

N e ig h b o r o f J o r d a n 's

JACK E. PETERSON
66 4 F o r e s t G ro v e C i r c l e
B r o o k f i e l d , W is c o n s in

F orm er Dow e m p lo y e e who
a d d r e sse d in d u s tr y
r e p r e s e n ta tiv e s a t
M a rch , 1 9 6 5 m e e t in g
c o n c e r n in g r a b b i t e a r
te s tin g

F . H. PLACET
WILLIAM L. POPHAM

C o n s u lt a n t to NACA

DONALD PURDY
16 0 F r e d e r ic k s b e r g D r iv e

D e p o se d J a n u a r y 5 , 1 9 8 4

12

Avon L a k e , Ohio
THOMAS RAFERTY
New York C i t y

W it h Mike Ryan i n
Vietnam

VIRGIL B. ROBINSON
2620 Q u ail H i l l D r iv e
Upper S t . C l a i r , P a . 1 5 2 4 1

Deposed October 19, 1983

V. K. ROWE

Dow's former C h ie f
T oxicologist - lia b ilit y
i s s u e s as w e ll as
c a u s a t i o n q u e s t i o n s ; Dow
knowledge of extreme
t o x i c i t y and f a i l u r e t o
w a r n . D e p o s e d March 1 6 ,
1983.

ROBERT R. RUMER

D e p o s e d November 1 8 , 198

CECIL RUSSELL
46 WINGFIELD ROW
GLENDALE, MO.

D e p o s e d May 2 , 19 8 3

MAUREEN RYAN
K i n g s P a r k , N .Y .

S c h o o l P r i n c i p a l who
knows K e r r y ' s e d u c a t i o n

MICHAEL RYAN
54 W o o d s d a l e A v e .
K i n g s P a r k , N .Y .

Mike R y a n ' s F a t h e r

VICKY RYAN
54 W o o d s d a l e A v e .
K ings Park, N.Y.

K e r r y 's Grandmother

HENRY SADLER
Florida

Boyhood f r i e n d o f
L a m b i o t t e ' s who was
w i t h him i n V i e t n a m

UMBERTO SAFFIOTTI

Government c a u s a t i o n
w itn ess with fa ctu a l
t e s t i m o n y re govern m en t
contract defense,
l i a b i l i t y i s s u e s and
issuance of B io n etics
L aboratories Report.
D e p o s e d M a r c h , 1984

DR. SALTER

D r . who t o l d L a m b i o t t e
to s t o p w orking.

ED SAWGRASS
S i s t e r of George Ewalt

SUSAN SCANLON
- 13 -

13827

ft

0

Ri p i en S t r e e t
Ph i l a d e l p h j. a , Pa .
WI LLIAM R. SCHAMBRA
14 11 W. S t . . A n d r e w s
Mi d l a n d , MiL c hi g an

Dow f o r m e r e m p l o y e e r e
f a i l u r e t o warn and
business of s e llin g
h e r b i c i d e s to the
governm ent. Deposed
November 1 6 , 1 9 8 3

ARTHUR J . SCHLESSINGER
OLGA SCHNELL
U n i v e r s i t y H e i g h t s Dr .
S to n y Brook, N.Y.

Neighbor of the Ryans

W. SCHUBACK
LAPIN 0 . SCOTT
R. B. SCOTT

H ercules em ployee.
ed .

Depos­

RICHARD SCOTT

Drafted with Lambiotte
and saw i n V i e t n a m

SGT. SHARKEY

David L a m b i o t t e ' s
platoon Sergeant
in Vietnam

DEXTER B. SHARP
13042 W e a th e r fie ld D rive
S t . L o u i s , Mo.

Deposed O ctober 20 , 1983

A. E. SIDWELL

H ercules em ployee.
ed .

LARRY SILVERSTEIN

Dow f o r m e r e m p l o y e e r e
March, 1965 m e e t i n g s a t
Dow and o t h e r l i a b i l i t y
i s s u e s and h e a l t h
e f f e c t s t o Dow e m p l o y e e s .
Deposed March, 198 4 .

BETTY SMAYDA
1 8 9 9 R a p i d s Rd .
Hayram, Ohio

B u sin ess p artn ers - Chris
F o r d 's , p lu s good f r i e n d .
What F o r d s w e n t t h r o u g h
and p e r s o n a l s t r a i n s

J . G. SMERALDI

Deposed August 17, 1 983.

CAPT. SMITH

Wit h E w a l t i n s p r a y a r e a s

PLATOON LT. SMITH

W it h E w a l t i n s p r a y a r e a s

Depos­

13828
14

TOM K SMITH
ROBERT SNODGRASS
H u n t i n g t o n , W. Va.

W it h Danny Fo rd i n S p r a y e d
areas

HOWARD C. SPENCER
1 1 0 0 8 Cameo D r i v e
Sun C i t y , A r i z o n a 8 5 3 5 1

Developed r a b b it ear t e s t
i n 19 4 1 w h i l e a Dow
em ployee. Deposed October
21, 1983

L. P. SEITZ
A. JOHN SPEZIALE
Deposed O ctober 2 6 ,1 9 8 3
311 N. U m be r la nd A v e n u e
Redwood C i t y , C a l i f o r n i a 9 4 0 6 1
JOHN A. STEPHENS
800 N. L i n d b e r g h B l v d .
St. Louis, M issouri

D e p o s e d O c t o b e r 1 7 , 19 8 3

D e p o s e d O c t o b e r 1 9 , 19 83
FREDERICK G. STEWARD
173 Wo odl and F o r e s t , S e c t i o n 3
T u s c a l o o s a , Alabam a 3 5 4 0 5
CHARLES N. STEWART

D e p o s e d A u g u s t 1 7 , 19 83

MICHAEL STRANGE
521 Bomber Road
F t . Worth T e x a s

F r i e n d o f Danny J o r d a n

FREDERICK STRANSKY
53 S . M a l l a r d
S e i d e n , N .Y .

Mike R y a n ' s B r o t h e r - i n Law

SGT. STRAWBERRY

Was w i t h E w a l t i n s p r a y
areas

DEIRDRE STRANSKY
24 Alma A v e .
S e id e n , N.Y.

T e a c h e r - kn ow s K e r r y Ryan
- a s p e c i a l i s t in l e a r n i n g
d isab ilities

PATRICIA STRANSKY
53 S . M a l l a r d
S e i d e n , N .Y .

N u r s e and F a m i l y
C o u n s e l l e r f o r Ryan
fam ily

JACK STRUM
712 S h o r t Spo on C i r c l e
North C arolin a

Deposed December 16 , 1983

JOHN S. SULLIVAN
WINFIELD W. SUNDERLAND
5 3 0 0 W e s t p a t h Way

Deposed November 2 , 1983

13828

15

B e t h e s d a , Maryland
DANIEL W. SWEET

Deposed J u l y 6 , 1983

MILTON A. TAVES
210 N. S p r i n g V a l l e Road
W ilm ington, Delaware

H ercules employee.
ed .

CLINTON TAYLOR

Business partner of
David L a m b i o t t e ' s

Depos­

R. D. THOMPSON
WILLIAM THOMPSON
318 GEORGINA AVE.
SANTA MONICA, CAL.

D e p o s e d March 2 4 , and
September 16, 1983

A. L. TREISBECK

H ercules em ployee. Depos­
ed .

DAN TWISS
W oodland S t r e e t
S l y v i a n , Ohio

U n i o n c o m m i s s i o n man a t
Danny F o r d ' s j o b . A l s o
a f r i e n d o f D a n ' s . Has
in fo r m a tio n about union
c o n t r a c t ( c u r r e n t ) and
p e r so n n e l m a t t e r s . See
also Twiss.

DAN TWIFF
4 9 1 0 Woodland
S y l v a n i a , Ohio

C o m m i t t e e man a t AMC J e e p
See T w iff above

WILLIAM R. UDELL
60 TEALWOOD
CREVE COEUR, MO.
EDWIN T. UPTON

T-H l i a b i l i t y i s s u e s
D e p o s e d A p r i l 7 , and
A p r i l 8 , 19 83

W. VANDERVENTER

Deposed June 3, 1983

JANE WARD
3 5 2 7 M. 151
Temperance, Mich. 48182

Neighbor of Fords

ROBERT T. WEBBER
4 M edia D r i v e
S t . L o u is, M isso u r i 63146

D e p o s e d O c t o b e r 3 1 , 1 98 3

ADAM WENKUS
R o u t e 5 - Box 9 04
Waupaca, W is c o n s in

S u p p l y and d i s t r i b u t i o n ,
d e fe n d a n ts' f a i l u r e to
warn; f o r m e r D e f e n s e
M ilita r y Supply O ffic e
16

13830

employee
Served w ith Jo rd a n in
Vietnam

BUTCH WESTERLAND
HARTLEY WILDER
SGT. J . WILLIS

S e r v e d w i t h Danny J o r d a n
in Vietnam

MARK G. WILTSE

Deposed December 2, 1983

N. WIRZ
U n i o n S t e w a r t a t Danny
F o r d ' s - knew Dan when
he had t h e c a n c e r and
the wages a t the time
and t h e c h a n g e s i n Dan

WILBUR WOHLGAMUTH
49-21 Barton P lace
S l y v i a n , Ohio
L. K. WOOLFOLK
JOHN WRIGHT
R. WRIGHT
R. T. YATES

Fo rmer e m p l o y e r o f
Lamb i o t t e

YORK HOSPITAL
MITCHELL ZARON
KETTERING LABS
CINCINNATI, 0 .

D e p o s e d May 3 , 19 8 3

CHARLES P. ZORSCH
ROUTE 5 , BOX 30
PACIFIC, MO.

The names a b o v e w i t h o u t i d e n t i f y i n g i n f o r m a t i o n a r e
l i s t e d on t h e p a r t i e s ' p r i o r i t y l i s t s and w i l l be d e p o s e d a t
future dates.
I t is the p l a i n t i f f s ' u n d erstan d in g th a t th e s e
l i s t s may be s u p p l e m e n t e d a s t h e d e p o s i t i o n s a r e t a k e n .
AGENT ORANGE PLAINTIFFS'
MANAGEMENT COMMITTEE
By
March 2 7 , 1984

13831
17

AGENT ORANGE PLAINTIFFS' MANAGEMENT COMMITTEE
26 COURT STREET - SUITE 905
BROOKLYN, NEW YORK 1 1 2 4 2
212-330-0900
)

,
Hon. S h i r a A. S c F i e i n d l i n
U.S. M a g istra te
U. S . D i s t r i c t C o u r t
E a s t e r n D i s t r i c t o f New York
225 Cadman P l a z a W e st
B r o o k l y n , New York 1 1 2 0 1

Dear M a g i s t r a t e S c h e i n d l i n ;
You
List of
original
today.

March 2 7 , 1 9 8 4

In r e " A g e n t Or ang e"
Product L ia b ilit y L itg a t i o n - MDL N o . 381

w i l l f i n d e n c l o s e d Ch am be rs c o p y o f P l a i n t i f f s ' Amended
F a c t W i t n e s s e s , p e r y o u r P r e t r i a l O r d e r N o. 1 8 , t h e
o f which has been f i l e d w ith th e C lerk o f th e Court

I w i l l hand d e l i v e r c o p i e s t o d e f e n s e c o u n s e l a t t h e t i m e o f
th e h e a r in g b e f o r e you tomorrow m orning.
Yours very truly,

By Hand
cc; A ll Counsel

13832

Law Offices of Benton Musslewhite, Inc.
Counselors at Law
609 Fannin
Suite 517
Houston, Texas 77002

(713) 222-2288

Ad r i

Telex: 775-446
Telex Call Back: LOBM HOU

I 984

M r s , Sh i r a S c h e i n d l i n
Mag i s t r a f e
United States D i s t r i c t Court
E a s t e r n D i s t r i c t o f New Y o r k
2 2 5 Cadman P l a z a E a s t
Room 28 5
B r o o k l y n , New Y o r k I I 20 I
Re:

Dear

Mrs,

E x p a n d e d and R e v i s e d S u mma r i e s
Non-Causation Experts

of

Scheindlin:

Pursuant
s h o u l d be e x p a n d e d
expanded summaries

to y o u r r e c e n t r u l i n g s t h a t the summaries
a n d g i v e n i n mor e d e t a i l
I am e n c l o s i n g
in c o n n e c t i o n w i t h t h e f o l l o w i n g :

1.

D r . R. K e n n e t h G o d w i n , an e x p e r t on e n v i r o n m e n t a l
p o l i c y and r e l a t i o n s h i p s bet ween b u r e a u c r a t i c r u l e s
and o r g a n i z a t i o n a n d p u b l i c p o l i c i e s .

2.

D r . J a me s 0 . R a s m u s o n , s p e c i a l i s t i n a n a l y t i c a l
c h e m i s t r y , i n s t r u m e n t a t i o n and g e n e r a l i n v e s t i g a t i v e
c h e m i s t r y and e n v i r o n m e n t a l c h e m i s t r y .

3.

D r . W i l l i a m B.
engineering.

4.

D r . R u p e r t C. B u r t a n ,
me n t a l m e d i c i n e .

5.

Dr.

Clifton

6.

Dr .

Gary

7.

Dr. D a n i e l T e i t e l b a u m , c l i n i c a l t o x i c o l o g i s t
e m p h a s i s on e n v i r o n m e n t a l m e d i c i n e .

8.

Dr.

Douglas

9.

Dr.

Jay

C.

Retallick,

expert

Crutchfield,

B a k k e n , human

Muster,

Young,

expert

in

factors

and

chemical

industrial

industrial

mechanical

chemist

in

and

and

chemical

process

and e n v i r o n ­

hygienist.

safety

safety

engineering.
with

engineer.

labeling

expert.

13833o -

Mrs. S h i r a S c h e i n d l i n
A p r i l I , 1984
P a g e Two________

10.

Dr.

Dennis

George

Haack,

statistican

and

epidemiologist.

11.

An a d d i t i o n a l c o p y o f t h e o p i n i o n s o f D r . A r t h u r W.
G a l s t o n , Ph.D.
The r e a s o n t h a t t h i s o n e i s i n c l u d e d
i s t h a t he w i l l g i v e h i s o p i n i o n on t h e a l t e r n a t i v e
a n d s u b s t i t u t e h e r b i c i d e s w h i c h do n o t c o n t a i n d i o x i n .

We h a v e n o t e x p a n d e d on t h e s u mma r y o f D r . S t e v e n W y a t t ,
t h e e c o n o m i s t , i n a s m u c h a s y o u r P r e - T r a i l O r d e r No. 17 s e e ms t o
i n d i c a t e t h a t i t w i l l be a n t i c i p a t e d t h a t t h e e c o n o m i c s u m m a r i e s
w i l l be p r o v i d e d a t a l a t e r t i m e .
I n a n y e v e n t , t h a t s u mma r y
s h o u l d be c o m p l e t e d i n t h e n e x t few d a y s , i n a s m u c h a s t h e e c o n o m i c
d a t a h a s now b e e n t r a n s m i t t e d t o D r . W y a t t f o r t h e c o m p l e t i o n o f
h i s e x p a n d e d s u mma r y .
W i t h r e s p e c t t o t h e s u mma r y o f D r . J a y
Y o u n g we a r e h o p i n g t h a t t h a t s u mma r y w i l l be c o m p l e t e d t h i s
week .
We h e r e b y a d v i s e y o u t h a t we do n o t i n t e n d t o c a l I a s a
w i t n e s s W i l l i a m S . Wood, c h e m c i a l s a f e t y c o n s u l t a n t .
In a d d i t i o n ,
p l e a s e be n o t i f i e d t h a t we a r e s e e k i n g an e x p e r t i n t h e f i e l d o f
a g r i c u l t u r a l h e r b i c i d e p r o d u c t s , t h a t i s s o me o n e i n t h e f i e l d who
h a s k n o w l e d g e o f how t h e v a r i o u s h e r b i c i d e s t h a t h a v e been on
t h e ma r k e t s i n c e t he e a r l y 1 9 6 0 ' s work w i t h r e s p e c t t o d i f f e r e n t
t y pe s of p l a n t s .
T h i s w i t n e s s would comp l i ment the t e s t i m o n y
o f Dr, G a l s t o n in t h a t a r e a o f c o n c e r n .
T h e r e i s s t i l l s ome
h o p e t h a t we w i l l be a b l e t o g e t t h é s u mma r y o f D r . T h e o d o r e
G o l d f a r b of the C h e m i s t r y Department of the S t a t e U n i v e r s i t y
o f S t o n n i b r o o k and Dr. C o n r a d B e r e n s o n , e c o n o m i s t a t B a r u c h
C o l l e g e i n New Y o r k .
M r s . S c h e i n d l i n I u n d e r s t a n d t h a t y o u a r e u p s e t by
t h e d e l a y i n g e t t i n g t h e s e s u m m a r i e s e x p a n d e d a n d by t h e f o r m
the summaries have t a k e n .
I u n d e r s t a n d y o u r c o n c e r n and I
a p p r e c i a t e and a d m i r e t h e m a n n e r i n w h i c h y o u a r e t r y i n g t o p u s h
t h i s case to e a r l y p r e p a r a t i o n f o r t r i a l .
I r e c o g n i z e t h i s as
an u n u s u a l c a s e and r e q u i r e s mo r e s t r i n g e n t c o m p l i a n c e w i t h t h e
usual d i s c o v e r y r u l e s .
H o w e v e r , I do w a n t t o r e i t e r a t e s ome o f
t h e a r g u m e n t s we h a v e made p r e v i o u s l y a n d i n a d d i t i o n t o c i t e
a c o u p l e of c a s e s which i n d i c a t e t h a t p e r h a p s the h y p e r t e c h n i c a l i t y
of the d e f e n d a n t s hasg o t t e n out of hand.
You have
i n d i c a t e d on
s e v e r a l o c c a s i o n s you
r e c o g n i z e t h a t t h i s s i t u a t i o n i s much
d i f f e r e n t than the c a u s a t i o n e x p e r t w i t n e s s e s - t h a t is a s i t u a t i o n
dealing with a no n-c ausation expert w it n e ss .
T h i s s tems from the
f a c t t h a t mos t o f t h e
e v i d e n c e t h e s e p e o p l e need t o r e a l l y e x p r e s s
detailed o p in io n s is
i n t h e h a n d s o f t h e d e f e n d a n t s a n d w h i l e s o me

13834

M r s . Sh i ra S c he i n dI i n
A p r i l I , 1984
P a g e T h r e e _____________

o f i t i s a v a i l a b l e much o f i t h a s n o t y e t b e e n made a v a i l a b l e
a n d we a r e s e e k i n g t h r o u g h a d d i t i o n a l d i s c o v e r y .
In a n y e v e n t
t h e s e p e o p l e h a v e g i v e n , I s u b m i t , mor e t h a n i s n e c e s s a r i l y
r e q u i r e d by R u l e 2 6 ( b ) ( 4 ) ( A ) ( I ) .
In H o c k l e y v s . Z e n t I n c o p o r a t e d ,
31 F R S 2 d 1225 ( D . C . M a r y l a n d , 1 9 8 0 ) t h e C o u r t e x p r e s s l y h e l d
that a l l th at is re qu ire d under Rule 2 6 ( b ) ( 4 ) ( A ) ( I ) is a general
s u mma r y and e n o u g h w i t h i n t h e s u mma r y t o p l a c e t h e o p p o s i n g p a r t y
on n o t i c e o f t h e g e n e r a l n a t u r e o f t h e t e s t i m o n y o f t h e e x p e r t
witness.
T h a t c a s e r e v e a l s t h a t we h a v e c l e a r l y c o m p l i e d w i t h
t h e s p i r i t and t h e t e r ms o f R u l e 2 6 ( b ) ( 4 ) ( A ) ( I ).
We a l s o a s k
t h a t y o u n o t e t h e d i c t a i n Dow C h e m i c a l C o mp a n y v s . T a y l o r ,
20 F R S 2 d 6 7 3 ( D . C . E . D . M i c h i g a n , 1 9 7 6 ) .
The d i c t a i n t h a t
c a s e f u r t h e r i n d i c a t e s t h a t we a r e i n c o m p l e t e c o m p l i a n c e w i t h
b o t h t h e t e r m s and s p i r i t o f t h e r u l e s .
I need n o t r e mi n d t h e
d e f e n d a n t s of t h e t e r ms and p r o v i s i o n s of R u l e I o f t h e F e d e r a l
R u l e s of C i v i l P r o c e d u r e and t h a t t h e e n t i r e c o n c e p t o f t h e F e d e r a
R u l e s is t o deal wi t h each p a r t y w i t h i n the s p i r i t o f f a i r n e s s
and r e a s o n a b l e n e s s .
It is q u i t e o b v io us that the defendants
h a v e be c o me t o t a l l y u n r e a s o n a b l e .
The r u l e s , a s we a l l k n o w,
eschew h y p e r t e c h n i c a l i t y .
O b v i o u s l y i t is to the d e fe ndan t s
b e n e f i t t o ha v e t h e c o u r t i mpos e s t r i c t t i me l i m i t s , v e r y t e c h n i c a
r e q u i r e m e n t s w i t h r e s p e c t t o d i s c o v e r y m a t t e r s and t o l o a d t h e
c a s e up w i t h u n n e c e s s a r y t e c h n i c a l i t y .
I do n o t mean t o i m p l y
t h a t any of t h e r e q u i r e m e n t s t h a t you have i mpos ed to d a t e ar e
unnecessary or not a p p r o p r i a t e .
I s i m p l y s a y t h a t I w o u l d hope
t h a t n o b o d y ' s r i g h t t o t h e i r d a y i n c o u r t i s g o i n g t o be p r e ­
j u d i c e d by a d h e a r i n g t o t h e c o u r s e d e s i r e d by t h e d e f e n d a n t s
w h i c h i s o n e o f h y p e r t e c h n i c a l i t y and o v e r l y b u r d e n s o m e r e q u i r e ­
ments.
In s ummar y , t h e c a s e s and t h e r u l e s c l e a r l y i n d i c a t e t h a t
we h a v e g i v e n t h e d e f e n d a n t s f a i r n o t i c e o f w h a t t h e s e e x p e r t s
w i l l t e s t i f y a b o u t and t h a t i s a l l t h a t i s r e q u i r e d by t h e r u l e s ,
p a r t i c u l a r l y Rule 2 6 ( b ) ( 4 ) ( A ) ( l ) .
Mrs. S c h e i n d l i n ,
I want to t a k e t h i s o p p o r t u n i t y t o
a p o l o g i z e f o r any d e l a y s t h a t you f e e l h a v e been u n r e a s o n a b l e .
We h a v e do n e o u r b e s t t o d e a l w i t h t h i s d i f f i c u l t m a t t e r a n d
i t h a s b e e n p a r t i c u l a r l y d i f f i c u l t f o r me i n v i e w o f t h e f a c t
t h a t I ha v e been in b a c k - t o - b a c k t r i a l s f i r s t in a m a r i t i m e c a s e
i n v o l v i n g a s i n k i n g o f a s h i p wher e I r e p r e s e n t t h e f a m i l i e s of
t wo p e o p l e who l o s t t h e i r l i v e s i n t h a t c a t a s t r o p h e a n d t h e n
t h i s week I h a v e be en i n t r i a l
in a h e l i c o p t e r case i n v o l v i n g
t h e d e a t h o f e i g h t f ami I i e s , w h o s e s u r v i v o r s I r e p r e s e n t .
I
h a v e a r r a n g e d my s c h e d u l e s o t h a t t h e s e a r e t h e l a s t t r i a l s I
wi l l p a r t i c i p a t e in p r i o r to t h e A g e n t Or a n g e c a s e g o i n g t o t r i a l .

13835

Mr s . S h i r a S c h e i n d l i n
A p r i I I , 1984
P a g e F o u r ______________

Whi le I h a v e d e l e g a t e d a p o r t i o n o f t h e w o r k w i t h r e s p e c t t o
the n o n - c a u s a t i o n e x p e r t s , t h e s e are e x p e r t s t h a t I have used
t o s ome e x t e n t ; I am f a m i l i a r w i t h t h e m, a n d t h e y a r e r e l y i n g
upon me t o w o r k w i t h t h em i n t h e c o m p l e t i o n o f t h e s e s u m m a r i e s
In s u mma r y , I do b e l i e v e we h a v e c o m p l i e d w i t h t h e r u l e s a n d I
r e s p e c t f u l l y submit t h a t t h e s e w i t n e s s e s c e r t a i n l y s h o u l d not
be p r e c l u d e d .
S i n ce r e I y
LAW O F F I C E S

OF BENTON

Benton
BM : t h
Enclosures
cc:

A L L C O U N S E L OF RE CORD
( S E E ATTACHE D S E R V I C E

LIST)

MUSSLEWHI TE,

Musslewhite

I NC.

SERVICE LIST
Morton B. Silberman, Esq.
CLARK, GAGLIARDI & MILLER
The Inns of Court
99 Court Street
White Plains, New York 10601

Howard Lester, Esq.
LESTER, SCHWAB, KATZ & DWYER
120 Broadway
New York, New York 10271

Wendell B. Alcorn, Jr., Esq.
CADWALADER, WICKERSHAM & TAFT
One Wall Street
New York, New York 10005

Stephen J. Schlegel, Esq.
SCHLEGEL & TRAFELET, LTD.
One North LaSalle Street
Suite 3900
Chicago, Illinois 60602

John Sabetta, Esq.
TOWNLEY & UPDIKE
405 Lexington Avenue
New York, New York 10174

Leonard R i v k i n , Esq.

William Krohley, Esq.
KELLEY, DRYE & WARREN
101 Park Avenue
New York, New York 10178

Thomas H e n d e r s o n , E s q .

D a v i d R. G r o s s , E s q .

V i c t o r J . Yannacone, J r . , Esq.
YANNACONE & YANNACONE
P o s t O f f i c e Box 109
P a t c h o g u e , New York 11722

BUDD, LARNER, KENT, GROSS,
PICILLO & ROSENBAUM
33 Washington Avenue
Newark, New Jersey 07102

Thomas A. B e c k , E sq .
ARTHUR, DRY & KALISH, P.C.
1230 Avenue of the Americas
New York, New York 10020

RIVKIN, LEFF, SHERMAN & RADLER
100 Garden City Plaza
Garden City, New York 11530
BASKIN & SEARS
Frick Building, 10th Floor
Pittsburgh, Pennsylvania 15219

D a v i d D e a n , E sq .
DEAN, FALANGA AND ROSE
One Old Country Road
Carle Place, New York 11514

Arvin Maskin, Esq.
DEPARTMENT OF JUSTICE
Safeway Building
Room 904 D
Washington, D.C. 20530

Sol Schreiber, Esq.
Special Master
MILBERG, WEISS, BERSHAD
& SPECTHRIE
One Pennsylvania Place
Room 4915, 49th Floor
New York, New York 10019

Richard Goldstein, Esq.
SHEA & GOULD
330 Madison Avenue
15th Floor
New York, New York 10017

Clerk of the Panel
Judicial Panel on Multidistrict
Litigation
1120 Vermont Avenue, N.W.
Suite 1002
Washington, D.C. 20005

P a u l E s p o s i t o , E sq .

LEWIS, OVERBECK & FURMAN
135 South La Salle Street
Suite 1060
Chicago, Illinois 60603

Newton B. Schwartz, Esq.
Houston Bar Center Building
723 Main, Suite 325
Houston, Texas 77002

Stanley Chesley, Esq.
WAITE, SCHNIDER, BAYLEFF
& CHESLEY
1318 Central Trust Tower
Cincinnati, Ohio 45202

Phillip E. Brown, Esq.
HOBERG, FINGER, BROWN, COX
& MOLLIGA
703 Market Street, 18th Floor
San Francisco, California 94103

John 0. O'Quinn, Esq.
O'QUINN, HAGANS & WETTMAN
3200 Texas Commerce Tower
Houston, Texas 77002

Robert A. Taylor, Jr., Esq.
ASHCRAFT & GEREL
2000 L Street N.W., Suite 700
Washington, D.C. 20036

Neal R. Peterson, Esq.
GREITZER & LOCKS
1500 Walnut St., 22nd Floor
Philadelphia, Pa. 19102

Ms. Nancy Petrillo, Clerk
United States District Court
Eastern District of New York
225 Cadman Plaza East - Room 285
Brooklyn, New York 11201

Hon. Shira Scheindlin
Magistrate
United States District Court
Eastern District of New York
225 Cadman Plaza East
Room 285
Brooklyn, New York 11201
Stephen Schlegel
Agent Orange Management
Committee
26 Court Street, 9th Floor
Brooklyn, New York 11242
Professor Michael Martin
165 W. End Avenue, Apt. 21-R
New York, New York 10023
Benton Musslewhite, Esq.
LAW OFFICES OF BENTON
MUSSLEWHITE, INC.
609 Fannin, Suite 517
Houston, Texas 77002

Irving Like, Esq.
LAW OFFICES OF REILLY & LIKE
200 W. Main Street
Babylon, New York 11702
Professor Aaron D. Twerski
HOFSTRA LAW SCHOOL
1000 Fulton Avenue
Hempstead, New York 11554
Ms. Jan Levien
Agent Orange Management
Committee
26 Court Street, Room 905
Brooklyn, New York 11242
Allan Freidman, Esq.
Chambers of Judge Weinstein
United States District Court
225 Cadman Plaza East
Brooklyn, New York 11201

The Honorable Jack B. Weinstein
United States District Judge
Eastern District of New York
225 Cadman Plaza East
Brooklyn, New York 11201

13338
-2-

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

CED

,N

.. _
CLERK’S OFFICE
U- o. DISTRICT COURT G.D. f

x

' ° n Ï983

In re

MDL 381

"AGENT ORANGE'

Tiy.Z A.M.
p.t.

(All Cases)

PRODUCT LIABILITY LITIGATION
X

PLAINTIFFS' SUMMARY PURSUANT TO RULE 26 OF
THE FEDERAL RULES OF CIVIL PROCEDURE OF DOCTOR
ALLISTER HAY, AN EXPERT WITNESS TO BE CALLED
BY PLAINTIFFS CONCERNING NON-CAUSATION MATTERS

DATED: MARCH 2 6 , 1 9 8 4
PLAINTIFFS' MANAGEMENT COMMITTEE
26 C o u r t S t r e e t
B r o o k l y n , New York 1 1 2 4 2
(212) 3 3 0 -0 9 0 0

SUMMARY PURSUANT TO RULE 26 OF THE FEDERAL RULES OF CIVIL
PROCEDURE OF DOCTOR ALLISTER HAY, EXPERT WITNESS TO BE
CALLED BY THE PLAINTIFFS CONCERNING NON-CAUSATION MATTERS

I.

QUALIFICATIONS
D r . H a y ’ s c u r r i c u l u m v i t a e wa s a t t a c h e d t o h i s summary
w ith r e s p e c t to the c a u s a t io n q u e s t i o n s .
R e f e r e n c e i s now made
t o t h a t c u r r i c u l u m v i t a e and i s i n c o r p o r a t e d h e r e i n by r e f e r e n c e .

II.
SUMMARY OF SUBJECT MATTER OF WITNESS TESTIMONY
Dr. H a y 's t e s t i m o n y w ith r e s p e c t to n o n - c a u s a t i o n
m a t t e r s r e l a t e s t o g o v e r n m e n t a l a u t h o r i t y and t h e d e c i s i o n m a k i n g
a u t h o r i t y w it h in the U nited S t a t e s Government, w ith r e s p e c t to
t h e u s e o f h e r b i c i d e s i n V i e t n a m . He w i l l be b a s i n g h i s o p i n i o n s
upon t h e e x t e n s i v e r e s e a r c h d o n e b y him i n p r e p a r a t i o n o f h i s
b o o k , "The C h e m i c a l S c y t h e , L e s s o n s o f 2 , 4 , 5 - T and D i o x i n " ;
upon h i s s c i e n t i f i c k n o w l e d g e ; and upon o t h e r d o c u m e n t s and
r e le v a n t a u t h o r i t y w ith r e s p e c t to the workings o f the U nited
S t a t e s Government in c o n n e c tio n w ith th e use o f h e r b i c i d e s in

13840

Vietnam and with

respect

to

the

lines

of

authority

relative

to

the exercise of such authority.

III.
FACTS UPON WHICH WITNESS WILL BASE OPINIONS
The f a c t s upon w h i c h D r . Hay w i l l b a s e h i s o p i n i o n s a r e
t h o s e f a c t u a l m a t t e r s e l i c i t e d b y him d u r i n g h i s i n v e s t i g a t i o n
and r e s e a r c h i n p r e p a r a t i o n f o r t h e w r i t i n g o f t h e a b o v e
r e f e r r e d t o b o o k , The C h e m i c a l S c y t h e , and on t h e b a s i s o f o t h e r
r e s e a r c h and
investigation
and f i r s t
hand c o n t a c t w i t h
s c i e n t i s t i s t and o t h e r p e o p l e r e l a t e d t o o r i n v o l v e d i n t h e u s e
o f h e r b i c i d e s in Vietnam du rin g th e 1 9 6 0 ' s .
The f a c t u a l b a s i s
f o r m o s t o f t h e o p i n i o n s e x p r e s s e d b y D r . Hay a r e s p e c i f i c a l l y
s t a t e d in the above r e f e r r e d to book.
IV. & V.
OPINIONS AND THE BASES THEREFOR

1 . I t i s t h e o p i n i o n o f D r . Hay t h a t t h e d e c i s i o n s t o
u s e h e r b i c i d e s i n V i e t n a m , t o e x p a n d t h e u s e t h e r e o f , and t o
c o n t i n u e to u s e s u c h h e r b i c i d e s w e r e made a t t h e h i g h e s t l e v e l s
o f g o v e r n m e n t ; s p e c i f i c a l l y , t h e i n i t i a l d e c i s i o n was made a t a
l e v e l no l o w e r t h a n D e p u t y S e c r e t r y o f d e f e n s e R o w e l l G i l p a t r i c k
and i n c l u d e d S e c r e t a r y o f S t a t e Dean R u s k , S e c r e t a r y o f D e f e n s e
R o b e r t MacNamara, and P r e s i d e n t K e n n e d y h i m s e l f .
It is his
o p i n i o n t h a t in s u b s e q u e n t a d m i n i s t r a t i o n s th e d e c i s i o n making
was t h e s a m e .
2 . I t i s t h e o p i n i o n o f D r . Hay t h a t t h e r e i s n o t h i n g i n
the s t a t u t e s , r e g u la t io n s , e x e c u t iv e o r d e r s , d i r e c t i v e s , custom s,
p r a c t i c e s , p o l i c i e s or p r i o r modus o p e r a n d i w h i c h w o u l d p e r m i t o r
su g g e s t th a t the d e c is io n s r e fe r r e d
to in (1 ) above c o u ld b e ,
have b e e n , or even sh o u ld b e , d e l e g a t e d b elo w th e h i g h e s t l e v e l s

13841

of the government.
3.

I t i s t h e o p i n i o n o f D r . Hay t h a t a l l s u b s e q u e n t
decisions
to
expand
the
program
sp ecifically
required
p r e s i d e n t i a l a p p r o v a l. T h is would i n v o l v e , o f c o u r s e , P r e s i d e n t s
K e n n e d y , J o h n s o n and N i x o n .
4 . I t i s Dr . H a y ’ s o p i n i o n t h a t t h e d a y - t o - d a y d e c i s i n s
a s t o w h e r e t h e s p r a y i n g o f t h e h e r b i c i d e s w o u l d t a k e p l a c e , and
a s t o t h e s p e c i f i c t i m e s f o r t h e u s e o f t h e h e r b i c i d e s , was
d e l e g a t e d t o t h e U n i t e d S t a t e s A m b a s s a d o r i n S a i g o n and t o t h e
U n i t e d S t a t e s M . A . C . V . ( M i l i t a r y A s s i s t a n c e Command, V i e t n a m ) .
However,
these
persons
and e n t i t i e s
did not have
any
r e s p o n s i b i l i t y f o r , or power to make, th e u l t i m a t e d e c i s i o n o f
w hether to use or to c o n t i n u e to use the h e r b i c i d e s in V ietnam .
5 . I t i s t h e o p i n i o n o f D r . Hay t h a t t h e s p r a y i n g o f
c r o p s w ith th e h e r b i c i d e s r e q u ir e d a r e q u e s t from th e South
V ie tn a m e se a u t h o r i t i e s b e f o r e such c r o p s c o u ld be s p r a y e d .
6 . I t i s t h e o p i n i o n o f D r . Hay t h a t t h e B i o n e t i c s s t u d y

was t h e f i r s t i n d i c a t i o n t o p e r s o n s a t a h i g h e n o u g h l e v e l o f
a u t h o r i t y t o h a v e any i m p a c t upon u l t i m a t e d e c i c i s o n m a k i n g t h a t
t h e Agent Orange b e in g used in V ietnam m igh t have a c o n ta m in a n t
i n i t w h i c h c o u l d p o s e a d a n g e r t o h e a l t h . T h i s s t u d y wa s p l a c e d
in the hands o f Deputy S e c r e t a r y o f D e fe n s e David Packard in
O c t o b e r , 1 9 6 9 . He a l m o s t i m m e d i a t e l y i n s t r u c t e d t h e J o i n t C h i e f s
o f S t a f f to l i m i t the s p r a y in g o f th e Agent Orange to a r e a s
r e m o t e from p o p u l a t i o n a r e a s and r e m o t e from camp a r e a s , p e n d i n g
f u r t h e r s t u d y and d e c i s i o n s a b o u t 2 , 4 , 5 T i n t h e U n i t e d S t a t e s
dom estic market.
7 . I t i s t h e o p i n i o n o f D r . Hay t h a t i n J u n e o f 1 9 7 0 Dr .
K is s in g e r , a fte r gain in g knowledgeof the B io n e tic s rep o rt,
p u r s u a d e d D r . Lee D u B r i d g e o f t h e P r e s i d e n t ' s S c i e n c e A d v i s o r y
C o m m i t t e e t o recommend t o P r e s i d e n t N i x o n t h a t t h e s p r a y i n g

p r o g r a m be s t o p p e d a l t o g e t h e r .
P r e s id e n t Nixon then asked the
Deputy S e c r e ta r y of D efen se
for
an e v a l u a t i o n
of
the
e f f e c t i v e n e s s o f t h e p r o g r a m and t h e d a n g e r s i n v o l v e d .
Though
t h e r e was some e f f o r t on t h e p a r t o f t h e J o i n t C h i e f s o f S t a f f t o
h a v e t h e s p r a y i n g c o n t i n u e d on a l i m i t e d b a s i s , P r e s i d e n t N i x o n
c o n t i n u e d t h e r e s t r i c t i o n s i n e f f e c t a t t h a t t i m e and r u l e d t h a t
the use o f the h e r b i c i d e s must conform to a l l th e e v o lv in g
r e s t r i c t i o n s o n t h e i r u s e i n t h e d o m e s t i c U n i t e d S t a t e s . In t h i s
c o n n e c t i o n , i t i s Dr. H ay's o p i n i o n t h a t in J a n u ary 1 9 7 0 , th e
Department o f A g r i c u l t u r e s a id t h a t in th e f u t u r e 2 ,4 ,5 T sh o u ld
c o n t a i n l e s s than one p a r t per m i l l i o n d i o x i n .
8 . I t i s f u r t h e r t h e o p i n i o n o f D r . Hay t h a t i n March o f

1971 the P r e s i d e n t ' s S c ie n c e A d v iso r y Committee a d v is e d the
P r e s i d e n t and S e c r e t a r i e s o f D e f e n s e t h a t t h e minimum a l l o w a b l e
l e v e l o f d i o x i n s h o u l d be r e d u c e d from 1 p a r t p e r m i l l i o n t o 0 . 1
p a r t per m i l l i o n .
9 . I t i s t h e o p i n i o n o f D r . Hay t h a t , on A p r i l 1 3 , 1 9 7 1 ,
a f t e r f u r t h e r i n v e s t i g a t i o n had c o n t i n u e d and r e v e a l e d t h e
p r o b a b i l i t y o f s e v e r e a d v e r s e h e a l t h e f f e c t s from d i o x i n ,
S e c r e t a r y o f D efen se M elvin Laird ordered a l l r e s i d u a l s t o c k s o f
A gent Orange w it h l e s s than 1 p a r t per m i l l i o n be r e t u r n e d to th e
U n i t e d S t a t e s and w i t h r e g a r d t o t h o s e s t o c k s c o n t a i n i n g an y
h ig h e r d e g r e e o f d i o x i n , he o r d e r e d t h a t t h e y be i n c i n e r a t e d .

10.
I t i s t h e o p i n i o n o f D r . Hay t h a t t h e P r e s i d e n
S c i e n c e A d v i s o r y C o m m i t t e e had no d e c i s i o n m a k i n g p o w e r , o n l y
" a d v i s o r y " p o w e r , and i t ' s f u n c t i o n was t o make r e c o m m e n d a t i o n s
to the P r e sid e n t w ith r e sp e c t to m atters of s c i e n t i f i c i n t e r e s t .
11.
I t i s t h e o p i nDi ro. n Hay
of th a t the relev a n t
me mbers o f t h e P r e s i d e n t ' s S c i e n c e A d v i s o r y C o m m i t t e had no
knowledge of the p o t e n t i a l
health hazards of the h erb icid es
b e in g used in V ietnam u n t i l A ugust - O ctober o f 1 9 6 9 . I t i s Dr.
H a y ' s o p i n i o n t h a t had t h e U n i t e d S t a t e s g o v e r n m e n t had b e e n
0O 4 0^

advised of the danger of Agent Orange, i t could have used Agent
W h i t e i n s t e a d o f A g e n t O r a n g e , a l t h o u g h A g e n t W h i t e was a s l o w e r
acting d e fo lia n t.
12.
I t i s t h e o p i n i o n o f D r . Hay t h a t e v e n t h o u g h
B i o n e t i c s R e p o r t was r e l e a s e d i n May o r J u n e o f 1 9 6 8 t o some
government o f f i c i a l s , w h ile the P r e s id e n t 's S cien ce A dvisory
C o m m i s s i o n d i d n o t r e c e i v e t h e r e p o r t u n t i l 1 9 6 9 , t h e r e had b e e n
s u b s t a n t i a l s p r a y i n g o f A gent Orange in V eitnam and, as a r e s u l t ,
c o n s i d e r a b l e q u a n t i t i e s o f TCDD had b e e n d e p o s i t e d .
T h a t TCDD
w o u l d p e r s i s t i n t h e e n v i r o n m e n t and s t i l l b e a d a n g e r ( i . e . ,
s u b j e c t t o e x p o s u r e t o t h o s e i n p r o x i m i t y t o t h e TCDD) t h r o u g h
1 9 6 9 . I t i s t h e o p i n i o n o f D r . Hay t h a t no a g e n c y o f t h e U n i t e d
S t a t e s g o v e r n m e n t a t t h e d e c i s i o n - m a k i n g l e v e l was a w a r e o f t h e
h e a l t h r i s k s i n 2 , 4 , 5 - T u n t i l A u g u s t - O c t o b e r , 1 9 6 9 . no a g e n c y
o f t h e U n i t e d S t a t e s g o v e r n m e n t a t t h e d e c i s i o n m a k i n g l e v e l was
a w a r e o f t h e h e a l t h r i s k s i n 2 , 4 , 5T u n t i l A u g u s t - O c t o b e r ,
1969.
on t thhaet ,
13.
I t i s t h e f u r t h e r o p i n i o n o f D r . Hay
o t h e r hand s i n c e b e f o r e 1 9 6 5 , t h e D e f e n d a n t s ' p o s s e s s e d a f a r
g r e a t e r and v a s t e r k n o w l e d g e a b o u t t h e p r e s e n c e o f d i o x i n i n t h e
2 , 4 , 5 T ; t h e s e v e r e h e a l t h r i s k s t o t h o s e who w e r e i n v o l v e d i n t h e
manufacture of the 2 ,4 ,5 T ; the se v e r e r is k s o f adverse h e a lth
a f f e c t s t o t h o s e who w e r e e x p o s e d t o t h e u s e o f t h e 2 , 4 , 5T; and
t h e p r o c e s s e s t h r o u g h w h i c h t h e d i o x i n c o n t a m i n a n t i n t h e 2 , 4 , 5T
c o u ld be s u b s t a n t i a l l y red u ced .
1 4 . I t i s Dr. H a y ' s o p i n i o n t h a t n o n e o f t h e d e f e n d a n t s
made a bo na f i d e e f f o r t t o s h a r e t h e k n o w l e d g e r e f e r r e d t o i n
(1 3 ) a b o v e u n t i l Dow w r o t e t h e S e c r e t a r y o f D e f e n s e i n M a r c h ,
1 9 7 0 , a f t e r i t wa s t o o 1 i t t l e , t o o l a t e .
1 5 . I t i s D r . Hay ' s summary o p i n i o n t h a t t h o s e who had
th e r e s p o n s i b i l i t y fo r making th e d e c i s i o n s t o u s e , or to c o n t i n u e
to use, or expand the use of, herbicides in Vietnam conflict, did

n o t u n t i l O c t o b e r , 1 9 6 9 t o A p r i l , 1 9 7 1 kno w, o r h a v e r e s o n t o
s u s p e c t , t h a t t h e c o n t a m i n a n t p o s e d a d a n g e r t o human h e a l t h , and
t h a t t h e r e w e r e m e a ns f o r r e d u c i n g t h e amo unt o f t h e c o n t a m i n a n t
i n t h e end p r o d u c t .

Respectfully submitted:

Thomas H e n d e r s o n

13845

CERTIFICATE OF SERVICE
EDWARD F. HAYES, I I I do h e r e b y c e r t i f y t h a t t h e
f o r e g o i n g R u l e 26 Summary was s e r v e d upon t h e d e f e n d a n t s by
F ed era l E xpress by d e l i v e r i n g tr u e c o p i e s t h e r e o f d i r e c t e d to
them a t t h e f o l l o w i ng a d d r e s s e s :
I,

R i v k i n , L e f f , Sherman & R a d l e r
A t t o r n e y s f o r Dow C h e m i c a l Company
100 G ar d e n C i t y P l a z a
Garden C i t y , N.Y. 11530

Townely & Updike
A t t o r n e y s f o r M o n s a n t o Co.
405 L e x i n g t o n A v e n u e
New Y o r k , New York 1 0 0 1 7

C a d w a lla d e r , Wickersham & T a ft
A t t o r n e y s f o r Diamond-Shamrock
One W a l l S t r e e t
New Y o r k , New York 1 0 0 0 5

A r t h u r , Dry & K a l i s h
A ttorneys for U niroyal, Inc.
1 2 3 0 Av e nu e o f t h e A m e r i c a s
New Y o r k , New York 1 0 0 2 0

S h e a & G o ul d
A ttorneys for U niroyal, Inc.
330 M a d i s o n A v e n u e
New Y o r k , New York 1 0 0 1 7

Clark, G agliardi & M iller
A t t o r n e y s f o r T&H A g r i c u l t u r e
99 C o u r t S t r e e t
W h i t e P l a i n s , New York 1 0 6 0 1

Budd, L arn er, K ent, G r o ss,
P i c i l l i o & Rosenthal
A t t o r n e y s f o r Thompson C h e m i c a l
33 W a s h i n g t o n S t r e e t
N e w a r k , New J e r s e y 1 7 1 0 2

C ivil D ivision
U nited S t a t e s Department o f
Justice
S a f e w a y B u i l d i n g , Room 9 0 4 0
W ash in gton , D.C. 20530

K e l l e y D r y e & Warren
A ttorneys for H ercules, Inc.
101 P a r k A v e n u e
New Y o r k , N . Y . 1 0 1 7 8
D a t e d : March 2 6 , 1984

13346

-/ -« •T

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

In re

)
"AGENT ORANGE"

Product Liability Litigation

)
)

MDL No. 381
(All cases)

PLAINTIFFS' INTERROGATORIES TO DEFENDANTS

MARCH 23, 1984

13847

k. Ansul
O

. r

T £

i..

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

In re

)
"AGENT ORANGE"

Product Liability Litigation

)
)

MDL No. 381
(All cases)

PLAINTIFFS' INTERROGATORIES TO DEFENDANTS

MARCH 23, 1984

1.

Did you ever supply 2,4,5-T (in acid, salt, este

other form) to any of the following companies (please respond ]
or no for each company listed):
a. Dow Chemical Company
b. Monsanto Company
c. Diamond-Shamrock
d. Uniroyal, Inc.
e. T&H Agriculture
f. Hercules, Inc.
g. Thompson Chemical Company
h. Hooker Chemical Company
i. Riverdale Chemical Company
j . Hoffman-Taft

JL384&

a. Dow Chemical Company
b . Monsanto Company
c. Diamond-Shamrock
d. Uniroyal, Inc.
e. T&H Agriculture
f. Hercules, Inc.
g. Thompson Chemical Company
h. Hooker Chemical Company
i. Riverdale Chemical Company
j . Hoffman-Taft
k. Ansul
4. If your answer to any of interrogatory number 3 (a
through k) is anything other than an unqualified "no", please
state for each such party the following:
a. Describe the writings relating to the (1) nego­
tiations leading up to, (2) the finalization of and (3) dealing
pertaining to said receipt;
b. For each such receipt occurrence, state
(1) Was any of the 2,4,5-T received obtained from some
other source and, if so, please describe the source and the
date thereof;
(2) The identification of your employee who was in
charge of the receiving procedure;
(3) The identification of the employee of the supplier
who was in charge of the supply;
(4) The date(s) of each such receipt;
(5) The amount received on each occasion of receipt;
(6) Whether there was any effort made by any person to

13849

determine the existence of and/or the amount of a dioxin
content and, if so, the results obtained and the identity of
all persons possessing the records pertaining thereto.
c.

For each such receipt occurrence, please att

writings relating to or referred to in 4.(a) and 4.(b) above and
all writings relating to notice to any government entity concern­
ing any dioxin content therein.
5. Did you ever supply 2,4,5-TCP (in acid, salt, ester or
other form) to any of the following companies (please respond yes
or no for each company listed): and list each of the defendants
a. Dow Chemical Company
b . Monsanto Company
c. Diamond-Shamrock
d. Uniroyal, Inc.
e. T&H Agriculture
f. Hercules, Inc.
g. Thompson Chemical Company.
h. Hooker Chemical Company
i. Riverdale Chemical Company
j . Hoffman-Taft
k. Ansul
6.

If your answer to any of interrogatory number 5 (a

through k) is anything other than an unqualified "no", please
state for each such party the following:
a. Describe the writings relating to the

(1) nego­

tiations leading up to, (2) the finalization of and (3) dealings
pertaining to said supplying;
b. For each such supply occurrence, state

’

4

"

13350

(1) Was any of the 2,4,5-TCP supplied obtained from
some other source and, if so, please describe the source and
the date thereof;
(2) The identification of your employee who was in
charge of the supply procedure;
(3) The identification of the employee of the recipient
who was in charge of the receipt;
(4) The date(s) of each such supply;
(5) The amount supplied on each occasion of supply;
(6) Whether there was any effort made by any person to
determine the existence of and/or the amount of a dioxin
content and, if so, the results obtained and the identity of
all persons possessing the records pertaining thereto.
c.

For each such supply occurrence, please at

writings relating to or referred to in 6.(a) and 6.(b) above and
all writings relating to notice to any government entity concern­
ing any dioxin content therein.
7.

Did you ever receive 2,4,5-TCP from any of the follow

chemical companies

(please respond yes or no for each party

listed):
a. Dow Chemical Company
b. Monsanto Company
c. Diamond-Shamrock
d. Uniroyal, Inc.
e. T&H Agriculture
f. Hercules, Inc.
g. Thompson Chemical Company
h. Hooker Chemical Company

-5-

i. Riverdale Chemical Company
j . Hoffman-Taft
k. Ansul
8.

If your answer to any of interrogatory number 7 (a

through k) is anything other than an unqualified "no", please
state for each such party the following:
a.

Describe the writings relating to the (1) nego-

tiations leading up to, (2) the finalization of and (3) dealings
pertaining to said receipt;
b. For each such receipt occurrence, state
(1) Was any of the 2,4,5-TCP received obtained from
some other source and, if so, please describe the source and
the date thereof;
(2) The identification of your employee who was in
charge of the receiving procedure;
(3) The identification of the employee of the supplier
who was in charge of the supply;
(4) The date(s) of each such receipt;
(5) The amount received on each occasion of receipt;
(6) Whether there was any effort made by any person to
determine the existence of and/or the amount of a dioxin
content and, if so, the results obtained and the identity of
all persons possessing the records pertaining thereto.
c. For each such receipt occurrence, please attach all
writings relating to or referred to in 8.(a) and 8.(b) above and
all writings relating to notice to any government entity concern­
ing any dioxin content therein.
9. Did you ever supply Agent Orange (in acid, salt, ester or

-6-

other form) to any of the following companies (please respond yes
or no for each company listed):
a. Dow Chemical Company
b. Monsanto Company
c. Diamond-Shamrock
d. Uniroyal, Inc.
e. T&H Agriculture
f. Hercules, Inc.
g. Thompson Chemical Company
h. Hooker Chemical Company
i. Riverdale Chemical Company
j . Hoffman-Taft
k. Ansul
10.

If your answer to any of interrogatory number 13 (

through k) is anything other than an unqualified "no", please
state for each such party the following:
a. Describe the writings relating to the (1) nego­
tiations leading up to, (2) the finalization of and (3) dealings
pertaining to said supplying;
b. For each such supply occurrence, state
(1) Was any of the Agent Orange supplied obtained from
some other source and, if so, please describe the source anc
the date thereof;
(2) The identification of your employee who was in
charge of the supply procedure;
(3) The identification of the employee of the recipient
who was in charge of the receipt;
(4) The date(s) of each such supply;

-7-

13353

(5) The amount supplied on each occasion of supply;
(6) Whether there was any effort made by any person to
determine the existence of and/or the amount of a dioxin
content and, if so, the results obtained and the identity of
all persons possessing the records pertaining thereto.
c.

For each such supply occurrence, please at

writings relating to or referred to in 14. (a) and 14. (b) above
and all writings relating to notice to any government entity
concerning any dioxin content therein.
11. Did you ever receive Agent Orange from any of the
following chemical companies (please respond yes or no for each
party listed):
a. Dow Chemical Company
b. Monsanto Company
c. Diamond-Shamrock
d. Uniroyal, Inc.
e. T&H Agriculture
f. Hercules, Inc.
g. Thompson Chemical Company
h. Hooker Chemical Company
i. Riverdale Chemical Company
j . Hoffman-Taft
k. Ansul
12. If your answer to any of interrogatory number 15 (a
through k) is anything other than an unqualified "no", please
state for each such party the following:
a.

Describe the writings relating to the (1

tiations leading up to, (2) the finalization of and (3) dealings

-8-

pertaining to said receipt;
b. For each such receipt occurrence, state
(1) Was any of the Agent Orange received obtained fror
some other source and, if so, please describe the source ar
the date thereof;
(2) The identification of your employee who was in
charge of the receipt procedure;
(3) The identification of the employee of the supplier
who was in charge of the supply;
(A) The date(s) of each such receipt;
(5) The amount received on each occasion of receipt;
(6) Whether there was any effort made by any person tc
determine the existence of and/or the amount of a dioxin
content and, if so, the results obtained and the identity o
all persons possessing the records pertaining thereto.
c. For each such receipt occurrence, please attach all
writings relating to or referred to'in 16.(a) and 16.(b) above
and all writings relating to notice to any government entity
concerning any dioxin content therein.
13.

Were

2,4,5-TCP;

any of

the aforementioned products

Agent Orange)

Government?

(2,4,5-T;

ever supplied to the United States

If so, for each incident of supply above described,

state the following:

a.

Describe which of the above products were

so

supplied;
b. Who supplied the product

to the United States

Government;
c. When was the product supplied to the United States

-9-

Government;
d. In what quantity was the produce supplied;
e. Was the origin of the product in any way described
to the United States;
f. From who did the supplier receive the material
ultimately shipped to the United States.

-10-

CERTIFICATE

OF S E R V I C E

The u n d e r s i g n e d , Edward F. H a y e s , I I I , d o e s h e r e b y
c e r t i f y t h a t on t h e 23d d a y o f M a r c h , 1 9 8 4 h e s e r v e d t h e e n c l o s e d
I n t e r r o g a t o r i e s on a l l t h o s e shown on t h e a t t a c h e d s e r v i c e l i s t
by d e l i v e r y to F ed era l E xpress w ith th e f o l l o w i n g e x c e p t i o n s ;
Cha mbe rs c o p i e s w e r e d e l i v e r e d p e r s o n a l l y b y hand t o J u d g e
W e i n s t e i n and M a g i s t r a t e S c h e i n d l i n , b e f o p a ^ h e h o u r o f 5 : 0 0 p . m .

13

ir'

O

■ *V

Rivkin, Leff, Sherman & Radler
Attorneys for Dow Chemical Co.
100 Garden City Plaza
Garden City, NY 11530
Townley & Updike
Attorneys for Monsanto Co.
405 Lexington Avenue
New York, NY 10017
Cadwalader, Wickersham & Taft
Attorneys for Diamond Shamrock
One Wall Street
New York, NY 10005
Arthur, Dry & Kalish
Attorneys for Uniroyal, Inc.
1230 Avenue of the Americas
New York, NY 10020
Shea & Gould
Attorneys for Uniroyal, Inc.
330 Madison Avenue
New York, NY 10017
Clark, Gagliardi & Miller
Attorneys for T&H Agriculture
99 Court Street
White Plains, NY 10601
Budd, Larner, Kent, Gross,
Picillio & Rosenthal
Attorneys for Thompson Chemical
33 Washington Street
Newark, NJ 17102
Civil Division
United States Department of Justice
Room 904D
Safeway Building
Washington, DC 25030
Kelley, Drye & Warren
Attorneys for Hercules, Inc.
101 Park Avenue
New York, NY 10178

1'

Q
■i.t

:'

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OP NEW YORK
x
IN RE

r\

"AGENT ORANGE"
MDL No. 381
(All Cases)

r\.

PRODUCT LIABILITY LITIGATION
x

\

SUPPLEMENTAL ANSWERS OF
DEFENDANT MONSANTO COMPANY
TO PLAINTIFFS' INTERROGA­
TORIES TO DEFENDANTS

oI

To w n l e y & U p d i k e .
CHRYSLER BUILDING
40 5 LEXINGTON AVENUE
NEW YORK, N. Y. 10174
TELEPH O N E

v

(2131 0 8 2 - * 5 6 7

• •*v

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

X
IN RE

MDL No. 381
(All Cases)
"AGENT ORANGE"

SUPPLEMENTAL ANSWERS OF
DEFENDANT MONSANTO COMPANY
TO PLAINTIFFS' INTERROGA­
TOR IES t o d e f e n d m s t s

PRODUCT LIABILITY LITIGATION
-X

Defendant Monsanto Company ("Monsanto"), pursuant to
Magistrate's Pretrial Order No. 2, dated February 10, 1984 and
as modified at a hearing that day before Magistrate Scheindlin,
supplements its answers to certain of Plaintiffs'
Interrogatories to Defendants, dated December 22, 1983, as
follows:
INTERROGATORY NO. 3
Did any herbicide containing 2,4,5-T manufactured and
ar sold by you contain any caution, warning, caveat or other
statement or explanation on the product or its packaging?
a)

If so, when did the warning or statement first
appear?

b)

What was the precise wording of the warning or
other statement when it first appeared?

c)

Has the warning or statement been altered,
amended or changed in any manner? If so, how and
when was it amended?

d)

Where was the warning or statement located on
each product or packaging?

13Ö&Q

Answer to Interrogatory No. 3
The information in Monsanto's possession that is
responsive to this interrogatory is found on the labels that
were affixed to the various herbicides containing 2,4,5-T
marketed by Monsanto.

The burden of deriving the precise

information sought in this interrogatory from those labels is
substantially the same for the interrogating plaintiffs as it
is for Monsanto.

Accordingly, pursuant to Fed. R. Civ. P.

33(c), specified below are the numbers of the documents from
which the answer to this interrogatory may be derived or
ascertained :
0074525-0074526
0074515-0074516
0023203
0074506-0074507
0074297
0074296
0074658
0074611
0074772
0008369
0055143
0074399
0074396
0074597-0074598
0074793-0074797
0074569-0074572
0074683-0074684
0046973-0046974
0075199
0084205
0075130
0074697-0074698
0084280-0084281
0023204-0023206
0075105
0007097
0075063-0075064

1386

^ -

/•s

0074642
0074624
0074622
0075118
0074738
0074409
0074114
0074103
0023214
0074310-0074311
0074677-0074678
0054465-0054466
0074865-0074866
0074359-0074360
0075075
0074675-0074676
0074333-0074334
0007092
0074320-0074321
0074925-0074926
0074826-0074827
0074719
0008238-0008239
0046969-0046970
0074770-0074771
0074718
0084210
0074679-0074680
0046965-0046966
0074717
0074280-0074281
0074278-0074279
0074099-0075623
0102064-0102065
0102066-0102067
0102068-0102069
INTERROGATORY NO. 7
Please list all scientific and medical periodical and
journals, both American and foreign, in which you claim the
toxic effects of dioxin were reported from 1945 to the present;
and, give the specific references to such reports for each such
periodical or journal.

138 AC A'
-3-

■0
Answer to Interrogatory No. 7
:

The information sought by this interrogatory is
presently being compiled by or for Monsanto in preparation for
trial.

The bibliographic references listed below —

which are publicly available —

all of

are thus not exhaustive.

In

listing them Monsanto does not waive, and hereby expressly
reserves, its right to offer as evidence at trial any
information concerning the toxicity of dioxin, regardless of
whether such information is contained in the references listed
below.

: r-s.

1.

"UK Ministry Gives Green Light to 2,4,5-T," Nature,
2708 (5703), 3/29/79.

2.

"Sponsors of Science Inc. on the Safety of 2,4,5-T and
Dioxin," Clinical Toxicology, 7, 1974.

3.

"National Health and Medical Research Council;
Statements Adopted at 85th Session, Adelaide, June
1978," Medical Journal of Australia, 2/Suppl. 3,
10/21/78.

4.

"Chlorinated Dioxins and Related Compounds:
Proceedings of the Third International Sumposium Held
at Salzburg, Austria, 12-14 October 1982,"
Chemosphere, 12 (4-5) 1983.

5.

"Epidemiologic Evidence Shows No Longterm Threat
Following Exposure to Dioxin," American Industrial
Hygiene Association Journal, 41(3), 1980.

6.

"No Excess in Cancer Deaths Found in Largest Group
Ever Studied for Long-Term Effects of Dioxin
Exposure," American Industrial Hygiene Association
Journal, 41(1), 10/80.

7.

"ACSH Notes Report Dioxin, DDT May Inhibit Cancer,"
Food Chemical News, 38, 11/28/83

8.

"Malformation at Birth Increased in Seveso Last Year,"
Nature, 280, 7/79

.

13863
-4-

"Dioxin Traces Found in Soldiers Exposed to Defoliant,
Nature, 282 (5742), 12/27/79.
"Dioxin and the Heart," Lancet, 1 (8183), 6/28/80.
"Resolution Conference Examines 2,4,5-T Safety," Farm
Chem, 142(12), 12/79.
"2,4,5-T and TCDD,"
10/76.

Naturwissenschaften,

63(10),

"Simmering 2,4,5-T Dispute Boiling Over," Chemical
Week, 126(15), 1980.
"TCDD: A Potent Inducer," Drug Metab Dispositions,
3(4), 1975.
"On the Trail of Dioxin," Scientific American,
11/73.
"Dioxin and 2,4,5-T:
284 (5752), 3/13/80.

What Are The Risks?"

229,

Nature,

"Another Herbicide on the Blacklist," Nature, 226,
1970.
"Cholorinated Phenoxy Acids and Their Dioxins:
Genetics Summary," Ecological Bulletin, 27, 1978.
"The Dioxin Curse,"
11/77.

Atlas World Press Review, 24,

"Dioxin: The 10-Year Battle That Began With Agent
Orange," Nature, 278, 3/8/79.
"Human Data (: A Short Article in William Robins'
Description of Dow Chemical Company's Sponsored
Studies SubjectingPrisoners to Dioxin)," Chemtech,
595, 10/83.
"2,4, 5-Trichlorophenol and TCDD,"
Naturwissenschaften, 63 (ISS 10), 12/23/76.
"The Strange Case of the Government vs. 2,4,5-T, Part
II,"Farm Cham, 133(3), 1970.
"Dioxin Tolerance Level of 5 ppt Petitioned by Public
Citizen," Food Chemical News, 10/24/83.
"Agriculture Group Says 2,4,5-T is Safe,"
9/11/78.

C&EN,

26.

"Government Steps Up Pressure on Pesticides: Recent
Joint Action Restricting Use of 2,4,5-T Herbicide
Portends Changes in Pesticide Regulations and
Testing," Chemical and Engineering News, 48(18),
4/27/70.

27.

"The Effects of Herbicides in South Vietnam, Part A:
Summary and Conclusions; Chapter VII: Effects on
Humans," 1974.

28.

"Mortality and Birth Defects from 1976 to 1979 in the
Population Living in the TCDD Polluted Area of
Seveso," 1982.

29.

"Chlorinated Dioxins," Science, 220 (4606), 6/24/83.

30.

"Data on Dioxin," Nature,

31 .

"Comparison on the Inducibilities of UDP-Glucuronosul
Transferase and Polysubstrate Mono Oxygenase
Activities in Mice Exposed to 20 Model Zenobiotics,"
Biochem Pharmacol, 32, 9/1/83.

32 .

"Effect of 2,3,7,8-TCDD on UDP Glucuronosul
Transferase Activities in the Gunn Rat," Int. Congr.
Ser-Excerpta Med., 440, 1978.

33 .

"Activiation and Inhibition of Rat Hepatic
UDP-Glucuronosyl Transferase by Mercuric Acetate,"
Xenobiotic, 11(2), 2/81.

34 .

"Organ Specific Induction of Drug Metabolizing Enzymes
by 2,3,7,8-TCDD in the Rat," Toxicol-Appl-Pharmacol,
44, 4/78.

35.

"Dioxins," Duodecim, 96(12), 1980.

36.

"Different Effect .of 2,3,7,8-TCDD on Glucouronide
Conjugation of Various Aglycones: Studies in Wista and
Gunn Rats," Toxicol Appl. Pharmacol, 47, 10/79.

37.

"Photochemical Reactions of Phenoxy Acids and
Dioxins," Ecol Bull, 27, 1978.

38.

"Effect of Hypophysectomy and Castration on Hepatic,
Pulmonary, and Intestinal Aryl Hydrocarbon Hydrolase
Activities in the Rat," J .’Pharmacol Exper. Ther.,
216, 3/81.

39.

"Radioimmunoassay for 2,3,7,8-TCDD," Environ. Health
Perspect., 20, 10/77.

295 (5845), 1/20/82.

¡r* IT*

-6 -

if

40.

"Effects of 2,3,7,8-TCDD on Lipid Profiles in Tissues
of the Fissher Rat," Chem-Biol. Interactions, 23,
12/78.

41.

"Health Implications of 2,3,7,8-TCDD Exposure in
Primates," Environ Sci Res., 12, 1978,

42.

"Morphological Changes in Monkeys Consuming a Diet
Containing Low Levels of 2,3,7,8-TCDD," Food Cosmet
Toxicol, 15, 10/77.

43.

"Response to Primates to 2,3,7,8-TetrachlorodibenzorhoDioxin," Toxicology Research Projects Di, 4(3),
1979.

44 .

"Response of Primates to 2,3,7,8-Tetracholordibenzorhodioxin," Toxicology Research Projects Di,, 5 (12),
1980.

45.

"Reproductive Effects of Halogenated Aromatic
Hydrocarbons on Nonhuman Primates," Ann. N.Y. Acad.
Sci., V.320, 5/31/79.

46 .

"Reproductive Dysfunction in Nonhuman Primates Exposed
to Dioxins," Toxicol■ Appl. Pharmacol., 41(1), 1977.

47.

"Reproductive Dysfunction in Nonhuman Primates Exposed
to Dioxins," Abstracts, Society of Toxicology, 3/30/77.

48.

"Implications of Low Level Exposure to Dioxins,"
Toxicology Research Projects Di, 5(6), 1980.

49.

"Dioxin Induced Toxicity and Carcinogenicity,"
Toxicology Research Projects Di, 4(6), 1979.

50.

"Implications of Low Level Exposure to Dioxins,"
Toxicology Research Projects Di, 4 (ISS 6), 1979.

51.

"Comparative Toxicology of Chlorinated Compounds on
Mammalian Species," Pharmacol Ther., 7(3), 1979.

52.

"Dioxin Induced Toxicity and Carcinogenicity,"
Toxicology Research Projects Di., 5(6), 1980.

53.

"Evaluation of D-Glucarie Acid, as an Index of Enzyme
Induction by 2,3,7,8-TCDD," (Original in Spanish),
Arch. Pharmacol Toxicol ., 2, 1976.

'S '

/■ s

54 .

"The Effects of 2,3,7,8-TCDD on the Renal Tubular
Secretion of Phenolsulfonphthalein," J. Pharmacol.
Exper. Ther., 207(3), 12/78.

-7-

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2
55.

"H.E.W., USDA Hold Firm: 2,4, 5-T Ruling Postponed,"
Chem, Enq. News, 48(7), 2/16/70.

56.

"Seveso-Gift und Seine Toxizitat: Erkenntnisse Zum
Wirkunqsmechanismus von 2,3 , 7 ,8-TCDD," Deutsche
Apotheker Zeitunq, 122(34), 1982.

57.

"Comparison of Hepatic Enzyme-Inducing Activities of
Chlorinated Dibensofuran and Chlorinated
Dibenzodioxin," Fukuoka-Igaku-Zasshi, 65(ISS 1), 1974.

58.

"Elimination of 2,3 . 7 , 8-TCDD. in Goat Milk,"
Lett. , 9(3), 11/81.

59 .

"Differential Induction of Murine Alt Locus-Associated
Mono oxygenase Activities in Rabbit Liver and Kidney,"
Biochem Pharmacol, col., 24, 11/15/75.

60.

"Genetic Association of Increases in Naphthalene,
Acetanilide and Piphensyl Hydroxylations with
Inducible Aryl Hydrocarbon Hydroxylase in Mice," Arch.
Biochem. Biophys . , 175(2), 1976.

61 .

"The influence of Phénobarbital, 3-Methylcholanthrene
and 2,3,7,8-TCDD on Glutathione S-Transferase Activity
of Rat Liver Cytossol," Biochem. Pharmacol., 27, 1978.

62.

"Teratogenic and Embryonic Effects of the Herbicides
2,4-D and 2,4,5-T," Acta Pharmacol. Toxicol. , 32.
1973..

63.

"Values of Various Blood Compounds in Guinea Pigs
After Acute 2,3,7,8-TCDD Poisoning," Med. P r . , 33
(5-6), 1982.

64 .

"Effects of Environmental Pollutants of the
Intestinal Absorption of Nutrients," Environ. Health
Perspect, 20, 10/77.

65.

"Intestinal Absorption of Nutrients in Rats Treated
with 2,3,7,8-TCDD," J. Toxicol. Environ. Health, 8,
10/81.

66.

"Binding of Polycholrinated Biphenyls Classified as
Either Phenobarbitone, 3-Methylcholanthrene, or
MixedType Inducers to Cytosolic AH Receptor," Chem.
Biol. Interactions, 39(3), 4/82.

67.

"Assessing Hazards from Prolonged and Repeated
Exposure to Low Doses of Toxic Substances," B r . Med.
Bull., 31, 9/75.

»

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Toxicol.

' \
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-8-

i^

68.
69.

"Hormonal Alterations in Female Rhesus Monkeys Fed a
Diet Containing 2,3,7,8-TCDD," Bull. Environ. Contam.
Toxicol., 21, 3/79.
"Field Studies of Wildlife Exposed to TCDD
Contaminated Soils," U.S. NTIS, Ad. Rep.,

70.

"Transfer of 2,3,7,8-TCDD to the Mouse Embryo, Fetus
and Neonate," Naunyn-Schmiedeberg's Arch. Phar., 316,
(suppl.), 1981.

71.

"Enhanced Thyrozine Metabolism and High Uptake Goiters
in Rats After a Single Dose of 2,3,7,8-TCDD,"
Endocrinology, 101, 7/77.

72 .

"Long-Term Effects of Dioxin Exposure," (Letter)
Lancet, 1 (8014), 4/2/77.

73 .

"Induction of DT-Diaphorase by 2,3,7,8-TCDD," Biochem,
Biophys. Res. Comm., 68, 1976.

74 .

"Evidence for a Role for DT-Diaphorase Induction in
the Toxicity of 2,3,7,8-TCDD," Pharmacologist, 18(2),
1976.

75.

"Studies of the Metabolism and the Possible Mechanisms
of Toxicity of TCDD (: Doctoral Dissertation), 8/77.

76.

"Effects of TCDD on Mammalian cells in Tissue
Cultures," Tox. Appl. Pharmacol., 31, 2/75

77.

"Effect of Alteration of Hepatic Mixed Function
Oxidóse activity on the Toxicity of 2,3,7,8-TCDD to
Rats," Toxicol. Appl. Pharmacol., 31, 2/75.

78.

"Induction of DT-Diaphorase Activity of Rat Liver by
2.3.7.8- TCDD," Toxicol. Appl■ Pharmacol., 37(1), 1976.

79.

"Effect of Alteration of Rat Hepatic Mixed-Function
Oxidóse (MDF) Activity on the Toxicity of
2.3.7.8- TCDD," Toxicol. Appl. Pharmacol., 45(2), 8/78.

80 .

"The Effect of Folate Overdose and of 2,3,7,8-TCDD on
Kidney and Liver Respectively of Rate and Mouse
Embryos," Teratology, 8(2), 1973.

81.

"Porphyria Cutanea Tarda, Update 1978,"
4/78

-9 i

3/75.

Cutis, 21(4),

"Lack of Tumor-Promoting Ability of Certain
Environmental Chemicals in a Two-Stage Mouse Skin
Tumorgenesis Assay," Res. Commun. Chem. Pathol.
Pharmacol., 20, 4/78.
"Transplacental Induction of Mixed-Function Oxygenases
in Extra-Hepatic Tissues by 2,3,7,8-TCDD," Biochem.
Pharmacol. 26, 8/1/77.
"Studies with Chlorinated Dibenzo-p-dioxins,
Polybrominated Biphenls and Polychlorinated Biphenyls
in a Two-Stage System of Mouse Skin Tumorigenesis:
Potent Anticarcinogenic Effects," Ann. N.Y. Acad.
Scie., 320, 5/31/79.
"Transplacental Induction of Carcinogehydroxylating
Systems with 2,3,7,8-TCDD," Toxicol. Appl. Pharmacol.,
36, 6/76.
"Transplantal Induction of the Biotransformation of
Chemical Precarcinogens by 2,3,7,8-TCDD,"
Pharmacologist, 17, 8/20/75.
"Pharmacokinetics and Ecodisposition of
Polyhalogenated Hydrocarbons: Aspects and Concepts,"
Drug Metab. Rev. , 11(2), 1980.
"The AH Regulatory Gene Product: Survey of Nineteen
Polycyclic Aromatic Compounds' and Fifteen
Benzo(A)Pyrene Metabolites' Capacity to Bind to the
Cytosolic Receptor," Toxicology Letters, 10(1), 1/82.
89.. "Non-Hodgkin's Lymphoma of the Scalp in Workers
Exposed to Dioxins," (Letter), Lancet, 2(8242),
8/15/81.
"Enzymic Modification of Environmental Intoxicants:
The Role of Cytochrome P450," Qj_ Rev. Biophys ■,
11(4), 1978.
"Methylochloanthrene and TCDD-Induced Alterations In
Microsomal Electron Transport in Inbred Mice," Int.
Symp. Microsomes Drug Oxid., 1979.
"Preliminary Results of a Neurological Investigation
of the Population Exposed to TCDD in the Seveso
Region," Riv. Patol. Nerv. Ment., 99, 4/78.
"Influence of 2,3,7,8-TCDD on Respiration in a Forest
Floor and Soil," Bull. Environ. Contam. Toxicol.,
22(4-5), 7/79.

13869

• . iv .. .. •

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a,

z

94.

"In the Wake of Seveso," Ambio, 7 (5-6), 1978.

95.

"Induction and Inhibition of the Formation of
Benzo(A)Pyrene Metabolites that Covalently Bind to DNA
by Inbred Mice," Pharmacoloqist, 18(2), 1976.

96.

"Effects of Microsomal Enzyme Inducers In Vivo and
Inhibitors In Vitro on the Covalent Binding of
Benzo(A)Pyrene Metabolites to DNA Catalyzed by Liver
Microsomes from Genetically Responsive and
Non-Responsive Mice," Biochemical Pharmacoloqy, 28(1),
1979 .

97.

"Assessment of Myelotoxicity Caused by Environmental
Chemicals," Environ. Health Perspect, 43, 2/82

98.

"Influence of Mycoplasma Arginini Infection on the
Induction of Aryl Hydrocarbon Hydroxylase by TCDD in
Rat Hepatoma Cell Cultures," Food Chem. Toxicol.,
20(5), 10/82.

99.

"Aryl Hydrocarbon Hydrolase Activity of Twenty-three
Haloqenated Dibenzo-p-dioxins, " Toxicol. Appl .
Pharmacol., 37(1), 1976.

100 .

"Detection of Chlorinated Dioxins: Induction of Aryl
Hydrocarbon Hydroxylase Activity in Rat Hepatoma Cell
Culture," Toxicol. Appl. Pharmacol., 33(1), 1975.

101 .

"Lectin-Medicated Attachment Assay for Teratogens:
Results with 32 Pesticides," J. Toxicol. Environ.
Health, 11, 1983.

V

102.

"Studies on Dioxin Emissions from Municipal Waste
Incinerators in Northrine-Westphalia," Enerqy Res.
Abstr., 7(24), 1982.

j

103.

"Genetic Effects of TCDD In Vitro and In Vivo Using D7
Strain of S. Cerevisial," Mutat. Res., 74(3), 1980.

104 .

"Organs as Targets of "Dioxin" (2,3,7,8-TCDD)
Intoxication,: Naturwissenschaften, 59(4), 4/72.

105.

"Enzymatic Functions as Targets of the Toxicity of
"Dioxin (2,3,7,8-TCDD)," Naturwissenschaften, 59(4),
4/72.

106.

"Canceromimetic Properties of 2,3,7,8-TCDD," CR. Acad.
Sci. , 272(10), 3/8/71.

' ■ "*>

i y 'L

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1

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i

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•*v.

107.

"The Mechanism by Which Chlorinated Hydrocarbons
Stimulate Liver Growth," Toxicology Research
Projects.Pi.. 5(ISS 11), 1980.

108.

"Laboratory Investigation for the Microbiological
Degradation of 2,3,7,8-TCDD in Soil by Addition of
Organic Compost," Pergamon Ser. Environ. Sci.,
5(PSSID2), 1982.

109.

"Effect of Exposure to Chemical Contaminants on
Susceptibility to Infection by Pathogenic Organisms,"
Toxicology Research Projects Pi., V, 4(5), 1979.

110.

111.

112.

"Induction of Mixed-Function Oxidase by Chronic
Treatment with 2,3,7,8-TCDD in Female Rats,"
Toxicology, 21, 1981.
"Porphyrogenic Effect of Chronic Treatment with
2,3,7,8-TCDD in Female Rats: Dose-effect Relationship
Following Urinary Excretion of Porphyrins," Tox. Appl.
Pharmacol., 57, 1981
"Analysis of Exposure to Environmental Contamination
by TCDD in Individuals Affected by Dermatological
Lesions," IG. Mod., 77, 1982.

113.

"Characterization and Regulation of an Intra-cellular
Receptor Protein for Co-Carcinogens: A Receptor
Regulating Chemical Initiation of Cancer," Cancer
Treat. Rep., 63(7), 1979.

114 .

"Ontogeny of the Rat Hepatic Receptor for 2,3,7,8-TCDD
and its Endocrine Independence," Cancer Res., 39(11),
11/79.

115.

"Interaction of the Hepatic Receptor Protein for
2,3,7,8TCDD with DNA," Biochem. Acta, 672, 1981.

116.

"TCDD: An Accidental Poisoning Episode in Horse
Arenas," Science, 188(4189), 5/16/75.

117.

"Analysis of Transport and Ground Deposition of the
TCDD Emitted on 10 July 1976 from the ICMESA Factory
(Seveso, Italy), Atmospheric Environment, 16(4), 1982.

118.

"Application of a Battery of Microbial Bioassays to
Evaluation of the Genotoxic Response of a Contaminated
Herbicide 2,4,5-T Containing Dioxin," Environ
Mutagenesis, 4, 1982.

-12-

13871

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119.

"Electronic Factors Affecting Receptor Binding of
Dibenxop-Dioxins and Dibensofurans," Int. J . Quantum
Chem., XVI, 1979.

120.

"Cardiovascular Teratogenicity of 2,3,7,8-TCDD in the
Chick Embryo," Tox. Appl. Pharmacol., 61, 1981

121.

"Relationship Between Induction of Aryl Hydrocarbon
Hydroxylase and de Novo Synthesis of Cytochrome P-488
(Pi-450) in Mice," Chem. Biol. Interact., 15, 9/76.

122.

"Selection of Inducers: An Important Factor in
Characterizing Genetic Differences to Induction of
Aryl Hydrocarbon Hydrolase in Strains of Mice," Life
Sci., 15, 1974.

123.

"Fouling One's Own Nest,"

124.

"Selective Suppression of Cytotoxic T-Cell (CTL)
Generation by Halogenated Aromatic Hydrocarbons,"
Fed. Proc. Fed. Am..Soc. Exp. Biol., 40 (3PT2), 1981.

125.

"Enhanced Suppressor Cell Activity as a Mechanism of .
Immunosuppression by 2,3,7, 8-TCDD," Proc. Soc. Exp.
Biol. Med., 168, 11/81.

126.

"Embryotoxicity of Chemical Contaminants in Foods,"
Food Cosmet . Toxicol., 9(12), 4/71.

127.

"Ultrastructural Comparison of Liver Tissues From
Field and Laboratory TCDD-Exposed Beach Mice,"
Environ. Sci. Res., 26, 1983.

128.

"Do Phenoxy Herbicides Cause Cancer in Man?"
1 (8280), 5/8/82.

129.

"Teratogenic Studies with 2,4,5-T and 2,4-D in the
Hamster," Bull. Environ. Contam. Toxicol., 6(6), 12/71.

130.

"A Hot Wind From the North,"
11/76.

131.

"US Air Force Studies on the Stability and Ecological
Effects of TCDD: An Evaluation Relative to the
Accidental Dissemination of TCDD at Seveso, Italy,"
(Part III; Summary and Conclusions and Appendix Only),
11/13/76.

132.

"Alteration of Cellular Utilization of Thymidine by
2,3,7,8-TCDD," Bull■ Environ. Contam. Toxicol., 13,
1/75 .

'"N

-1 3 -

Pediatrics, 62(4), 1978.

Lancet,

Hosp. Pract., 11(11),

j,9

I

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.3

t

133.

"Dioxin, Chloracne and Soft Tissue Sarcoma," Lancet,
1(8220 PT1), 3/14/81.

134.

"Mortality Experience of Employees Exposed to
2,3,7,8-TCDD," Jom, 22, 1980.

135.

"Inhibition by CO of Hepatic Benzo(A)Pyrene
Hydroxylation and Its Reversal by Monochromatic
Liqht," Eur. J. Biochem, 74, 3/15/77.

136.

"Continuing Uncertainties Overt 2,4,5-T," Food
Cosmet. Toxicol., 12, 1974.

137 .

"Dioxin: Teratogenicity and Reproductive Effects,"
Food Cosmet. Toxicol., 19(1), 1981.

138.

"Teratoqenic Evaluation of 2,4,5-T," Science, 168,
5/15/70.

139 .

"Mouse Teratology Studies with
Chlorodibenzo-p-dioxins, " Bull. Environ. Contam.
Toxicol., 16(6), 12/76.

140.

"Metabolic Studies with TCDD-Treated Rats,"
Environ. Contam. Toxicol., 7, 1978.

141 .

"Neuropsychopharmacological Effect of TCDD," (Original
paper in Italian), Boll. Soc . It. Biol. Sper, 54, 1978.

142.

"Pathological Effects of 2,3,7,8-TCDD on the Common
Bile Duct of Rats," Fed. Proc. Fed. Am. Soc. Exp.
Biol. , 36(3), 1977

143 .

"Environmental Deqradation of 2,3,7,8-TCDD," Science,
195(4284), 3/25/77.

144.

"The Hazards of Impurities," Environment,

145.

"Soft Tissue Sarcomas and Chlorinated Phenols,"
Lancet, 2(8242), 8/15/81.

146.

"Chloracne and Its Potential Clinical Implications,"
Clin. Exp. Derm. , V.6, 1981

147.

"Chloracne - An Up-To-Date Assessment,"
Hyq. , 21(3), 12/78.

148.

"Effect of TCDD on Growth Rate and the Synthesis of
Lipids and Proteins in Rats," Bull. Env. Contam.
Toxicol., 7, 1972.

Arch.

15(5), 1973.

Ann. Occup.

S

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••

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••/

149.

"Dioxin: An Emotive Word," Nature,

150.

"Update of 2,4,5-T,"

151.

"Toxicology of the Immune System," Histochem, J., 1 3 ,
1981.

284 (5751), 3/6/80.

Down Earth, 36(2), 1980.

152.

"Assessment of Immunobiological Effects Induced By
Chemicals, Drugs or Food Additives; Tier Testing and
Screening Approach," Drug Chem. Toxicol., 2, 1979.

153.

"Assessment of Immunotoxicity Induced by Environmental
Chemicals 2,3,7,8-TCDD, DES and Benzo(A)Pyrene," Adv.
Immunopharmacol. Proc. Int. Co., 37-50, 1981.

154 .

"Induction of Aldehyde Dehydrogenases,"
Pharmacol■, 27, 1978.

155.

"Induction of Different Rat Liver Supernatant Aldehyde
Dehydrogenases by Phenobarbital and TCDD," J .
Biol. Chem., 252, 9/10/77.

156 .

"Polychlorodibenzo-p-dioxins," Toxicology, 3, 1975.

157.

"Disposition of Chemicals in the Developing Embryo and
Fetus," Int. J. Biol. Res. Pregnancy, 3, 1982.

158 .

"Association Between the Presence of the AH Receptor
in Embryonic Murine Tissues and Sensitivity to TCDD
Induced Cleft Palate," Teratog. Carcinog. Mutagen., 1,
1981.

159.

"Effects of Polychlorinated Biphenyl Compounds, 2,3,7,
8-TCDD, Phenobarbital and Iron on Hepatic
Uroporphyrinogen Decarboxylase: Implications for the
Pathogenesis of Porphyria," Biochem, J ., 214, 1983.

160.

"Letter: Dangers of TCDD," Lancet, 2 (7981), 8/14/76.

161 .

"PCP Dioxins Found to Pose Health Risks," Nature,
283. (5746), 1/31/80.

162.

"Accidental Release of 2,3,7,8-TCDD at Seveso:
Assessment of Environmental Contamination and of
Effectiveness of Decontamination and of Effectiveness
of Decontamination Treatments," Codata Bui., 29, 1978.

163.

J. Biochem.

"Accidental Release of 2,3,7,8-TCDD at Seveso, Italy,
IV: Vertical Distribution of TCDD in Soil,"
Ecotoxicol Environ. Saf., 4(3), 1980.

-15-

138 4
’

•«k.

164.

"Tumor Initiating Activity of 9- and 10-Fluoro-7, 12
Dimethylbenz(A) anthracene (DMBA) and The Effect of
2,3,7,8-TCDD on Tumor Initiation by Monofluoro
Derivatives of DMBA in Senear Mice"/ Carcinogenesis,
4, 1983.

165.

"Time-Dependent Inhibition by TCDD of Skin
Tumorigenesis with Polycyclic Hydrocarbons," Cancer
Res., 40, 5/80

166.

"Effects of Pretreatment with 2,3,7,8-TCDD on the
Capacity of Hepatic and Extrahepatic Mouse Tissues to
Convert Procarcinogens to Mutagens for Salmonella
Typhimurium Auxotrophs," Toxicol■ Appl. Pharmacol.,
50(2), 9/15/79.

167.

"The Effects of 2,3,7,8-TCDD and Aroclor 1254 on 7,
12-DMBA Metabolism and Tumor Activity in Mouse Skin,"
(Meeting Abstract), Proc. Am. Assoc. Cancer Res., 19,
1978.

168.

"Tumor-Initiating Ability of 2,3,7,8-TCDD and Arochlor
1254 in the Two-Stage System of Mouse Skin
Carcinogenesis," Bull. Environ. Contam. Toxicol., 18,
11/77.

169.

"Enhancement of the Skin Tumor-Initiating Activity of
Polycyclic Aromatic Hydrocarbons by
Methyl-Substitution at Non-Benzo 'Bay-Region'
Positions," Carcinogenesis, 4, 1983.

170.

"2,3,7,8-TCDD Potent Anticarcinogenic Activity in CD-I
Mice," Biochem. Biophys. Res■ Comm., 86, 2/14/79.

171.

"The Study of X-Rays and TCDD Effects on Satellite
Associations May Suggest a Simple Model for
Application in Environmental Mutagenesis," Hum.
Genet., 61(1), 1982.

172.

"Non-Teratogenicity of 2,4,5-T in Monkeys Mucaca
Mulatta," Toxicol. Appl. Pharmacol., 25(3), 1973.

173.

"The Non-Teratogenicity of 2,4,5-T in the Rhesus
Monkey (Mucaca Mulatta), "Bull Environ. Contam.
Toxicol., 13, 1973.

174.

"Mutagenic, Teratogenic and Carcinogenic Properties of
Pesticides," Annual Rev. Entomol., 17, 1972.

175.

"Comparative Biochemistry of Benzo(A) Pyrene Resistant
Mouse Hepatoma Cell Mutants," J . Cell Biol., 91 (2
Part 2), 11/13/81.

-1 6 -

^

■

9
176.

"Immunoreactive Uroporphyrinogen Decarboxylase is
Unchanged In Porphyria Caused by TCDD and
Hexachlorobenzene," Biochem Biophys Res. Commun., 109,
11/16/82.

177.

"Neurochemical Effects of 2,3,7,8-TCDD in Wistar and
Gunn Rats," Res. Commun. Chem. Pathol. Pharmaco., 18,
11/77.

178.

"Teratogenic Study of 2,4,5-T in the Rat," Toxicol.
Appl. Pharmacol., 17, 1970.

179.

Teratogenic Study of 2,4,5-T in- the Rat and Rabbit,"
Teratology, 4, 1971.

180 .

"Teratological Hazards Due to Phenoxy Herbicides and
Dioxin Contaminants," Environ. Sci. Research, 2, 1973.

181.

"Case Control Study of Malignant Mesenchymal Tumors of
the Soft Tissue and Exposure to Chemical Substances".
Lakartindningen, 76, 1979.

182 .

"Modulation of Immune Function by Chemicals of
Environmental Concern," Environ Health Perspect, 20,
10/77.

183.

"Chemical Separation of Helper Cell Function and
Delayed Hypersensitivity Responses," Cell. Immunol.,
40, 10/78.

184 .

"Impairment of Thymus-Dependent Immune Functions By
Exposure of the Developing Immune System to TCDD," J .
Tox. Environ. Health, 3, 10/77

185.

"2,3,7,8-TCDD Levels in Cow's Milk From The
Contaminated Area of Seveso, Italy," Bull. Environ.
Contam, Toxicol., 24(4), 4/80.

186.

"TCDD Contamination in the Seveso Incident," Drug
Metab. Rev. (3), 1982.

187.

"Mutagenesis of Certain Activated Carcinogens in
Vitro, Associated with Genetically Mediated Increases
in Monoxygenase Activity and Cytochrome Pl-450," J.
Biol. Chem, 250, 1975.

188.

"The 2,3,7,8-TCDD: A Review," Eco. Bull, 27, 1978.

189.

"Dioxins as Food Contaminants," Toxicology Research
Projects D1., 6 (ISS 11), 1981.

-17-

”0

190.

"Mutagens and Potential Mutagens in the Biosphere: (I)
DDT and its Metabolites, Polychlorinated Biphenyls,
Chlorodioxins, Polycyclic Aromatic Hydrocarbons and
Haloethers," Sei. Total Envir., 4, 7/73.

191.

"Relative Toxicity of Chick Edema Factors", Poult
Sei., 52, 1973.

192.

"TCDD Induction of Renal Microsonal Enzyme Systems:
Ultrastructural Effects on Pars Recta (S3) Proximal
Tubule Cells of the Rat Kidney", J. Pharmacol. Exp.
Ther., 203, 12/77.

193.

"TCDD Induction of Renal Microsomal Enzyme Systems",
Toxicol. Appl. Pharmacol. 33(1), 1975.

194 .

"Ultrastructural Changes in Rat Liver Cells Following
a Single Oral Dose of TCDD", Environ. Health
Perspect., 5, 9/73.

195.

"Research Solving Body's Detoxifying System: P-450
Enzymes Rival The Immune System of the Body in
Complexity and May Explain How Toxins Such as Dioxin
Exert Their Effects:, Chem. Eng. News, 6/4/79.

196.

"Induction, Inhibition and Biological Properties of
Aryl Hydrocarbon Hydroxylase in a Stable Human
B-Lymphocyte Cell Line, RPM1-1788", Cancer Res., 39
(11), 11/79.

197.

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Workers Exposed to Dioxin in 1953", Am. J. Epidemiol.,
114 (3), 6/19/81.

198.

"Retention and Excretion of 2,3,7,8-TCDD By Rats", J .
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199.

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200.
201.
202.
203.

"The Ungreening of South Vietnam", Nat. Hist., 83(6),
1974 .
"Notes on Xenobiotic Metabolism", Ann. N.Y. Acad.
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"TCDD Toxicology with Particular Reference to Seveso:
Introductory Remarks", Drug Metab. Rev., 13(3), 1982.
TCDD Poisoning at Seveso", Biomedicine, 26(1), 2/77.

-18-

204.

"Absorption, Distribution and Metabolism of
2,3,7,8-TCDD in Experimental Animals", Environ. Sci
Res., 26, 1983.

205.

"The Effect of Total Parenteral Nutrition on the
Toxicity of 2,3,7,8-TCDD in the Rat", Fed. Proc., 38
(3 part 1), 1979.

206.

"The Examination and Quantitation of Tissue Cytosolic
Receptors for 2,3,7,8-TCDD Using Hydroxylapatite",
Anal. Biochem.. 124(1), 7/15/82.

207.

"Pharmacokinetic Studies in Evaluation of the
Toxicological and Environmental Hazard of Chemicals",
Adv. Med. Toxicol., 1 (Part 1), 1976.

208.

"Pharmacokinetics: First Order or Zero Order," Food
Cosmet Toxicol., 14(6), 12/76

209 .

"The Fate of 2,4,5-T Following Oral Administration to
Man", Toxicol. Appl. Pharmacol., 26, 1973.

210 .
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212.

"Chloracne and Clinical Impariment in a Group of
Subjects Over 14 Years of Age, Exposed to TCDD in the
Seveso Area," Ig. Mod., 77, 1982.
"Chloracne Due to TCDD in Children," Ann. Dermatol
Venerol., 104, 12/77.
"Effects of 2,3,7,8-TCDD Administered to Pregnant Rats
During the Preimplantation Period," Env. Res., 29,
10/82.

213 .

"Rabbit Teratology Study with 2,3,7,8-TCDD," Environ.
Res., 27 (1), 2/82.

214 .

"Perinatal Nephropathies", Environ Health Perspect,
15, 6/76.

215.

"Genetic Effects of Chlorinated Anilines and
Azobenzenes on Salmonella Typhimurium", Arch. Environ.
Contam. Toxicol., 9(5), 1980.

216.

"Extremely Severe Acute Chloracne Due to TCP
Decomposition Products: A Contribution to the Perna
Problem," Arbeitsmedizan. Soc. A r ., 7, 1972.

217.

"Assessment of the Contribution of Chlorinated
Dibenzo-pdioxins and Dibenzofurans to
Hexachlorobenzene-Induced Toxicity, Porphyria, Changes
in Mixed Function Oxygenases and Histopathological
Changes," Toxicol. Appl. Pharmacol, 46, 12/78.

-19-

A <

' *«v

218.
219.

220 .

"Induction of Hepatic Porphyria and Drug Metabolizing
Enzymes by 2,3,7,8-TCDD," Fed. Proc., 35 (3), 1976
"The Structure-Activity Relationships of Halogenated
Biphenyls as Enzyme Inducers," Ann. N.Y. Acad. Sci..
320, 5/31/79.
"Cytogenetic Effect of 2,3,7,8-TCDD on Rat Bone Marrow
Cells," FDA By-Lines, 6, 5/77.

221 .

"Biochemical and Morphological Changes Induced by TCDD
in the Rat Liver Cell Plasma Membrane," J ■ Appl.
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222.

"Effect of 2,3,7,8-Tetrachlorodibenzo-l,4,-dioxin on
Drug Metabolism in the Rat," Biochem. Pharmacol., 21,
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223.

"The Toxicology of 2,3,7,8- TCDD and Its Structural
Analogues," Ann. Occup. Hyg. 22, 1979.

224 .

"Toxic Effects of TCDD," Food Cosmet. Toxicol., 11,
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225.

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226.

"Estimation of Isozymes of Microsomal Cytochrome P 450 in Rats, Rabbits and Humans Using Immunochemical
Staining Coupled with Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis," Biochemistry, 21,
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227.

"Cytosolic Receptor for H Locus: Evidence for
Regulatory Gene Dysfunction in Nonresponsive Cell
Cultures Containing The Receptor," (Meeting Abstract),
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228.

"Evidence in Rat and Mouse Liver for Temporal Control
of Two Forms of Cytochrome P-450 Inducible by
2,3,7,8-TCDD," Eur. J. Biochem., 15, 11/15/78.

229 .

"Evidence for Possible Receptors Active in Aryl
Hydrocarbon Hydroxylase Induction in Established Cell
Lines by 2,3,7,8-TCDD," Fed. Proc. (Fed. Am. Soc. Exp.
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230.

"2,3,7,8-TCDD Covalent Binding of Reactive Metabolic
Intermediates Principally to Protein in Vitro,"
Pharmacology, 19, 1979.

-2 0 /

*\

V

231.

"Effects of 2,3,7,8-TCDD on the Distribution and
Biliary Excretion of Polychlorinated Biphenyls in
Rats," Toxicol. Appl. Pharmacol., 45(2), 8/78.

232.

"Pathologic Effects of 2,3,7,8-TCDD in Laboratory
Animals," Environ. Health Perspect., 5, 9/73.

233.

"Genetic Expression of Aflatoxin B1 Metabolism:
Effects of 3-Methylcholanthrene and 2,3,7,8-TCDD on
the Metabolism of Aflatoxins B1 and B2 By Various
Inbred Strains of Mice," Mol. Pharmacol., 18(2), 1980.

234.

"Mechanisms Involved in Tissue Responsiveness to
Chemical Carcinogens and in Formation of Carcinogenic
Metabolites From Aromatic Hydrocarbons," Toxicoloqy
Research Proiects D i ., 4, 1979.

235.

"Studies On the Induction of Sister Chromatid Exchange
in Human Fibroblasts by DES," (Meeting Abstract),
Clin. Genet., 14(5), 1978.

236.

"Effect of Microsomal Enzyme Inducers on 2,3,7,8-TCDD
Induced Depression in the Biliary Excretion of Ouabian
in Rats," Druq Metab. Dispos.. 6, 8/78.

237.

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to Phenoxyacids or Chlorophenols," Lancet, 1 (8286),
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238.

"Case-Control Study: Soft Tissue Sarcomas and
Exposure to Phenoxyacetic Acids or Chlorophenols," B r .
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239 .

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to Phenoxyacetic Acids or Chlorophenols," (Letter to
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240.

"General Biological Effects of TCDD in Laboratory
Animals," Environ. Health Perspect, V.5, 9/73.

241.

"A Field Study of Soil and Biological Specimens From A
Herbicide Storage and Aerial-Testing Staging Site
Followinq Lonq-Term Contamination with TCDD," Environ.
Sci. Res., 26, 1983.

242.

"Activity of Various Aldehyde-Metabolizing Enzymes in
Chemically Induced Rat Liver Hepatomas," Biochem.
Pharmacol., 31, 3/15/82.

243 .

"Induction of Multiple Forms of Mouse Liver Cytochrome
P-450," J. Biol. Chem., 251, 1976.

13880
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244 .

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245.

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246.

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247.

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248.

"Dioxin Source is 'Safe'," Nature, 274 (5671), 8/10/78.

249 .

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250 .

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284.(5751), 3/6/80.

251.

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252.

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253 .

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254 .

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255.

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256.

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257.

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258.

"Carcinogen Induction of Cytochrome-P448-Associated
Enzymes: Detection By In Vivo Breath Analysis," Clin.
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259 .

"Sequential Histopathologic, Hematologic and Blood
Chemistry Changes Induced in Mice By a Technical and a
Purified Preparation of 2,4,5-T," J. Toxicol. Environ.
Health, 1(3), 1/76.

260 .

"2,3,7,8-TCDD Elimination in the Rat: First Order or
Zero Order?" Food, Cosmet. Toxicol., 14(6), 12/76.

-2 2 -

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261.

"Immunotoxicity Assessment of Dioxins," HHS Pub. FDA.
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262.

’’Suppression of Host Defenses by Chlorinated
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263.

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264.

"Survey of the Death Causes in Forest Workers With and
Without Exposure to Phenoxyacid Chemicals,"
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265.

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266.

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2,3,7,8-Tetrachlorodibenzo-P-Dioxin", Biochem
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267.

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268.

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Metabolism of 2,5,2',5’-Tetrachlorobiphenyl (TCB), A
Component of Carcinogenic Polychlorinated Biphenyl
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269.

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Cutaneous Changes Induced by Topical Application of
Established Chloracnegens", Tox. Appi. Pharmacol, 64,
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270.

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Rat", Toxicol. Appi. Pharmacol, 61 (1), 8/82.

271.

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272.

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273.

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274.

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Decarboxylase and Aryl Hydrocarbon Hydroxylase
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J

f

9

/■ V

275.

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Eng. News. 58, 2/11/80.

276.

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Scientists and Regulators Examine Dow Chemical's
Claims That Most Dioxins Enter the Environment From
Combustion, Not Pesticides Manufacture", Chem. Eng.
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277.

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of 2,4-Diaminoanisole", Mutat. Res., 79, 1980.

278.

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279.

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280.

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281.

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282.

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283.

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Poisoning in the Seveso, Area", Placenta, 2, 3/81.

284.

"Mass Spectrometry in Toxicology : 1. Calculation of
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285.

"Mortality and Cancer Morbidity Among Chlorinated
Phenoxyacid Applications in Finland", Chemosphere, 12,
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286.

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Incinerator", Chemosphere, 12, 1983.

287.

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288.

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Fertility", Brit. Med. Bull, 26, 1970.

/~s

S\

289.

"The Sources and Routes of Childhood Chemical
Exposures", J . Pediatr., 97(5), 11/80.

-24l

*

290.

"Phénobarbital and Tetrachlorodibenzo-P-Dioxin Induce
Different Isoenzymes of Aldehyde Dehydrogenase", Fed.
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291.

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Oral Doses to Rats", Toxicol. Appl. Pharmacol, 33,
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292.

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293.

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294.

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295.

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on Sucubation With Isolated Rat Hepatocytes", Biochem.
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396.

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Hydrocarbon Hydroxylase and EthoxyresorufinU-Deethylase Enzyme Activities in Rat Hepatoma Cells",
Toxicol Letters, 13, 9/83.

397.

Cytogenetic and Genotoxic Studies on Rabbits, Cattle,
Mice, Rats and Human Cells Accidentally or
Experimentally Exposed to the Dioxin TCDD", Mutât■
Res., 83, 1981.

398.

"Activation of Nitrosamines to Mutagens by
Postmitochondrial Fraction of Hamster Pancreas",
Cancer Res., 40, 1/80.

399.

"Metabolism of the Pancreatic Carcinogin n-Nitroso-2,
6-Dimethylmorpholine by Hamster Liver and Component
Cells of the Pancreas, Cancer Res., 42, 1982.

300.

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Liver Microsomal Systems and In Living Mice", Arch.
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301.

"Effects of Selected Induction of Microsomal and
Nuclear Aryl Hydrocarbon Monooxygenase and Epoxidce
Hydrolase As Well as Cytoplasmic Glutathione-s-Epoxide
Transferase on the Covalent Binding of the
Carcinogenic Benzo-A-Pyrene to Rat Liver DNA In Vivo",
J. Cancer Res. Clin. Oncol., 98, 1?80.

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•fl •

302. f

"Time Course for the Induction of Aryl Hydrocarbon
Hydroxylase in Rat Liver Nuclei and Nicrosomezs by
Phénobarbital, 3 Methylcholanthrene, 2,3,7,8Tetrachlorodibenzo-P-Dioxin, Dieldrin and Other
Inducers", Biochem. Pharmacol., 27, 1978.

304.

"Methods to Monitor TCDD Presence in Atmosphetic
Particulate in the Seveso Area", Ann. 1st. Super
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305.

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(TCDD) in C57B1/6 Mice", Toxicol'. Appl. Pharmacol.,
29, 74.

306.

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Testing", Vet. Quart., 3, 10/81.

307.

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Mechanixms", Ecol. Bull., 27, 78.

308.

"Immune Suppression as Related to Toxicology", CRC
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309.

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Maternal Treatment with TCDD", Int. Arch Allerq. Appl.
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310.

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Mechanisms", Ecol. Bull., 27, 78.

311.

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Animals, Environ. Health Perspec., 5, 9/73.

312.

"Studies on 2,3,7,8-Tetrachlorodibenzo-P-Dioxin
Induced Immune Suppression and Decreased Resistance to
Infection: Endotoxin Hypersensitivity, Serum Zinc
Concentrations and Effect of Thymosin Treatment",
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313.

"Some Effects of 2,4-D and 2,4,5T on Ehrlich Ascites
Tumor Cells in Vivo and ih Vitro", Industr. Med., 41,
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314.

Sampling and Analytical Methodologies for PC DDs and
PCDFs in Incenerators and Wood Burning Facilities",
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315.

"Properties of Hypolipidemic Peroxisome Proliferators
in the Lymphocyte (3H) Thymidine and Salmonella
Mutagenesis Assays", J . Cancer Res., 40, 80.

-26-

-<%
»

316.

A Review of the Genetic Toxicology of Chlorinated
Dibenzo-P-Dioxins", Mutat. Res., 47, 78.

317.

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Concentration in Rat Liver", Drug Metab. Dispos.,
VII/l, 83.

318.

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Rat Liver UDP-Glucuonosyltransferases", Tox. Appl.
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319.

"Negative Finding of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin in Cooked Fat Containing Actual and
Fortified Residues of Ronnel and/or 2,4,5-Trichlorophenol", J. Ass. Offic. Anal. Chem., 56/4, 73.

320.

"Fate of 2,3,7,8 Tetrachlorodibenzo-p-Dioxin
Metabolites from Dogs in Rats", Xenobiotica, 12, 6/82.

321.

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Pigs", Toxicol. Lett. (Netherlands), 14, 11/82.

322.

"Contact Acne: A Typical Civilizational Dermatosis",
Derm. Beruf. Umwelt, 26, 78.

323.

"Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Upon
Hemostasis and Hematologic Function in the Rat",
Environ. Health Perspect., 5, 9/73.

324 .

"Application of a Bioassay for the Determination of
Picogram Levels of 2,3,7,8-Tetrachlorodibenzo-pDioxin", Naunym-Schmiedeberg's’Arch. Phar ■, 302
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325.

"Inhibition in Vivo of the Formation of Adducts
Between Metabolites Benzo-Pyrene and DNA by Aryl
Hydrocarbon Hydroxylase Inducers", Cancer Res., 41,
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326.

"Interrelations of. Humans, Dogs, and Rodents",
Science, 176, 1/24/72.

327.

"Studies of the Effects of 2,3,7,8Tetrachlorodibenzop-Dioxin on Mammalian Hepatic Delta-Aminolovulinia
Acid Synthetase", Env. Health Perspect., 5, 9/73.

328.

"Occupational Health 4: Clouds of Misery", Nurs.
Mirror, 151/8, 8/21/80.

329.

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Hydrocarbon Hydrolase of Rats and Mice", Chem-Biol■
Interactions, 37, 11/81.
^
----------133'^

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<? .

330.

"Effect of Halogenated Dibenzo-p-Dioxins on Plasma
Disappearance and Biliary Excretion of quabain in
Rats"/ Toxicol. Lett., 15/2-3, 2/83.

331.

"Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin of
Plasma Disappearance and Biliary Excretion of Foreign
Compounds in Rats", Toxicol. Appl . Pharmacol., 40,
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332.

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on Primary Cultures of Adult Rat Hepatocytes", Arch.
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333.

""Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)
on Plasma Disappearance and Biliary Exretion of
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334.

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Aquatic Model Ecosystem", Chemosphere, 7/3, 78.

335.

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in an Ecosystem Treated with Massive Quantities of
2,4,5 T Herbicide", Proc■ West . Soc ■ Weed Sci., 34,
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336.

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TCDD in a natural Ecosystem", 26, 83.

337.

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Human Adipose Tissue", Proc. Symp. Public Health
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338.

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339.

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340.

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2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Laboratory
Animals", Environ. Health Perspect., 5, 9/73.

341.

"Contamination of the Bay of Fundy-Gulf of Maine Area
with Polychlorinated' Biphenyls, Polychlorinated
Tertphenyls, Chlorinated Dibenzodioxins, and
Dibenzofurans", Environ. Health Perspect., 1, 4/72.

A

/-\

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342.

"Application of a New Bioassay to Screen the Toxicity
of Polychlorinated Biphenyls on Blue-Green Algae",
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343.

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Vitamin A-Deficient Rats", Chemosphere, 12, 83.

344.

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Hepatic Storage of Retinol in Rats with Different
Dietary Supplies of Vitamin A Retinol, Arch. Toxicol.,
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345.

"Effects of Dietary Vitamin A (Retinol) on the
Reduction of Hepatic Retinol Storage Caused by
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Environ. Sci., 8, 80.

346.

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P-450 Content by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin",
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347.

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348.

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349.

"Carcinogenic Bioassay of the Herbicide 2,4,5-Trichlorophenoxyethanol (TCPE) with Different 2,3,7,8-Tetra­
chlorodibenzo-p-Dioxin (Dioxin) Content in Swiss Mice,
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350.

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351.

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352.

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353.

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Sources and Define Background Levels of Dioxins in the
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138&8

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4»'
354 .

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Environment: An Update and Extension of the Present
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355.

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356.

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Cell Cultures by Aroclors, Residues from Yusho Oil
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357 .

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358 .

"Rapid Vertical Tube Rotor Gradient Assay for Binding
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Receptor", Can. J. Physiol. Pharmacol., 59/9, 9/81.

359.

"The Experimental Approach to Teratogenicity",
Ecotoxicol. Environ. Safety, 4/4, 12/80.

360 .

"The Seveso Accident: Present Data on the Human Preand Postnatal Development", Bull. Acad. Nat. Med.,
162, 78.

361 .

Quantitation of Hepatic Cytochrome PI-450 mRNA with
the Use of a Cloned DNA Probe: Effects of Various
P-450 Inducers in C57BL/6N and DBA/2N Mice", Mol.
Pharmacol., 22, 82.

362 .

"Rat Metabolism of Polychlorinated Dibenzo-p-Dioxins",
Chemosphere, 7, 78.

363.

"Primary Liver Cancer in Vietnam", Chirurqie, 99,
5/16/73.

364 .

"Liver Morphology in Guinea Pigs Administered Either
Pyrolysis of a Polychlorinated Biphenyl Transformer
Fluid or 2,3,7,8-Tetrachlorodibenzo-p-Dioxin",
Toxicol. Appl . Pharmacol., 67, 3/15/83.

365.

"Quantitative and Qualitative Changes in the
Metabolism of Benzo(A)Pyrene in Rat Tissues After
Intraqastic Administration of TCDD" , Toxicol . Appl .
Pharmacol., 46, 12/78.

366.

"The Metabolism of 3H-Benzo(A)Pyrene by Hepatic
Microsomes from Rats Treated with Tetrachlorodibenzop-Dioxin", Arch. Toxicol. (Suppl. 1), 259, 78.

•

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13 8 £9

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367

"Induction and Suppression of Hepatic and Extrahepatic
Microsomal Foreign Compound-Metabolizing Enzyme
Systems by 2,3,7,8-TCDD", Chem.-Biol. Interactions,
10, 3/75.

368.

"Stimulation and Suppression of Hepatic and
Extrahepatic Microsomal Mixed-Function Oxidases
(MFD's) by 2,3,7,8-TCDD", Toxicol■ Appl. Pharmacol.,
33, 1975.

369.

"2,3,7,8-TCDD-Induced Changes in the Hydroxylation of
Biphenyl by Rat Liver Microsomes", BiochemPharhmacol., 24, 1975.

370

"Dioxin Dangers to Man", (News), Food Cosmet Toxico l ■,
18/5), 10/80.

371

"The Agent Orange Controversy: Physician's Dilemma",
Wisconsin Medical Journal, 80(3), 3/81.

372

"A Wire Reclamation Incinerator as a Source of
Environmental Contamination with TCDD's and TCDF's",
Arch. Environ. Health , 36(5), 9/81.

373

"Liver Microsomal DT-Diaphorase Solubilization and
Purification", Fed. Proc., 36(3), 1977.

374

"Health Hazards From Chemical Impurities: Chlorinated
Dibenzodioxins and Chlorinated Dibenzofurans", In t . J .
Environ. Stud., 6(1), 1974.

375

"Chlorinated Dibenzodioxins and Dibenzofurans",
Environ. Health Perspect., 5, 9/73

376

"Mutagenic Effects of TCDD on Bacterial Systems",
Ambio, 1, 1972.

377

Effect of 2,3,7,8-TCDD on the Biliary Excretion of
Indosyanine Green in Rat", Environ. Health Perspect.,
5, 9/73.

378

"An Estradiol-Responsive Mouse Endometrial Cell Strain
with Inducible Aryl Hydrocarbon Hydroxylase Activity",
J. Cell Physiol■, 116, 8/83.

379

"Induction of mRNA Specific for Cytochrome) P-450 in
Wild Type and Variant Mouse Heptoma Cells", J. Biol.
Chem., 258, '9/10/83.

380

"Regulation of Mitosis: 3 Cytological Effects of
2,4,5-T and of Dibenzofurans Contaminants in 2,4,5T
Formulations", J . Cell Sci., 10, 1/72.

-31-

381.

"The Influence of Malnutrition on the Toxicity of
2.3.7.8- Tetrachlorodibenzo-p-Dioxin (TCDD) in Rats,
Toxicology, 21, 1981.

382.

"Epidemiological Case Control Study in Personnel
Exposed to 2,4,5--T", Chemosphere, 12, 1983.

383.

"Role of the Endocrine System in the Action of
2.3.7.8- Tetrachlorodibenzo-P-Dioxin (TCDD) on the
Thymus", Toxicology, 15, 1980.

384.

"Increased Incidence of Neoplasms in Rats Exposed to
Low Levels on TCDD", Chemosphere, 6, 1977.

385.

"Chronic Toxicity of 2,3,7,8-Tetrachlorodibenzo-PDioxin in Rats", Fed. Prog. Fed. Am. Soc. Exp. Biol.,
36/3, 1977.

386.

Tissue Distribution and Excretion of Tritiated
Tetrachlorodibenzo-P-Dioxin in Non-Human Primates and
Rats", Food Cosmet. Toxicol., 14, 1/76.

387.

Tetrachlorodibenzo-P-Dioxins in Chemical Wastes,
Aqueous Effluents and Soils", Chemosphere, 9(9), 1980

388 .

"Hazard to Man as a Component of an Ecosystem",
Ecotoxicol. Environ. Safety, 2, 12/78.

389 .

"Effect of Acute Exposure to 2,3,7,8Tetrachlorodibenzo-P-Dioxin on Humoral Antibody
Production in Mice", Chem. Biol. Interactions, 30,
1980.

390 .

"Immunosuppressive Effects of TCDD in Strains of Mice
with Different Susceptibility to Induction of Aryl
Hydrocarbon Hydroxylase", Tox. Appl. Pharmacol., 68,
5/83

391.

"The Effect of Acute Administration of
2.3.7.8- Tetrachlorodibenzo-P-Dioxin (TCDD) on Humoral
Antibody Production in Cell-Mediated Activities in
Mice", Arch. Toxicol., Suppl. 4, 1980.

392.

"Control of Benzo(A)Pyrene-Induced Mammalian Cell
Cytotoxicity, Mutagenesis and Transformation by
Exogenous Enzyme Fractions", Dev. Toxicol. Environ.
Sci., 2, 1977.

393 .

"The Differential Response of Isolated Intestinal
Crypt and Tip Cells to the Inductive Actions of TCDD"
Chem. Biol. Interact., 22, 9/78.

-3 2 -

13831

•"*»

.«

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394.

"Chemical Exposure and Intestinal Function", Environ.
Health Perspect., 33, 12/79.

395.

"The Mechanism of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin
Toxicity: Nutrient Assimilation," Fed. Proc., 41(4),
1982.

396.

"Clinical and Experimental Investigations Concerning
the Etiology of Chloracne", Arch. Klin. Exp.
Dermatol., 206, 1957.

397.

"Clinical Picture and Etiology of Chloracne",
Arbeitamed Sozial Arbeitshyqien, 3, 2/68.

398.

"Dutch Dumps", Nature, 289(5796), 1/29/81

399.

"Toxicological Properties of Pentachlorophenol
Relative to Its Content of Chlorinated
Dibenzo-P-Dioxins", Pharmacologist, 15(2), 1973.

400.

"Enhanced Incorporation of 3H Thymidine into Liver DNA
in TCDD Treated Rats", Pharmacologist, 22(3), 1980.

401.

"Blood Clearance Tests for Detecting 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Hepatotoxicity in Rats and
Rabbits", Arch. Environ. Contam. Toxicol., 9, 1980.

402.

"Effects of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin on
Indocyanine Green Blood Clearance in Rhesus Monkeys:
Macaca Mulatta", Toxicology, 14, 1979.

403.

"Analysis of Toxicants in Agricultural Environments",
Basic Life Sciences, 21, 1982.

404.

"A Survey on the Mutagenicity of Various Pesticides",
Experientia, 15, 1973.

405.

"A Search for 2,3,7,8-Tetrachlorodibenzo-P-Dioxin
(TCDD) in an Environment Exposed Annually to
2,4,5-Trichlorophenoxyacetic Acid Ester (2,4,5,-T)
Herbicides", Bull. Environ. Contam. Toxicol., 18(4),
10/1977.

406.

"Effects of TCDD on Splenic Lymphocyte Transformation
in Mice after Single and Repeated Exposures", Ann.
N.Y. Acad. Sci, 320, 1979.

407.

"Reversal of Immunologic and Toxicologic Effects of a
Single Exposure of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin
in Mice", Trace Subst ._Environ. Health, 12, 1978.

■^
V.

-3 3 -

••

408.

"Immunotoxicologic Studies Involving TCDD in Mice and
Rabbits", Toxicol■ Appl. Pharmacol., 45, 1978.

409 .

"Mutagens and Teratogens", Congenital Anomalies, 15,
1975.

410 .

"TCDD Toxicity", Med. Pr., 29(1), 1978.

411.

"Chloracne: Three Cases", Proc. R. Soc. Med■, 65, 8/72.

412.

"A Residue Study of Beef Cattle Consuming
2.3.7.8- TCDD", J. Agri. Food Chem., 29(2), 1981.

413.

"Residue Studies for 2,4,5-T and 2,3,7,8-TCDD in Grass
and Rice", 2/83.

414 .

"TCDD and Chloracne", Trans. St. Johns Hosp.
Dermatol. So., 58, 1972.

415.

"The TCDD Receptor in Rat Intestinal Mucosa and Its
Possible Dietary Ligand", Nutrition and Cancer, 3,
1982.

416.

"Contrasting Properties of Cytochrome P-450 Isozymes:
Characterization, Identification and Significance of
Multiple Forms of Rabbit Microsomal Cytochrome P-450",
Dev. Biochem., 13, 1980.

417.

"Purification of the Major Cytochrome P-450 of Liver
Microsomes from Rabbits Treated with 2,3,7,8-TCDD",
Biochem. Biophys. Res. Comm., 76(3), 6/6/77.

418 .

"Resolution of Two Forms of Cytochrome P-450 From
Liver Microsomes of Rabbits Treated with
2.3.7.8- TCDD", J. Biol. Chem., 252, 5/10/77.

419 .

"Dioxin Found in the Great Lakes Basin", AMBI, 10(1),
1981.

420.

"Comparative Toxicity of Polychlorinated Biphenyls and
Dibenzofurans in Rats", Toxicol. Appl. Pharmacol., 43,
1/78.

421 .

"The AH Receptor: A Specific Site for Action of
Chlorinated Dioxins?", Environ: Sci. Res., 25, 1983.

422 .

"Temperature-Dependent Cytosol-to-Nucleus
Translocation of the AH Receptor for 2,3,7,8-TCDD in
Continuous Cell Culture Lines", J. Biol. Chem., 255
(23), 1980.

-3 4 -

13893

423.

"Binding of 3-Methylcholanthrene and 2,3,7,8-TCDD to
Common AH Receptor Site in Mouse and Rat Hepatic
Cytosols", Eur. J. Biochem., 127, 9/82.

424.

"Regulatory Gene Product of the AH Locus:
Characterization of the Cytosolic Inducer-Receptor
Complex and Evidence for its Nuclear Translocation",
J. Biol. Chem., 254, 11/25/79.

425.

"Toxicity of 2,3,7,8-TCDD in the Golden Syrian
Hamster", Toxicol. Appl. Pharmacol., 55, 1980.

426.

"Tissue Distribution, Excretion and Metabolism of
2,3,7,8-TCDD in the Golden Hamster", Toxicol. Appl.
Pharmacol., 56, 1980.

427.

"Evidence for Genetic Differences in the Structure of
UDP--Glucuronyl Transferase in Inbred Mice",
Pharmacologist, 18, 1976.

428.

"Effects of TCDD (2,3,7,8-Tetrachlorodibenzo-P-Dioxin)
on Striatal or Hypothalamic Adenylate Cyclase of Rat",
Riv. Tossicol. Sper. Clin., 8, 1978

429 .

"Aryl Hydrocarbon Hydroxylase Induction and its
Relationship to the Toxicity of Halogenated Aryl
Hydrocarbons", Toxicol. Environ. Chem., 4, 1981.

430 .

"Induction of Drug Metabolizing Enzymes in Different
Rat Tissues by TCDD", Arch. Toxicol., 1, 1978.

431.

"Analysis of Lipids and Dioxin in Chloracne Due to
TCDD", Brit J. Derm., 105, 1981.

432.

"Chemistry and Toxicology of Polychlorodibenzo-PDioxins", Chem. Ind., 9, 5/1/82.

433.

"Effects of 2,3,7,8-TCDD on Serum Concentrations and
the Uterotrophic Action of Exogenous Estrone in Rats",
Toxicol. Appl. Pharmacol., 65, 8/82.

434.

"Usage Patterns of Chemically Treated Wood on Michigan
Dairy Farms”, Bull. Env. Contam. Tox., 26, 4/81.

435.

"Effects of Pesticides on the Reproductive System",
Acta Pharm. Jugosl., 80(2), 1980.

436.

"Nerve Conduction Velocity Studies of Workers Employed
in the Manufacture of Phenoxy Herbicides", Environ.
Res. 29, 1982.

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$

437.

"TCDD in Hexachlorophene", Chem. Eng. News, 59(18),
5/4/81.

438.

"Mutagenic Substances as Possible Senility Factors",
Pharmacol. Res. Comm., 10(9), 10/78.

439 .

"Sex-Dependent Effects of Prenatal, 2,4,5,-TCD on Rats
Open-Field Behavior", Physiol. Behav., 9, 9/72.

440 .

"Hepatic Toxicity and Uroporphyrinogen Decarboxylase
Activity Following a Single Dose of 2,3,7,8-TCDD to
Mice", Biochem. Pharmacol., 30/ 10/15/80.

441.

"Hepatic Toxicity and Uroporphyrinogen Decarboxylase
Activity Following a Single Dose of 2,3,7,8-TCDD to
Mice", Biochem. Pharmacol., 30, 10/15/80.

442 .

"Teratogenicity of TCDD in CF-1 Mice", Tox. Appl.
Pharmacol■, 38, 12/76.

443 .

"Dioxins Have Been Present Since the Advent of Fire,
Says Dow", Science, 202(4373), 12/15/78.

444 .

"Classes of Hepatic Microsomal Mixed Function Oxidase
Inducers", Pharm. Ther■, Part A7, 1979.

445 .

"Effect of 2,4,5-Trichlorophenoxyacetic Acid and Its
Butyl Ester on Rat Embryogenesis", Bull Exp. Biol.
Med., 6, 7/73.

446.

"Xenobiotics and Molecular Teratology", Clin. Obstet.
Gynecol., 18, 1975.

447 .

"Study of the Effects of High Levels of
2,4,5-Trichlorophenoxyacetic Acid on Foetal
Development in the Rat", FDA Cosmet. Toxicol., 9, 8/71.

448 .

"Study of Teratogenicity of 2,3,7,8-TCDD in the Rat",
Food Cosmet. Toxicol., 9(3), 6/71.

449 .

"Mutagenicity and DNA Damage Induced by Arylamines in
the Salmonella/Hepatocyte System", Carcinogenesis, 4,
1983.

450 .

"Combustion of Several 2,4,5-Trichlorophenoxy
Compounds", Science, 197 (4307), 9/2/77.

451.

"Difficulty of Evaluating the Toxicity and
Teratogenicity of 2,4,5-T from Existing Animal
Experiments", Science, 174, 12/71.

/■ s

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k

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138S5

452.

"Effect of Vitamin A on the Induction of Benzopyrene
Metabolism by 2,3,7,8-TCDD in Primary Hepatocyte
Cultures", Pharmacologist, 2303, 1981.

453.

"Induction of Benzo(A)Pyrene Metabolism by
2,3,7,8-TCDD in Primary Cultures of Adult Rat
Hepatocytes", Toxicol. Appl. Pharmacol., 59(3), 7/81.

454 .

"Lipid Peroxidation as a Possible Cause of TCDD
Toxicity", Biochem. Biophys. Res. Commun., 111(3),
3/29/83.

455.

"Detection of Chemical-Induced Porphyria in Man:
Possibilities in Biomonitoring of Exposure to
Chemicals", Dev. Toxicol. Environ. Sci., 8, 1980.

456.

"Health Aspects of Rabbits in a Low-TCDD-Contaminated
Area, Int.
Biochem., 12 (5-6), 1980.

457 .

"Porphyrins in Urine as an Indication of Exposure to
Chlorinated Hydrocarbons", Ann. N.Y. Acad. Sci., 31,
5/31/79.

458.

"The Incidence of Chronic Hepatic Porphyria in an
Italian Family", Int . J . Biochem., 12(5-6), 1980.

459 .

"Porphyrins in Urine as an Indication of Exposure to
Chlorinated Hydrocarbons (In Health Effects of
Halogenated Aromatic Hydrocarbons)", Ann. N.Y Acad.
Sci■, 320, 1979.

460 .

"Research Related to the Herbicide Burinol, Especially
for Possible Carcinogenicity", IARC Sci■ Publ., 25,
1979 .

461.

"Missouri's Costly Dioxin Lesson", Science, 219
(4583), 1/28/83.

462.

"Dioxin's Uncertain Legacy, "Science, 219 (4584),
2/4/83.

463.

"Long-Term Health Effects of Exposure to 2,4,5-T
and/or its Contaminants", Chemosphere, 12, 1983.

464 .

"Studies of the Mechanism of Action of Hepatotoxicity
of 2,3,7,8-TCDD and Related Compounds", Environ. Sci.
Res., 26, 1983.

465.

"On the Mechanism of Porphyria Due to Chloronated
Hydrocarbons", Excerpta Med. - Int. Conqr. Ser., 440,
1978.

-3 7 -

13836

• •»V

*

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:

466.

"Characterization of the Hyperlipidemia in Guinea Pigs
Induced by 2,3,7,8-TCDD, Toxicol. Appl. Pharmacol..
7/81.

467.

"Study of Acute and Chronic Effects of Single Doses of
TCDD in Wistar Rats", Rocz Panstu Zakl Hiq, 30(3),
1979.

468.

"Acute and Chronic Effects of Administering Single
Doses of 2,3,7,8-TCDD to Wistar Rats", Annals of the
State Hygiene Ins., 30, 1979.

469.

"Laboratory Handling and Disposal of Chlorinated
Dioxin Wastes", Environ. Sci. Res., 26, 1983.

470.

"Dioxin: A Possible Solution", Recherche, 8(80), 1977.

471.

"Environmental Chloracne: Update and Overview", A n n ■
N.Y. Acad. Sci ■, 320, 1979.

472.

"Studies of the Hepatic Uptake of 2,3,7,8-TCDD in the
Mouse", Fed. Proc_._FecL Am. Soc. Exp. Biol., 37(3),
1978.
...........
..... .

473.

"Considerations on the Epidemiology of the Seveso
Accident", Toxicol. Evr. Res., 3, 9/81.

474.

"Absence of TCDD Toxicity to a Rodent Population
Following Massive Filed Applications of 2,4,5-T
Herbicide, J. Am. Vet. Med. Assoc., 167(9), 1975.

475.

"Long-Term Field Studies of a Rodent Population
Continuously Exposed to TCDD", Environ. Sci. Res., 26,
1983.

476.

"Enhancement of Carrageenan and Dextran-Induced Edemas
by TCDD and Related Compounds", J. Pharmacol. Exp.
Ther■, 225, 6/83.

477.

"Enhancement of Carrageenin-Induced Paw Edema in
2,3,7,8 Tetrachlorodibenzo-P-Dioxin Treated Rats and
Inhibition by Indomethacin", Pharmacologist, 22(3),
1980 .

478.

"The Effects of Low Levels of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) on Mouse Peritoneal Exudate (PE)
Cell Number, Cell Viability, Differential Cell Count
and on Macrophage Phaocytic Function", Abstr. Annu.
Meet. Am. Soc. Microbio., 78, 1978.

13 no o>jr /

j

-3 8 -

Jt A ‘ t

479.

"The Effect of Perinatal Exposure to
Tetrachlorodibenzo-P-Dioxin on the Immune Response of
Young Mice", Drug Chem. Toxicol., 2(1-2) 1979.

480.

"Deadly Legacy: Dioxin and the Vietnam Veteran",
Bull. At. Sci., 35, 5/79.

481.

"Effect of Microsomal Enzyme Inducers on the Soluble
Enzymes of Hepatic Phase II Biotransformation",
Toxicol. Appl. Pharmacol., 66, 1982.

482.

"Multiple Forms of Cytochrome P-450: Catalytic
Differences Exhibited by Two Homogenous Forms of
Rabbit Cytochrome P-450", Mol. Pharmacol., 15, 15/79.

483 .

"A Technique for Testing Acnegenic Potency in Rabbits
Applied to the Potent Acnegen, TCDD", J. Invest.
Dermatol., 9'i 1962.

484 .

"Pathological Changes in the Liver of Mice
2.3.7.8- TCDD", Experienta, 31, 11/15/75.

485 .

"A Histochemical Study of the Liver Lesion Induced by
2.3.7.8- TCDD in Rats", J. Pathol., 116, 6/75.

486.

"A Morphological Study of the Liver Lesion Induced by
2.3.7.8- TCDD in Rats", J. Pathol., 112, 2/74.

487 .

"Dependence of the Porphyrogenic Effet of 2,3,7,8^-TCDD
Upon Inheritance of Aryl Hydrocarbon Hydroxylase
Responsiveness, Toxicol. Appl. Pharmacol., 53, 1980.

488.

"The Role of Iron in the Toxicity of 2,3,7,8-TCDD",
Toxicol. Appl. Pharmacol., 61, 1981.

489 .

"Iron Deficiency Prevents Liver Toxicity of
2.3.7.8- TCDD", Fed. Proc■ Fed. Am. Soc. Exp. Biol.,
38(3), 1979.

490 .

"Chlorinated Dioxins and Furans in the Environment",
Environ Sci. Technol, 17(3), 1983.

491 .

"Ontogenetic Expression of Regulatory and Structural
Gene Products Associated with the AH Locus:
Comparison of Rat, Mouse, Rabbit and Sigmoden
Hispedis", Dev. Pharmacol. Ther■, 1980.

492.

"Chlorinated Phenoxyacids and Their Dioxins",
(Editorial), Lakartidningen, 75(36), 9/6/78.

493.

"Metabolic Structure-Activity Relationship for a
Homologous Series of Phenacetin Analogs", J.
Pharmacol. Exp. Ther., 209, 1979.

494 .

"TCDD in the Environment: Sources, Fate and
Decomposition", Environ Health Perspect., 5, 9/73.

495.

"Correlation of Bioconcentration Factors of Chemicals
in Aquatic and Terrestrial Organisms With Their
Physical and Chemical Properties, "Environ. Sci.
Techno1, 14(5), 5/80.

496.

"Environmental Toxicity of TCDD", Environ. Sci. Res.,
26, 1983.

497 .

"Polychlorodibenzo-P-Dioxins: Perinatal Effects and
the Dominant Lethal Test in Wistar Rats", Adv. Chem.
Ser., 120, 1973.

498 .

"The Toxicity of Polychlorinated Polycyclic Compounds
and Related Chemicals", CRC Crit. Rev. Toxicol., 2(4),
1/74.
......

499.

"Disposition and Body Burdens of Halogonated Aromatic
Compounds: Possible Association with Health Effects in
Humans, "Drug Metab. Rev., 13, 1982.

500 .

"The Carcinogenic and Other Chronic Effects of
Persistent Halogonated Organic Compounds . . .: Health
Effects of Halogonated Aromatic Hydrocarbons, "Ann
N.Y. Acad. Sci., 320, 1979.

501 .

"Epidemiology and Pathology of a TCDD Poisoning
Accident", Arch. Environ. Health, 32, 4/77.

502.

"Chlorinated Aromatic Cyclic Ethers as the Cause of
So-Called Chloracne, "Naturwissenschaften, 44, 1957.

503 .

"Structural and Functional Studies of Ligandin, a
Major Renal Organic Anion-Binding Protein, "J. Clin.
Invest., 55, 5/75.

504 .

"2,3,7,8-TCDD Effects on Hepatic Microsomal
Cytochromic P-448-Mediated Enzyme Activities",
Toxicol. Appl. Pharmacol., 47, 3/15/79.

505.

"Effects of TCDD on the Disposition of Heme and
Heme-Containing Proteins in Mammalian Tissues",
Toxicology Research Projects Pi., 5(ISS2), 1980.

506.

"2,3,7,8-TCDD-Induced Alterations in Microsomal Heme
Protein-Mediated Enzyme Activity in Mammalian Liver",
Environ. Health Perspect., 20, 1977.

507.

"2,3,7,8-TCDD-Induction of Aryl Hydrocarbon
Hydroxylase, AHH, in Hepatic Microsomes From Female
Rats, Toxicol. Appl. Pharmacol., 45(1), 1978.

508.

"2,3,7,8-TCDD Induction of Aryl Hydrocarbon
Hydroxylase in Female Rat Liver: Evidence for DeNovo
Synthesis of Cytochrome' P-448", Mol. Pharmacol., 14,
1978.

509.

"2,4,5-T and Cancer", NZ Med. J ., 91, 1980.

510 .

"Modifying Effects of Environmental Chemicals on Drug
Metabolism", Mutat■ Res■, 46(3), 1977.

511.

"Influence of Inducers and Inhibitors of Xenobiotic
Transformation on Chemical Mutagenicity and
Carcinogenicity", Pol. J. Pharmacol. Pharm., 31, 1979.

512.

"Effects of Environmental Chemicals on Kidney
Metabolism and Function", Kidney Int., 18, 11/80.

513 .

"TCDD Toxicity In Vivo and In Vitro . . . Toxicology
of Halogenated Hydrocarbons", Health Ecol. Eff., 1981.

514 .

"2,3,7,8-TCDD Failure to Demonstrate Toxicity in
Twenty-Three Cultured Cell Types", Toxicol■ Appl .
Pharmacol■, 54, 1980.

515.

"A Search for the Presence of 2,3,7,8-TCDD in Beef
Fat", Bull. Environ. Contam. Toxicol., 19(2), 2/78.

516 .

"Toxicity of 2,3,7,8-TCDD", Drug Metab. Rev., 13, 1982

517.

"Long-term Toxicologic Studies of 2,3,7,8-TCDD in
Laboratory Animals", Ann. N.Y. Acad. Sci., 5/31/79.

518.

"Long-term Toxicologic Studies of 2 ,.3,7,8-TCDD in
Laboratory Animals . . .: Health Effects of
Halogenated Aromatic Hydrocarbons", Ann■ N.Y. Acad.
Sci., 320, 1979.

519.

"2,3,7,8-TCDD: Results of a 13-Week Oral Toxicity
Study in Rats", Toxicol. Appl. Pharmacol., 35, 3/76.

520.

"2,3,7,8-TCDD: Results of a 13-Week Oral Toxicity
Study in Rats", Toxicol. Appl. Pharmacol., 33(1), 1975

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13900

• .«V,

521.

"Retinoids Inhibit 2,3,7,8-TCDD-Induced Activity of
Benzopyrene(A) Metabolizing Enzymes in Human Diploid
Fibroblasts", Carcinogenesis, 1(9), 9/80.

522.

"Effects of Environmental Contaminants on the Immune
System", Adv. Vet. Sci. Comp. Med., 23, 1979.

523.

"Dioxins and Dibenzofurans", Lakartidningen, 76(7),
1979.

524.

"Specificity of 2,4,5-T on Tetraethylammonium
Transport", Toxicol. App. Pharmacol., 38, 1976.

525.

"The Metabolism and Distribution of 2,4,5-T in
Pregnant Mice", J. Environ. Sci. Health, 13, 1979.

526.

"Aryl Hydrocarbon Hydroxylase Induction in Human
Lymphocyte Cultures by 2,3,7,8-TCDD", Life Science,
15, 1975.

527.

"The Dioxins: Toxic and Still Troublesome",
Environment, 23(1), 1/81.

528.

"Differential Effect of 2,3,7,8-TCDD on Nuclear RNA
Polymerase Activity in the Rat Liver and Thymus",
Biochem. Pharmacol.,31,8/1/82.

529 .

"Mechanism of Action of 2,3,7,8-TCDD on Hepatic RNA
Synthesis", Dev.Biochem^, 13, 1980.

530.

"Further Characterization of the Dioxin Receptor in
the Rat Deciduoma", Biochem. Int., 68, (ISS 3), 1983.

531.

"Accumulation of Polychlorinated Dibenzofurans in the
Livers of Monkeys and Rats", Food Cosmet. Toxicol.,
18(4), 8/80.

532.

"The Effect of Environmental Pollutants on Human
Reproduction, Including Birth Defects", Environ. Sci.
Techno1., 15(6), 6/81.

533.

"Evaluation of 2,4-D, 2,4,5-T and 2,3,7,8-TCDD
Toxicity in C57B1/6 Mice: Reproduction and Fertility
in Treated Male Mice and Evaluation of Congenital
Malformations in Their Offspring", National Toxicology
Program, NTP-80-44.

534.

"Toxicity of Chlorinated Phenoxy Acids in Combination
with 2,3,7,8-TCDD in C57B1/6 Male Mice", J. Toxicol.
Environ. Health, 8, 12/81.

-42-

1 39 0 1

s*'V

535.

"Effect of Dioxin Exposure", Lancet, 8028, 7/9/77.

536.

"Agent Orange and Birth Defects", (Letter)-N. Eng. J.
Med., 308(12), 3/24/83.

537.

"Exposure Measurements of Applicators Spraying 2,4,5-T
in the Forest", J. Aqric. Food Chem., 28, 6/80.

538.

"Dioxin (Dilemma)", Med. J. Aust., 1(13), 6/30/79.

539 .

"Metabolism of Benzo(A)Pyrene By Isolated Perfused Rat
Testis", Cancer Res■, 40, 1980.

540 .

"Environmental Effects of Chlorinated Dioxins", Chem
Mag, 413-16, 7/81.

541.

"Effect of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin on
Renal Function in the Rat", J . Toxicol. Environ.
Health, 2, 1976.

542.

"Depression of Guinea-Pig Testicular Microsomal
Cytochrome P-450 Content by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin TCDD", Pharmacologist, 21(3), 1979.

543.

"Induction of Cytosolic Aldehyde Dehydrogenase
Isozymes: Influence on Acetaldehyde Metabolism",
Alcohol Aldehyde Metab.Syst, 2, 1977.

544 .

"Role of Liver Cytosolic Aldehyde Dehydrogenase
Isozymes in Control of Blood Acetaldehyde
Concentrations", J. Pharmacol. Exp. Ther., 201, 5/77.

545.

"Excretion and Bile Flow Depression of Adenosine
Triphosphate Activities in Isolated Liver Surface
Membranes of TCDD Treated Rats: Correlation with
Effects on Ovabain Biliary", J. Pharmacol. Exp. Ther.,
201, 5/77.

546 .

"Reversal of 2,3,7,8-Tetrachlorodibenzo-D-Dioxin
Induced Depression of Ovabain Biliary Excretion by
Pregnenolone-16-Alpha-Carbonitrile and Spironolactone
in Isolated Perfused Rat Livers", Toxicol. Appl.
Pharmacol., 50, 9/30/79.

547.

"Depression of Adenosine Triphosphatase Activities in
Isolated Liver Surface Membranes of
2,3,7,8-Tetrachlorodibenzo-P-Dioxin Treated Rats:
Correlation with Effects on Ovabain Biliary Excretion
and Bile Flow", J. Pharmacol. Exp. Ther., 210, 1979.

-4 3 -

1

o. r- A o

548 .

"Effects of Pregnenolone 16-Alpha Carbonitrile and
Spirino lactone on Biliary Excretion Ovabain in
2.3.7.8- Tetrachlorodibenzo-P-Dioxin Treated Rats",
Toxicol. Appl. Pharmacol., 45(1), 1978.

549 .

"A Microbial Metabolite of TCDD", Experientia, 38(6),
6/15/82.

550 .

"Toxicant Deregulation of Endocrine Heme
Bio-synthesis", Toxicology Research Projects DI/4,
Iss. 06, 1979.

551 .

"Technical Pentachlorophenol: Origin and Analysis of
Base-Insoluble Contaminants", Environ. Health
Perspect., 15, P41-8, 9/1979.

552 .

"Photolysis of TCDD and Trifluralin on Silica and
Soil", Bull. Environ. Contam. Toxicol., 20(1), 87-92,
7/78.

553 .

"Foreward to Papers I-VI: Accidental Release of
2.3.7.8- Tetrachlorodibenzo-P-Dioxin (TCDD) at Seveso,
Italy", Ecotoxic. Environ. SAF, 4(3) 282, 1980.

554 .

"Increase of Hepatic and Serum Aldehyde Dehydrogenase
Activity After TCDD Treatment", Arch. Toxicol (Suppl),
1, 1978.

555.

"Studies on the Bioaccumulation and Microbial
Degradation of 2,3,7,8-TCDD, Environ. Health
Perspect■, 5, 9/73.

556.

"Absorption, Accumulation, and Elimination of
Pesticides by Aquatic Organisms," Environ. Sci. Res.,
10, 1977.

557.

"Microbial Degradation of TCDD in a Model Ecosystem",
Environ. Sci. Res., 26, 1983.

558 .

"Biochemical Aspects of Action-Mechanisms of
2.3.7.8- TCDD and Related Chemicals in Animals",
Pharmacol. Ther., 19, 1983.

559.

"Toxic effet of Chlorinated and Pyrethroid
Pesticides", Toxicology Research Projects Pi., 5
(ISS 08), 1980.

560.

"Factors Affecting the Disposition and Persistence of
Halogenated Furans and Dioxins", Environ. Sci. Res.,
26, 1983.

1C-44-

561.

"Survey about Toxicological Data of 2,3,7,8-TCDD,
Monoqr. Giovanni Lorenzini Foun, 1, 1978.

562.

"Gonadal Aryl Hydrocarbon Hydroxylase in Rats and
Mice", Cancer Res., 38, 5/78.

563.

"Oocyte Destruction by Polycyclic Aromatic
Hydrocarbons", American J. of Industrial Med., 4, 1983.

564.

"Ovarian Aryl Hydrocarbon Hydroxylase Activity and
Oocyte Destruction", Microsomes, Drug Oxid., Chem.
Carci., 2, 1980.

565.

"Tetrachlorodibenzodioxin: A Survey of Subjects Ten
Years After Exposure", Br■ J ■ 2nd Med., 39(2), 5/82.

566 .

"A Study of Subjects 10 and 14 Years After Exposure,"
Chemosphere, 12, 1983.

567 .

"Chloracne From the Accidental Production of TCDD"
Brit. J. Indus. Med., 30, 7/73.

568.

"Tetrachlorodibenzodioxin: A Survey of Subjects Ten
Years After Exposure", B r . J. Ind. Med., 39(2), 1982.

569.

"The Comparative Toxicity of Chlorinated
Dibenzo-pdioxins In Mice and Guinea Pigs," Toxicol.
Appl. Pharmacol., 44, 1978.

570 .

"Toxicity of 2,3,7,8-TCDD in Rhesus Monkeys (Macaca
Mulatta) Following a Single Oral Dose," Toxicol. Appl ■
Pharmacol■, 43(1), 1/78.

571.

"Toxicity of Chlorinated Dibenzo-p-Dioxins in Mice,
Guinea Pigs, and Rhesus Monkeys," Environ. Health
Perspect., 20, 1977.

572.

"Mechanism of 2,3,7,8-TCDD in Rats," Toxicology
Research Projects Pi., 4(6), 1979.

573.

"The Comparative Toxicity of Chlorinated
Dibenzo-p-dioxins in Mice and Guinea Pigs", Toxicol.
Appl. Pharmacol., 44, 5/78

574.

"Structure-Activity Relationships in Halogenated
Biphenyls: Unifying Hypothesis for Structural
Specificity," Chem. Biol. Interact., 33(2-3), 1/81.

575.

"The Study of Toxic Effects of Environmental Chemicals
on Spermatogenesis", Toxicology Research Projects Pi.,
56(ISS8), 1980.

-45-

576.

"Induction of Aryl Hydrocarbon Hydroxylase Activity in
the Rat Prostate Glands by 2,3,7,8-TCDD", J .
Pharmacol. Exp. Ther■, 215, 1980.

577.

"Metabolism of Benzo(A)Pyrene in Rat Prostate Glands
Following 2,3,7,8-TCDD Exposure, Carcinogenesis, 2,
1981.

578.

"Factors Influencing Reproduction and Genetic Toxic
Effects on Male Gonads", Environ. Health Perspect.,
24, 1978.

579 .

"Genetic Differences in Benzo(A)Pyrene-Initiated
Tumorigenesis in Mouse Skin," Pharmacol■, 20, 1980.

580 .

"Differential Induction by 2,3,7,8-TCDD of Multiple
Forms of Rabbit Microsomal Cytochrome P-450: Evidence
for Tissue Specificity", Mol. Pharmacol., 18(3), 1980.

581 .

"Differential of Normal and Inducible Rat Liver
Dehydrogenases By Disulfurame Inhibition in Vitro,"
B iochem. Pharmacol., 29, 11/1/80.

582 .

"Rat Liver Aldehyde Dehydrogenase Immunochemical
Identity of 2,3,7,8-TCDD-Inducible Normal Liver and
2-Acetylamino Fluorene-Inducible Hepatoma Isozymes,"
Biochem^_Pharmaco 1_., 27, 1978.

583 .

"Environmental Pollution and Pregnancy Risks:
Uncertainties for the Fetus and Infant", Am._J ■
Obstet. Gynecol., 137(2), 5/15/80.

584 .

"In Vivo Cytogenic Studies on Mice and Rats Exposed to
TCDD," Environ■ Sci., 5, 1982.

585.

"Fire: The Dioxin Story to Date", Chemtech, 13, 10/83.

586.

"Measurement of Enzymes in Environmental
Intoxications", Ann. Clin. Lab. Sci., 7, 1977.

587.

"Postnatal Stimulation of Hepatic Microsomal Enzymes
Following Administration of TCDD to Pregnant Rats,"
Chem Biol. Interact.,11, 7/75.

588 .

"Perinatal Development of Conjugative Enzyme Systems,"
Environ. Health Perspect., 18, 12/76.

589 .

"TCDD-Induced Changes in Rat Liver Microsomal
Enzymes," Environ. Health Perspect., 5, 9/73.

-46-

13905

• .»v

*

¿

590 .

"Metabolic Activation/Deactivation Reactions During
Perinatal Development," Environ. Health Perspect.. 29,
4/79.

591 .

"Nature of the Enhancement of Hepatic Uridine
Diphosphate Glucuronosyl Transferase Activity by,
2.3.7.8— TCDD in Rats," Biochem. Pharmacol., 24, 1975.

592.

"Effects of Brief In Vitro Exposure to TCDD on Mouse
Lymphocytes," J. Environ. Path. Toxicol., 2, 4/79.

593 .

"Immunochemistry of Dioxin Action on the Lymphocyte,"
Toxicology Research Projects Di., 4(ISS6), 1979.

594 .

"Immunochemistry of Dioxin Action on the Lymphocyte
and Other Halogenated Aromatic Hydrocarbons",
Toxicology Research Projects Pi. , 365 (ISS 7), 1980.

595.

"Inability of Passive Antibodies to Reverse the
Effects of Dioxin Toxicity", Chemosphere, 7(1), 1978.

596.

"Examination of Bone Marrow Immunologic Parameters and
Host Susceptibility Following Pre- and Postnatal
Exposure to 2,3,7,8-TCDD", Int. J. Immuno Pharmacol.,
2, 1980.

597 .

"Altered Immune Functions in Rodents Treated with
2.3.7.8- TCDD, Phorbol-12-Myristate-13-Acetate and
Benzo(A)Pyrene", Banbury.Rep., 11, 1982.

598 .

"Metabolism of Carcinogens to Mutagens by Mammary
Tissue Extracts", Proc. Am. Assoc. Cancer Res., 19,
3/78.

599 .

"Differences in the Nature of Induction of Mixed
Function Oxidase Systems of the Rat Liver Among
Phenobarbital, DDT, 3-Methylcholanthrene and TCDD",
Toxicol■ Appl. Pharmacol., 61, 1981.

600.

"Comparison of Induction Patterns of Rat Hepatic
Microsomal Mixed-Function Oxidases By Pesticides and
Related Chemicals", Pest. Biochem. Physiol., 11, 1979.

601.

"Search for the Presence of 2,3,7,8-TCDD in Bovine
Milk", Bull. Environ. Contam. Toxicol., 18(2), 8/77.

602.

"Induction of UDP-Glucuronosyl Transferase Activity in
the Reuben H-4-II-E Hepatoma Cell Culture", Mol.
Pharmacol■, 16, 1979.

-47-

390-

•

603.

"Studies on the Requirements for Induction of UDPGlucuronosyl Transferase Activity in the Reuben
Hepatoma H-4-II-E Established•Cell Line", (Meeting
Abstract), Pharmacologist, 19(2), 1970.

604 .

"Induction of Bilirubin UDP-Glucuronosyl Transferase
Activity in Mice by 3-Methycholanthrene aijd
2.3.7.8- TCDD", Pharmacologist, 20, 1978.

605.

"Persistent Tissue Levels of TCDD in the Mouse and
Their Reduction as Related to Prevention of Toxicity",
Drug Metab. Rev■, 13, 1982.

606.

"Studies of the Mecahnism of Toxicity of
2.3.7.8- TCDD", Ann. NY Acad. Sci., 320: 204-13,
5/31/79.

607.

"The Toxicokinetics of TCDD In Mammalian Systems",
Drug Metabol■ Rev., 13:355-85, 1982.

608 .

"Induction of Intestinal Iron Transport by
2.3.7.8- TCDD, an Environmental Pollutant and Potent
Inducer of Aryl Hydrocarbon Hydroxylase," Clin. Res.,
25(3), 1977.

609 .

"Intestinal Organic Union Transport Glutathione
Transferase and Aryl Hydrocarbon Hydroxylase Activity:
Effect of Dioxin," Life Sci■, 24, 4/9/79.

610 .

"Stimulation of Iron Absorption by Polychlorinated
Aromatic Hydrocarbons," Physiologist, 21(4), 1978.

611.

"Induction of Iron Transport by a Potent Inducer of
Aryl Hydroxylase, 2,3,7,8-TCDD," Arch. Environ.
Health, 34, 6/79.

612.

"Effects of Polyhalogenated Aromatic Hydrocarbons on
Benzo (A) Pyrene Hydroxylase Activity in the Intestine
and Liver," Life Sci. 26, 1980.

613 .

"Stimulation of Iron Absorption By Polychlorinated
Aromatic Hydrocarbons," Am. J. Physiol., 236, 6/79-.

614 .

"Effect of 2,3,7,8-TCDD on Macrophage and Natural
Killer-Cell Mediated Cytotoxicity in Mice,"
Biomedicine, 32, 12/80.

615 .

Alterations in the Herme Biosynthetic Pathway as an
Index of Exposure to Toxins," Con. J. Physiol.
Pharmacol., 60, 1982.

-48-

"Responses of the D-Glucuronic Acid Pathway in Rat
Tissues To Treatment with TCDD," Xenobiotica, 8, 7/78
"Comparison of Phénobarbital - and Carcinogen Induced Aldehyde Dehydrogenzses in the Rat," Biochem.
Biophys. Acta, 583, 2/19/79.
"High-Affinity Binding of 2,3,7,8-TetrachlorodibenzoP-dioxin in Cell Nuclei from Rat Liver", Biochimica et
Biophysica Acta, 714, 2/25/82.
"Xenobiotic Metabolism in Marine Fish Treated 2,3,7,8
tetrachlorodibenzo-P-dioxin (TCDD), 3-Methylcholantrene (3-MC), or 1,2,3,4-Dibenzanthracene (DBA)",
Pharmacologist , 10(2), 1976.
"Cytochrome P450 Content and Mixed Function Oxidase
Activity in Microsomes Isolated from Mouse Skin:,
Pharmacologist, 16(2), 1974.
"Biological Degradation of TCDD in Rats", Nature, 281:
10/25/79
"Chlorinated Dibenzo-P-Dioxins: Potent Inducers of
Amino Levulinic acid synthetase and Aryl Hydrocarbon
hydroxylase II. A study of the structure-activity
relationship". Mol. Pharmacol. 9, 1973.
"2,3,7,8-Tetrachlorodibenzo-P-dioxin and Related
Halogenated Aromatic Hydrocarbons: Examinations of the
Mecahnism of Toxicity", Ann. Rev. Pharmacol. Toxicol .,
22, 1982.
"The Induction of Aryl Hydroxylase by
2.3.7.8- TetrachlorodibenzoP-Dioxin evidence for a
Receptor Mutation In Genetically Nonresponsive Mice:,
Pharmacologist, 16 (2), 1974.
"A Model for the Mechanism of Action of TCDD", Dev.
Toxicol. Environ. Sci., 5, 1980.
"Stereospecific High Affinity Binding of
2.3.7.8- Tetrachlorodibenzo- P-Dioxin By Hepatic
Cytosol", J. Biol. Chem., 251, 8/25/76.
"Chlorinated Biphenyl Induction of Aryl Hydrocarbon
Hydroxylase Activity: A Study of the StructureActivity Relationship", Mol. Pharmacol., /13, 9/77.
Comparison of TCDD, a Potent Inducer of Aryl
Hydrocarbon Hydroxylase, With 3-Methyl-Cholanthrene",
Mol. Pharmacol., 10, 1974

-49-

13908

629.

"2,3,7,8-Tetrachlorodibenzo-P-Dioxin Environmental
Contaminant and Molecular Probe" Fed. Proc. 35, 1/76

630.

"Studies on the Mechanism of Action of the Chlorinated
Dibenzo-P-Dioxins and Related Compounds:, Annals of
the N. Y. Academy, 320, 1979.

631.

Genetic Expression of Aryl Hydrocabron Hydroxylase
Activity", J. Biol. Chem., 249, 9/10/74.

632.

"Increased Total and High Density Liprotein
Cholesterol With Apoprotion Changes Resembling
Stretozotocin Diabetes In Tetrachlorodibenzodioxin
(TCDD) Treated Rats", Biochem. Pharmacol., 29, 1980

633 .

"Hypothyroxinemia and Hypothermia In Rats In Response
To 2,3,7,8-Tetrachlorodibenzo-P-Dioxin
Administration", Toxicol. Appl. Pharmacol. 69, 1983

634.

"Teratogenetic Effects of Dioxin", Nature, 266,
3/10/77.

635.

"Kenetics of N- and C- Hydroxylations of
2-Acetylaminofluorene in Male Sprague-Dawley Rat Liver
Microsomes: Implications for Carcinogenesis", Cancer
Res. 43(8), 8/83.

636 .

"Persistence of TCDD in Monkey Adipose Tissue", Food
Chem. Toxicol, 20(6), 12/82.

637.

"PCB and TCDD Orofacial Teratogeneis in M. Mulata",
Toxicology Research Projects, Di 4, 1979.

638.

"Toxicity of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin for
Rhesus Monkeys: Brief Report", Bull. Environ. Contam
Toxicol., 18(1), 7/77.

639.

"Mutagenic Study of Chlorinated Derivatives of
Azobenzene", Arch. Int. Physiol. Biochem., 86, 4/8/78.

640 .

"Biochemical and Genetic Analysis of Variant Mouse
Hepatoma Cells Defective in the Induction of
Benzo(A)Pyrene-Metabolizing Enzyme Activity", J. Biol.
Chem., 258, 1983.

641.

"Hetorogeneity in the Rate of Benzo(A)Pyrene
Metabolism in Single Cells: Quantification Flow
Cytometry", Mol. Cell Biol., 2, i.982.

642.

Immunologic Response and Factors Affecting Its
Assessment", Environ. Health Perspec., 18:125-131,
12/1976.

-50-

643.

"Toxicity of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin",
ECO. Bull., 27, 1978.

644 .

"Evaluating the Rodent Immune System As a Focus for
Teratogenic Effects", Teratology, 9(3), 1974.

645.

"Characterization and Interpretation of Kidney
Anomalies Associated with 2,3,7,8-TetrachlorodibenzoP-Dioxin: TCDD", Teratology, 7(3), 1973.

646.

"Long-Term Status of Workers Previously Exposed to
2.3.7.8- Tetrachlorodibenzo-P-Dioxin in the Manufacture
of 2,4,5-T", Abst. Pap. Am. Chem. Soc ■, 182(o),
8/28/81.

647 .

"Soft Tissue Sarcomas" Phenoxy Herbicides and
Chlorinated Phenols", Lancet, 1 (8234), 6/20/81.

648 .

"Evaluation of Results of Chromosome Analysis on
Lymphocytes of TCDD Exposed Subjects After the
Services Accident", Mutat. Res-., 35, 1981.

649 .

"Three-Generation Reproduction Study of Rats Given
2.3.7.8- Tetrachlorodibenzo-P-Dioxin (TCDD) in the
Diet", Tox. Appl. Pharmacol., 50, 9/15/79.

650 .

"A Comparative Study of Polychlorinated
Dibenzofurans, Polychlorinated Biphenyls and
2.3.7.8- Tetrachlorodibenzo-P-Dioxin on Aryl
Hydrocarbon Hydroxylase Inducing Potency in Rats",
Arch. Toxicol., 53, 1983.

651.

"Comparison of Benzo(A)Pyrene Metabolism by Testicular
Homogenate and the Isolated Perfused Testis of Rat
Following 2,3,7,8-Tetrachlorodibenzo-P-Dioxin
Treatment", Arch. Toxicol., 51, (2)8, 1982.

652 .

"Morphologic Alterations Induced by TCDD
(2,3,7,8-Tetrachlorodibenzo-P-Dioxin) in Epithelate
Monolayer Cultures of Human and Rodent Fetal Lung,
Kidney and Liver", Int. J. Biol. Res. Pregnancy, 2,
1981.

653 .

"Transfer of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin
(TCDD) The Mouse Embryo and Fetus", Toxicol■, 20,
1981.

654 .

"Factors Affecting the Induction of DT-DIA Phorase by
2.3.7.8- Tetrachlorodibenzo-P-Dioxin (TCDD)", Biochem.
Pharmacol., 27, 2/15/78.

-51-

■ >PW «ii

655.

"Influence of Enzyme Induction On TCDD Toxicity",
Monoqr. Giovanni Lorenzini Found, 1, 1978.

656.

"Genetic Expression of Aryl Hydrocarbon Hydroxylase
Activity in the Mouse", J. Cell. Physiol., 85, 4/75.

657.

"Effects of Environmental Chemicals on the Genetic
Regulation of Microsomal Enzyme Systems", Pharmacol.
Ther., 22, 1977.

658.

"Structural Gene Products of the Alt Locus: Genetic
and Immunological Evidence For Two Forms of Mouse
Liver Cytochrome P-450 Induced by 3Methycholanthrene", J . Biol. Chem., 254, 1979.

659 .

2,3,7,8-Tetrachlorodibenzo-P-Dioxin in Vitro Binding
to Rat Liver Microsomes", Bull, Environ. Contam.
Toxicol., 18(1), 7/77.

660 .

"A Survey of the Embryotoxic Effects of TCDD in
Mammalian Species", Environ Health Perspect., 5, 9/73

661.

"Potential Exposure of Humans to 2,4,5-T and TCDD in
the Oregon Coast Range", Fundam. Appl■ Toxicol., 1(4)
1981.

662 .

"Exposure of Forest Herbicides to 2,3,7,8-Tetrachlorodibenzo--P-Dioxin (TCDD) in Areas Sprayed with
2,4,5T", Bull. Environ. Contam,. Toxicol., 20(6),
12/78.

663 .

"Comparison of Hyperkeratosis Induced PCBs, PCFD and
PCDD Application", Fukuaka Acta Med., 66, 10/75.

664 .

"Elimination and Tissue Distribution of 2,3,7,8-Tetra
chlorodibenzo-P-Dioxin (TCDD) In Female Guinea Pigs
Following A Single Orazl Dose", Toxicol. Appl.
Pharmacol ., 48(1), 1979.

665.

"Biological Responses of the Nonhuman Primate,
Chicken, and Rat to Chlorinated Dibenzo-P-Dioxin
Ingestion", Environ. Health Perspect., 5, 9/73.

666.
667.

"Chlorinated Aromatic Hydrocarbon Induced
Modifications of the Hepatic Endophasmic Reticulum",
Environ. Health Perspect., 1, 4/72.
"Seveso: The Problems Deepen", Nature, 264(5584),
11/25/76.

1

-52-

668.

"Cytochrome P-450 Form 4, A Major Determinant of
2-Aminoanthracene Mutagenezsis", Microsomes Drug Oxid.
Chem. Carci, 2, 1980.

669.

"Identification of the Major Cytochrome P-450 Form
Transplacentally Induced in Neonatal Rabbits by
2,3,7,8-Tetrachlorodibenzo-P-Dioxin", J. Biol. Chem.,
253, 12/10/78.

670.

"The Toxicity of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin
(TCDD) In Guppies (Poccilia Reticulatus Peters)",
Bull. Environ. Contam. Toxicol., 12(1), 7/1974.

In addition, Monsanto refers plaintiffs to the
following compendia of references responsive to this
interrogatory, both of which have been produced in this
litigation by the United States.

/-N

National Agricultural Library, The Toxicity of
Herbicides to Mammals, Aguatic Life, Soil
Microorganisms, Beneficial Insects and Cultivated
Plants, 1950-65:__A List of Selected References, U .S .
Dep't of Agriculture, April, 1968 (i695 references).
Veterans Administration, Review- of Literature on
Herbicides, Including Phenoxy Herbicides and
Associated Dioxins, Veterans Administration, October,
1981 (1116 references).
INTERROGATORY NO, 8

''“V

State whether you knew health hazards, physical
disorders, injuries, irritations or diseases were associated
with exposure to, or use of herbicides containing 2,4,5-T.

If

your answer is affirmative, state or identify:
a)

the date you acquired such knowledge, belief or
suspicion;

b)

the manner in which you gained such knowledge,
belief or suspicion;

c)

the type of health hazards, physical disorders,
injuries, irritations or diseases;

-5 3 -

4

*' • ' *

Departments of Agriculture, the Interior, and Health,
Education, and Welfare of the immediate suspension by USDA of
certain registered uses of 2,4,5-T.

Dated:

New York, New York
February 17, 1984

13914
-5 5 -

VERIFICATION
STATE OF MISSOURI

)
) ss.:
COUNTY OF ST. LOUIS )

J. R. BLEY, JR., being duly sworn, deposes and says
that he is an assistant secretary of defendant Monsanto Company,
a corporation; that he has read the foregoing Supplemental
Answers of Defendant Monsanto Company to Plaintiffs' Interroga­
tories to Defendants and is familiar with the contents thereof;
that deponent is without personal knowledge of the matters stated
in the foregoing Supplemental Answers and is informed and be­
lieves that no officer or employee of Monsanto Company has
personal knowledge of all such matters; that the foregoing
Supplemental Answers have been assembled by authorized employees
and counsel of Monsanto Company, who have informed deponent that
the foregoing Supplemental Answers are true; and that to the
best of deponent's knowledge those Supplemental Answers are
true.

Sworn to before me this

.'cyf, February, 1984.

13915
*?Sary P i ^ , A SCHR0EDER
NOTARY FU3LIC, STATE OF MISSOURI
•MY COMMISSION EXPIRES 8/29/87
Si.
•' |'Y
_____

CERTIFICATE

OF

SERVICE

I HEREBY AFFIRM THAT I am an attorney duly admitted to
practice in the State of New York and in the Eastern District of
New York. I HEREBY CERTIFY that on February 17, 1984 I caused
to be served a true and correct copy of the Supplemental Answers
of Defendant Monsanto Company to Plaintiffs' Interrogatories to
Defendants by courier on all counsel on the attached service
list.

V,

SERVICE LIST
Michael M. Gordon, Esq.
Cadwalader, Wickersham & Taft
One Wall Street
New York, New York 10005
Leonard L. Rivkin, Esq.
Rivkin, Leff, Sherman & Radler
100 Garden City Plaza
Garden City, New York 11530
William Krohley, Esq.
Kelley Drye & Warren
101 Park Avenue
New York, New York 10178

Stephen J . Schlegel, E s q .
Schlegel & Trafelet, Ltd.
One North LaSalle Street
Suite 3900
Chicago, Illinois 60602
Benton Musselwhite, Esq.
Law Offices of Benton
Musselwhite, Inc.
Suite 517
609 Fannin
Houston, Texas 77002

Howard Lester, Esq.
Lester Schwab Katz & Dwyer
120 Broadway
New York, New York 10005

Thomas W. Henderson, Esq.
Baskin & Sears
Frick Building,
10th Floor
Pittsburgh, Pennsylvania
15219

Paul V. Esposito, Esq.
Lewis, Overbeck & Furman
135 South LaSalle Street
Suite 1060
Chicago, Illinois 60303

Victor J. Yannacone, Jr.,
Esq.,
Yannacone & Yannacone
Post Office Drawer #109
Patchogue, New York 11772

David R. Gross, Esq.
.Budd, L a m e r , Kent, Gross,
Picillo & Rosenbaum
33 Washington Street
Newark, New Jersey 07102

David J. Dean, Esq.
Dean, Falanga, Sinrod &
Rose
One Old Country Road
Carle Place, New York
11514

-.

Irving Like, Esq.,
Reilly, Like and
Schneider
200 West Main Street
%
Babylon, New York 11772 .

(

Judge Morton B. Silberman
Clark, Gagliardi & Miller
99 Court Street
White Plains, New York 10601
Thomas Beck, Esq.
Arthur, Dry & Kalish
1230 Avenue of the Americas
New York, New York 10020
Richard M. Goldstein, Esq.
Shea & Gould
330 Madison Avenue
New York, New York 10017
L. Kenneth Sheridan, Esq.
Executive' Assistant U.S. Attorney
United States Attorney's Office
225 Cadman Plaza East
Brooklyn, New York 11201

■V* -

Arvin Maskin, Esq.
Trial Attorney, Torts
Branch, Civil Div.,
U.S. Department of
Justice
;
Safeway Building
:£■
Washington, D.C. 20530

V.

Clerk of Panel
Judicial Panel on
Multidistrict Litigation
1120 Vermont Avenue, N.W.
Suite 1002
.
H
Washington, D.C. 20005 1 . 3 9 1 “

13818

NUMBERS

SOURCE

FOLDER TITLE (OR OTHER
FILE DESCRIPTION)

00031370ft00031391

Registration Correspondence
Files of Registration Depart­
ment, ftg Chon Division

Line Rider 22
Brushkiller
(677-95)

00031391A00031414

Registration Correspondence
Files of Registration Depart­
ment, ftg Chem Division

Line Rider 4T
Brushkiller
(677-97)

00031414ft00031436

Registration Correspondence
Files of Registration Depart­
ment, ftg Chan Division

Line Rider LV 3D/3T
Brushkiller (677-102)

00031436A00031468

Registration Correspondence
Files of Registration Depart­
ment, ftg Chem Division

Brushkiller Dormant Cane
LV 3D/3T - OS

00031468ft00031502

Registration Correspondence
Files of Registration Depart­
ment, Ag Chem Division

Dormant Cane Concentrate
LV-6T-OS (677-104)

00031502A00031525

Registration Correspondence
Files of Registration Depart­
ment, ftg Chem Division

Line Rider Amine 4T Brush­
killer (677-133)

DOCUMENT

13919

-1 -

DOCUMENT

FOLDER TITLE (OR OTHER
FILE DESCRIPTION)

NtlMRERS

SOURCE

00031525A00031559

Registration Correspondence
Files of Registration Depart­
ment, Ag Chem Division

Fence Rider 6T Brushkiller (677-136)

00031559A00031583

Registration Correspondence
Files of Registration Depart­
ment, Ag Chem Division

Line Rider LV-21
Brushkiller (677-141)

00031583A00031605

Registration Correspondence
Files of Registration Depart­
ment, Ag Chera Division

Line Rider Invert T
Concentrate (677-172)

00031605A00031623

Registration Correspondence
Files of Registration Depart­
ment, Ag Chem Division

Invert D/T
Concentrate (677-174)

00031623A00031657

Registration Correspondence
Files of Registration Depart­
ment, Ag Chem Division

Dacamine 4T Brushkiller (677-195)

00031657A00031722

Registration Correspondence
Files of Registration Depart­
ment, Ag Chem Division

Dacamine 2D/2T (677-196)

03
CO
o

DOCUMENT
NUMBERS

<U5
cc

FOLDER TITLE (OR OTHER
SOURCE

FTT.E DEflr.RTPTTON)

00031722A
00031795

Registration Correspondence
Files of Registration Depart­
ment/ Ag Chon Division

Trailway 2D/2T Diamine
Salt of 2,4-D and 2,4,5-T
(677-238)

00031795A00031799

Registration Correspondence
Files of Registration Depart­
ment/ Ag Chan Division

Technical 2-Ethylhexyl-T
(677-247)

00031799A00031806

Registration Correspondence
Files of Registration Depart­
ment/ Ag Chen Division

Technical Isopropyl-T
(677-248)

00031806A00031810

Registration Correspondence
Files of Registration Depart­
ment/ Ag Chen Division

Technical Butyl-T
(677-250)

00031810A00031822

Registration Correspondence
Files of Registration Depart­
ment/ Ag Chen Division

Technical Butyl-T
(677-253)

00031822A00031827

Registration Correspondence
Files of Registration Depart­
ment/ Ag Chen Division

Diamond Chem. 2,4,5-T
Acid (677-267)

-3 -

DOCUMENT

NT1MRERS

to

tO
to

FOLDER TITLE (OR OTHER
SOURCE

FTT.E DESCRTPTTDNi

00031827A00031874

Registration Correspondence
Files of Registration Depart­
ment, Ag Chan Division

Trailway 4T (677-273)

00031874A00031885

Registration Correspondence
Files of Registration Depart­
ment, Ag Chen Division

Technical Isooctyl Ester of
Silvex (677-287)

00031885ft00031901

Registration Correspondence
Files of Registration Depart­
ment, Ag Chem Division

Amine 2D/2T (677-297)

00031901A00031915

Registration Correspondence
Files of Registration Depart­
ment, Ag Chen Division

LO-VOL 2D/2T
(677-301)

00031915A00031928

Registration Correspondence
Files of Registration Depart­
ment, Ag Chen Division

LO-VOL 6T
(677-303)

00031928A
00031943

Registration Correspondence
Files of Registration Depart­
ment, Ag Chen Division

Silvex 4-TP
(677-305)

-4 -

DOCUMENT
NUMBERS

O
co
to
■O

FOLDER TITLE (OR OTHER
FILE DESCRIPTION)

SOURCE

00031943A
00031956

Registration Correspondence
Files of Registration Depart­
ment, Ag Chera Division

LO-VCL (677-306)

0003195700031958

Ag Chero Registration Roan

Phenoxy - Flash Point

0003195900032306

Ag Chem Registration Rocm

Phenoxy Miscellaneous

0003230700032310

Ag Chem Registration Room

2,4-D General

0003231100032923

Ag Chem Registration Rocm

2,4,5-T Silvex

0003292400032945

Ag Chem Division Document
Storage

Contract Formulations

0003294600032961

Files of Diamond Shamrock
Corporate Insurance Department

Workmen's Compensation
Newark - 1971-72

0003296200033057

Files of Diamond Shamrock
Corporate Insurance Department

Workmen's Compensation
Claims - Newark Plant
Chloracne

-5 -

DOCUMENT

POLDER TITLE (OR OTHER

NUMBERS .
0003305800033108

SOURCE

FILE DESCRIPTION)___

Files of F.R. Kenned/

Personnel

0003310900033318

Files of F.G. Steward

Newark - Workmen's Compensation

0003331900033334

Diamond Shamrock Law Dept.

Environmental Health:
New Jersey State Dept, of
Health Survey of Former
Newark Plant Personnel

0003333500033812

Files of Diamond Shamrock
Agrochemicals Ltd.

2,4,5-T Files of
David H. Spranklin

0003381399934311

Files of Diamond Shanrock
Agrochemicals Ltd.

2,4,5-T

00034311A00034421

Files of Diamond Shamrock
Agrochemicals Ltd.

2,4,5-T Filés from
Bob Beale

0003442200034722

Files of Diamond Shamrock
Agrochemicals Ltd.

2,4,5-T Files fran
R.E. Snell
-6-

NQMBEBS-

SOORCE

FOLDER TEILE (OR CODER
FILE DESCRIPTION) _

0003472300036221

Files of Diamond Shamrock
Agrochemicals Ltd.

2,4,5-T Files from
Betts Wood Offices

DOCUMENT

AFFIDAVIT OF SERVICE
STATE OF NEW YORK

)
: ss.:
COUNTY OF NEW YORK )
JEFFREY SAPER, being duly sworn, deposes and says:
1.

I am not a party to this action, am over 18 years

of age and reside in Queens County, New York.
2.

On March 6, 1984, I served the annexed Defendant

Diamond Shamrock's Index of Additional Documents Available for
Inspection and Copying in Post-Phase I Discovery, Dated March 6
1984 on each of the persons named on the annexed list by deposi
ting a true copy of same enclosed in a postpaid properly ad­
dressed wrapper, in an official depository under the exclusive
care and custody of the United States Postal Service within the
State of New York.

A copy was also sent by Federal Express to

the Agent Orange Plaintiffs' Management Committee, 26 Court
Street, Suite 905, Brooklyn, New York 11242, and to Victor Don
Russo, Jr., Esq., 7 Bonnie Drive, Northport, New York 11768.

Sworn to before me this
4 - K day of March, 1984.

1
No. 31-4645996

Qn.Httod in New York County a rnmiMim Expires
Bvnires March 30.
CoipjnlMion
30,19.0.—

semer

list

roe defendants
Leonard L. Rivkin
Rivkin, Leff, Sherman & Radier
(for DOW CHEMICAL)
100 Garden City riera
Garden City, New York 11530
Morton G. Silbernen
Clark, Gagliardi 4 Miller
(for T H AGRICULTURE &
NUTRITION COMPANY, INC.)
The Inna of Court
99 Court Street
White Pleine, New York 10601
John C. Sabetta
Townley 4 Updike
(for MONSANTO)
405 Lexington Avenue
New York, New York 10174
William Krohley
Xelley Drye 4 Warren
(for HERCULES, INC.)
101 Park Avenue
New York, New York 10178

Arvin Maskin
Department of Justice
(for THIRD PARTY DEFENDANT USA)
Safeway Building
521 12th Street, N.W.
Washington, D.C. 20530
L. Kevin Sheridan
Executive Assistant
U.S. Attorney
Eastern District of New York
United States Courthouse
225 Cadman Plaza East
Brooklyn, New York 11201
COPIES OF ALL DOCUMENTS MUST
BE 5EXT TO:__________ _
Clerk of the Panel
Judicial Panel on Multidistrict
Litigation
1120 Vermont Avenue, N.W.
Suite 1002
Washington, D.C. 20005

John M. Fitzpatrick
Dilworth, Paxson, Xaliah 4 L e w
(for HOOKER PLASTICS 4
CHEMICALS CORP.)
2600 The Fidelity Building
Philadelphia, Pennaylvania 19109

Victor J. Yannaeone, Jr.

Richard Goldstein
Shea 4 Gould
330 Madison Avenue
New York, New York

Stephen J. Schlegel
Schlegel 4 Trafelet, Ltd.

10017

Thomas Seek
Arthur, Dry 4 Relish, P.C.
(for UNIROYAL)
1230 Avenue of the Americas
New York, New York 10020
David R. Gross
Budd, Larner, Kent, Gross,
Pieillo 4 Rosenbaum
(for THOMPSON CHEMICALS)
33 Washington Street
Newark, New Jersey 07102

TOR PLAINTIFFS
Yannacone 4 Yannaeone
Post Office Drawer <109
Patchogue, New York 11772

One North LaSalle Street
Suite 3900
Chicago, Illinois 60602
Benton Musselwhite
Law Officvof Benton Musselwhite,
Inc.
Suite 517
609 Fannin
Houston, Texas 77002
Thomas Henderson
Baskin 4 Sears
Frick Building - 10th Tloor
Pittsburgh, Pennsylvania 15219
David J. Dean, Esq.
Dean, Falange 4 Rose
1 Old Country Road
Carle Place, New York

11514'

i&xzcduxzdxder', 'l^ccA e^à uon/ &
A

1333

N EW

H A M P S H IR E

P A R T N E R S H IP IN C L U D IN G

J f% /.S 0 0 0 5

A V E , N .’

W A S H IN G T O N , D .C . 2 0 0 3 6
(2 0 2 )

P R O F E S S IO N A L C O R P O R A T IO N S

24»
PA LM

2 9 3 -6 3 0 0

RO YAL

(3 0 S )

T W X : 7 I O - 6 2 2 - l» 3 4

PA LM

W AY

R EAC H , FLA. 3 3 4 6 0
6 6 3 -9 6 0 0

TW X: S IO * 9 3 2 * 7 6 2 6

S fy jic n * : (ê * 2 ) 0 0 6 -7 0 0 0

C A B LE A D D R ESS : LABELLU M
t e l e x : 12 » 1 4 6 / 6 9 7 4 6 5

R A P I F A X : (212) 2 6 9 - 2 3 2 1
X E R O X : (212) 7 6 6 * 1 6 3 0

, March 6, 1984
Stephen J. Schlegel, Esq.
Agent Orange Plaintiffs'
Management Committee
26 Court Street
Brooklyn, New York 11242
Re:

In re "Agent Orange"
Product Liability Litigation,
MDL No. 381

Dear Stephen:
I enclose Diamond Shamrock's Index of Additional
Documents Available for Inspection and Copying in Post-Phase
I Discovery, Dated March 6, 1984. The documents referenced
by the Supplemental Index are available for microfilming or,
as plaintiffs have done in the past, for review at our offices
to identify those documents you would like to order.
The documents included in Diamond Shamrock's postPhase I production consist almost entirely of two categories
of material. First, over half the documents. (Doc. Nos.
00033335-36221) are files from Diamond Shamrock Agrochemicals
Ltd. which were forwarded'to us from the United Kingdom. As
explained in the Responses of Defendant Diamond Shamrock
Chemicals Company to Plaintiffs' Interrogatories to Defendants,
served on January 16, 1984, Agrochemicals' plant never manu­
factured trichlorophenol, but did produce some herbicides con­
taining 2,4,5-T, using 2,4,5-T acid purchased from another party.
However, Agrochemicals' operations were only acquired by a sub­
sidiary of Diamond Shamrock on December 1, 1977. Accordingly,
while the Agrochemicals documents may arguably be responsive to

13928.

Stephen

J.

Schlegel,

Esg.

-2 -

March 6 , 1984

one of plaintiffs' earlier document requests in this litiga­
tion, you may wish to review the Agrochemicals documents at
our offices before ordering copies of them.
Virtually all of the remaining documents referenced
by the Index are from the second category, which consists of
post-1970 materials that might otherwise be responsive to
plaintiffs' Interrogatories to Defendants (First Wave), dated
April 19, 1983. Since these documents did not pertain to the
relevant time period for the government contract defense, they
were not produced as part of Phase I discovery.
Pursuant to the Court's protective order dated Febru­
ary 6, 1981, we will serve within the next several days a Notice

of Confidentiality and Updated Index of Confidential Documents
that identifies the documents referenced by the enclosed Index
which Diamond Shamrock has designated as "Confidential".
If you have any questions concerning the documents
referenced by the Index, please contact me at your earliest
convenience.
Very truly yours,

Michael M. Gordon
MMG/mam
Enclosure
BY COURIER
cc(w/encl.):

Clerk of the Court
Magistrate Shira A. Scheindlin
Service List
Victor Don Russo, Jr., Esq.

13929

<\ -

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

X

In Re
"AGENT ORANGE"
Product Liability Litigation
X

Defendant The Dow Chemical Company's
Amended Answers to Plaintiffs'
Interrogatories to Defendants_ _ _ _ _
In accordance with Magistrate's Pretrial Order No. 2 dated
February 10, 1984, defendant The Dow Chemical Company ("Dow") hereby
amends its Answers and Objections to Plaintiffs' Interrogatories to
Defendants dated January 16, 1984.

Dow reserves its right to supple­

ment or to amend further its answers as Dow acquires additional infor­
mation in the course of its continuing preparations for trial.

Dow

also reserves all objections to the admission in evidence of its
answer or the subject matter thereof in any proceeding or trial in
this or any other action.
Schedules of documents produced in response to Interroga
tories 2, 3, 4, 5, 9, and 10 are attached as Exhibits A, B, C, D, E,
and F, respectively.
In addition, the answers to Interrogatories 8 and 11 are
amended as follows:
Interrogatory 8
State whether you knew health hazards, physical disorders
injuries, irritations or diseases were associated with exposure to, or
use of herbicides containing 2,4,5-T. If your answer is affirmative,
state or identify:

13930

a)

the date you acquired such knowledge, belief or
suspicion;

b)

the manner in which you gained such knowledge belief or
suspicion;

c)

the type of health hazards, physical disorders,
injuries, irritations or diseases;

d)

all documents and communications which refer, reflect,
relate to, or embody the information sought by this
interrogatory.

Answer
Dow knows of no health hazards, physical disorders, injuries,
irritations, or diseases associated with exposure to or use of its
herbicides containing 2,4,5-T when used as directed.
Interrogatory 11
Did you at any time between 1961 and 1973 recommend to the
government that any herbicide containing 2,4,5-T be replaced because
of possible health problems associated with its use?
Answer
No
Dated:

Garden City, New York
February 17, 1984
RIVKIN, LEFF, SHERMAN & RADLER
for the Dow Chemical Company
(A Member oo f the Firm)
100 Garden City Plaza
Garden City, New York 11530
(516)746-7500

Ì3 9 3 1

Dow Docum ents R esp o n siv e t o C a u sa tio n In te r r o g a to r y 2

DOW0022120
DOW0023058-0023060
DOW00359 73
DOW0038002-0038003
DOW0038004
DOW0038347-0038348
DOW0040310-0040311
DOW0040324
DOW0045028
DOW0045665
DOW0045667-0045668
DOW0229696
DOW0333791-0333836
DOW0382816
DOW0446119-0446120
DOW0446121
DOW0446122
DOW0446123
DOWO587486-0587489
DOW0587502
DOW0587550
DOW0587690
DOW0775003- 0775007
DOW0775008-0775014
DOW0901792

DOW1162289

1393?

DOW1474553-1474555
DOWl552165-1552173
DOW1601589-1601593
DOW1601862
DOW1601864-1601865
DOW1601872-1601873
DOW1716325
DOWl749939-1749940

Dow Documents

Responsive

to C a u s a t i o n

Interrogatory

3

DOW0183335-0183336
DOW0312587
DOW0363666
DOW0363668
DOW0363676
DOW0363678
DOW0363689
DOW0363691
DOW0363699
DOW0363707
DOW0363709-0363710
DOWO 363827-0363840
DOW037739 7
DOW0377398
DOW0377399
DOW0377400
DOW0377401
DOW0377402
DOWO378502-0378505
DOW0428299-0428302
DOWO438023-0438024
DOWO438042-0438054
DOW0438163
DOWO438261-0438262
DOWO438281-0438294
DOW0439197

13934

DOW0439200
DOW0439206
DOW0439251
DOW0439254
DOW0439309
DOW0439311
DOWO439344
DOW0439346
DOW0439348
DOWO439355
DOW0439357
DOW0439359
DOW0439361
DOW0439369
DOW0439372
DOW0439382
DOW0439384
DOW0439392
DOW0439396
DOWO439399-0439400
DOW0439407-0439408
DOW0439410
DOWO 500580-0500584
DOWO 521676-0521678
DOWO521934-0521936
DOWO521971-0521973
DOW0523812
DOW0524022
DOW0525786

-13935

i9
'S .

DOW525791
DOWO5 2 5 8 2 2 -O525823
DOWO525825-0525826
DOWO525908-0525909
DOWO525911-0525912
DOWO525963-0525964
DOWO525966-0525967
DOWO525999-0526000
DOW0526020-0526029
DOWO526032-0526041
DOWO534687-0534688
DOWO535945-0535946
DOWO535949
DOWO536591
DOWO536665-0536666
DOW0536797
DOWO536806-0536807
DOWO536849-0536850
DOWO536861
DOWO536894-0536895
DOW0618734-0618736
DOWO720171-0720174
DOWO721744-0721753
DOWO721755-0721756
DOWO817344-0817350
DOWO820386-0820392
DOW0820969
DOW 820976-820977

t ^^

1393g

D O W 8 21214-0821216
-3-

DOWO821224-0821233
DOWO821252-0821259
DOW0821281
DOW0821292-0821294
DOW,0853510-0853511
. DOWO853513-0853514
DOW0930305-0930307
DOWO930798-0930800
DOWO937219-0937220
DOW1171625
DOWl171626-1171627
DOW1171633
DOW1171634
DOW1171635
DOW1171637-1171639
DOW1171640
DOW1406308
DOW1406312
DOW1406342
DOW1962461
DOW1992285
DOW2022546-2022547

H9
/
-4-

DOW DOCUMENTS

DOW0011959
DOWOO32302-0032324
DOWO032707-0032713
DOW0282117
DOWO556228-0556230

RESPONSIVE

TO

CAUSATION

INTERROGATORY

4

DOW DOCUMENTS

DOWO171108-0171111
DOWO171112-0171115
DOW0274515-0274517
DOW0441623-0441624
DOWO731412-0731414
DOW1320042-1320044
DOWO345368-1345370
DOWl421577-1421583
DOW1520974-1520978
DOW1587601-1587609

RESPONSIVE

TO CAUSATION

INTERROGATORY

5

Dow Documents Responsive to Causation Interrogatory 9

DOW0091999
DOW0037484-■0037485
DÒW0101686-■0101694
DOW0105153-■0105167
DOW0120640-•0120663
DOW0121686-•0121688
DOW0203438-■0203446
DOW0271733-■0203757
DOW0273187-■0273200
DOW0274755-■0274757
DOW0280618-■0280632
DOW0341469
DOW0379469
DOW0363570-■0363575
DOW0376087
DOW0383682-•0393685
DOW0390506-■0390507
DOW0396891
DOW0442260-■0442261
DOW0442329--00442333
DOW0445868-■00445877
DOW0804169-■0804183
DOW0947878--0947885
DOW1155346--1155350
DOW1172151--1172159
DOW1172171--1172185
DOW1172160-1172170

1

DOWll72854-1172855
DOW1172857
DOW1172871
DOW1172872
•DOW1172883
P9^1172886
DOWl377253-1377331
DOW1519607-1519616
DOW1544160-1544161

-2 -

13941

DOW DOCUMENTS

DOWOO23737-0023762
DOWO023948-0023963
DOW0273805-0273809
Ì5ÒW0281777-028177 8
DOWO384279-0384291
DOWO397546-0397573
DOWO397627-0397629
DOW0414141-0414145
DOW0856323-0856324
DOW0914690-0914692
DOW0992595-0992517
DOWl603607-1603608
DOW16 03609
DOWl613599-1613641

RESPONSIVE

TO

CAUSATION

INTERRORAGATORY

10

VERIFICATION
LESLIE R. BENNETT, being duly sworn, deposes and says:
1.

I am a member of the firm of RIVKIN, LEFF, SHERMAN

& RADLER, attorneys for The Dow Chemical Company, a defendant in
the above-entitled action, and I am the agent of that corporation
for the purpose of answering the interrogatories served upon the
corporation by plaintiffs on December 22, 1983 and for making this
verification.
2.

I have read the said interrogatories and the fore­

going answers thereto are true according to the best of my
knowledge, information and belief.

Sworn to before me this
17th day of February, 1984.

Notary Pub

’!*as!csS**Y'*

STATE OF NEW YORK
COUNTY OF NASSAU

)

)

)

Sharon A. Vento, being duly sworn, deposes and says:
deponent is not a party to the action, is over 18 years of age and
resides at Oceanside, N.Y.
On February 17,
19 84 , deponent served the with.in
Defendant The Dow Chemical Company's Amended Answers to Plaintiffs'
Interrogatories to Defendants
upon the attorneys below set forth represent­
ing the parties, as indicated, at the addresses shown, said addresses
being designated by said attorney for that purpose.
ATTORNEY:
SEE ATTACHED SERVICE LIST

by depositing a true copy of same enclosed in a postpaid properly
addressed wrapper in an official depository under the exclusive care
and custody of the United States Post Office Department within the
State of New York.
5

Sworn to before me this
/ 7** day of
, 19

Notary

Term¿(pires M
arch 30, 19^

A

.(ja^r—

R ivkin , Leff , S herman & Radler
TO:
MORTON B. SILBERMAN, ESQ.
Clark, Gagliardi & Miller
The Inns of Court
99 Court Street
White Plains, NY 10601
WENDELL B. ALCORN, JR., ESQ.
Cadwalader, Wickersham & Taft
One Wall Street
New York, NY 10005
JOHN SABETTA, ESQ.
Townely & Updike
405 Lexington Avenue
New York, N.Y. 10174
WILLIAM KROHLEY, ESQ.
Kelley, Drye & Wareen
101 Park Avenue
New York, NY 10178
DAVID R. GROSS, ESQ.
Budd, Larner, Kent, Gross,
Picillo & Rosenbaum
33 Washington Avenue
Newark, NJ 07102
THOMAS A BECK, ESQ.
Arthur, Dry & Kalish, P.C.
1230 Avenue of the Americas
New York, NY 10020
ARVIN MASKIN, ESQ.
Department of Justice
Safeway Building
Room 904D
Washington, DC 20530
JUDY SPANIER, ESQ.
Shea & Gould
330 Madison Avenue
15th Floor
New York, NY 10017
PAUL ESPOSITO, ESQ.
Lewis, Overbeck & Furman
135 South LaSalle Street
Suite 1060
Chicago, IL 60603

HOWARD LESTER, ESQ.
Lester, Schwab, Katz & Dwyer
120 Broadway
New York, NY 10271
STEPHEN J. SCHLEGEL, ESQ.
Schlegel & Trafelet, LTD.
One North LaSalle Street
Suite 3900
Chicago, IL 60602
BENTON MUSSELWHITE, ESQ.
Suite 517
609 Fannin
Houston, Texas 77002
THOMAS HENDERSON,. ESQ.
Baskin & Sears
Frick Building - 10th Floor
Pittsburgh, PA 15219
VICTOR J. YANNACONE, ESQ.
Yannacone & Yannacone
35 Baker Street
P.O. Box 109
Patchogue, NY 11772
DAVID DEAN, ESQ.
Dean, Falanga & Rose
One Old Country Road
Carle Place, NY 11514
SOL SCHREIBER, ESQ.
Special Master
Milberg, Weiss, Bershad
& Specthrie
One Pennsylvania Plaza
Room 4915, 49th Floor
New York, NY 10019
Clerk of the Panel
Judicial Panel on Multidistrict
Litigation
1120 Vermont Avenue, N.W.
Suite 1002
Washington, DC 20005
Magistrate Shira A. Scheindlin
United States District Court
Eastern District of New York
225 Cadman Plaza East
Brooklyn, NY 11201
Agent Orange Plaintiffs'
Management Committee
Suite 905
Brooklyn, NY 11242

V

LAW O F F IC E S

R ivkin , Leff , Sherman & Radler
lOO GARDEN" CITY PLAZA
GARDEN" CITY, NEW YORK 1 1 3 3 0
TELEPH O N E

TELEX

CA8LE ADDRESS

TE LE C O P IE R

S U I T E 3 9 0 0 * 3 0 N O R T H LA S A L L E S T R E E T

(5 IS ) 7 4 6 * 7 5 0 0

8 4 5 -0 7 4

A T IA W G R C Y

(5 1 6 )7 4 7 -2 8 4 3

C H I C A G O , ILLINOIS 6 0 6 0 2 - ( 3 l 2 ) 7 8 2 - 5 6 8 0

W R IT E R S D IR E C T d i a l : ( s i 6 )

228-4291

March 2, 1984

Clerk
United States District Court
Eastern District of New York
US Courthouse
225 Cadman Plaza East
Brooklyn, NY 11201
Re:

Agent Orange Product Liability Litigation
MDL No. 381

Dear Sir or Madam:
I-.-encl.pse-for filing in the above-captioned litigation'The
Dow Chemical Company’s Amended Answers to Plaintiffs’ Interroga­
tories to Defendants which were served on all parties on February
17, 1984.
Thank you for your cooperation.
Very truly yours,
RIVKIN, LEFF, SHERMAN & RADLER

Steven Brock •
SB:clb
Enclosure
cc:

Attached Service List w/o enclosures

T H E P A R T N E R S H IP IN C L U O E S O N E O R M O R E P R O F E S S IO N A L C O R P O R A T IO N S

R ivk in , Le f f , S h erm an & R adler
TO:
Morton B. Silberman, Esq.
Clark, Gagliardi & Miller
The Inns of Court
99 Court Street
White Plains, NY 10601

Howard Lester, Esq.
Lester, Schwab, Katz & Dwyer
120 Broadway
New York, NY 10271

Wendeïl B. Alcorn, Jr., Esq.
Cadwalader, Wickersham & Taft
One Wall Street
New York, NY 10005

Stephen J. Schlegel, Esq.
Schlegel & Trafelet, Ltd.
One North LaSalle Street
Suite 3900
Chicago, IL 60602

John Sabetta, Esq.
Townley & Updike
405 Lexington Avenue
New York, NY 10174
William Krohley, Esq.
Kelley, Drye & Warren
101 Park Avenue
New York, NY 10178
David R. Gross, Esq.
Budd, Larner, Kent, Gross,
Picillo & Rosenbaum
33 Wshington Avenue
Newark, NJ 07102
Thomas A. Beck, Esq.
Arthur, Dry & Palish .
1230 Avenue of the Americas
New York, NY 10020
Arvin Maskin, Esq.
Department of Justice
Safeway Building
Room 904 D
Washington, DC 20530
Judy Spanier, Esq.
Shea & Gould
330 Madison Avenue
15th Floor
New York, NY 10017
Paul Esposito, Esq.
Lewis, Overbeck & Furman
135 South LaSalle Street
Suite 1060
Chicago, IL 60603
Agent Orange Plaintiffs'
Management Committee
26 Court Street
Suite 905
Brooklyn, NY 11242

Benton Musselwhite, Esq.
Law Offices of Benton Musselwhite,
Suite 517
609 Fannin
Houston, TX 77002
Thomas Henderson, Esq.
Baskin & Sears
Frick Building - 10th Floor
Pittsburgh, PA 15219
Victor J. Yannacone, Jr., Esq.
Yannacone & .Yannacone
P.O. Box 109
35 Baker Street
_
Patchogue, NY 11772
David Dean, Esq.
Dean, Falanga & Rose
One Old Country Road
Carle Place, NY 11514
Sol Schreiber, Esq.
Special Master
Milberg, Weiss, Bershad & Specthrie
One Pennsylvania Plaza
Room 4915, 49th Floor
New York, NY 10019
Clerk of the Panel
Judicial Pane'l on Multidistrict Lit
1120 Vermont Avenue, NW
Suite 1002
Washington, DC 20005
Magistrate Shira A. Scheindlin
United States District Court
Eastern District of New York
225 Cadman Plaza East
Brooklyn, NY 11201

13947

R ivkin , Leff , S herm an & R adler
Service List
Page 2
Phillip E. Brown, Esq.
Hoberg, Finger, Brown, Cox & Molliga
703 Market Street
18th Floor
San Francisco, California 94103
Stanley Chesley, Esq.
Waite, Schnider, Bayleff & Chesley
1218 Central Trust Tower
Cincinnati, Ohio 45202
John Q. O'Quinn, Esq.
O'Quinn, Hagans & Wettman
3200 Texas Commerce Tower
Houston, Texas 77002
Neal R. Peterson, Esq. and
Gene Locks, Esq.
Greitzer & Locks
1500 Walnut Street
22nd Floor
Philadelphia, Pennsylvania
Newton B. Schwartz, Esq.
Houston Bar Center Building
723 Main
Suite 325
Houston, Texas 77002

19102

s

UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

■X
In re
"AGENT ORANGE"

NOTICE OF CONFIDENTIALITY
AND UPDATED INDEX OF
CONFIDENTIAL DOCUMENTS OF
DEFENDANT THE DOW CHEMICAL
COMPANY
MDL No. 381 (GCP)
(All Cases)

Product Liability Litigation
X

Defendant, The Dow Chemical Company,

("Dow"), pursuant to

the Protective Order regarding Production of Confidential
Documents by Defendants dated February 6, 1981 (the "Confiden­
tiality Order"), annexes hereto a Notice of Confidentiality
(Exhibit A) and an Updated Index of Confidential Documents
(Exhibit B) for those documents referenced in the Defendant The
Dow Chemical Company's Answers to Plaintiffs' Interrogatories to
Defendants (First Wave), dated February 13, 1981, which Dow has
designated as "CONFIDENTIAL."
In accordance with paragraph 14 of the Confidentiality Order,
Dow reserves its right to prepare and distribute further notices
of confidentiality and indexes as the need arises, and to avail
itself of the procedures set forth in the Confidentiality Order
for the documents identified therein.
Dated:

Garden City, New York
March 1, 1983
RIVKIN, LEFF, SHERMAN & RADLER

By :

TO:

ATTACHED SERVICE LIST

A Member ot the Firm
Attorneys for The Dow Chemical Company
100 Garden City Plaza
Garden City, N.Y. 11530
(516) 746-7500

NOTICE OF CONFIDENTIALITY AND
UPDATED INDEX OF CONFIDENTIAL
DOCUMENTS OF THE DOW CHEMICAL
COMPANY

NOTICE OF CONFIDENTIALITY

w

m

)

)

Dow Number

Date

Author

00883470088348*

701217

Dow
Hoyle, HR
Norris, JM

00883490088350*

701217

Dow
Norris, JM

00886490088650*

590122

Dow
Hoyle, HR
McCollister, DD
Wolf, MA

0088651 *

590500

Dow

00889110088913*

660506

Dow
Hoyle, HR
McCollister, DD
Olson, KJ

00889140088916*

771001

Dow

00889300088962*

661209

Dow

00889690088972*

670316

Dow
Hoyle, HR
Olson, KJ
Oyen, F

00889730089003*

690515

Buerge, TE
Dow

Recipient

)
)

Page 1
Distributees

General Subject Matter
M-3592 (Data sheet of properties,
health hazards, and precautions
for safe handling of materials)
M-32592 (Medical Information)
Forron Brush K ille r (Data sheet of
properties health hazards and pre­
cautions for safe handling of
materials)
Forron Brush K ille r M-1368, Safety
data sheet
M-2993 (Data sheet of properties,
health hazards, and precautions
for safe handling of materials)
Tordon 155 Mixture Brush K ille r
(Material safety data sheet)
2M0-3083-1 (Request for screening
or application testing)
Tordon 105 Mixture (Data sheet of
properties, health hazards, and
precautions for safe handling of
materials)
Toxicological properties and
Industrial handling hazards of

Dow Number

Date

Author
Norris, JM
Torkelson

00911730091176*

670316

Buerge, TE
Dow
Lynn, GE
Olson, K
Oyen, F

00911770091178*

670227

Dow
Hoyle, HR
Olson, KJ
Oyen, F

Recipient

f

to
IO

2
CO
Distributees

Page

General Subject M atter^
Tordon 225 Mixture herbicide
(M-3199X)

Boundy, RH
Dean, P
Dow
Elshere, D
Holder, BB
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Moss, RD
Sheetz, DP
Shrader, SA
Wilson, AW
Wright, N

Toxicological properties and
Industrial handling hazards of
Tordon 105 Mixture
(T2.M031-3132-1) (CRI 123032)

Boundy, RH
Dean, P
Dow
Elshere, D
Holder*, BB
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Moss, RD
Sheetz, DP

Tordon 105 Mixture data sheet of
properties, health hazards, and
precautions for safe handling of
materials (T2.MO-3132-1)

Dow Number

Date

Author

02783850278390*

540106

Dow
Wolf, MA

02783900278392*

531230

02783930278395*

540106

02783960278404*

540106

0503923 *

000000

Dow

05648500564851*

000000

Dow
Hoyle, HR
JMN

07251790725184*

650615

Dow

07503320750354*

571122

Dow
McColHster
Olson, KJ

M

" CO

(£)

CJX

C75

Recipient

DO

Page 3
Distributees

General Subject Matter
M-213 (Acute oral toxicity)
M-213 (Acute oral toxicity)
M-213
M-213 (Skin Irrita tio n )
Esteron 76BE
Tordon 225 herbicide (Data sheet
of properties, health hazards, and
precautions for safe handling of
materials)
Pulsafeeder test sheet hydroch­
lo r ic acid

A llln son, RL
Athay, RN
Beshgetoor, AW
Boundy, RH
Colby, RW
Dosser, RC
Dow

Results of range finding toxicolo­
gical tests on Brush K ille r X,
Weed K ille r X, and Brush K ille r
TX

I

)

Dow Number

Date

Author

Recipient

07504650750469*

501017

Adams, EM
Dow
M cCollister, DD
Rowe, VK

Allen, WW
Alquist, FN
Britton, JW
Dosser, RC
Dow
Dutton, WC
Irish , DD
Kagy, JF
Lynn, GE

07504700750484*

530217

Dow
RJE
M cCollister, DD
Oyen, F

05

<£}
“si

)
)

Page 4
Distributees

General Subject Matter

Elshere, D
Gay, HH
Greene, LM
Hart, A
Hymas, TA
Jones, GD
K ilia n , DJ
Luce, EN
Martin, D
McIntyre, HH
Mussel!, DR
Perkins, RP
Tisdale, WO
White, LC
Wright, N
Results of skin irrita tio n and
skin sensitization tests conducted
on human subjects with Esteron 245
(New Ester)

Allen, WW
Allinson, RL
Alquist, FN
Beshgetoor, AW
Boundy, RH
Britton, EC

Results of range finding toxicolo­
gical tests on Esteron 245

Dow Number

Date

Author

07505600750587*

531030

Adams, EN

Oyen, F

Recipient

)

;

)

Page 5
Distributees

General Subject Matter

Britton, JW
C o llie r, B
Davidson, JH
Dow
Dutton, WC
Gay, HH
Gibson, J
Greene, LN
Heath, SB
Johnson, JE
Kagy, JF
Kelly, JA
Kriner, RR
Luce, EN
Lynn, GE
MacCutcheon
Melass, VH
Nation, HA
Otis, CE
Prendergast, DT
Southwick, L
Sunderland, WW
Vanhorn, JC
Walker, H
White, LC
Wright, P
Zuhl, HH
Allen, WW
Alllnson, RL
Alqulst, FN
Barrons, KC
Beshgetoor, AW

Results of range finding toxicolo­
gical tests on Dow Brush K ille r T

ì

)

Dow Number

Date

Author

07506020750633*

560501

Dow
M cColllster, DD
Torkelson, TR

Recipient

13959

)

Page 6
Distributees

General Subject Matter

Boundy, RH
Britton, EC
Davidson, JH
Dow
Dutton, WC
Gay, HH
Greene, LM
Kagy, JF
Luce, EN
Lynn, GE
MacCutcheon, SM
Prescott, RF
Sunderland, WW
White, L
Wright, P
AlUnson, RL
Beshgetoor, AW
Boundy, RH
Britton, EC
Coulter, LL
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A
K ilia n , DJ
Luce, EN
McCutcheon, SM
Martin, D
Scoles, G
Sunderland, WW
Wright, N

Results of range finding toxicolo­
gical tests on M-631 (Esteron
245-Type Formulation)

*

I

I

}

Dow Number

Date

Author

07506660750693*

560409

Dow
M cCollister, DD
Wolf, MA

07506940750714*

560702

Dow
M cCollister, DD
Olson, KJ

CO

CO
05
O

Recipient

)

Page 7
Distributees

General Subject Matter

AlHnson, RL
Beshgetoor, AW
Boundy, RH
Britton, EC
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A
Kagy, JF
K e lly, J
K111an, DJ
Luce, EN
Lynn, GE
MacCutcheon, SM
Sunderland, W
W
Wright, N

Results of range finding toxicolo­
gical tests on formulations of
Reddon (M-640 and M-713)

Alllnson, RL
A lqulst, FN
Barrons, KC
Beshgetoor, AW
Boundy, RH
Britton, EC
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A
Kagy, KF
K e lly, JA

Results of range finding toxicolo­
gical tests on Esteron Brush
K ille r O.S. (M-726)

Dow Number

Date

Author

07507190750726*

570806

Dow
Hoyle, HR
Wolf, MA

07507270750736*

570510

Babcock, I
Dow
Dunn, EE

co
CO

05

Recipient

Dow
Wolf, MA

;

J

Page
Distributees

General Subject Matter

K ilia n , DJ
Luce, EN
Lynn, GE
MacCutcheon, SM
Sunderland, WW
Wright, N
Allinson, RL
Athay, RM
Beshgetoor, AW
Boundy, RH
Colby, RW
Dow
Eishere, D
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K ilia n , DJ
Luce, EN
Lynn, GE
M cCollister, DD
McIntyre, HH
Musseil, DR
Perkins, RP
Scoles, GW
Tisdale, WL
Wright, N

Results of rant*® finding toxicolo
glcal tests on N-1085 (A 245T
Triethyl amine Liquid Formulation)

Request for application testing
for M-1085 with eye and skin
contact tests attached

)

Dow Number

Date

Author

Recipient

KS
MAW

07507390750740*

570510

Dow
Hoyle, HR
McCollister, DD
Wolf, MA

07507410750743*

000000

Dow
Hoyle, HR
McCol lis t e r , DD
Wolf, MA

07507440750746*

580521

Dow
Coulter, LL
McCollister, DD Dow
Olson, KJ

07507470750764*

580425

Dow
Hoyle, HR
McCollister, DD
Olson, KJ

CO
03
CD

I

I

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Page 9
D1strlbutees

General Subject Matter

M-1085 data sheet of properties,
health hazards, and precautions
for safe handling of materials
M-1085 data sheet of properties,
health hazards, and precautions
for safe handling of materials
Results of range finding toxicolo­
gical tests on Weed K ille r
Formulation M-1094 containing a
245T Ester
AlUnson, RL
Athay, RM
Beshgetoor, AW
Boundy, RH
Colby, RW
Coulter, LL
Dow
Elshere, D
Fletcher, FW
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Jones, GD
Kagy, JF

M-1094 Weed K ille r Formulation
Data sheet of properties, health
hazards and precautions for safe
handling of materials

I
)

Dow Number

Date

Author

07507690750790*

610316

Hoyle, HR
Olson, KJ
Oyen, F
Thompson, E

07507910750793*

000000

Hoyle, HR
Olson, KJ
Oyen, F

K*
Co
CO
CO

Recipient

Page 10
Distributees

General Subject Matter

K1l1an, DJ
Luce, EN
McIntyre, HH
Perkins, RP
Scoles, GW
Tisdale, WL
Vanvalkenburg, W
Wright, N
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Falkensteln, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Shrader, SA
Tisdale, WL
Vanvalkenburg, W
Wright, N

Results of range finding toxicolo­
gical tests on M-1123

V.
T

M-1123 data sheet of properties,
health hazards, and precautions
for safe handling of materials

Dow Number

Date

Author

07507950750813*

600125

Dow
Oyen, F
Wolf, MA

07508140750827*

610601

Dow
Olson, KJ
Oyen, F

Recipient

/

Page 11
Distributees

General Subject Matter

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K ilia n , DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Stenger, VA
Tisdale, WL
Wright, N

Results of range finding toxlcolo
glcal tests on Esteron 245 OS
(M—1257)

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Falkenstein, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K1l1an, DJ

Results of range finding toxicolo­
gical tests on Esteron 245 OS
(Replacement for present
Formulation M-1257)
V
•*

}

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Co
CD
CJ?

Dow Number

Date

Author

07508330750854*

571122

Dow
McColHster, DD
Olson, KJ

07508550750873*

590818

Olson, KJ
Oyen, F

Recipient

)

)

)

Page 12
Distributees

General Subject Matter

Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Shrader, SA
Tisdale, WL
Whlte, LC, J r.
Wright, N
AlUnson, RL
Athay, RM
Beshgetoor, AW
Boundy, RH
Colby, RW
Dosser, RC
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A
Hymas, TA
Jones, GD
K111an, DJ
Luce, EN
Martin, D
McIntyre, HH
Mussell, DR
Perkins, RP
Tisdale, WL
White, LC
Wright, N

Results of range finding toxicolo­
gical tests on Brush K ille r X,
Weed K ille r X, and Brush K ille r
TX

Barrons, KC
Boundy, RH

Results of range finding toxicolo­
gical tests on M-1413 (Formulation

)

/

Dow Number

Date

Author

07508740750876*

590706

Dow
Hoyle, HR
Olson, KJ
Oyen, F

07508780750903*

590506

Dow
McCollister, DD
Wolf, MA

Recipient

Page 13
Distributees

General Subject Matter

Colby, RW
Dow
Elshere, D
Gay, HH
Gray, HE
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Scoles, G
Stenger, VA
Tisdale, WL
Wright, N

of Dowanol Ester 245T) made for
the Stull Chemical Company

M-1413 Formulation of K 7856
(Dowanol Ester 245T). Data sheet
of properties, health hazards and
precautions fo r safe handling of
materials
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH

Results of range finding toxicolo­
gical tests on M-1447 and M-1443
Weed K ille r Formulations (Similar
to Esteron 245 OS and Esteron
Brush K ille r OS respectively)

Dow Number

Date

Author

07509150750940*

590506

Dow
McCollister, DD
Wolf, MA

Recipient

)

j

\

Page 14
Distributees

General Subject Matter

Gray, HE
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Stenger, VA
Tisdale, WL
Vanvalkenburg, JW
Wright, N
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Gray, HE
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, JD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE

Results of range finding toxicolo­
gical tests on M-1447 and M-1433
Weed K ille r Formulations (Similar
to Esteron 245 OS and Esteron
Brush K ille r OS respectively)

i

Dow Number

Date

Author

Recipient

07509510750952*

591209

Dow
Wolf, MA

McIntyre, HH

07509560750974*

590903

Dow
Olson, KJ
Oyen, F

CO
CD

CO
00

Page 15
Distributees

General Subject Matter

McIntyre, HH
Perkins, RP
Stenger, YA
Tisdale, Wl
Vanvalkenburg, JW
Wright, N
Dow
Wolf, MA

Toxicological information on
Esteron 99 granules (M-1741)
suitable for presentation to the
USDA

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hynas, TA
Jones, GD
Kagy, JF
K ilian , DJ
Leasure, JK
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Scoles, G
Stenger, YA
Tisdale, WL
Wright, N

Results of range finding toxicolo­
gical tests on Agricultural
Chemical Formulation M-1511 con­
taining Dowanol 97B70 Ester 245T
(K—7856)

)

>
>

Dow Number

Date

Author

07509750750976*

590811

Dow
HRH
Olson, KJ
Oyen, F

600216

Dow
Olson, K
Oyen, F

600223

Dow
Olson, KJ
Oyen, F

07509770550996*

07509980751016*

ZOùD.

03

C£>

Recipient

I

Page 16
Distributees

General Subject Matter
M-1511 Data sheet of properties,
health hazards and precautions for
safe handling of materials

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Scoles, GW
Stenger, VA
Tisdale, WL
Wright, N

Results of range finding toxicolo­
gical tests on Agricultural
Chemical Formulation M-1683
(Esteron 245 Type)

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D

Results of range finding toxicolo­
gical tests on Agricultural
Chemical Formulation M-1684
(Esteron Brush K ille r Type)

*

/

Dow Number

Date

Author

07510560751058*

611120

Dow
Olson, KJ
Oyen, F
Plomer, ET
Scoi es, GW

Recipient

13970

)

}

Page 17
Distributees

General Subject Matter

Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K11Ian, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Scoles, GW
Stenger, VA
Tisdale, WL
Wright, N
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Falkensteln, W
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K lU a n , DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, P

Results of range finding toxicolo­
gical tests on M-2115, an
agricultural chemical formulation
containing 245T and tr1ethyl
amine

•>

)

Dow Number

Date

0751059 *

611120

07510600751075*

611106

Author

Dow
Hoyle, HR
Olson, KJ
Oyen, F
Plomer, ET

Recipient

13971

)

)

Page 18
Distributees

General Subject Matter

Scoles, GW
Shrader, SA
Tisdale, WL
Wright, N
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Falkensteln, W
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, P
Scoles, GW
Shrader, SA
Tisdale, WL
Wright, N

F irs t aid measures

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Falkensteln, W
Gay, HH

M-2115 data sheet of properties,
'
health hazards and precautions for
safe handling of materials

Dow Number

Date

Author

07510780751080*

620403

Dow
Olson, KJ
Oyen, F
Vanvalkenburg, W

Recipient

13972

)

)

Page 19
Distributees

General Subject Matter

Greene, LM
Hart, A
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, P
Scoles, GW
Shrader, SA
Tisdale, WL
Wright, N
Barrons, KC
Boundy, RH
Brown, R
Colby, RW
Dow
Elshere, D
Falkenstein, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Nash, HA
Perkins, RP
Shrader, SA

Results of range finding toxicolo­
gical tests on M-2235, an emulsi­
z a b le formulation of 24D and 245T
Dowanol Esters 1n kerosene

)

)

)

Dow Number

Date

0751081 *

620323

07510820751098*

620323

K*
Co
CO
•N l
co

Author

Dow
Hoyle, HR
01 son, KJ
Oyen,

Recipient

Page 20
Distributees

General Subject Matter

Yanvalkenburg, W
Wilson, AW
Wright, N
Barrons, KC
Boundy, RH
Brown, R
Colby, RW
Dow
Elshere, D
Falkenstein, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HI
Nash, HA
Perkins, RP
Shrader, SA
Yanvalkenburg, W
Wilson, AW
Wright, N

F ir s t aid measures

Barrons, KC
Boundy, RH
Brown, R
Colby, RW
Dow
Elshere, D

M-2235 data sheet of properties,
health hazards, and precautions for
safe handling of materials

Dow Number

Date

Author

07510990751101*

630809

Hoyle, HR
Olson, KJ
Oyen, F

0751102 *

620124

Dow
Wolf, MA

07512090751210*

630225

Dow
Olson, KJ
Oyen, F

Recipient

Dow
McIntyre, HH

)

I

)

Page 21
Distributees

General Subject Matter

Falkensteln, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Nash, HA
Perkins, RP
Shrader, SA
Yanvalkenburg, W
Wilson, AW
Wright, N
Verton T sales specification

Suggested precautionary labeling
for M-2235
Barrons, KC
Boundy, RH
Brown, R
Colby, RW
Dow
Elshere, D
Falkensteln, WJ
Gay, HH
Greene, LM

Results of range finding toxicolo­
gical tests on agricultural cheml- v
cal formulation M-2422 containing '
91 percent Dowanol PIB Ester of
245T

>

.)

Dow Number

Date

0751211 *

630225

Co

QD
'OT

)

Author

Recipient

)

}

)

I

Page 22
Distributees

General Subject Matter

Hart, A
Jones, GD
Kagy, JF
K ilia n , DJ
Luce, EN
Lynn, GE
McIntyre, HH
MulHson, WR
Nash, HA
Norton, TR
Shrader, SA
Wilson, AW
Wright, N
Barrons, KC
Boundy, RH
Brown, R
Colby, RW
Dow
Elshere, D
Falkenstein, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K ilia n , DJ
Luce, EN
Lynn, GE
McIntyre, HH
Mullison, WR
Nash, HA
Norton, TR

F irs t aid measures

*

)

I

)

)

Dow Number

Date

Author

07512120751213*

630220

Dow
Hoyle, HR
01 son, KJ
Oyen,

07512140751236*

630225

QJ
QD
'" '3

Recipient

I

)

)

)

Page 23
D1strlbutees

General Subject Matter

Shrader, SA
Wilson, AW
Wright, N
Barrons, KC
Boundy, RH
Brown, R
Colby, RW
Dow
Elshere, D
Falkenstein, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K ilia n , DJ
Luce, EN
Lynn, GE
McIntyre, HH
Mullison, WR
Nash, HA
Norton, TR
Shrader, SA
Wilson, AW
Wright, N

M-2422 data sheet of properties,
health hazards and precautions for
safe handling of materials

Barrons, KC
Boundy, RH
Brown, R
Colby, RW
Dow
Elshere, D

Toxicological properties of
Formulation M-2422

*

}

Dow Number

Date

Author

07522640752265*

670328

Dow
Hoyle, HR
M cCollister, DD
Olson, KJ

0752266 *

661220

Buerge, TE
Dow

07523600752361*

670410

07523850752386*

690415

CQ

CO
-si.

Dow
Norris, JM
Torkel son, TR

Recipient

Dow
Lynn, 6E

)

)
)

Page 24
Distributees

General Subject Matter

Falkensteln, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
MulHson, WR
Nash, HA
Norton, TR
Shrader, SA
Wilson, AW
Wright, N
M-3060 data sheet of properties,
health hazards and precautions for
safe handling of materials
M-3060 request for screening or
application testing
M-3060, Safety Data and
Formulation
Axe, FD
Barton, J
Beauchamp, RR
B la ir, EH
Burgert, BE

M-3401 Brush K1ller-A Tordon Acid
Formulation

)

Dow Number

Date

Author

07523880752389*

690320

Dow
Hoyle, HR
Norris, JM
Torkelson, TR

07523900752395*

690417

Dow
N orris, JM

07525500752552*

700130

Dow
Gowell, JH
Loucks, MF
Lynn, GE
Naegele, RE

eg
-s?
CD

Recipient

)

)

Page 25
Distributees

General Subject Matter

Dow
Edwards, H
Elshere, D
Gordon, HL
Holder, BB
Johnson, JE
Kagy, JF
K11Ian, DJ
Klmmel, CE
Lloyd, BH
MacCutcheon, SM
M cCollister, DD
McIntyre, HH
Morse, D
P1tman-Moore
Robinson, VB
Schwartz, AJ
Wright, N
M-3402 Brush K ille r data sheet of
properties, health hazards and
precautions for safe handling of
materials
Toxicological properties of M-3401
Brush KH ler-A Tordon acid for- *
mulatlon
i
Tordon 225 herbicide release to
sales

hr

)

Dow Number

Date

Author

Recipient

Newport, JJ
Ridner, JM
Seymour, KG
Stein, JS
Williams, CS
Williams, RW
Wolf, MA
07525530752554*

690429

Dow
Hoyle, HR
Norris, JM

07624930762496*

500829

Dow
Rowe, VK
Spencer, HC

0762497 *

000000

0762498 *

490309

Dow
Irish , DD
M cCollister, DD
Rowe, VK
White, L

0762499 *

490412

Dow
Wyse, H

^4
CO

CS
KS

to

Allen, W
W
Barrons, KC
Britton, JW
Dosser, RC
Dow
Dutton, WC
Irish , DD
Kagy, JF
Lynn, GE

)

;

Page 26
Distributees

General Subject Matter

Tordon 225 mixture herbicide data
sheet of properties, health
hazards and precautions for safe
handling, of materials
Results of range finding toxicolo­
gical tests on Esteron 245T for­
mulations

Summary of toxicological Infor­
mation on 24D & 245T formulations
Esteron 245T (New formulation)
(Request for biological test)

K7716-1 Esteron 245T (New
formulation) (Acute oral
toxicity)

'
'

)

13980

Dow Number

Date

Author

0762500 *

490321

Dow
Wyse, H

07625010762504*

490000

Dow
Wyse, H

0762505 *

490517

Dow
Wyse, H

0762506 *

490225

Dow
HAS
RSH
Irish
Rowe, VK
White, L

0762507 *

490414

Dow
Wyse, H

0762508 *

490321

Dow
Wyse, H

07625090762512*

490000

Dow
Wyse, H

0762513 *

490517

Dow
Wyse, H

07666980766699*

690415

Beauchamp, RR
Dow
Norris, JM

Recipient

)

I

I

Page 27
Distributees

General Subject Matter
Esteron 245T (New formulation)
K7716-1 Esteron 245T (New
formulation) (Skin Irritatio n )
K7716-1 Esteron 245T (New
formulation) (Single absorption
exposure record)
Esteron 245T formulation (Request
for biological test)

K7716-2 Esteron 245T formulation
(acute oral toxicity)
Esteron 245T formulation
K7716-2 Esteron 245T formulation(Skin irrita tio n )
v.
K7716-2 Esteron 245T formulation
(Single absorption exposure
record)
Axe, FD
Barron, J
Beauchamp, RR

M-3401 Brush K1ller-A Tordon Acid
Formulation

)

!

\

)

Dow Number

Date

Author

Recipient

Torkel son, TR

07667000766701*

690320

Dow
Hoyle, JR
Norris, JM
Torkel son, TR

07667020766708*

690417

Dow
Norris, JM

0766709 *

681008

Beauchamp, RR
Byrd, BC
Dow
Dow
McCol H s t e r , DD Hoerger, FD
M cCollister, DD

Co
CO
QD

^«4

)

\

)

Page 28
Pistrlbutees

General Subject Matter

B la ir, EH
Burgert, BE
Dow
Edwards, H
Elshere, D
Gordon, HL
Holder, BB
Johnson, JE
Kagy, JF
K ilia n , DJ
Kimmel, CE
Lloyd, BH
MacCutcheon, SM
M cCollister, DD
McIntyre, HH
Morse, D
Robinson, VB
Schwarz, AJ
Wright,. N
M-3401 Brush K ille r (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)
Toxicological properties of M-3401
Brush K ille r , a Tordon acid
formulation
Proposed name, Tordon 124V Brush
K ille r (M3401) (Request for
screening or application testing)

Dow Number

Date

Author

0766710 *

681008

Dow

07667110766726*

680000

Dow
L itc h fie ld , N
Norris, JM

07667270766729*

690310

Dow
Norris, JM

07667300766737*

680000

Dow
King, CD
L itc h fie ld , N
Sparschu, GL
T rice , V

07667380766740*

681000

Dow
Dunn, FL

07667410766744*

681104

Dow
Dunn, FL

07667450766746*

690128

Dow
Dunn, FL

07667470766750*

690000

Dow
L itc h fie ld , N

07667510766765*

690123

Dow
Norris, JM

0766766 *

690123

Dow

CO

QO
C£>

to

Recipient

Page 29
Distributees

General Subject Matter
Toxolcology work sheet (Tordon
124V Brush K ille r)
Tordon 124V Brush K ille r (Acute
oral toxicity)
M-3401 Brush K ille r , oral dosage
to male rats
Tordon 124V Brush K ille r (Request
for pathology)

Tordon 124V Brush K ille r (Eye con­
tact test)
Tordon 124V Brush K ille r (Skin
contact, Irritation )
M-3401 Tordon 124V Sample 2, (Skin
contact, Irritation)
Tordon (Skin contact absorption)
Toxicological properties of Tordon
124V Brush K ille r made with CA
Tordon acid
Tordon 124V Brush K ille r
(Toxicology work sheet)-

*

Dow Number

Date

Author

0766767 *

681008

Beauchamp, RR
Dow
McCollister, DD

07667680766769*

000000

Dow

07667700766800*

680000

Dow
Dunn, FL
L itc h fie ld , N

07668010766821*

680000

Conran, PB
Dow
King, CD
L itc h fie ld , N
Sparschu, GL
Trice, V

07668220766823*

690107

Beauchamp, RR
Dow
Leong, BKJ
Trice, VR

07668240766847*

690113

Beauchamp, RR
Conran, PB
Dow
Leong, BKJ
Sparschu, GL
T rice, VR

fazrè.

Go
CO
CD

CO

Recipient

)

J

Page 30
Distributees

General Subject Matter
Proposed name Tordon 124V Brush
K ille r (Request for screening or
application testing)
M3401 Brush K ille r (Data sheet of
properties, health hazards and
precautions for safe handling of.
materials)
Tordon 124V Brush K ille r , male rat
testing
Tordon 124V Brush K ille r (Request
for pathology)

Summary report on the effect of
acute Inhalation of the vo latile
components of California Tordon
Acid and Texas Tordon Acid
(Biochemical Res Lab Sample 1)
Summary pathology report on the
effect of acute Inhalation of the
v o la tile components of California
Tordon Acid and Texas Acid
(Blochem Res Lab Pathology Report
Sample)

Dow Number

Date

Author

07670180767019*

560412

Dow

07670200767021*

610525

Dow
Hoyle, HR
Olson, KJ
Oyen, F

07670220767023*

790216

Dow
Fishbeck, WA
Keeler, P

07670240767025*

720329

Dow

07670260767027*

580613

Dow
McCollister, DD
Wolf, MA

07670280767029*

610525

Dow
Olson, KJ
Oyen, F

0767030 *

610531

Dow

0767031 *

000000

Dow

0767032 *

700721

Dow

QO
oo

Recipient

)

Page 31
Distributees

General Subject Matter
Esteron Brush K ille r OS M-726
(T2.30-71-1), safety data sheet
with formulation
Esteron 99 data sheet of proper­
tie s , health hazards and pre­
cautions for safe handling of
materials
Esteron 99 medical Information

Esteron 99 material safety data
sheet
Esteron 99 data sheet of proper­
tie s , health hazards and pre­
cautions for safe handling of
materials
Esteron 99 data sheet of proper­
tie s , health hazards and pre­
cautions for safe handling of
materials
Esteron 99 (Replacement
formulation)
Esteron 99 medical Information
symptomatology and treatment
Esteron 99 toxicology, anticipated
human response

}

)

Dow Number

Date

Author

07670330767034*

720329

Dow

07670540767055*

570514

Dow
Hoyle, HR
M cCollister, DD
Wolf, MA

07670560767057*

580514

Dow
Hoyle, HR
M cCollister, DD
Wolf, MA

0767058 *

000000

Dow
Hoyle, HR
Wolf, MA

07670590767060*

710900

Dow

0767061 *

580716

Dow
Wolf, MA

Dow
McIntyre, HH

0767062 *

610112

Dow
Wolf, MA

Dow
McIntyre, HH

07670630767064*

580425

Dow
Hoyle, HR
M cCollister, DD
Olson, KJ

0767065 *

580717

Dow
Hoyle, HR
Olson, KJ

CO
CO
c©

Recipient

)

)

Page 32
Distributees

General Subject Matter
Esteron 99 material safety data
sheet
M-1086 data sheet of properties,
health hazards and precautions for
safe handling of materials
Veon brush k ille r (M-1086) data
sheet of properties, health
hazards and precautions for safe
handling of materials
M-1086 (A herblcldal formulation
T2.3098), safety data sheet
Veon brush k ille r
Suggested precautionary labeling
for M-1094
Suggested precautionary labeling
for M-1094
M-1094 weed k ille r formulation
data sheet of properties, health
hazards and precautions for safe
handling of materials
M-1094 containing 245T Ester T2,
30-112-1, safety data sheet

4

Dow Number

Date

Author

Recipient

0767066 *

570730

Dow
Wolf, MA

Coulter, LL
Dow

07670670767068*

571120

Dow
Hoyle, HR
McCollister, DD
Olson, KJ

07670690767070*

571028

Dow
Hoyle, HR
McCollister, DD
Olson, KJ

0767071 *

571206

Dow
Hoyle, HR
Olson, KJ

0767072 *

571206

Dow
Hoyle, HR
Olson, KJ

0767073 *

610112

Dow
Wolf, MA

07670730767074*

610311

Dow
Hoyle, HR
Olson, KJ
Oyen, F

0767075 *

610400

Dow

07670920767098*

531029

Adams, EM

Dow
McIntyre, HH

)

>

Page 33
Distributees

General Subject Matter
Inverton, a le tte r showing concern
for hazards
Inverton M-1116 data sheet of pro­
perties, health hazards and pre­
cautions for safe handling of
material s
M-1116 dilution Cl-14-100 data
sheet of properties, health
hazards and precautions for safe
handling of materials
Inverton weed k ille r (M-1116)
T2.30-101-1, safety data sheet
M-1116 dilution Inverton for­
mulation
Suggested precautionary labeling
for M-1123
M-1123 data sheet of properties, ;
health hazards and precautions for
safe handling of materials
^
M-1123, safety data sheet

Allen, WW

Results of range finding toxlcolo-

't

Dow Number

Date

Author
Dow
Eslunn, E
Maxey, JS
Oyen, F

07670990767119*

530325

Dow
HCS
Rowe, VK
Wolf, MA

07671530767160*

570806

Dow
McCollister, DD
Wolf, MA

b**
Go
CO

CO

"sj

Recipient

)

}

)

/

Page 34
Distributees

General Subject Matter

Allinson, RL
Alqulst, FN
Barrons, KC
Beshgetoor, AW
Boundy, RH
Britton, EC
Davidson, JH
Dow
Dutton, WC
Gay, HH
Greene, LM
Kagy, JF
Luce, EN
Lynn, GE
MacCutcheon, SM
Prescott, RF
Sunderland, WW
White, LC
Wright, P'

gical tests on Dow Brush K ille r
50-50

Toxicity of Dow Brush K ille r 50-50
(T2.30-28-1 )

AlHnson, RL
Athay, RM
Beshgetoor, AW
Boundy, RF
Colby, RW
Dow
Elshere
Gay, HH

Results of range finding toxicological tests on M-1085 (A 245T
triethyl amine liq u id formulation
T2.30-97-1)

it
’

Dow Number

Date

Author

07671540767155*

571005

Dow
Hoyle, HR
McCollister
Wolf, MA

0767161 *

570228

Dow

0767162 *

570301

Dow

07671630767164*

570402

Babcock, D
Dow
Wolf, MA

07671650767166*

570415

Dow .

Recipient

Barrons, KC
Dow

)

)

Page 35
Distributees

General Subject Matter

Greene, LM
Hart, A
Jones, GD
Kagy, JF
K111an, DJ
Luceen
Lynn, GE
McIntyre, HH
Mussel 1, DR
Perkins, RP
Scoles, GW
Tisdale, WL
Wright, N
M-1085 (A 245T alkyl amine
formulation) data sheet of pro­
perties, health hazards and pre­
cautions for safe handling of
materials
Sample 1, M-1085 (T2.30-97-1), eye
and skin contact
M-1085 request for applications
testing (2.30-97-1)
Sample 1 (2.30-97-1) (eye contact -i
test)
Sample 1 M-1085 skin contact I r r i­
tation T2.30-97-1

>

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)

J

Dow Number

Date

Author

07671840767191*

570806

Dow
McColUster, DD
Wolf, MA

07671850767186*

570511

Dow
Hoyle, HR
McColUster
Wolf, MA

0767192 *

570228

Dow
Wolf, MA

0767193 *

570227

Dow
Scoi es, G

CO

CO
ce­

co

Recipient

Barrons, KC
Dow

)
)

Page 36
Distributees

General Subject Matter

A lliso n , RW
Athay, RM
Barrons, KC
Beshgetoor, AW
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Russel, DR
Scoles, G
Tisdale, WL
Wright, N

Results of range finding toxicolo­
gical tests on M-1086 (A 245T and
24D alkyl amine formulation)

M-1086 (Data sheet of properties,
health hazards and precautions for :
safe handling of materials)
»
Sample 1, M-1086 (Toxicology work
sheet)
M-1086 (2.30-96-1) (Request for
applications testing)

]

)

I

>

Dow Number

Date

Author

07671940767195*

570326

Dow
Stagerstron, E

07671960767197*

570228

Dow

07672130767222*

580521

Dow
M cCollister, DD
Olson, K

07672160767217*

580425

Dow
Hoyle, HR
McColHster, DD
Olson, KJ

CO
CO
Co
o

Recipient

)

Page 37
D1strlbutees

General Subject Matter
Eye contact test M-1086,
T2.30-96-1
M-1086 (Skin contact Irritatio n )
(T2.30-96-1)

Allinson, RL
Athay, RM
Beshgetoor, AW
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Jones, GD
Kagy, OF
K ilia n , DJ
Luce, EN
McIntyre, HH
Perkins, RP
Scoles, GW
Tisdale, WL
Vanvalkenburg, W
Wright, N

Results of range finding toxicolo­
gical tests on weed k ille r for­
mulation M-1094 containing a 245T
Ester (T2.30-112-1)

*

•k
r

M-1094 Weed K ille r formulation
(Data sheet of properties, health
hazards, and precautions for safe
handling o f materials)

/

J

t

Dow Number

Date

Author

0767223 *

580225

Dow

0767224 *

000000

Dow
Scoles, G

0767225 *

580218

Coulter, LL
Dow

0767226 *

580225

Dow
NCG

07672270767228*

530311

Dow
NCG

07672290767230*

580525

Dow
NCG

0767231 *

580402

Coulter, LL
Dow

07672430767251*

571220

Dow
McCollister, DD
Olson, KJ

tjj

r
cb

Recipient

Dow
Rowe, VK

Dow
Rowe, VK

)

)
Page 38
Distributees

General Subject Matter
Sample 1 Weed K ille r formulation
(M-1094) (Toxicology work sheet)
245T (Request for screening or
application testing)

Dow
Fletcher, FW
Scoles, GW
Vanvalkenburg, W

Formulation M-1094, contemplated
sales program

Sample 1 Weed K ille r formulation
(M-1094) (T2,30-112-1) (acute oral
toxicity)
Sample 1 Weed K ille r formulation
(M-1094) (eye contact test)
Sample 1, weed k ille r formulation
(M-1094) (T2.30-112-1) (skin con­
tact Irritatio n )
Dow
Fletcher, FW
Scoles, GW
Vanvalkenburg, JW

M-1094, w ill remain 1n development
during 580000
*

AlUnson, RL
Beshgetoor, AW
Boundy, RH
Colby, RW
Coulter, LL
Dow

Results of range finding toxicolo­
gical tests on Inverton (brush
k ille r ) . (T2.30-101-1)

)

)

)
)

>-■4
CO
CQ
CD
ro

Dow Number

Date

Author

07672450767246*

571120

Dow
Hoyle, HR
McCollister, DD
Olson, KJ

0767252 *

570520

Dow

0767253 *

000000

0767254 *

570520

Dow

07672550767256*

570520

Babcock, D
Dow

Dow
Scoles, G

Recipient

)

)

)

)

Page 39
D1strlbutees

General Subject Matter

Elshere, D
Gay, HH
Gray, HE
Greene, LM
Hart, A
Hymas, TA
Jones, GD :
Kagy, JF
K1Han, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Mussel 1, DR
Perkins, RP
Scoles, GW
Tisdale, WL
Wright, N

U rt

Inverton M-1116 (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)
Sample 1 M-1116 (T2.30-101-1)
(Toxicology work sheet)

4
■y

M-1116 (Request for applications
testing) (2.30-101-1)
Sample 1 M 1116 (Acute oral
toxicity) (T2.30-101-1)
Sample 1 M-1116 (Eye contact test)
(T2.30-101-1)

)

I

)

CO

CO

CO

Co

Recipient

Dow Number

Date

Author

07672570767258*

570624

Babcock, D
Dow

07672590767260*

570730

Dow
Wolf, MA

Coulter, LL
Dow

0767261 *

580221

Dow

Dow
Olson, KJ

0767262 *

580408

Dow
Wolf, MA

Dow
McIntyre, HH

07672630767267*

610316

Dow
Olson, KJ
Oyen, K
Thompson, E
Vanvalkenburg

)

;

Page 40
D1strlbutees

General Subject Matter
Sample 1 M-1116 (Skin contact
irrita tio n ) (T2.30-101-1)
Inverton, a le tte r showing concern
for hazards
Request for report
Suggested precautionary labelling
for Inverton (M-1116)

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Falkensteln, WJ
Gay, HH
Greene, LM
Hart
Jones, GD
Kagy, JF
K11ian, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Shrader, SA
Tisdale, WL
Vanvalkenburg, W
Wright, N

Results of range finding toxicolo­
gical tests on M-1123
(T2.30-201-1)

Dow Number

Date

Author

07672680767269*

610311

Dow
Hoyle, HR
Olson, KJ
Oyen, F

0767270 *

601228

Dow

0767271 *

601229

Dow

0767272 *

601223

Dow
Dow
Vanvalkenburg, W Olson, KJ

0767273 *

610106

Dow
Wolf, MA

0767274 *

601228

Dow

07672750767276*

610110

Dow
Thompson, E

07672770767280*

601228

Dow
Thompson, E

07672810767282*

610120

Dow
Thompson, E

07672880767300*

610601

Dow
White, LC, Jr.

CO
CD
CD
i4^ì

Recipient

Dow
Ri tty , PM

Page 41
Distributees

General Subject Matter
M-1123 (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
M-1123 (Toxicology work sheet)
(T2.30-201-1 )
M-1123 (request for screening or
application testing)

Dow
Johnson, JE
Ri tty , PM

M-1123, Formulation, use, release
to sale plans
Formulation for M-1094, no data
available on to x icity for M-1123
Sample 1 M-1123 (Acute oral
toxicity) (T2.30-201-1 )
Sample 1 M-1123 (Eye contact test)
(T2.30-201-1 )
Sample 1 M-1123 (Skin contact
1r r lta tlo n ) (T2.30-201-1)
Sample 1 M-1123 (Skin contact
absorption) (T2.30-201-1)

Barrons, KC
Boundy, RH
Colby, RW

Results of range finding toxlcolo?1cal tests on Esteron 245-OS
replacement for present for-

>

Dow Nunber

Date

Author

07673010767314*

600125

Dow
Wolf, MA

Recipient

1.3 9 S 5

)

I
)

Page 4<
Distributees

General Subject Matter

Dow
Elshere, D
Falkenstein, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Oyen, F
Perkins, RP
Shrader, SA
Tisdale, WL
White, LC, J r.
Wright, N

mulatlon M-1257) (BC T2.30-167-2)

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN

Results of range finding toxicolo­
gical tests on Esteron 245
OS(M.1257) (BC T2.30-167-1)

■r<

CO
Cip

Dow Number

Date

Author

0767309 *

591102

Dow
Dow
Vanvalkenburg,JW Wolf, MA

591028

Dow
R1tty, PM

Recipient

'
0767315 *

Dow
Wolf, MA

Page 43
Distributees

General Subject Matter

Lynn, 6E
McIntyre, HH
Oyen, F
Perkins, RP
Stenger, VA
Tisdale, WL
Wright, N
Barrons, KC
Boundy, RH
Colby, RW
Coulter, LL
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Heath, SB
Hymas, TA
Jones, GD
Kagy, JF
K ilia n , DJ
Luce, EN
Lynn, GE
McIntyre, HH
Oyen, F
Perkins, RP
Stenger, VA
Tisdale, WL
Wright, N

Esteron 245 OS (M-1257), For­
mulation plans for toxicological
evaluat1on

Barrons, KC
Boundy, RH

Need toxicology information
sheets on Esteron Brush K ille r

V
r

Dow Number

Date

Author

07673210767342*

571122

Dow
Olson, KJ

Recipient

)

)

)

I

Page 4
Distributees

General Subject Matter

Colby, RW
Coulter, LL
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Heath, SB
Hymas, TA
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Oyen, F
Perkins, RP
Stenger, VA
Tisdale, WL
Wright, N

O.S.

AlUnson, RL
Athay, RM
Beshgetoor, AW
Boundy, RH
Colby, RW
Dosser, RC
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A

Results of range finding toxicolo­
gical tests on Brush K ille r X, Weec
K ille r X and Brush K ille r TX
{T2.30-76-1 T2.30-77-1
T2.30-78-1)

)
)

Dow Number

Date

Author

07673660767385*

590423

Dow
Wolf, MA

Co

CO
CD

CD

Recipient

)

)

.1

)

Page 45
Distributees

General Subject Matter

Hymas, TA
Jones, GD
K111an, DJ
Luce, EN
Martin, D
M cColllster, DD
McIntyre, HH
Mussel 1, DR
Perkins, RP
Tisdale, WL
White, LC
Wright, N
Athay, RM
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
M cColllster, DD
McIntyre, HH
Perkins, RP
Stenger, VA

Results of range finding toxicolo­
gical tests on Forron brush k ille r
(M-1368) (T2.30-123-1)

V

)

J

)

)

r

Dow Number

Date

Author

07674170767418*

590506

Dow
M cCollister, DD
Wolf, MA

07674190767421*

590202

Dow
Hoyle, HR
M cCollister, DD
Wolf, MA

07674220767930*

590202

Dow
Hoyle, HR
M cCollister, DD
Wolf, MA

CO

CD

CD

CO

Recipient

I

)

I

I

)

Page 46
Distributees

General Subject Matter

Tisdale, WL
Vanvalkenburg, W
Wright, N
Results of range finding toxicolo­
gical tests on M-1447 and M-1433
weed k ille r formulations (Similar
to Esteron 245 OS and Esteron
Brush K ille r respectively)
A concentrate formulation of 245T
Dowanol 97B70 Ester data sheet of
properties, health hazards and
precautions for safe handling of
material s
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Gray, HE
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH

A concentrate formulation of 24D
and 245T Dowanol 97B70. Esters data
sheet of properties, health
hazards and precautions for safe
handling of materials

;

>

>

)
)

Date

Author

0767431 *

590127

Dow

0767432 *

581120

Dow
Wade, J

0767433 *

581121

Dow
Dow
Vanvalkenburg,JW Olson, KJ

07674340767439*

581120

Dow

07674400767441*

590506

Dow
M cCollister, DD
Wolf, MA

07674420767444*

590202

Dow
Hoyle, HR
M cCollister, DD
Wolf, MA

14000

Dow Number

Recipient

)

Page 47
Distributees

General Subject Matter

Perkins, RP
Stenger, VA
Tisdale, HH
Vanvalkenburg, W
Wright, N
M-1433 Toxicology work sheet
A concentrate brush k ille r for­
mulation of 31b. 24D and 31b. 245T
acid equlv per gal. based on
Dowanol 97B70 Esters. Request for
screening or application testing
Coulter, LL
Dow
Heath, SB

M-1433 and M-1447, formulations

M-1433 eye contact test
Results of range finding toxicolo­
gical tests on M-1447 and M-1433
weed k ille r formulations (Similar
to Esteron 245 OS and Esteron
Brush K ille r OS respectively)
M-1447 A concentrate formulation
of 245T Dowanol 97B70 esters. Data
sheet of properties, health
hazards and precautions for safe
handling of materials

Dow Number

Date

Author

07674450767453*

590202

Dow
Hoyle, HR
M cCollister, DD
Wolf, MA

0767454 *

590127

Dow

07674550767456*

581120

Dow
Vanvalkenburg, JW

07674570767462*

581120

Dow

07674630767464*

590202

Dow
Hoyle, HR

Recipient

I

I

>

)

Page 48
Distributees

General Subject Matter

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Gray, HE
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K11ian, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Stenger, VA
Tisdale, WL
Vanvalkenburg, JW
Wright, N

M-1433 A concentrate formulation
of 24D and 245T Dowanol 97B70
esters. Data sheet of properties,
health hazards and precautions for
safe handling of materials

M-1447 toxicology work sheet
M-1447 request for screening or
application testing
M-1447 acute oral toxicity
M-1433 A concentrate formulation
of 24D and 245T Dowanol 97B70

)

Dow Number

Date

Author
McColllster, DD
Wolf, MA

07674650767466*

700709

Dow

07674780767479*

590713

Dow
McColllster, DD
Wolf, MA

07674800767485*

590414

Dow
McColllster, DD
Peterson, JE
Wolf, MA

O
O
ro

Recipient

)

)

)

)

Page 49
Distributees

General Subject Matter
esters. Data sheet of properties,
health hazards and precautions for
safe handling of materials
Dowanol 97 B-70 medical Infor­
mation
Results of range finding toxicolo­
gical tests on Forron 235T

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer,. OH
Hart, A
Hymas, TA
Jones, GS
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Stenger, VA
Tisdale, WL
Vanvalkenburg, W
Wright, N

Forron 245 M-1456 data sheet of
properties, health hazards and
precautions for safe handling of
materials

V
•>

)
)

Recipient

Dow Number

Date

Author

0767486 *

590319

Dow

0767487 *

590127

Dow

0767488 *

590113

Dow
Dow
Vanvalkenburg,JW Olson, RJ

07674890767493*

590127

Dow

0767494 *

000000

Dow
Wolf, MA

07674950767497*

590610

Dow
M cCollister, DD
Peterson, JE
Wolf, MA

0767498 *

590722

Dow
Olson, K
Oyen, F

07674990767504*

590702

Dow
Hoyle, HR
Olson, KJ
Oyen, F

O
o

.CO

)

Page 50
Distributees

General Subject Matter
M-1456 (Forron 245T) toxicology
work sheet
M-1456 (Contains K-7756) (Forron
245) Request for screening of
application testing

Coulter, LL
Dow
Heath, SB

Formulation M-1456

M-1456 acute oral toxicity

Suggested precautionary labeling
for Forron 245
Forron 245 (M-1456) Data sheet of
properties, health hazards and
precautions for safe handling of
materials
Results of range finding tox1colo-k
glcal tests on M-1459. Formulation,
of K-7797 and K-7856
Athay, RM
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D

M-1459 formulation of K-7797 and
K-7856

)

I

)

Dow Number

Date

Author

0767505 *

590618

Dow

0767506 *

590216

Dow

07676350767637*

590901

Dow
Olson, K
Oyen, F
Scoi es, GE

^*4
O
O

Recipient

)

)

Page 51
Distributees

General Subject Matter

Gay, HH
Gray, HE
Greene, LM
Hammer, OH
Hart, A
Hymas, T
Jones, GD
K111an, DJ
Lynn, GE
Martin, D
McIntyre, HH
Perkins, RP
Scoles, GE
Stenger, VA
Tisdale, WL
Wright, N
M-1459 Toxicology work sheet
M-1459 formulation of K-7797 and
request for screening or applica­
tion testing
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hymas, TA

Results of range finding toxicolo­
gical tests on M-1586 (Formulation
containing Dowanol 97B70 Esters of
24D and 245T)(t2.30-156-1)

}

Dow Number

Date

Author

07676380767639*

590811

Dow
Hoyle, HR
Olson, KJ
Oyen, F

0767640

590729

Oow
KO

0767641

590611

Oow
Scoles, G

0767642 *

590610

Dow
Scoles, GW

O
o

Of

Recipient

Dow
Olson, KJ

Distributees

General Subject Matter

Jones, GD
Kagy, JF
Kilian, DJ
Leasure, JK
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP
Scoles, GE
Stenger, VA
Tisdale, WL
Wright, N
M-1586 (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
M-1586 (Toxicology work sheet)
(T2.30-156-1 )
Coulter, LL
Dow
Scoles, G

Formulation containing the Dowanol
97B70 Esters of 24D and 245T
(M-1586) (Request for screening or
application testing)

Coulter, LL
Dow
Dosser, RC
Heath, SB
Maddox, JF
White, LC

Improved Esteron formulation

)

)

)

I

)

Dow Number

Date

Author

0767643 *

590710

Dow
Greenhoe, NC
KO

07676440767646*

590721

Dow
Greenhoe, NC
KO

07676470767649*

590727

Dow
Greenhoe, NC
KO

590811

Dow
Hoyle, HR
Olson, KJ
Oyen, F

600331

Dow
Olson, KJ
Scoles, G

07676500767652*

07677670767780*

Recipient

)

)

Page 53
D1strlbutees

General Subject Matter
M-1586 (Acute oral toxicity)
(T2.30-156-1)
M-1586 (Eye contact test)
(T2.30-156-1)
M-1586 (Skin contact Irritation)
(T2.30-156-1)

M-1586 (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE

Results of range finding toxicolo­
gical tests on agricultural chemi­
cal formulation M-1639 (Veon brush
k ille r type)

>

Dow Number

Date

Author

07677920767793*

600128

Dow
Hoyle, HR
Olson, KJ
Oyen, F

0767794 *

600313

Dow

0767824 *

600216

Dow
Olson, KJ
Oyen, F

CD

CD
!I

I

)

)

Recipient

)

!

)

Page 54
Distributees

General Subject Matter

McIntyre, HH
Oyen, F
Perkins, RP
Scoles, G
Stenger, VA
Tisdale, WL
Wright, N
M-1639 (Veon brush k ille r type)
(Data sheet of properties, health
hazards and precautions for safe
handling of materials)
M-1639 (Veon brush k ille r type),
Safety data sheet
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K1l1an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Perkins, RP

Results of range finding toxicolo­
gical tests on agricultural chemi­
cal formulation M-1683 (Esteron
245 Type)

)

I

)

I

i

M

O
O
0O

Dow Number

Date

Author

07678250767828*

600223

Dow
Olson, KJ

07678290767830*

600126

Dow
Hoyle, HR
Olson, KJ
Oyen, F

07678310767841*

600000

Dow
E0
NS
O'Connor
Scoles, GW
Torkelson, TR

07678510767852*

600126

Dow
Hoyle, HR
Olson, KJ
Oyen, F

R e d pi ent

)

)

)

)

Page 55
Distributees

General Subject Matter

Scoles, G
Stenger, VA
Tisdale, WL
Wright, N
Corrections in biochemical
research laboratory reports
(T2.30-177-1) Results of range
finding toxicological tests on
agricultural chemical formulation
M-1683 (Esteron 245 Type),
Results of range finding
toxicological tests on Bis
Acetonltrllo Decaborane (Band)
(T23.14-94-2); Results of range
finding toxicological tests on
Alpha Phenoxy Propionic Acid
M-1683 (Esteron 245T) (Data sheet
of properties, health hazards and
precautions for safe handling of
materials)
Toxicology work sheet, acute oral
to x icity , eye contact test, skin
contact Irrita tio n , single vapor
exposure record (M-1683)

M-1683 (Esteron 245T) (Data sheet
of properties, health hazards and
precautions for safe handling of
materials)

'
"

)
)

Dow Number

Date

Author

0767853 *

600212

Dow

0767854 *

551108

Dow

0767872 *

600406

Dow
Wolf, MA

07678730767875*

600215

Dow
01 son, KJ
Oyen, F

07679880767990*

611031

Dow
01 son, KJ
Oyen, F

07679940767997*

611106

Dow
Hoyle, HR
Oyen, F
Plomer, ET

07680100768025*

611117

Dow
01 son, KJ
Plomer, ET

1^4

o

CO

Recipient

Dow
McIntyre, HH

)

I

I

)

'
D1strlbutees

Page 56

General Subject Matter
AG chem formulation M-1683
Esteron 245T, safety data sheet

Dow
Sales
Wolf, MA

Suggested precautionary labeling
for M-1684

Dow
Hoyle, HR

M-1684 (Esteron Brush K ille r type)
Data sheet of properties, health
hazards and precautions for safe
handling of materials

Dow
Hoyle, HR

M-2016 data sheet of properties,
health hazards and precautions for
safe handling of materials

Dow
Hoyle, HR

M-2115 data sheet of properties,
health hazards and precautions for
safe handling of materials

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Falkensteln, W
Gay, HH
Greene, LM
Hart, A
Jones, GD

Results of range finding
toxicological tests on M-2115, an
agricultural chemical formulation
containing 245T acid and tr1ethyl
amine

)

Dow Number

Date

Author

07681040768143*

631129

Dow
Lynn, GE
Olson, KJ

^4
o
M
O

Recipient

)

\

)

Page 57
Distributees

General Subject Matter

Kagy, JF
K111an, DJ
Luce, EN
Lynn, 6E
McIntyre, HH
Oyen, F
Perkins, RP
Scoles, GW
Shrader, Sa
Tisdale, WL
Wright, N
Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Epstein, J
Falkensteln, WJ
Gordon, HL
Greene, LM
Hake, CL
Hart, A
Jones, GD
Kagy, JF
K111an, DJ
Koerker, FW
Luce, EN
Lynn, GE
McIntyre, HH
MulHson, WR
Norton, TR
Oyen, F

Results of range finding toxicolo­
gical tests on Verton T herbicide
(M-2137) a formulation containing
Dowanol Ester of 245T

V

;

Dow Number

Date

Author

07682970768299*

630108

Dow
Hoyle, HR
Olson, KJ
Oyen, F

07683000768301*

710400

0768302 *

630507

Dow

07683030768304*

720328

Dow

07683050768306*

780401

Dow

07686800768699*

660526

Dow
Stevenson, GT

Recipient

)
)

Page 58
Distributees

General Subject Matter

Shrader, SA
Wilson, AW
Wright, N
M-2422 (Data sheet of proportions
for safe handling of materials)

Esteron 245 concentrate
Esteron 245 concentrate (Sales
specification)
Esteron 245 concentrate brush and
weed k ille r (Material safety data
sheet)
Esteron 245 concentrate brush and
weed k ille r (Material safety data
sheet)
Dow
Haagsma, TA
BLS
GTS

A summary of acute oral toxicity
LD50 studies 1n poultry from
TOX-37 thru TOX-66 Inclusive
(Report GH-A 186)

KJO
Prod. Plan Target Team
Mgr.
Robinson, VB
RJS
RMS
RYJ

^

)
)

Dow Number

Date

Author

07689840769027*

660510

Dow
Lynn, GE
Olson, KJ

0769080 *

001216

Dow
Getzendaner, ME
Herman, JL
Moss, RD

O

Recipient

Page 59
Distributees

General Subject Matter

Barrons, KC
Boundy, RH
Dow
Elshere, D
Falkensteln, WJ
Hart, A
Holder, BB
Johnston, RV
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE
McCollister, DD
McIntyre, HH
Moss, RD
Mull Ison, HR
Norton, TR
P1tman-Moore
Shrader, SA
Wilson, AW
Wright, N

Toxicological properties of her­
bicide formulation M-2993 con­
taining 4-am1no-356-tr1chloroplcoUnlc acid, Isooctyl ester and
245T polypropylene glycol butyl
ether ester

Barrons, KC
Baurledel, WR
Dow
Dowel 1, FH
Hanson, RG
Hymas, TA
Johnston, RV
Kagy, JF
Lanlng, ER
Ludwig, PD

A residue study plcloram and 245T
1n grass from application of
M-3060 formulation (GH-C 343)

O
Co

Dow Number

Date

Author

07690810769082*

670410

Dow

07690830769085*

661205

Dow
01 son, KJ
Oyen, F
Wllson, H

07690860769087*

661108

Dow
Hoyle, HR
01 son, KJ
Oyen, F
Wllson, H

07690880769094*

660816

Dow
Wllson, H

07691600769162*

670316

01 son, KJ
Oyen, F

Recipient

)

Page 60
Distributees

General Subject Matter

Moss, RD
Osborne, DW
Popoff, FP
Ridner, JM
Rowe, VK
Seymour, KG
Shaver, RJ
Spalding, JL
Williams, CS
M-3060, safety data sheet
Dow
Lynn, GE

Results of range finding toxicolo­
gical tests on Esteron O.S.
(M—3094) (T2.3094-1)
Esteron 245 O.S. (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)
Esteron 245 O.S. (M-3094) Toxico- ;
logy work sheets

Boundy, RH
Buerge, TE
Dean, P
Dow
Elshere, D
Holder, BB

Toxicological properties and
Industrial handling hazards of
Tordon 105 mixture^
(T2.MO-3132-1)

?■

)
)

Dow Number

Date

Author

07691630769179*

660000

Dow
Tinker, B
Wilson, H

07692680769271*

671224

Dow
M cCollister, DD
Olson, KJ

07692720769297*

680104

Dow
Lynn, 6E
Olson, KJ

o
h

Recipient

)
)

Page 61
Distributees

General Subject Matter

Jones, GD
Kagy, JF
K llla n , DJ
Luce, EN
Lynn, GE
McIntyre, HH
Moss, RD
Sheetz, DP
Shrader, SA
Wilson, AW
Wright, N
Tordon 105 mixture {Toxicology
worksheet)
Tordon 144 mixture data sheet of
properties, health hazards and
precautions for safe handling
Boundy, RH
Dean, P
Dow
Elshere, D
Hoider, BB
Jones, GD
Kagy, JF
Luce, EN
McCollister, DD
McIntyre, HH
Moss, RD
Olson, KJ
Robinson, VB

Toxicological perpertles and
Industrial handling hazards of
Tordon 144 mixture herbicide

>

o
t
CM-

Dow Number

Date

Author

07693510769352*

690121

Dow
Hoyle, HR
Norris, JM

07693530769354*

700130

Bjork, C
Dow
Gowel1, JH
JBD
Loucks, MF
Nagele, RE
Newport, JJ
Seymour, KG
Sheldon, HW
Stein, JS
Talcott, AT
Williams, CS
Wolf, MA

07693550769356*

681213

Dow
Norris, JM

07700430770058*

571122

Dow
Olson, KJ

Recipient

>

I
)

Page 62
Distributees

General Subject Matter

Sheetz, DP
Shrader, SA
Wilson, AW
Wright, N
M-3199X Tordon 225 mixture her­
bicide data sheet of properties,
health hazards and precautions for
safe handling of materials.
(T2.M0-003199-1)
Tordon 225 herbicide release to
sales

M-3199X Tordon 225 herbicide
v
(T2.M0—003199—(1)), safety data >
sheet
All Inson-, RL
Athay, RM
Beshgetoor, AW
Boundy, RH

Results of range finding toxicolo­
gical tests on Brush K ille r X,
Weed K ille r X and Brush K ille r TX

^

O
f
as

Dow Number

Date

Author

07700440770045*

571115

Dow
M cCollister, DD
Olson, KJ
Peterson, JE

07700470770048*

571115

Dow
M cCollister, DD
Olson, KJ
Peterson, JE

0770049 *

000000

Dow

Recipient

;

)

\

Page 63
Distributees

General Subject Matter

Colby, RW
Dosser, RC
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A
Hymas, TA
Jones, GD
K ilia n , DJ
Luce, EN
Martin, D
McCollister, DD
McIntyre, HH
Mussel 1, DR
Perkins, RP
Tisdale, WL
White, LC
Wright, N
Brush K ille r TX (Data sheet of
properties, health hazards and
precautions for safe handling of
materlals)'
v
■>
Weed K ille r X (Data sheet of pro­
perties, health hazards and pre­
cautions for safe handling of
materlals)
Brush K ille r X (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)

I

)
)

Dow Number

Date

Author

07700500770052*

571115

Dow
McCollister, DD
Olson, KJ
Peterson, JE

0770059 *

560308

Dow
White, LE

07700600770061*

560424

Dow

07700620770063*

560521

Dow

07700640770065*

571115

Dow
McCollister, DD
Olson, KJ
Peterson, JE

07706650770684*

660526

Dow
Stevenson, GT
Stock, BL

07817910781794*

501017

Dow
Rowe, VK

o
“S i

Recipient

Allen, WW
A lquist, FC
B ritton, JW
Dosser, RC
Dow

)

)

I
)

Page 64
Distributees

General Subject Matter
Brush K ille r X (Data sheet of pro­
perties, health hazards and pre­
cautions for safe handling of
material s)
Brush K ille r TX (Request for
application testing)
Brush K ille r TX (Eye contact
test)
Brush K iile r TX (Skin contact
irrita tio n )
Brush K ille r TX (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)

BLS
GTS
KJO
RJS
RMS
RVJ
TAH
VBR

A summary of acute oral toxicity
LD50 studies in poultry from
TOX-37 thru TOX-66 inclusive (GH-A
186)

Results of skin ir rita tio n and
skin sensitization tests conducted
on human subjects with Esteron 245
(New Ester) (T2.30-3-1)

)

Dow Number

Date

Author

Recipient
Dutton, WC
Irish , FN
Kagy, JF
Lynn, GE

0781795 *

500405

Dow
REW
Streeter, LE

Dow
White, L

07817960781810*

530217

Dow
Oyen, F

Allen, WW
Alllnson, RL
A lqulst, FN
Beshgetoor, AW
Boundy, RH
Britton, EC
Britton, JW
C o llie r , B
Davidson, JH
Dow
Dutton, WC
Gay, HH
Gibson, J
Greene, LM
Heath, SB
Johnson, JE
Kagy, JF
K e lly, JA
Krlner, RR
Luce, EN
Lynn, GE
MacCutcheon, SM
Mel ass, VH
Nation, HA

O
h4
00

)

)

I

)

Page 65
Distributees

General Subject Matter

Esteron 245T (Main lab report
sheet)
Results of range finding toxicolo­
gical tests on Esteron 245
(T2.30-3-2)

>

Dow Number

;

Date

Author

Recipient
0t1s, CE
Predergast
Southwlck, L
Sunderland, WW
Vanhorn, JC
Walker, H
White, LC
Wright, P
Zuhl, HH

07820850782091*

531030

Dow
Oyen, F

0782092 *

530305

Dow
Rowe, VK

o
M

)

]

I

}

Page 66
Distributees

General Subject Matter

Allen, W
W
AlUnson, RL
A lqu lst, FN
Barrons, KC
Beshgetoor, AW
Boundy, RH
Britton, EC
Davidson, JH
Dow
Dutton, WC
Gay, HH
Greene, LM
Kagy, JF
Luce, EN
Lynn, GE
MacCutcheon, SM
Prescott, RF
Sunderland, WW
White, L
Wright, P

Results of range finding toxicolo­
gical tests on Dow Brush K ille r T

V
v

Dow Brush K ille r T (Request for
biological test)

Dow Number

Date

Author
Spencer, HC
White, L

07820930782100*

530000

Dow
Wolf, MA
Wyse, H

07821010782103*

530000

Dow
Wyse, H

07821040782112*

530000

Dow
Wyse, H

07821130782114*

700721

Dow
HCS

0782115 *

000000

Dow

07821160782117*

710714

Dow
Hoyle, HR
Wolf, MA

07821180782119*

710920

Dow
Wolf, MA

07821780782198*

560501

Dow
M cCollister, DD
Torkel son, TR

o

ro
o

Recipient

)

Page 67
Distributees

General Subject Matter

Dow Brush K ille r T (Acute oral
toxicity)

Brush K ille r T (Eye Irritation )
Brush K ille r T (Skin Irritation )
Brush K ille r T, safety data sheet
Brush K ille r T (Medical
Information)
Brush k ille r T (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)
Brush K ille r T (Medical
Information)
Alllnson, RL
Beshgetoor, AW
Boundy, RH
Britton, EC
Coulter, LL
Dow

Results of range finding toxicolo­
gical tests on M-631 (Esteron 245
type formulation) (BC T2.30-67-1)

Dow Number

Date

Author

07821990782200*

580916

Dow
Hoyle, HR
Torkel son, TR

0782201 *

560504

Dow

07822020782220*

560409

Dow
McCol11 ste r, DD
Wolf, MA

O
to

Recipient

)

)

>

)

Page 68
Distributees

General Subject Matter

Elshere, D
Gay, HH
Greene, LM
Hart, A
K111an, DJ
Luce, EN
MacCutcheon, SM
Martin, D
Scoles, G
Sunderland, W
W
Wright, N
Esteron 245 type formulation
(M-631) (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
M-631 (Esteron 245 type for­
mulation) (T2.30-67-1), safety
data sheet
AlUnson, RL
Beshgetoor, AW
Boundy, RH
Britton-, EC
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A
Kagy, JF
K e lly, J

Results of range finding toxicolo­
gical tests on 2 formulations of
Reddon (M-640 and M-713)

v
y

}

Dow Number

Date

Author

07822850782306*

560503

Dow
Lockwood, D
McColHster, DD
Torkel son, TR

07823790782393*

560702

Dow
Lockwood, D
McColHster, DD
Olson, KJ

Recipient

}

)
)

Page 69
Distributees

General Subject Matter

K1l1an, DJ
Luce, EN
Lynn, GE
MacCutcheon, SM
Sunderland, W
W
Wright, N
AlUnson, RL
Beshgetoor, AW
Boundy, RH
Britton, EC
Coulter, LL
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A
K111an, DJ
Luce, EN •
MacCutcheon, SM
Martin-, D
Scoles, G
Sunderland, WW
Wright, N

Results of range finding toxicolo­
gical tests on M-697 (Esteron
Brush K ille r type formulation)
(T2.30-66)

A lllnson, RL
A lqulst, FN
Barrons, KC
Beshgetoor, AW
Boundy, RH
B ritton, EC
Colby, RW
Dow

Results of range finding
toxicological tests on Esteron
Brush K ille r OS (M-726)
(T2.30-71-1)

14023

Dow Number

Date

Author

07869420786954*

000000

Dow

07869550786975*

000000

Dow

07870000787030*

680122

Delong, HC

09703300970343*

700901

B la ir, EH
Dow

0979734 *

670914

EMS

0979735 *

670914

EMS

0979736 *

670914

EMS

Recipient

)

)
}

Page 70
Distributees

General Subject Matter

Eishere, D
Gay, HH
Greene, LM
Hart, A
Kagy, JF
Kelly, JA
K ilia n , DJ
Luce, EN
Lynn, GE
MacCutcheon, SM
Sunderland, W
W
Wright, N
24D Esters-process information
Direct Ester process
Acid Ester operating instructions
489 Bldg
Chemistry of the Dow agricultural
department
k
Chloroacetic acid plant unit
ratios
Crystalline chloroacetate acid unit
ratios.
Butyl chloroacetate plant unit
ratios

^
tfv-

Dow Number

Date

Author

09799890979994*

670417

Del Isle, NG
EMS

12321171232129*

570806

Dow
McCol lis t e r , DD
Wolf, MA

12321301232143*

600331

Dow
Olson, KJ
Oyen, F

12323551232378*

571122

Dow
McCol lis t e r , DD
Olson, KJ

Recipient

)

>

Page 71
Distributees

General Subject Matter
Flow sheets on 24D butyl ester
acid
Results of range finding toxicolo­
gical tests on Ml 086 (A 245T and
24D alkyl amine formulation)

Barrons, KC
Boundy, RH
Colby, RW
Dow
Elshere, D
Gay, HH
Greene, LM
Hammer, OH
Hart, A
Hymas, TA
Jones, GD
Kagy, JF
K ilia n , DJ
Luce, EN
Lynn, GE
McIntyre, HH
Scoles, G
Stenger, VA
Tisdale, WL
Wright, N

Results of range finding toxicolo­
gical tests on agricultural chemi­
cal formulation Ml639 (Veon Brush
K ille r type)

AlUnson, RL
A lliso n , WE
Athay, RM
Beshgetoor, AW
Boundy, RH

Results of range finding toxicolo­
gical tests on Brush K ille r X,
Weed K ille r X and Brush K ille r TX

■r

)
)

„K, ‘

r
o

Dow Number

Date

Author

12982971298299*

741204

Dow
JNJ

1298300 *

640921

Dow
EMS

12983011298302*

000000

Dow

12983°3 *

000000

Dow

Recipient

)

i

}

)

Page 72
D1strlbutees

General Subject Matter

Colby, RW
Dosser, RC
Dow
Elshere, D
Gay, HH
Greene, LM
Hart, A
Hymas, TA
Jones, GD
K1l1an, DJ
Luce, EN
Martin, D
McIntyre, HH
Mussel 1, DR
Perkins, RP
Tisdale, WL
White, LC
Wright, N
2-(2-4 dlchlorophenoxy) proprlonlc
acid (Physical properties data
sheet)
Dowanol Ester of 245T (Physical
properties data sheet)
SHvex (Physical properties data"
sheet)
24D NA s a lt monohydrate (Physical
properties data sheet)

)

)

)

Dow Number

Date

Author

12983041298305*

681030

Dow
Erickson, AC

1298306 *

741202

Dow
JNJ

12983071298309*

730315

Dow

12983101298312*

490720

Dow
BFW
WJC
Luce, EN
Waling, BF

12983131298315*

680826

Dow
JJ
RH
Stobby, G

12983161298320*

731128

Dow
Messing, S

t

o
02

Recipient

Dow
Schrauf, B

Dow
Hart, JP

)

J

)

)

Page 73
Distributees

General Subject Matter
245-Trlchlorophenol (Physical pro­
perties data sheet)
245T (Physical properties data
sheet)

2

Freezing point molten 24D H O
24D report sheet (Main lab No. SSR
146-851)

Colby, A
Dow
Hoi deman, GE
K1ley, L
Shrader, S
Wengert, GB

Herbicides, vapor pressure data
(Analytical laboratories report
AL 79-202)

Arestln,
Blelwelss, J
Chase, F
Dhlngra, Y
Dow
Haberstroh
Jones, W
Lafevor, D
Manfrom, R
Martin, R
M ille r, B

24D acid ester process
so lu bllItles

Dow Number

Date

Author

12983211298322*

670327

Dow
S t u ll, DR
Walker, LC

12983231298326*

691022

Dow
S1nke, GC
S t u ll, DR

1298328 *

710917

Dow
G ilbert, PW
Hawley, HM
Hoi deman, GE
Loucks, MF
MacDonald, LA
Relgler, PF
Talcott, AT

1298329 *

720615

Blosser, KC
Chase, FT
Dow
Flannery, RF
Fraser, JM
G111, HH
Hoff, RC
Hoi deman, GE
Talcott, AT
Woodward, R

Recipient

)
)

Page 74
Distributees

General Subject Matter

M1ntz, M
Morehouse, DS
Yeager, L
Dow
Fernander, J

Thermal data for process steps 1n
synthesis of 24D (HL-304)

Holdeman, GE

Heat of reaction of dimethyl amine
and 24D (HL-527)

Dow
G ilbert, PW
Hawley, HM
Holdeman, GE
Loucks, MF
MacDonald, LA
Relgler, PF
Talcott, AT
Tree, RM

2,4-D1chlorophenol, technical
(product specification)

Blosser, KC
Chase, FT
Dow
Flannery, RF
Fraser, JM
G i l l , HH
Hoff, RC
Talcott, AT
Woodward, R

245T propylene glycol butyl ether
esters (Product specification)
V
•r

)

)

)
)

Dow Number

Date

Author

1298330 *

720615

Dow

1298331 *

710118

Chase, FI
Dow
Hawley, HM
Hoi deman, GE
Loucks, MF
MacDonald, LA
Reigler, PF
Seymour, KG
Ta1t, SR
Talcott, AT
Woodward, RE

1298332 *

730412

Blosser, KC
Chase, FI
Dow
Flannery, RF
Fraser, JM
Hoff, RC
Hoi deman, GE
Seymour, KG
Talcott, AT
Woodward, RE

1298333 *

710601

Chase, FI
Dow
Hawley, HM
Hoi deman, GE
Loucks, MF
MacDonald, LA

v "» .-" i'

C

00

Recipient

)

I

Page 75
Distributees

General Subject Matter
245T propylene glycol butyl ether
esters (Sales specification)

Chase, FI
Dow
Hawley, HM
Hoi deman, GE
Loucks, MF
MacDonald, LA
Relgler, PF
Seymour, KG
Ta1t, SR
Talcott, AT
Woodward, RE

Formula 40 Weed k ille r M-3604
(Product specification)

Blosser, KC
Chase, FI

DMA-6 unsequestered M-2255
(Product specification)

Dow
Flannery, RF
Fraser, JM
Hoff, RC
Hoi deman , GE
Seymour, KG
Talcott, AT
Woodward, RE
Chase, FI
Dow
Hawley, HM
Hoi deman, GE
Loucks, MF
MacDonald, LA

V

DMA-6 sequestered M-3637 (Product
specification

)

)

)

;

Dow Number

Date

Author
Relgler, PF
Seymour, KG
Ta1t, SR
Talcott, AT
Woodward, RE

| w * ik Ä

O

1X1

1298334 *

000000

Dow

1298335 *

000000

Dow

1298336 ★

000000

Dow

1298337 *

000000

Dow

1298338 *

000000

Dow

1298339 *

000000

Dow

1298340 ★

710316

Dow

1298341 *

720117

Blosser, KC
Chase, FI
Dow

Recipient

>

)

)

Page 76
Distributees

General Subject Matter

Relgler, PF
Seymour, KG
Ta1t, SR
Talcott, AT
Woodward, RE
Propylene glycol butyl ether
esters of Sllvex (Physical
properties)
Isooctyl esters of 245T (Physical
properties)
Low v o la tile esters of 245T Dow
sales grade 245T, propylene glycol
(C3H60 to C9H1803) butyl ether
esters (Physical popertles)
Isooctyl esters of 24D (Physical
properties)
N-Butyl ester of 24D (Physical
properties)
24D Butyl esters (Physical
properties)
24D propylene glycol butyl etHier
ester (Product specification)
Blosser, KC
Chase, FI
Dow

24D (Product specification)

Dow Number

Date

Author
Flannery, RF
6111., HH
Hoff, RC
Hoi deman, 6E
Scoles, GW
Talcott, AT
Woodward, RE

1298342 *

000000

Dow

12983431298344*

611017

Dow
Hoyle, HR
Olson, KJ

1298345 *

000000

Dow

12983461298347*

570927

Dow
Hoyle, HR
Peterson, JE

12983481298349*

000000

Dow

1298350 *

741202

Bethke
Boust, HF
Dersnah

Recipient

I

)

I

)

Page 77
Distributees

General Subject Matter

Flannery, RF
G111, HH
Hoff, RC
Hoi deman, GE
Scoles, GW
Talcott, AT
Woodward, RE
Tordon 101 mixture (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)
Dowanol PIB mix ester of 24D (Data
sheet of properties, health
hazards and precautions for safe
handling of materials)
245-Tr1chlorophenol (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)
24D (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
Consequences of overexposure for v
chemicals 1n 489 building
B1s-(24D) (Reactive chemical
hazard data)

J

Dow Number

Date

;

Author

)

Recipient

Dow
Jones, W
1298351 *

750109

Dersnah
Dow
Fey, K

1298352 *

700801

Abegg, CF
Dow
Harris, VI
Higgins, HS

1298353 *

741211

Woznlak, LJ

1298354 *

750123

Dersnah
Dow
Jones, JN, J r .

1298355 *

750123

Dersnah
Dow
Jones, JN, J r .

1298356 *

750123

Dersnah
Dow
Jones, JN, J r.

12983571298360*

741204

Dow
Jones, J

12983611298362*

710526

Boggs, GU
Dow

1

O

Dow
Dunlap, R
Haberstroh, WH
Higgins, HS
Thels, JM

}

)

■)

)

Page 78
Distributees

General Subject Matter

Ethylene Glycol W/ 24D acid;
molten 24D process (Reactive che­
mical hazard data)
24D (Reactive chemical hazard
data)

DE waste treatment plant
Waste treatment, butyl ester of
24D, d is tilla tio n feed (Reactive
chemical hazard data)
Waste treatment, butyl ester of
24D solvent (Reactive chemical
hazard data)
Waste treatment of butyl ester of
24D tars (Reactive chemical hazard
data)
Alcohols, and molecular weight
data summary
Direct ester MT" waste 710309 from
489 (Analytical laboratories
report AL28-830)

)

)

)

)
)

05
VO

Dow Number

Date

Author

12983631298369*

730000

Dow
Southwlck, L

12986031298605*

000000

Dow

12986061298607*

650119

Dow
Hoyle, HR
Olson, KJ
Oyen, F

12986081298609*

650125

Dow
Hoyle, HR
Olson, KJ

12986101298611*

740300

Dow

12986121298614*

780601

Dow

12986151298617*

780601

Dow

12986181298620*

780601

Dow

12986211298623*

780601

Dow

Iec1p1ent

)

)

)

)

Page 79
Distributees

General Subject Matter
Kuron Silvex herbicide continues
to gain acceptance (Ind vegetation
mgnt 5(2), 18-24)
Properties and hazards, flash
points of various products
Tordon 50D formulation (Data sheet
of properties, health hazards and
precautions fo r safe handling of
materials) (T2.M0-2777X-1)
Tordon 101 mixture (Data sheet of
properties, health hazards and
precautions for safe handling of
materials) (T2.MO-2439-1 )
Tordon 101 mixture weed and brush
k ille r (Material safety data
sheet) (Form 336-158-74)
Tordon (R) 101 mixture weed and
brush k ille r (Material safety data
sheet)
Tordon (R) 101 mixture weed and
brush k ille r private label
(Material safety data sheet)
Tordon (R) 101R forestry herbicide
(material safety data sheet)
Tordon (R) 155 mixture brush
k ille r (Material safety data
sheet)

J

)
)

Dow Number

Date

Author

12986241298625*

660412

Dow
Hoyle, HR
M cCollister, DD
Olson, KJ

12986261298627*

740300

Dow

12986281298629*

660201

Dow
Hoyle, HR
McColllster, DD
Olson, KJ

12986301298632*

780601

Dow

12986331298634*

671031

Dow
Hoyle, HR
Norris, JM
Olson, KJ

12986351298636*

760800

Dow

12986371298638*

780601

Dow

12986391298640*

771001

Dow

12986411298643*
CO

780601

Dow

O

os

Recipient

)

)

.)

)

Page 80
Distributees

General Subject Matter
1 Tordon 155 (Data sheet of pro­
perties, health hazards and pre­
cautions for safe handling of
materials) (T2.MO-2993-1)
Tordon 155 mixture brush k ille r
(Material safety data sheet)
Tordon 202 mixture (Data sheet of
properties, health hazards and
precautions for safe handling of
materials) (T2.M0-2861-1)
Tordon (R) 202C mixture herbicide
(Material safety data sheet)
Tordon 212 (Data sheet of proper­
t ie s , health hazards and pre­
cautions for safe handling of
materials) (T2.M0-3200-1)
Tordon 212 mixture herbicide
(Material safety data sheet) (Form
336-161-76)
Tordon (R) 212 mixture herbicide
(Material safety data sheet)
Tordon (R) 225 herbicide (Material
safety data sheet)
Tordon (R) 225E mixture herbicide
(Material safety data sheet)

]

)
)

O

Dow Number

Date

Author

12986441298651*

750811

Dow
Gutenkunst, V
Porter, DF
Skelly, NE

12986521298653*

700514

Dow
Hoyle, HR
Norris, JM

12986541298655*

750600

Dow

12986561298658*

780601

Dow

12986591298660*

710422

Dow
Hoyle, HR
Norris, JM

12986611298662*

710917

Dow
Hoyle, HR
Wolf, MA

12986631298664*

750310

Dow
Silverstein, LG
Wolf, MA

12986651298666*

760823

Dow
Langner, RR

Recipient

)

)
)

■ Page 81
Distributees

General Subject Matter
Analytical method Tordon 225E mix­
ture herbicide by liq u id chroma­
tography (Method 87141)
Tordon 472 herbicide (Data sheet
of properties, health hazards and
precautions for safe handling of
materials) (BC12.MO-3427-1 )
Tordon 472 herbicide (Material
safety data sheet) (Form
336-166-75)
Tordon (R) 472 weed k ille r
(Material safety data sheet)

■

DMA4 (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
(NB T2.MO-3538-1)
245T Dowanol 97B ester (Data sheet
of properties, health hazards and ;
precautions for safe handling of
materials) (K-7856 NB725.14-106) J
24D Triisopropanolamine salt (Data
sheet of properties, health
hazards and precautions for safe
handling of materials) (K-8866)
DMA-6 (Data sheet of properties,
health hazards and precautions for

)

)

)

}

)

Dow Number

Date

Author

Recipient

Wroblewski, D
1298667 *

000000

Dow
Lamott, S

12986681298670*

760800

Dow

12986711298672*

710917

Dow
Hoyle, HR
Wolf, MA

12986731298674*

650125

Dow
Hoyle, HR
Olson, KJ

12986751298676*

690909

Dow
Hoyle, HR
Norris, JM

12986771298678*

650119

Dow
Hoyle, HR
Olson, KJ
Oyen, F

12986791298680*

660412

Dow
Hoyle, HR
McColllster, DD
Olson, KJ

Rafos, G

)

Page 82
D1stributees

General Subject Matter
safe handling of materials)
(M—3637)
Cover memo for data sheets
Tordon 212 mixture herbicide
(Material safety data sheet)
(Form 336-161-76)
245T Dowanol 97B ester (Data sheet
of properties, health hazards and
precautions for safe handling of
materials) (K-7856 NBT25.14-106)
Tordon 101 mixture (Data sheet of
properties, health hazards and
precautions for safe handling of
materials) (T2.MO-2439-1)
Tordon 472 herbicide (Data sheet
of properties, health hazards and
precautions for safe handling of
materials) (BC T2.M0-3472-1)
Tordon 50D formulation (Data sheet *
of properties, health hazards and t
precautions for safe handling of
materials) (BC T2.M0-2777X-1)
Tordon 155 (Data sheet of proper­
tie s , health hazards and pre­
cautions for safe handling of
material s ) (T2.MO-2993-1 )

Dow Number

Date

Author

12986811298682*

751009

Dow
Hoyle, HR
Yakel, HO

12986831298684*

700319

Dow
Hoyle, HR
Norris, JM

1298685 *

750711

Dow
Krumel, KL

12986861298689*

750711

Dersnah, H
Dow

1298690 *

711116

Brown, M
Dow
JL
Robb, J

12986911298692*

000000

Dow

1298693 *

741031

Dow
Hebbourn, R
Kerby, JE

12986941298695*

690716

Dow

Recipient

Dow
Krumel, KL

I

I

)

)

)

Page 83
Distributees

General Subject Matter
Tordon 212 mixture herbicide (Data
sheet of properties, health
hazards and precautions for safe
handling of materials) (HET
M—3179-(2))
Tordon 212 mixture herbicide (Data
sheet of properties, health
hazards and precautions for safe
handling of materials)
(T2.M0-3179-1)
24D (Reactive chemical hazard
data)
Dust explosion properties of 24D
acid (Analytical report)
DMA-6 (unsequestered) (Reactive
chemical hazard data)

24D (Summary of chemical react ilv it y precautions and
properties)
24D PGBEE (Reactive chemical
hazard data)

Tordon 212 mixture (Summary of

Dow Number

Date

Author
Dullap, RL
Mandrell, ME

12986961298697*

690716

Dow
Dunlap, RL
Mandrell, ME

1298698 *

750206

Bethke
Dersnah
Dow
Hoi deman, G
Keeney, N
Vanhorn, R

12986991298700*

691003

Dow
G ilbert, PW
Mandrell, ME

1298701 *

710830

Dow
CJR
JRL
RSS

12987021298703*

690716

Dow
Dunlap, RL
Mandrell, ME

12987041298714*

710125

Dow
Prophet, H
S tu ll, DR

1298715 *

710801

Dersnah, H
Dow
McCarty, WM

Recipient

\

)

)

)

)

Page 84
Distributees

General Subject Matter
chemical re a ctiv ity precautions
and properties)
Tordon 101 mixture (Summary of
chemical re a ctiv ity precautions
and properties)
Tordon 101 R (Reactive chemical
hazard data)

Tordon acid (Summary of chemical
rea ctivity precautions and
properties)
Tordon 225 (Reactive chemical
hazard data)

Tordon 155 mixture (Summary of
chemical re a ctiv ity precautions
and properties)
Studies of hazardous chemicals and
th e ir reactions, kinetics of che­
mical destruction by burning
(NCT-5007)
Esteron 245 CONC (Reactive chemi­
cal hazard data)

)

;
)

CÜD
to

œ

Dow Number

Date

Author

12987161298717*

690627

Dow
G ilbert, PW
Mandrell, ME

12987181298719*

690718

Dow
G ilbert, RW
Mandrel 1, ME

13394201339423*

650810

Barrons, KC
Lynn, GE
McCoy, WJ
Southwlck, L
Wolf, MA
Vanvalkenburg,W
Sachs, SB
Branaman, J
G U I, WM
Delong, HC
Matutz, H
Davis, H
Corbin, WL
Johnson, J
CEO
DEP

13418341341853*

700422

Fauver, VA

Recipient

MacDonald,LA

i

Page 85
Distributees

General Subject Matter
Dowanol PIB esters of 245T
(Summary of chemical reactivity
precautions and properties)
24D TIPA mix (Summary of chemical
reactivity precautions and
properties)
Esteron TR2 (Release to Sales 12)

Demott, DN
Hanners, HH
Martin, RA
Tree, RM
Dellne, DD
Kennedy, TL
Robbins, LA
Plepys, RA

High purity 245-tr1chlorophenol,
state of the art review

v
i

)

)
)

H*.
^

to
CO

Dow Number

Date

Author

14107901410792*

701217

Dow
Gehrlng, PJ
Norris, JM
Williams, CS

14107931410794*

701228

Dow
Hoyle, HR
Norris, JM

Recipient

)

Page 86
Distributees

General Subject Matter

Stamand, VE
Clark, 6A
Spencer, RA
Dylewski, SW
Ble1we1ss, JC
Barton, J
B la ir, EH
Burgert, BE
Clegg, DH
Dow
Edwards, H
Frevel, LK
Gordon, HL
Goring, Ca
Holder, BB
Johnson, JE
K111an, DJ
Klmmel, CE
Lloyd, BH
MacCutcheon, SM
M cCollister, DD
McIntyre, HH
Morgan, RW
Morse, D
Pltchforth, L
Robinson, VB
Schwarz, BA
Williams, CS

Toxicological properties and
Industrial handling hazards of
formulation M-3592 containing the
propylene glycol butyl ether ester
of 245T

i-

M-3592 (Data sheet of properties,
health hazards, and precautions
for safe handling of materials)

)

)

)
)

yrrtà.

O
O-

Dow Number

Date

Author

14107951410798

701217

Dow
Norris, JM

14107991410800*

701119

Bourne, JE
Dow

14108011410802*

701228

S llversteln , EH

14108031410804*

701110

S llverstein , EG

1410805 *

701106

Sllversteln , EH

14108061410807*

701210

S llve rste ln , EH

14108101410811*

701210

Sllversteln , EH

14108121410813*

701210

S llve rste ln , EH

14108141410815*

701217

Dow
Gehrlng, PJ
N orris, JM
Williams, CS

Recipient

)

Page 87
Distributees

General Subject Matter
Acute toxicological properties of
Formulation M-3592 containing the
propylene glycol butyl ester of
245T
M-3592 (Acute oral toxicity)
M-3592 (Acute oral toxicity)
M-3592 (Eye irrita tio n )
M-3592 (Primary skin Irritation patch test (household chemical))
M-3592 (Skin contact absorption)
M-3592 (Skin contact absorption)
M-3592 (Skin contact absorption)

Bergert, BE
Blair., EH
CI egg , DH
Dow
Frevel , LK
Gordon, HL
Goring, CA

Toxicological properties and
Industrial handling hazards of
formulation M-3592 containing the
propylene glycol butyl ether ester
of 245T

Dow Number

Date

Author

14108161410817*

701217

Dow
Hoyle, HR
Norris, JM

14108181410821*

701217

Dow
Norris, JM

14108221410823*

701119

Bourne, JE

14108241410825*

701228

S1lverste1n, EH

14108261410827*

701110

S11verstein, EH

^ 1410828 *

701106

S ilverstein , EH

O

Recipient

J

)

Page 88
Distributees

General Subject Matter

Holder, BB
Johnson, JE
Klmmel, CE
Lloyd, BH
MacCutcheon, SM
McCollister, DD
McIntyre, HH
Morgan, RW
Morse, D
Pltchforth-, L
Robinson, VB
Schwarz, AJ
Williams, CS
M-3592, (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
Acute toxicological properties of
formulation M-3592 containing the
propylene glycol butyl ether ester
of 245T
M-3592 (Acute oral toxicity)
M-3592 (Acute oral toxicity)
M-3592 (Eye Irritation)
M-3592 (Primary skin Irritation patch test (household chemical))

)

I

)
)

CD
to

Dow Number

Date

Author

14108291410830*

701210

SH versteln, EH

14108311410832*

701210

S llve rste ln , EH

14108331410834*

701210

S llve rste ln , EH

14108351410836*

701210

S llversteln , EH

14108801410902*

630225

Dow
Olson, KO
Oyen, F
Scoles, G

Recipient

)

t

)

Page 89
Distributees

General Subject Matter
M-3592 {Skin contact absorption)
M-3592 (Skin contact absorption)
M-3592 (Skin contact absorption)
M-3592 {Skin contact absorption)

Barrons, KC
Boundy, RH
Brown, R
Colby, RW
Dow
Elshere., D
Falkenstein, WJ
Gay, HH
Greene, LM
Hart, A
Jones, GD
Kagy, JF
K111an, DJ
Luce, EN
Lynn, GE
McIntyre, HH
Mullison, HR
Nash, HA
Norton, TR
Scoi es , G
Shrader, SA

Results of range finding toxicolo­
gical tests on agricultural chemi­
cal formulation M-2422 containing
91 percent Dowanol PIB ester of
245T (Biochemical Research
Laboratory)

)

.)

)
)

Dow Number

Date

Author

14109031410909*

531030

Dreyer, F

14286101428611*

611228

Dow
Winston, AW, Jr.

14312591431263*

000000

Ivon Watkins

O 1436354iG* 1436364*

000000

Recipient

)

Page 90
Distributees

General Subject Matter

Wilson, AW
Wright, N
Adams, EM
Allen, WW
AlHnson, RL
A lqulst, FN
Barrons, KC
Beshgetoor, AW
Boundy, RH
Britton, EC
Davidson, JH
Dow
Dutton, WC
Gay, HH
Greene, LM
Kagy, JF
Luce, EN
Lynn, GE
MacCutcheon, SM
Prescott, RF
Sunderland, WW
White, L
Wright, P

Results of range finding toxicolo­
gical tests on Dow Brush K ille r T

Fish to x icity of some herbicide
formulations and their Ingre­
dients
IWD 245T Esters
Compounds showing toxicity to fish
at 5 MG/L or less

v

}

)

)
)

K4
o
¡£lt*

Dow Number

Date

Author

14370601437102*

660622

Graves, HH
DRE

14439211443922*

701217

Dow
Gehrlng, PJ
Norris, JM
Williams, CS

Recipient

)

Page 91
Distributees

General Subject Matter

Goergen,GG
Lueck,A
Sauers, RC
W1d1ger, AH
Tuttle, FC
Poffenberger, N
Wolf, RR
E lg stl, DR
Hillman, RE
Anderson, RE
Graves, HE
Coulter, KE
Snyder, AP
Del Isle, NG

P ilo t Plant Study of the Caustic
Hydrolysis of 1245 Tetrachlorobenzene CF-1043-2

Barton, J
B la ir, EH
Burgert, BE
Clegg, DH
Dow
Edwards, H
Frevel, LK
Gordon, HL
Goring, CA
Holder, BB
Johnson, JE
K111an, DJ
Klmmel, CE
Lloyd, BH
MacCutcheon, SM
McCollister, DD
McIntyre, HH
Morgan, RW

Toxicological properties and
Industrial handling hazards of
formulation M-3592 containing the
propylene glycol butyl ether of
245T

V

)

V“4 .
o
tí-

Dow Number

Date

Author

14439231443924*

701217

Dow
Hoyle, HR
Norris, JM

14439251443928*

701217

Dow
Norris, JM

14439291443932*

700000

Bourne, JE
Dow
S1lverste1n, EH

14439331443934*

761110

Dow
S llversteln , EH

1443935 *

701106

Dow
S llversteln , EH

14439361443941*

701210

Dow
S llve rste ln , EH

1511476 *

800606

K&E
Wine, LM

15515891551591*

580417

Dow
Stevenson, GT

Recipient

Braun, WH
Dow

)

Page 92
Distributees

General Subject Matter

Morse, D
Pltchforth, L
Schwarz, AJ
Williams, CS
M-3592 (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
Acute toxicological properties of
formulation M-3592T
M-3592 (Acute oral toxicity)

M-3592 (Eye Irritation)
Primary skin Irrita tio n patch test
(household chemical) (M-3592)
M-3592 skin contact absorption
Dow
Tucker, M
Barrons, KC
B la ir , EH
Boundy, RH
Colby, RW
Coulter, LL

Inverton (brush.killer) hay spray
ca ttle feeding test

)
)

Dow Number

Date

Author

15685591568560

650000

Dow

15686271568630

641208

Sauers, RC

15686661568667

641208

Sorge

1573474*

700915

Haberstroh, WH

O"
Ob-

Recipient

Savaso, JC

)

)

Page 93
Di stributees

General Subject Matter

Dow
Green, J
Hymas, TA
Johnson, JE
Kagy, JF
Lipple, LJ
Lynn, GE
Norton, TR
Nutting, HS
Perkins, RP
Rowe, VK
Spalding, J
Vanvalkenburg, JW
Analysis of caustic Insoluble oil
and 245 Trlchlorophenol for com­
position by gas liqu id chroma­
tography
Chronological survey of the f ir s t
production period of 245T produc­
tion
Chronological, survey of the f ir s t
production period of 245T
production.
Blelwelss, JC
Deline, DD
Henry, HE
Hensley, EF
Schmidt, BV
T e fft, TH

24D Capital Estimates

)

Dow Number

Date

Author

15734751573482*

700910

Haberstroh, WH
Seidel, EM

15805421580566*

680514

JFL
Kern, WG
Fernandez
Gorgasz
Dal man

15805671580585*

680822

Dow

15819831582013*

620700

G1lzorr1lla, F
FGZ
CAH

15826541582657*

H 6,
O

McCauley, V
Mathew, BA

15836671583675*

000000

M1llh1sler, RD

15836901583691*

721125

Vanhorn, R
Bethke

1630441*

500600

1630444*

510228

1630446*

501000

Dupont

Recipient

Page 94
Distributees

General Subject Matter
Revision of 24D Capital Estimates
Technology review of Industrial
chloracetlc acid

Dowanol, Butyl 4 Isooctyl
Chloroacetate technology review
Preliminary engineering study for
Dow Qulmlca Argentina, SA
Tordon 105 Manufacture
Tordon 225E
M3990 or Tordon 225E reactive
chemical hazard data
24D Amine Weed K ille r
(Raw materials description and
specifications)
Raw material specification
24D Amine Weed K ille r
(Raw materials handling 4
storage conditions)

I
j

o
GO

Author

Dow Number

Date

16304471630473*

501000

1630466

500810

16304741630478*

491200

16304791630483*

500201

Jlrouch, EA

1630485*

500510

Dupont

16304891630490*

491200

Ott, RC

16304911630494*

491200

16426901642691*

000000

JRU

16450901645098*

550826

Bennett, CM
W1d1ger, A
Dugan, G

Recipient

'

)

)

Page 95
Distributees

General Subject Matter
24D Amine Weed K ille r
(operating directions)
Effect of DMA Concentration on PH
of 24D Amine Weed K ille r
24D Amine Weed K ille r
(Operational hazards)
Tentative Operating Instructions,
Dimethyl amine
24D Amine Weed K ille r
Specifications & average analysis
24D Amine Weed K ille r
(Labor Required for Operation).
24D Amine Weed K ille r
(Production and Yield Accounting
Methods and Information)
Trlchlorophenol Manufacturing

Griswold, A
Williams, WH
Britton, EC
A lqu lst, FN
Colby, A
Vanarsdale, J
Reese, R

Phenol, 245 Trlcholor

*

)

tP®*
O
ZD

Dow Number

Date

Author

16500791650081*

630429

Barrons, KC
Coulter, LL
Johnson, JE
Lynn, GE
Wolf, MA
Hunt, M
Loucks, MF
Vanvalkenburg, W
Fayerweather, BL
McIntyre, HH
Branaman, J
Lang, HC
Falkenstein, WJ
Davis, HW
A llen, W
W

16501391650141*

670522

Barrons, KC
Byrd, BC
Wolf, MA
Gowel 1
Loucks, MF
Falsey, MP
Buerge, TE
McIntyre, HH
Hammer, OH
G U I, WM
H1ghh1ll, CA
Woodward, RE

Recipient

J

)

>

I

Page 96
Distributees

General Subject Matter

Brainerd, A
Poffenberger, N
W1d1ger, A
Dugan, G
Verton CE with o il
(Release to Sales)

Tordon 155 Mixture
(Release to Sales 9)
V

)

)

I

)

Dow Number

Date

Author

Recipient

Davis, H
Corbin, WF
Nummy, WR
DEP
CJK
JLS
16501461650148*

671009

Dow

1650262
1650264*

630517

Barrons, KC
Coulter, LL
Johnson, JE
Lynn, 6E
R1tty, PM
Wolf, MA
Loucks, MF
Vanvalkenberg,W
Branaman, J
Lang, HC
Fai kenste1n, WJ
Allen
Saunders, ES

16504661650468*

621012

Amstutz, FC
Barrons, KC
Johnson, JE
Lynn, GE
Southwlck, L
Wolf, MA

O
o\
©

Woodward, RE

)

)

»

Page 97
Distributees

General Subject Matter

Dosser, RC
Hoff, RC
Matuska, R
Colby, A
Stone, F

Sales Release Tordon 155

Verton T (Release to Sales 16)

v

Esteron 245 Concentrate
(Proposed Release to Sales 21)

)

Dow Number

)

Date

Author
Vanvalkenberg.W
McIntyre,HH
Branaman.J
Lang, HC
Allen, W
W
JLS
KEE
ES
PMR
Saunders, E

o
CJS

17279671727968*

580630

Dow
McColHster, DD
Wolf, MA

17280491728050*

590702

Dow
Olson, KJ
Oyen, F

17280531728054*

630108

Dow
Olson, KJ
Oyen, F

17280571728058*

621214

Dow
Olson, KJ
Oyen, F

17280591728060*

660412

Dow
McCollister, DD
Olson, KJ

Recipient

I

)

)

Page 98
Distributees

General Subject Matter

Dow
Hoyle, HR

Dow 245T amine weed k ille r (Data
sheet of properties, health
hazards and precautions for safe
handling of materials)

Dow
Hoyle, HR

M-1459 formulation of K-7797 and
K-7856 (Data sheet of properties,
health hazards and precautions for
safe handling of materials)

Dow
Hoyle, HR

M-2422 (Data sheet of properties,
health hazards and precautions for
safe handling of materials)

Dow
Hoyle, HR

M-2468 (Data sheet of properties, :
health hazards and precautions forv
safe handling of materials)
'

Dow
Hoyle, HR

M-2993 (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
(T2.MO-2993-1 )

)

i

)

Dow Number

Date

Author

17280611728062*

700514

Dow
Norris, JM

17281011728102*

580616

Dow
McCollister, DD
Wolf, MA

17281031728104*

580630

Dow
McCollIster, DD
Wolf, MA

17281671728168*

580514

Dow
McColl!ster, DD
Wolf, MA

1765919*

650919

Sinke, GC

17663001766308

661104

Wldiger, AH
Johnson, RL
Dugan, GF

ocn
to

Recipient

)

;

Page 99
Distributees

General Subject Matter

Dow
Falkenstein, WJ
Hoyle, HR

M-3427 (Data sheet of properties,
health hazards and precautions for
safe handling of materials)
(BC T2.MO-3427-1)

Dow
Hoyle, HR

Reddon (Data sheet of properties,
health hazards and precautions for
safe handling of materials)

Dow
Hoyle, HR

Reddon concentrate (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)

Dow
Hoyle, HR

Veon brush k ille r (Data sheet of
properties, health hazards and
precautions for safe handling of
materials)
Heat of reaction data per
GC S1nke of the Thermal Lab

Widiger, AH
Coulter, KE
Johnson, R
Thurston, D
Dugan, G
Haberstroh, WH
Goergen, GG
Sauers, RC
Bender, S
Wolf, RR
Louck, A

Phenol, 245 Trichloro study
of Chloracne problem
Preparation of 245 Trlchlorophenol
from Trichlorobenzene

)

I

Dow Number

Date

Author

17663091766336*

650203

Poffenberger,N
Bradley, K
Ebert
Warren

17666511766660*

641125

17666811766686*

650107

CD

Poffenberger, N

Recipient

)

)
)

Page 100
Distributees

General Subject Matter

Poffenberger, N
Bailey, CZ
Putnam, MS
Nielson, WH
StaehUng, EC
Bradley,K
Graves, H
Dylewskl , S
Haberstroh, WH
Sauers, R
Trapp, W
Poffenberger, N
W1d1ger, AH
Coulter, KE
Goergen, GG
Luecic, A
Redmond, W
Del Isle-, NG
StaehUng, EC

Phenol 245 Trlchloro
Preliminary Process Design
Using 100 percent NAOH,
PL2028-4

Trlchlorophenol Process
Poffenberger, N
Sauers, RC
Trapp, WB
W1d1ger, A
Luecic, A
Holmes, R
Bradley, K
Goergen, GG

245 Trlchlorophenol - Outline of
Requirements

*■

*

>

)

'•

\

h*4
f-P*«

O

en

Dow Number

Date

Author

Recipient

17666871766694*

650112

Poffenberger, N

17666951766698*

650105

Poffenberger, N

17667041766708*

641120

Holmes, R

17667131766730*

641224

Sorge

Sauers

17667341766736*

691212

W1d1ger, A

Chang, KY

)

1

>

Page 10]
Distributees

General Subject Matter

Poffenberger, N
D e lisle , NG
Sauers, R
Trapp, WB
Widlger, A
Lueck, A
Holmes, R
Bradley, K
Goergen, G

Appendix to Report PL2028-3
(245 Trichlorophenol)

Poffenberger, N
Sauers-, R
Trapp, W
Lueck, A
Widlger, A
Bradley, K
Goergen, G
Holmes, R

245 Trichlorophenol Process
Information

Hydrolysis of Tetrachlorobenzene
using flake caustic
Description and prints for th>e
current production methods fo r
obtaining 245 Trichlorophenolate
solution 1n building 74 {Report :50]
Leavlttg, FC
Demott-, DN
Poffenberger, N
Tree, R
Plepys, RA
Schmidtke, DJ

Progress report on research
on blooming of 245 Trichlorophenol

»

)
)

Q.

en

Dow Number

Date

Author

Recipient

17667391766750*

700720

Chang, KY
Tou, JC

1766760
1766761*

641118

W1d1ger, AH
Holmes, RD

Grelss, GA

17667621766764*

640730

Holmes, R

Hoyle, HR

17667661766769*

641120

Holmes, RD

17667701766771*

000000

Dow

)

Page 102
Distributees

General Subject Matter

Chang, KY
Tou, JC
Look, A
Leavitt, FC
Demott, DN
Poffenberger, N
Gum, WF
Plepys, RA
Pierce, JK
Frevel , LK
Potts, WJ
Westover, LB
Fauver, VA
Kennedy, TL
Widiger, AT
Pews, G
Rodla, RM
Nummy, WR
Blue, RD
D e lisle , NG
Sheetz, DP

Oxygen 18 labeling study on
the mechanism of caustic
hydrolysis of 1245 tetrachlorobenzene 1n methanol

Goergen, GG

199 Bldg Production of
Sodium 245 Trichlorophenate
Manufacture of Trichlorphenol at
199 Bui ding
Hydrolysis of Tetrachlrobenzene
using flake caustic
TCP Process Flow Sheet

v
■