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3 WSZZ 3 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
e, “Se WASHINGTON, D.C. 20460
4c pate”
OFFICE OF
PESTICIDES AND TOXIC SUBSTANCES
SUMMARY OF THE IBT REVIEW PROGRAM ;
OFFICE OF PESTICIDE PROGRAMS
. JULY 1983
pre S747
2 r  \ % ..
3 SZ 3 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
%, oe WASHINGTON, D.C. 20460
7, ;
OFFICE OF
PESTICIDES AND TOXIC SUBSTANCES
The IBT Review Program
This report summarizes the findings of the joint
” program conducted by the Environmental Protection Agency
(EPA) and the Health Protection Branch of Health and
Welfare Canada to reexamine the validity of health effects
studies on pesticides tested by Industrial Bio-Test
Laboratories, Inc. (IBT). This program is one result of :
discoveries made during a series of audits beginning in
1976 by the Food and Drug Administration (FDA) and EPA
which revealed serious deficiencies in IBT tests conducted
to support the registration of numerous pesticides and
some drugs in both the United States and Canada. This
report assesses the impact of the IBT situation on the
registration status of the chemicals involved and describes
the steps the Agency has taken to resolve this problem and
to prevent its recurrence.
Exhibit A shows how many IBT and non-IBT tests are
available to EPA in each testing category for the pesticide
chemicals having some IBT conducted studies in their :
data base. As these tables show, a large majority (93%) of
the pesticides tested by IBT, also have non-IBT data
available. Only 12 of the pesticides listed have a data .
base entirely of ,IBT studies. However, seven of these are
either not registered for use in this country or are
cancelled or discontinued products. Some of the IBT ;
studies on the remaining five chemicals are at least
partially valid or "supplemental", meaning the data can be
used to support the findings of other studies.
2

; These tables also indicate the pesticides for which
new data have been required as a result of EPA regulatory

, actions. These include risk/benefit reviews undertaken

: - because. of specific evidence of.a hazard (known as . a
Rebuttable Presumption Against Registration, listed as
"RPAR" in-tables) or EPA's regular program for reregister-
ing all previously registered pesticides (in tables, 7
“Registration Standard" and “Data Call-In"). The reregis-
tration program is not specifically connected to the IBT ,
case, but serves the purpose of bringing the data on older
chemicals, including some tested by IBT, up to current , >
scientific standards. Under the authority of section
3(c)(2)(8) of the Federal Insecticide, Fungicide, and
Rodenticide Act (FIFRA) the Agency can require additional ;
data to maintain a registration, and may suspend a product's
registration if the registrant does not agree to provide
the data or if it is not provided pursuant to an agreement
with the Agency. .
Attached is also a list (Exhibit 8) of major health
effects studies on pesticides conducted by IBT identifying
which have been found valid or invalid, and which have
been or are in the process of being replaced. This list
covers 801 studies on 140 pesticides. An earlier draft
list of IBT tests prepared by EPA in May 1983 identified
1205 tests on 212 pesticides. The current list has
eliminated duplicative entries, preliminary range finding
and similar tests which were not true health effects
studies, and short-term, acute toxicity tests which
generally do not create a significant data gap and which
will be replaced if needed, through the existing reregis-
tration program described above. Thus, the current list | ,
of 801 studies covers health effects considered significant.
to regulatory decisions, such as induction of benign or
malignant tumors (oncogenicity), birth defects (teratogeni-
city), genetic mutations, other adverse reproductive effects,
and neurotoxicity. Of the 801 IBT studies in the pivotal
categories, 594 (74%) have been found invalid. To date,
of the invalid studies, 212 (36%) studies have been replaced
or are in progress, 38 (7%) are under discussion for possible
replacement, and 45 (7%) are of a type no longer required
for registration.
One way to assess the impact of I8T is to consider

the effect of invalid studies on the data base supporting
pesticides used in high volume. Although hundreds of
pesticides are registered, only 25 insecticides account for
85% of the actual pounds of insecticides used, 32 herbicides
account for 82%, and only 8 fungicides account for 71%
of the volume of those products used. Of these 65 most
heavily used pesticides, only 18 have IBT data in One or
3
_more important categories. Of those 18, all but one also
have non-IBT data available in some or all of the same
cagetories. The exception, prometon, a herbicide not used
_on food crops, has one partially valid IBT study. and many Loe
non-IBT acute and subacute studies. Sixteen of these high
volume chemicals are the subject of one of the regulatory
procedures described above requiring additional data.
Thus, the data bases for the high volume chemicals to
which people are most likely to be exposed are for the
most part unaffected by the IBT situation, and where there
. is an impact, EPA has-taken active regulatory steps to }
_ abtain replacement data.

The principal remaining task of the IBT program
is to clarify the status of the invalid studies for which
registrants have indicated they do not intend to provide -
replacements, or have not communicated an intention one way .
or the other to EPA. Atthough around 300.studies are in .
this category, a significant number (140) of negative and .
non-responses involve discontinued or cancelled products,
or pesticides of such low volume use that registrants may
choose not to invest in further testing needed to maintain
registrations. The replacement status column of Exhibit 8B
indicates that there are 159 invalid studies (26% of invalid
IBT tests) for which there is negative or no response. a
However, as previously noted, most of these chemicals have
non-IBT data available. Exhibit A shows that only five
chemicals still registered and actually used have entirely
IBT data bases. The 17 studies involved with those 5
chemicals constitute 3% of invalid IBT studies. A registra-
tion standard will result in replacement of 6 of these
studies. This leaves only 11 studies or 2% of.the invalid
IBT tests which constitute the sole support of registered .
pesticides, and for ‘which no regulatory action to generate
replacement data has yet been initiated. Several of these
11 are valid or have at least supplementary value.

This report is being furnished to the registrants
of the affected chemicals for which negative or no responses .
have been received concerning replacement of invalid IBT
studies. We are also sending the registrants 3(c)(2)(8)
notifications which-require a registrant to make a specific
commitment within 90 days or the registration may be .
suspended. In some cases, EPA and a registrant may agree
that a specific study does not need to be replaced.

The IBT case caused serious concern and uncertainty.
about the potential hazards of the hundreds of pesticides
involved, both for EPA and the public. Although it was .
advocated by some that all 212 pesticides tested in whole
or in part by IBT be removed from the market pendihg , -
retesting, that option is not. available under current law. __.
4
The regulatory response authorized by FIFRA requires
valid evidence of risk, as opposed to a lack of information, ;
: before removing a product from the market, and allows for
_the replacement of inadequate data. As we reach the final
resolution of the IBT problem, it appears that this approach
was appropriate and adequate to deal with this event.
The IBT scandal shook the industry and government
regulators. Obviously, steps had to be taken, not just
to deal with the IBT situation itself, but to ensure that
data providing the foundation of regulatory decisions in
the future are adequately prepared and scrutinized. Thus,
another result of the IBT case was the establishment in
1977 of a joint EPA-FDA audit program to help ensure that
another IBT situation has not occurred and will not in
the future. The lab audit program includes visits to
laboratories to inspect their procedures, facilities and
staff qualifications, and about sixty audits per year of
labs and/or individual pesticide studies to see if the ;
reported results are supported by the "raw" laboratory
records and data. In the past six years, we have found
the large majority of laboratories to be in compliance ;
with current standards, and producing scientifically valid
Studies. An important effect of the IBT case has been to
make the testing community, the industries which use their
services, and government regulators keenly aware of the
need to maintain high standards of quality control over
health effects testing.
EPA ASSESSMENT OF THE 801 MAJOR IBT TESTS
SUPPLEMENTAL
"1 VALIOR
PENDING REVIEW
malt tie it Ree inne:
. REPLACEMENT UNDER DISCUSSION
ZA TYPE OF TEST NO LONGER REQUIRED
TEST REPLACED » CTR *
OR IN PRGGRESS ah, Ween ere
NEGATIVE
RESPONSE ;
NO RESPONSE: ——
BUT REGISTRATION
1 Nee. CANCELLED, PRODUCT
et, CEE ee DISCONTINUED, NO a
, ae pete: PRODUCT REGISTERED
it Meats 2 IN U.S, OR NO CURRENT
i ahs ae PRODUCTION
.. 9 S STUDIES WITH NO AND .
; s NEGATIVE RESPONSES
NEGATIVE RESPONSE: = . REQUIRING REGULATORY
; - BUT REGISTRATION ACTION
: CANCELLED, PRODUCT
"DISCONTINUED, NO
- PRODUCT REGISTERED .
. IN U.S., OR NO CURRENT ;
PRODUCTION \
INVALID IBT STUDIES \ ‘
a PROVIDING SOLE VA bn
: SUPPORT FOR ab .
. REGISTRATION ct
INVALID IBT STUDIES
ON PESTICIDES WHICH
. ALSO HAVE NON-IBT
, STUDIES . ;
5
. . ; tone - 7 . _ ° _ . : -- a + «
EPA ASSESSMENT OF EFFECT OF IBT DATA
; ON 65 LARGEST USE PESTICIDES *
PESTICIDES
| WITH NO IBT DATA
ys )
CE  -:-
| £
SS
x —-—nov?Z—
Ezz gs! .
PESTICIDES WITH
a SOME IBT DATA
_ ° TWO PESTICIDES WITH -
THAT WERE THE REGULATORY ACTION
SUBJECT OF RPAR,
DATA CALL IN, OR .
| REGISTRATION STD. .
*25 INSECTICIDES ACCOUNTING FOR 85% OF POUNDAGE USED,
_ 32 HERBICIDES ACCOUNTING FOR 82% OF POUNDAGE USED,
- AND 8 FUNGICIDES ACCOUNTING FOR 71% OF POUNDAGE USED, -
IN 1980,
, SUMMARY STATISTICS: IBT .
TOTALS _ ; :
. 38 COMPANIES :
140 -CHEMICALS _ OO
| 801 STUDIES | | |
| STUDY VALIDATION STATUS a
131 16% VALID oo |
| 44 6% SUPPLEMENTAL
32. 4% PENDING .
- §84 74% INVALID
| 801 100%
| INVALID STUDY REPLACEMENT STATUS ;
| 212 36% STUDY REPLACED OR IN PROGRESS | |
38 6% REPLACEMENT UNDER DISCUSSION
45 8% STUDY NO LONGER REQUIRED _
116 20% NEGATIVE RESPONSE BUT PRODUCTS ARE CANCELLED, —
. DISCONTINUED, NOT REGISTERED IN THE U.S., OR HAVE
NO PRODUCTION. — |
24 4% NO RESPONSE BUT PRODUCTS ARE CANCELLED, DISCONTINUEL
: NOT REGISTERED IN THE U.S., OR HAVE NO PRODUCTION.
86 14% NEGATIVE RESPONSE AND INVALID --
: 73 12% NO RESPONSE AND INVALID | |
| 594 100% | |
IBT STUDIES PROVIDING SOLE SUPPORT FOR REGISTRATION
| 17 3% IBT STUDIES PROVIDE SOLE SUPPORT FOR REGISTRATION
=8 1% CHRONIC STUDIES GENERATED BY REGISTRATION STANDARD
11 2% _ ~
gerey
>; && 4 -
4 SZ 3 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
, ef WASHINGTON, D.C. 20460
Ae page?
: PEesTicipes ANO TOXIC SUBSTANCES
ADDITIONAL BACKGROUND ON THE IBT REVIEW PROGRAM
In 1976, during a routine lab. inspection of one of IBT's
facilities, FDA discoverd deficiencies in the manner in which
studies were being conducted and discrepancies between those
studies and their raw data. In 1977, EPA placed a moratorium
on registration actions involving data developed at [BT as a
result of this information. In the same year, EPA notified
registrants that they were required to audit the raw data
and validate both those IBT studies which were pivotal to the
data base of pesticides already registered and all those
which were supporting new registration actions.
In 1978 a joint EPA/FDA audit of IBT's two other
facilities uncovered problems similar to those discovered
during the initial audit. In March of that year EPA required
registrants to submit to EPA the raw data for the IBT studies
so that a review of registrant audits could be conducted.
EPA referred this case to the Department of Justice for
; investigation in April 1978. At approximately the same time,
the U.S. and Canada were negotiating an agreement to share
- the task of spot checking registrants' audits of IBT studies.
Through these checks, however, it became apparent that
registrants’ audits routinely overlooked some areas of concefn.
As a result, Canada and the U.S. agreed to review each audit
' and study.
Mutual agreement was reached as to which studies would
be reviewed by each country. It was also decided that each
country would accept the other's determination as to validity.
However, due to differences in data requirements, each country
would independently evaluate whether studies met their
regulatory requirements, and determine the need for replacement
studies. ,
8
After two years experience of the review program
a decision was made to reconsider past policies regarding ;
IBT data. A policy statement reflecting decisions made as a
~ result of this analysis was sent to registrants in July 1980.- -.--- ----
The decisions were: 1) that the moratorium on registration
actions was lifted unless a valid IBT study was essential to
the approval of a specific action, 2) that registrants would -
be required to fill data gaps resulting from invalid IBT
studies, 3) minor data gaps would be considered through
normal registration channels, 4) if the entire data base was
invalid, EPA would consider cancellation action, and 5) if
previously unreported adverse effects were discovered, the
study would have to be replaced, and in addition the Agency
would consider initiating either an intensive risk/benefit.
review, or formal hearings on a chemical's registration
status.
' The IBT Review Program consisted of validation review,
evaluation review, and data gap review. Validation review -;
was designed to determine whether the information in the
final report was supported by the raw data. Evaluation of
whether a study met Agency guidelines for studies used to.
support registration, was performed on studies determined
to be valid or at least reliable enough to supplement other
valid data. Data gap review was a search through a chemical's
entire data base to determine which invalid studies needed
to be replaced.
Because our experience with data gap. review proved it
to be extremely time consuming, options for completing the
IBT program more expeditiously were considered. As a result,
‘ several policy changes were adopted and conveyed to registrants
in a letter in April 1982 which stated: 1) that acute IBT .
studies would no longer be reviewed through the IBT program.
Instead, they would be reviewed through normal registration
channels; 2) that studies which were considered invalid
because the registrant initially chose not to audit them,
would not be reviewed by the Agency and our presumption would
be that they had to be replaced; 3) that EPA would no longer
perform a data gap review of a chemical's data base to
determine if other studies existed to replace the IBT studies,
instead we would assume that replacement was necessary unless ;
the registrant could convince us otherwise; and 4) that EPA
would not review an IBT study if the registrant identified a
replacement and agreed to have the IBT study considered
invalid. , .
The review stage of the IBT program is essentially
complete. The remainder of the program consists of obtaining
replacement studies and tracking commitments to replace
studies. -
9
a EXHIBIT A
THE DATA BASE FOR INDUSTRIAL BIO-TEST CHEMICALS
Exhibit A quantitatively presents the data base of the
chemical compounds for which studies were.conducted by
Industrial Bio-Test Laboratories. The IBT studies are
designated by the letter 0. Studies in the EPA data base
done by labs other than IBT are designated by the letter

X. ,

The studies are arrayed across six categories of chronic _ .
effects. These chronic effects are: oncogenicity, terato-
genicity, mutagenicity, reproductive effects, neurotoxicity,
'and other chronic effects. ;
Some of the chemicals in this exhibit appear to have no

IBT studies because the studies conducted for these chemicals
by IBT were all in the acute categories. The chemical names
used are those that were listed in the IBT records. There

is no designation of the validity or invalidity of the IBT
studies presented. Specific information of th@ss nature is
in Exhibit B.

Exhibit A also notes any ongoing regulatory activity ©

that will generate chronic data ror these chemicals. ~— me
The types of regulatory activity that cause the generation
of data are: the registration standard program, the data
call in program, the rebuttable presumption against
registration program, and any special action employing

the 3c2b provision of the Federal Insecticide, Fungicide,
Rodenticide Act. There are approximately 2830 chronic
studies indicated in this data base.
CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: -
_QUANTITATT UBMITTED T AND OTHER .LABORATORIES.
- &€ | bE OU |
4 ~- = : - YO oO
4 ni - <
E, o) Zz DW re) my) . ot
“ ij re) ni ar re i .
, ©) & rT) ou - oO OU ; ;
re) s < om & yu ;
9 ee . EB . Be bis be REGULATORY ACTIVITY TO
CHEMICALS S. . oF 3 ea bi fa © ti GENERATE CHRONIC DATA LO
' Alar x xX XX X x : Registration Standard
a 0 : |
Atrazine Tx XX XXXXXXX | xX | XXX Data Call In
_ | . | 00 7 |
 Avadex: XXXX “XX XXX X Registration Standard
ct 0 0 00 7
a A a
) ; Qo = IBT :
CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: -
ES SUBMITTED EP AND OTHER LABORATORIES.
r 5 EUS FB |
-< ram r rs) u oO
; wi it) = a) :
Zz, o zm 37) oe tu a
Hy & G oO S  & SO . |
: s e EB Be bs = bs REGULATORY ACTIVITY TO.
CHEMICALS «= =§ (Ga ( CO be ial Bo. 6 GENERATH CHRONIC DATA .
’ . 1000 . . . +7
-“Baygon XX. xx xxxxx” x XXXXXKXXK | XXX yoo |
0 XXXXXX a .

' “Bladex _ X, XX , XXX Data Call In
7 | 00 , | |
Bolero _ xx X XXX XXXXXXX |X XX a | |
_ (thiobencarb) : 00 00 0 99 9000 :
_, Brodifacoum . |X te |
- (Talon) a ; —_
Bux X ; X Data Call In —_

—_ ; , Qo oe Not’ registered in U A.

5 : 1
: A, = TRT |
CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: - | |
_ RQUANTTTATIVE PRESENTATION OF STUDIES SUBMITTED TO EPA BY TBT AND OTHER LABORATORIES. -
r 5 : B Fg : |
“ oo. “ Uo oO
UW z . YX 5 - fF ;
- : fj F3) oo < .
hi ye) ij Ar i i | .
gS €& 8 | ee —_
: g Ps a. hs 5 = ot REGULATORY ACTIVITY TO |
~ CHEMICALS 6. OF 2 ear E 6 ti GENERATE CHRONIC DATA eo
| Captan ReccCaME CCCCcO mE Docccoeee bee mx fee | :
: 00 900000 ~—s«| 000 00 oe, oe
 Carbaryl XXXXXXX PAX XXXX OOO — (NOI) XXX RPAR. 3c2b ;
} | KxGGKKXX 0 a
| Carbofuran XXXXX XXX XXX —kxxx XxXxX . | Data Call In
: 00 : 00000 — boone 000. —
: Chlorobenzilate | x po PPP XXXXXXXX | RPAR  — Data Call In |
_ Chloropropham = | XXXX XX XX X XX Data Call In ~ S|
| Chlorothalionil | xxx XXXXXXAXX] XXXX. po XXxxxX | Data Call In -. |
+, Chloropropylate | 4 Data Call In ee
CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: - 7 —
K-QUANTITATY ES SUBMITTED TO EP AND OTHER LABORATORIES. . .
. : a 7 |
He | on . -
~ aos ~ - uo: oO ; ; . ;
& Zz Uo on] : i
~ ul a oO << f i
oo 2, o z Dw re) nv | . 2
re) re) ij Ab = rs
, © i] o : ou Oo mw ” . : ‘
Q <j < eu ee ie . mo
. S e2 : Obs bn REGULATORY ACTIVITY TO 7
CHEMICALS 5 . & 2 hi 3 © ui GENERATE CHRONIC DATA
- Cidial,Phenthoade 0 » X X "|. RPAR- Registration Stnd. _
. Dimethoate 00. ; ; tg
:  Curacron XX XX | xx XXXXXXX | XXXXXX | XXX | So ,
':  (Profenofos) 0 ; 07 00 )
: Cycle ; X Discontinued Product FO
- | 0000 | | | : |
| Cyprazine 0 P| Data Call In §'. 7 |
- . Discontinued Product.
_° ‘Dasanit | X X | XXXXXXXX] XX Data Call In |
i bo . {o | XXXXXX |
| O « IBT .
| CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: - | |
K_QUANTITATIV UBMITTED TO EP AND OTHER LABORATORIES. .
: re 5 r BS Fg |
Lo ~ . H -~ - 1S ] oO ; .
: u xz 1S) 5 - & ;
I su - < ;
z Oo . 5 Dw 2 . 2 | - 3
ia ‘s) Ae = t .
: o < < arn fe om 0600 | —_
| S 2 an 8 Eis ss REGULATORY ACTIVITY TO. |
: CHEMICALS 6. . E S ot" Be Oui GENERATE CHRONIC DATA r
. Delnav -| XX AXXXXXXXK] XXX Ss || Data Call In* |
: XXXXXX eo _
. Diazinon XXX XXXXX jon for fess | XXXXXX - | Data Call In | ho
' Dicamba fo ss [xxxxx x XXX XXXX Data Call In —
: 0 000 0 . 1. : _
7 Dichlobenil XX Data Call In bo
| 00 |
_ Difolatan |x 00000000 XXXX Data Call In |
; ; 000 .
. Dinoseb X xX . X XX . . -
Diquat Xx. “WXXX XXX x XXXX - oo poe bo
: . | ; 00 0 ms 7 —
 ‘Disyston | X | xx XX X=19 oo
| 0 ) o | Data Call In a
A CC
O «= TRT .
CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: - .
: ES SUBMITTED TO EP AND OTHER LABORATORIES.
- r ; r : Fog
: ~ a) = - ©) (fe)
a v he v 5 ome f
ad (1) a i
Zz uO - a ne Dw ve) 7) . . oo
' Ww re) i A - | t~ :
oO | & Q ou re) 0 a . |
| 8 os a = Et i REGULATORY ACTIVITY TO
-” CHEMICALS 5... B att) z On GENERATE CHRONIC DATA :
D :
'<Endothall XXX XXXXXX | XXXXXXXX ef ee |
BPN XX X X . [X=30 RPAR
| 0000 |
Ethiolate 7 sO . . {
Discontinued Product
Ethion lo X XX XXXXXXXXX Data Call In’ |
, ° 0 0 00 | :
. Fenvalerate XX - {XXXX XXXXXXXXXAXAXXXXXXXXA X=24 X=23 Data Call In; -
ae . | | . X . | oo, a
: “1 Uo ene .
CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: -
K-QUANTTTATY UBMITTED P AND OTHER LABORATORIES.
. E | bg
fe U 's Ss Zz
' wo >, pw fo) wv“) oy
inj re) i AK & bt
o < < ar] fe ei 7 3
| 8 a E Bt = br i REGULATORY ACTIVITY TO |
CHEMICALS Oo - +» & oe 14 z on GENERATB CHRONIC DATA .
— *Folpet 5 ss XX XXXXXX | XXXX | x + |. Data Call Int
| 00000 Oo. 00 —_ SG
. 0 Oo 7 ——
— ‘Burloe XXXXXX | XXXX XXXX XX X XXX
. (Chloropropham) ” 0 - .
| Glyphosate 0 XX xX XXX | | xX | | a
| 000 0000 00 Data Call. In de
_- Heptachlor Epox} XXXXXXXX] XXXXX XXXXX — |XXXXXXXX |X XXXXXXXX | All uses canceljed
oe | XX 0 XXXXXX Ce |
_. Ivrgasan 00 X XXXXXKXX |X XX 7 | . 7 :
| | oO.  . | Xxxx 00 0... moe ee
| : Ow BT gy
. HEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: -
K-QUANTTTATT NT S SUBMITTED TO EPA. AND OTHER LABORATORIES. .
“ - Land “w uU oO ;
-4 by Lan . .
A oo a nw oO . ni
i re) a) Af ik & ; :
- S PF: aa & BI REGULATORY ACTIVITY TO
CHEMICALS rt & e ar F arr GENERATE CHRONIC DATA -
Lasso X XXX XXX x XX °
| o fo 00000 0 00 ~ | Mata Call In
Machete 0 x _ [XXXXXX XXXXXX | X Data Call In |
| - 10 0000 00 | 7 |
| X XXX XXXXXXXX [XXXXXKX : :
Megurol | ) 0) XXXX 00 .
Meta-Systox R | X ~ x XXXXXXXX PX : aa
QO . tor
. CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: - _
K_QUANTITATIV! S SUBMITTED TO EP BT_AND OTHER LABORATORIES.
| |
| co tO
~ a mH U o
pe) _ os .
Z, Te) Zz mo) S) n -
inj re) i AK & Fe oo, ;
oe) & ce ou re) wae) oo ;
. ° 7 sg <, mm 1 & by a .
. 2 6 A, be 2 at REGULATORY ACTIVITY TO
CHEMICALS & . B oa Hi re Ou GENERATE CHRONIC DATA -
‘. Metobromuron'. ee ee ~ Not registered in U.S.A.
- Methazole 00 Rd XXXXXXXX aa 00000 Data. Call In a °
. 0 |
Methomyl XXXXXX = JXX XX XXXXXXXXX] XXXXXX : .
XX Registration Standard
Methoprene XX XXXXXXXX , | XXXX Registration Standard :
. Metolachlor X XX ' | XX xX XXX Registration Standard
: ° 0 | } !
Mocap X- x XX | !
'  (Ethoprop) . 7
' Monitor X x XX X=11 Registration Standard |
'  (Methamidophos) 00 ce) a) 0=7 | rf
| Morestan x |x x XXX ro. ;
- Naled . | X XX XXXXXX | 00000 Data. Call In | fo
= { 0 000 7
Nemacur Tx x 000K | 100KX a re
CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: - - | |
QUANTITATIVE” PRESE UBMITTED TO EPA BY IBT AND OTHER LABORATORIES. -
r 5 bf. eB Cg
- H ~ H 1S) _o :
i ay a os ;
i : rr w Z Du. iS) ” a
w & C, oo ° as) . .
o. < < x ge pe |
| | 8 E Bb : eT REGULATORY ACTIVITY TO
CHEMICALS 5S. . OR ea Be On GENBRATB CHRONIC DATA
Nemefene XXX X . .
_'* Omadine  }aaooanx | x X XXXXX | XX Discontinued Product |
00000000 | 00 | 000 { Data Call In
_ Orthene | xxx XX X xxxx' | X=12 XxxX | 7 |
(Acephate) 0. 00 | 0 ‘| 000 oo000 «= fo00—(—ssiC‘iT;:CttC |
. Paraquat Xo. “T XXXXX XXXXX XXXXXXX a ee Date Call In — - |
 PCNB XXX XXXXXX" | XXXX XXXX a | | |
- ' * (ethyl parathion) © . OO a ;
| : O «= IBT nO !
| EMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: - | | .
| K-QUANTITATIV S SUBMITTED TO EP AND OTHER LABORATORIES. . .
fr O fs is = re
. ~ i) - aa) wu Oo
m ig m 8) je; f |
. . = o a — ar!) ) Oo ny - -
 § iS oy | ob S eG " ;
4 2] 122 oe
7 3 pS pS Qi REGULATORY ACTIVITY TO
: CHEMICALS Bo . . &B 2 obi = on GENERATB CHRONIC DATA A
: (methyl parathio 8) _ . —
9) .
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' Phosphamidon XXXXXXX - '
| 000000 Data Call In
Picloram 4X XX . XXX X Data Call In .
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CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: - | —— OT
K-QUANTITATIV! UBMITTED p AND OTHER LABORATORIES. . .
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_ CHEMICALS é . .& 2 oe i E Ohi GENERATE CHRONIC DATA 7
_ Rabon XXX XXXXX XXXXX | XXX XXXXXXX - | —
_ Ramyod o. |x Ix on |
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COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: : a
K-QUINTITATIVE " BMITTED P AND OTHER LABORATORIBS.
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CHEMICALS B&B . . B.. 2 | ean Be O hi GENERATE CHRONIC DATA
Resmethrin PXXXX | KAKXX | XXXX XXX fF xxxx Ee xxxxx of; 7: . oO
000 = |
| Rydex — X 0000 ‘| Not Registered i
'  (Prodiamine) 0) ; .
| Santophen X —
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POUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: - a
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_ CHEMICALS B.. B pa bl POS GENERATE CHRONIC-DATA
. Supracide | X X=14 X=26 XXXXX a a
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| a
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CHEMICALS 5 . ££ B ee i PB on GENERATB CHRONIC DATA co
Torak Xx | 0000 XXXXXX Registration Standard ;
| (dialifor) ; 000000 -
- Toxaphene X XXXX XX XXXX :
0 0 00° RPAR
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0 0 ; Co , a
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K_QUANTITATIVE S SUBMITTED P AND OTHER LABORATORIES. . . .
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"CHEMICALS ZB. . Bp B m1 a On GENERATB CHRONIC DATA
Vitavax X XXX XXX XXXXXX
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BO EXHIBIT B
Te IBT TRACKING SYSTEM REPORT
IBT TRACKING SYSTEM REPORT
CODE DEFINITIONS

VALIDATE: a review designed to determine if the information
in the final report was supported by the raw data
from the study. ;

I - Invalid. The information in the final report was not supported

by the raw data from the study.
P - Pending. The study is still under validation review. 7)

S - Supplemental. Portions of the study are valid and can be used

., independently of the remainder of the study.
V - Valid. The information in the final report is supported by
the raw data from the study.

EVALUATE: a review designed to determine if a study meets Agency
guidelines for studies to be used in support of
pesticide registration.

C, CM - Core minimum. The study meets the regulatory data .

requirements to support pesticide registration.

S, CS - Core supplemental. The study is useful to supplement other
studies. ; . .

I, CI - Core invalid. The study does not meet the regulatory data
requirements to support registration. J

P - Pending. The study is still under evaluation review. ,

NA - Not applicable. The study was not given an evaluation status
if the validation process determined it to be invalid. ;

REPLACE: the column indicating the replacement status of the study.

' Replaced - Study replaced or in progress

Discussion - Replacement study under discussion

Not. Req - Study no longer required

No Resp - No response from registrant

Neg Resp - Negative response from registrant
IBY TRACKING SYSTEX REPORT
IBT_NUM CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE
B-1708 ALAR UNIROYAL TERATOLSGY RAT if NA REPLACED
B-4715 AMETRYN - CIBA GEIGY ORAL CHRONIC . =. RAT. I NA DISCUSSION
C-4716 AMETRYN CIBA GEIGY ORAL CHRONIC DOG I NA BISCUSSION
P-4709 AMETRYN CIBA GEIGY . REPRODUCTION RAT I NA DISCUSSION
2945 - AMETRYN CIBA GEIGY DERMAL - ~ RAT/RABBIT I WA NOT REO ;
601-4274 ANTOR - BFC DERMAL SUBACUTE - RABEIT - yo. - NO RESP
611-8169 ANTOR BFC ORAL SUBCHRONIC DOG y P REPLACED
622-0465 ANTOR BFC ORAL SUBCHRONIC RAT P NO RESP
22-305? ANTOR BFC ORAL SUBCHRONIC RAT I NA REFLACED
622-8165 ANTOR BFC ORAL SUBCHRONIC RAT -V NO RESP ;
9560-10525°  ANTOR BFC ORAL CHRONIC RAT V NO RES
8580-08351  ANTOR BFC ORAL CHRONIC MOUSE 7 oy NA NO RESP’
8550-9350  ANTOR BFC ORAL RAT I NA NO. RES
622-6769 ATRAZINE : CIBA GEIGY ORAL CHRONIC RAT S REPLACED |
8580-6906 ATRAZINE . CIBA GEIGY ORAL CHRONIC MICE S , NO RESF
59-13 AVALIEX MONSANTO ORAL SUBCHRONIC DOG I NA DISCUSSION
59-134 AVALEX MONSANTO ORAL SUBCHRONIC RAT I NA DISCUSSION
59-138 AVADEX MONSANTO ORAL SUECHRONIC DOG I NA TISCUSSION
59-13 AVALEX KONSANTO ORAL SUBCHRONIC RAT 1 NA DISCUSSION
- 22-5250 AVALEX MONSANTO ORAL CHRONIC - RAT I NA - DISCUSSION
622-5252 AVALEX MONSANTO ; MUTAGENICITY MOUSE I NA DISCUSSION
623-4841 AVADEX MONSANTO REFRODUCTION RAT y P NO RESP
651-5254 AVADEX MONSANTO TERATOLOGY RABRIT 1 NA . DISCUSSION
8530-9030  AVADEX MONSANTO CHOLINESTERASE RAT y NO RESF
. 8580-10580  AVALEX MONSANTO ORAL CHRONIC - DOG P NA NO RES
8532-10762  AVAREX MONSANTO ORAL MOUSE P NO RESF
8596-10813  AVADEX MONSANTO NEURO HEN V- F NO RES
8580-9119  _ AVADEX MONSANTO NEURO HEN v P NO RESF
- AVADEX . MONSANTO ORAL RAT I NA REFLACED
- AVADEX MONSANTO ORAL BOG I NA NES RESP
B-2793 BACILLUS THURING SANDOZ ORAL SUBACUTE RAT V NA REPLACED
8-595 BARBAN VELSICOL ORAL CHRONIC RAT 1 NA REPLACED
C-721 BARBAN VELSICOL ORAL CHRONIC DOG I NA REPLACED
1017 BARBAN VELSICOL ORAL CHRONIC RAT I NA REPLACED
543 BARBAN VELSICOL ORAL RAT . I NA REPLACED
E-8917 BAYGON CHEMAGRO MUTAGENICITY HOUSE I NA NES RESP
A-5372 BENZADOX GULF DERMAL SUBACUTE RABBIT 1 NA NO RESP
b-4381 BENZALOX GULF ORAL SUBACUTE RAT I NA NO RESP
C-4282 BENZALIOX GULF ORAL SUBCHRONIC DOG I NA NO RESP
A-1884 BIFENOX MOBIL DERMAL SUBACUTE RABBIT I NA NEG RESP
B-1474 BIFENOX MOBIL ORAL SUBCHRONIC RAT V P NO RESP
B-2156 BIFEROX MOBIL TERATOLOSY RAT y P NO RESE
C-1475 BIFENOX MOBIL ORAL SUECHRONIC DOS y P NO RESF
E-2155 BIFENOX ROBIL . MUTAGENICITY MOUSE I NA NEG RESP
J-1549 BIFENOX MOBIL CATARACTEGEN HEN I HA NEG RESF
J-782 BIFENOX MOBIL CATARACTEGEN HEN I NA NEG RESP
§21-5532 BIFENOX MOBIL ORAL CHRONIC DOG i) P NO RESP
621-5533 BIFENOX MOBIL ORAL CHRONIC RAT I NA . NEG RESP
§23-6793 BIFENOX MOBIL REPRODUCTION RAT y NO RESE
8530-8513 BIFENOX MOBIL DERMAL SUBACUTE "RABBIT V P NO RESF
8580-9571  BIFENOX MOBIL ORAL SUBACUTE QUAIL - I, NA NO RESF
BINAPACRYL . FHC ORAL CHRONIC CAT P NA NEG RESF .
BINAPACRYL FHC ORAL SUBCHRONIC RAT P NA. . NEG RESF
BINAPACRYL = FHC. ORAL SUBCHRONIC BOG P NA NEG RESS
. BINAPACRYL FAC PERCUTAN SUBACUTE RABBIT | Pp. . NA NES RESF
IBT_.NUM = CHEMICAL COMFANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE
B-2210. BINAPACRYL FHC ORAL CHRONIC RAT. I . WA NEG REE
82705 BINAPACRYL FAC REPRODUCTION RAT I NA NEG -RESF
C-1426 BINAPACRYL FHC CATARACTEGEN HEN I NA NEG RESP
C-2209 BINAPOCRYL FHC , ORAL CHRONIC DOG I NA NEG RESP
OFF BINAPACRYL FAC ORAL nos I WA’ NEG REEF
5-238 BLADEX SHELL TERATOLOGY RABBIT | NA REPLACED
BS30-11112 _ BLADEX SHELL _ TERATOLOGY . RABBIT _ I NA REPLACED = st
3-353 BOLERO 4. - . CHEVRON _ ORAL SUBACUTE RAT. I NA REPLACEL
C610 BOLERO CHEVRON ORAL SUBACUTE pos I NA REPLACED
401-5293 BOLERO _ CHEVRON DERMAL SUBACUTE RARBIT J NA NEG RESF
821-2095 BOLERO CHEVRON ORAL CHRONIC _RAT YI WA. REPLACED
621-4652 BOLERO CHEVRON ORAL CHRONIC RAT I NA > REFLACES
622-2449 BOLERO CHEVRON REPRODUCTION RAT I NA REPLACED
622-2440 BOLERO CHEVRON TERATCLOGY RAT I NA REPLACED
622-5225 BOLERO CHEVRON MUTAGENICITY HOUSE I NA REPLACED
451-2096 BOLERO CHEVRON ORAL «CHRONIC DOG I a) REPLACED
651-5142 BOLERO CHEVRON ORAL CHRONIC DOG I. MA REPLACED
651-5245 BOLERO CHEVRON TERATOLOGY RABBIT IT WA REPLACED
2532-10025 BOLERO CHEVRON MUTAGENICITY HOUSE a on NA REPLACED
651-7433 BOLERO CHEVRON HEN. v iY NEG RESP
8580-10025 BOLERO CHEVRON NEURO HEN 5 S REPLACED
C-6581 BROMCPHENOXIK CIBA GEIGY ORAL  SUBCHRONIC DOG I NA NEG RESP
B-5433 BROMOPROPYLATE © CIBA GEIGY ORAL CHRONIC RAT P NEG RESP
622-5433 BROMOFROPYLATE © CIBA GEIGY ORAL CHRONIC RAT I NA NES RESP
. 22-6724 BROMOPROFYLATE —CIBA SEIGY REPRODUCTION RAT p ; _ NO RESP
622-472  BROMOFROPYLATE  CIBA GEIGY CARCINOGENICITY HOUSE S S NEG RESP
8531-7996  BROMOPROFYLATE  CIBA GEIGY CHOLINESTERASE DOG I NA NES RESF
B-7120 BUSAN 74 BUCKMAN ORAL  SURCHRONIC RAT, I NA REPLACED
C-7121 BUSAN 74 BUCKMAN ORAL —- SUBCHRCHIC DOG ye NO RES
$11-07366  BUTAM GULF QRAL SUBACUTE DOG I NA NOT REO
622-03363  BUTAM GULF OC ORAL SUBACUTE RAT I NA NOT REQ
; A-B995 BUTYLTIN OXIDE DERMAL  SUBCHRONIC RABEIT I - NA NO RESP
A-3886  - BUX CHEVRON DERMAL SUBACUTE RABBIT I NA NEG RESF
' A- 4407 BUX CHEVRON DERMAL SUBACUTE RABBIT . I. NA NEG RESP
B-3422 BUX CHEVRON ORAL SUBCHRONIC DOG I N NEG RESP
B-3653 BUX CHEVRON ORAL —- SUBCHRONIC RAT I NA: NEG RESF
. B-4130 BUX CHEVRON CHOLINESTERASE RAT - I NA NEG RESF
; B-4339 BUX CHEVRON REPRODUCTION RAT I NA NEG RESP
C-3655 BUX CHEVRON ORAL —- SUBCHRONIC DOG I NA NEG RESP
J-4330 BUX CHEVRON DEXYELINATION HEN I NA NEG RESF
J-5536 BUX CHEVRON TERATOLOGY RAT I NA
J-5053 BUX CHEVRON TERATOLOGY RABBIT | NA NEG RESF
B-2804 CAPTAN AMER/ SEEL/CHEVRON REPRODUCTION RAT I NA .s- REPLACED
B-9267 CAPTAN AMER SEED/CHEVRON ORAL © CHRONIC RAT . I NA REPLACEE
B-9271 CAPTAN AMER SEED/CHEVRON CARCINOGENIC MOUSE “ Y NA REPLACED
J-139 CAPTAN CHEVRON ~ — TERATOLOSY RABEIT I NA REPLACED
53-5420 CAPTAN CHEVRON TERATOLOGY RAEBIT I NA NO RESP
J-5438 CAPTAN AKER SEED/CHEVRON PROGENY DOG I NA NO RESP
P-5397 CAPTAN AMER SEED/CHEVRON TERATOLOGY RAT I NA NG RESF
P-5398 CAPTAN AMER SEED/CHEVRON TERATOLOGY RABBT/HAMSTR I NA REPLACED
P-5570 CAPTAN AKER SEEL/CHEVRON MUTAGENICITY MOUSE I NA. REPLACED
porr-is CAPTAN AMER SEED/CHEVRON REPRODUCTN CHICKEN I NA NOT REQ
21-5519 CAPTAN AMER SEED/CHEVRON TERATOLOGY KONKEY I NA HO RESP
622-5998 CAPTAN AKER SEED/CAPTAN DOMINANT LETHAL HOUSE I * WA NO RESP
622-5998  CAPTAN AMER SEED/CHEVRON DOMINANT LETHAL MOUSE 1 NA sNC-RESF
8530-9020  CARBARYL * MONSANTO CHOLINESTERASE RAT y F NO RESP
1BT_NUM CHEMICAL COMPANY ROUTE TYPE SPECIES | VALIDATE EVALUATE REPLACE
A-7099 CARBOFURAN FHC ORAL SUBACUTE RABBIT I NA NOT REG
&-972 CARSOFURAN FAC CHOLINESTERASE RAT 1 NA «REPLACE
B-1590 CARBOFURAN FHC ORAL — SUBCHRONIC RAT I NA REPLACED
‘3-159! CARBOFURAN FHC ORAL  SUBCHRONIC RAT I NA NOT REQ
B-3113 CARBOFURAN = FHC ORAL  SUBCHRONIC RAT I NA REPLACED
B-3637 —”- CARBOFURAN FAC ORAL CHRONIC RAT I - NA REPLACED
B-3638 CARBOFURAN FHC REPRODUCTION RAT I WA = sREPLACEE
+ B-400A CARPOFURAN FMC _ CARCINOGENICITY MOUSE a WA OREPLACER =
84443 CARBOFURAN FHC CHOLINESTERASE RAT I WA REPLACED
B~ABAS CARPOFURAN FHC ORAL SUBACUTE . RAT. I NA REPLS*TE
B-973 -—-CARBOFURAN FHC CHOLINESTERASE RAT I WA REPLACES
C-3634 CARBOFURAN FHC ORAL CHRONIC bos I NA REPLECED
C-4442 ° —CARBOFURAN FHC CHOLINESTERASE DOG I NA REPLACES:
E-401A CARBOFURAN FHC MUTAGENICITY RAT v cI REPLACED
E-4018 CARBOFURAN FHC MUTAGENICITY MOUSE v cI REPLACED ~’
J5145 CARBOFURAN FHC TERATOLOGY RABBIT I. NA sOREPLACED
6296 CARBOFURAN FHC REPRODUCTION 0G v P NO RESF
N-5183 CARBOFURAN FHC INHALATION SUBACUTE GUINEA PIG =i NA REPLACED
P-4397 | CARBOFURAN FHC REPRODUCTION RAT I NA REPLACED
P-4802 CARBOFURAN FHC - REPRODUCTION —RAT 1 NA REPLACED
P-6315 CAREOFURAN FHC REPRONUCTION RAT I WA «REPLACE
3891 CARBOFURAN FHC PERCUTAN SUBACUTE RABBIT 1 NA NOT REQ
5144 CARBOFURAN FMC NEURO HEN I NA NOT REQ
622-S121A = CGA 42223 CIBA GEIGY ORAL SUBCHRONIC RAT I NA REPLACED
623-07922 CGA 12223 CIBA GEIGY REPRODUCTION RAT I NO RESF
8531-09995 CGA 12223 CIBA GEIGY CHOLINESTERASE DOG. vo. S$. NOT REO
8532-07921 CGA 12222 CIA GEIGY CARCINOGENIC . MOUSE P. NO RESP
6141-51228 CGA-12223 CIBA GEIGY ORAL : bOG § "§ REPLACED
8532-10507  CGA-12223 CIBA GEIGY ORAL RAT P NO RESF
BS20-10767  CGA-12223 CIBA GEIGY NEURO HEN § S$ - NO RESF
C-6785 CHLORBROMURON © CIBA GEIGY METHEHOGLOBIN CAT I NA NEG.“ RESP
A-S253 Ss CHLORBROMURON «© CIBA GEIGY © DERMAL RABBIT = sd NA° NEG RESP
B-5242 CHLORBROMURON © CIBA GEIGY ORAL RAT 1 NA NEG RESP
C-5264 CHLORBROMURON © CIBA GEIGY = ORAL _ DOG 1 NA NEG RESP
A-3512 CHLOROBENZILATE CIBA GEIGY  DERKAL . RABBIT = ws SOE NA NEG RESP
A-4646 CHLOROBENZILATE CIBA GEIGY © DERMAL RABBIT I . NA NEG RESF
90104 CHLOROPICRIN ORAL SUBACUTE RAT I NA + NO RESF
P-5e21 CHLOKOPROPHAM = PPG REPRODUCTION RAT ae NA REPLACED
623-05515  CHLOROPROPHAM = PPG REPRODUCTION = RAT P NO RESP
651-05514  CHLOROPROPHAM = PPG ORAL =’ CHRONIC HOUSE P NO RESP
C-4645 CHLOROPROPYLATE CIBA GEIGY ORAL . CHRONIC «=—s—i«<ws“‘<«é‘éi I NA NEG RESP
863-3477 CHLOROTHALONIL © DIAMOND SHELL INHALATION SUBACUTE RAT t NA DISCUSSION
B-8029 COBEX US BORAX ORAL _ SUBCHRONIC RAT I NA NEG RESP
B-9341 COBEX US BORAX CARCINOGENIC RAT I NA REPLACED
E-339 COBEX US BORAX . HUTAGENICITY HOUSE Vv NO RESP
38994 COBEX US BORAX TERATOLOGY RABBIT isi HA REPLACED
59081 COBEX US BORAX CATEROGEN «ss CHICKEN 1 _NA REPLACED
59402 COBEX US BORAX DERMAL CARCINOGEN MOUSE I NA REPLACED
A-1062 COBEX US BORAX DERHAL Tox RABEIT -I. WA NEG RESP
C-8830 COBEX US BORAX ORAL . DOG I NA REG.‘ RESP
$108 CORAL CHEAGRO DEMYELINIATION HEN I NA REPLACED
2570 CORAL CHEMAGRO ; REPRODUCTION HEN 1 NA DISCUSSION
17838 CORAL CHEMAGRO REPRODUCTION = HEN 1 NA —sdDISCUSSIEN -
611-5128 = CURACRON CIBA GEIGY ORAL SUBCHRONIC bos vy. CM REPLACED
611-5922A © CURACKON CIBA GEIGY ORAL SUECHRONIC DOG v NA HO RESP
$22-5121B CURACRON CIBA GEIGY ORAL SUBCHRONIC = «sRAT v CH. _REPLACED
622-6895 CUKACKON CIBA GEIGY ORAL CHRONIC RAT I NA REPLACE
. YBTLNUM CHEMICAL . COMPANY ROUTE TYFE SFECIES VALIDATE EVALUATE REPLACE
622-7923 CURACRON . CIBA GEIGY — CARCINOGENICITY MOUSE S$ NEG RESF
623-7924 CURACRON CIBA GEIGY REPRODUCT [0N RAT ¥ CH REPLACES
8531-099976-1  CURACRON CIBA GEIGY ; CHOLINESTER DOG P REPLACED
9531-9996(A)  CURACRON CIBA GEIGY CHOLINESTERASE DOG P NC RESF
8580-10426 CURACRON CIBA GEIGY NEURO HEN iY Ch NO RESP
8580-11187 CURACRCN CIBA GEIGY NEURO’ - HEN S$. cs DISCUSSION .
C-3595 CYCLE CIBA GEIGY ORAL DOG 1 NA NEG RESF
§11-03715 CYCLE CIBA GEIGY ORAL bOG I NA NEG RESF
622-03594 CYCLE CIBA GEIGY AT I NA NEG RESF
622-03719 CYCLE CIBA GEIGY ORAL , RAT I NA NEG RESF
A-295 CYPRAZINE GULF DERMAL SUBACUTE RABBIT I NA REPLACET
B-304 CYPRAZINE GULF ; TERATOLOGY RAT v NO RESP
B-8277 CYPRAZINE GULF ORAL SURACUTE RAT P NO RESF
B-988% - CYPRAZINE GULF CARCINOGENICITY © RAT I HA REFLACEE
C-6193 CYPRAZINE. GULE ORAL_ SUBCHRONIC DOG_ I : NA REPL ATS T
C-9148 CYPRAZINE GULF ORAL SUBACUTE _ * «BOG V cI NO REST
C-9678 CYPRAZINE GULF ORAL SUBACUTE DOG P NO RES?
Be 1275 CYPRAZINE - GULF ORAL SUBACUTE RAT P NO RESF
A-3010 CYPROMID GULF DERMAL SUBACUTE RABBIT I NA NEG RESF
B-3057 CYPROMID GULF ORAL RAT I NA NEG RESP
WORF 127 CYPROMID GULF - ORAL Doc I NA NEG RESP
621-06998 = B-PHENOTHRIN ORAL CHRONIC RAT I NA. = =-NO RES
651-0701  D-PHENOTHRIN TERATOLOGY RABBIT P NO RESF
8533-07000 — D-FHENOTHRIN REFRODUCTION RAT y . NO RESF
8580-06999 = B-PHENOTHRIN ORAL MOUSE I NA NEG RESF
8537-9671  DANTOIN “GLYCO DERMAL SUBCHRONIC RABBIT § $ NO RESF
E~8918 DASANIT CHEKAGRO MUTAGENICITY MOUSE ‘J NA REPLACED
J-9628 DASANIT CHEMAGRO TERATOLOGY RABBIT I NA DISCUSSION ‘
601-4020 DC 5700 DOW/CORNING DERMAL SUBCHRONIC RABBIT I NA REFLACEL
8535-10126 BC 5700 DOW/CORNING TERATOLOGY RAT I NA REPLACED
8533-10127 DC 5700 DOW/CORNING MUTAGENICITY RAT - I NA REFLACED
F-19095 BC 5700 DOW/CORNING PATCH TEST HUMAN I NA REPLACED
J-2369 DCPA DIAMOND SHAMROCK . REPRODUCTION HEN I NA NOT REQ
663-3477 BCPA DIAMOND SHAMROCK INHALATION SUBACUTE RAT I NA NOT REQ
P-2476 DELNAV BFC REPRODUCTION RAT I NA DISCUSSION
A-454 DESHEDIPHAK = =©-NOKAM C- DERMAL SUBACUTE RABBIT I NA DISCUSSION
A-455 DESMEDIPHAM = NORAM CHOLINESTERASE = RAT I NA BISCUSSION
B-396 -DESREDIPHAH == -NORAK ORAL SUBACUTE RAT I NA DISCUSSION
B-585 — DESHEDIPHAM © NORAM TERATOLOGY RAT I NA DISCUSSION
C-1441 DESKEDIPHAM © NORAM ORAL CHRONIC DOG V NO RESP
S397 DESHEDIFHAK © NORAM ORAL SUBCHRONIC DOG I NA DISCUSSION
N-459 DESHEDIPHAK = NORAM INHALATION SUBACUTE RAT S cS DISCUSSION
650-7187 DESMEDIPHAN © -MORAM TERATOLOGY RABPIT t NA NEG RESF
B-1349 DIAQUAT ORAL CHRONIC RAT I NA NO RESP
B-4321 DIAZINON CIBA GEIGY ORAL SUBACUTE HUMAN I NA NOT REQ
8580-9381 § DIAZINON CIBA GEIGY . CARCINOGENICITY  KQUSE I NA NEG RESP
E-9892 DICAHEA VELSICOL MUTAGENICITY MOUSE =~ I HA NO RESP
39012 DICAMBA VELSICOL TERATOLOGY MOUSE I NA REPLACED
623-7847 DICAMBA VELSICOL MUTAGENICITY MOUSE I NA. NO RESF
632-7848/A  DICAKBA VELSICOL MUTAGENICITY BACTERIA I NA NEG RESP
651-3279 DICAMBA 38+ = VELSICOL REPRODUCTION HEN I NA NOT REQ :
8520-10130  DICAMBA VELSICOL ORAL CHRONIC yCARCIN MOUSE P , NA
DICHLOBENIL © CASORAN PERCUTAN SUBACUTE I NA NO RESP -
B-2528 DICHLOBENIL = CASORAN ORAL RAT I NA __s«REFLACED
IBT_NUA CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REFLACE
471 DISYSTON CHEMAGRO NEURO . HEN a NA REPLACER
621-6138 = DOWD 233 DOW ‘ORAL CHRONIC RAT § S REPLACE?
C-2529 DICHLOZENIL © CASORAN ORAL DOG I _ NA | REFLACEE
a DICHLOBENTL © CASORAN _ PERCUTAN =~ SUBACUTE a I - WA NO RES?
B-1254 DIFOLATAN CHEVRON ORAL. =. CHRONIC | RAT - = T+ > NA REFLACED
B-2804 DIFOLATAN CHEVRON REPRODUCTION RAT I NA REFLACED
B-5397 DIFOLATAN CHEVRON TERATOLOGY RAT I NA REPLACED
C-1272 DIFOLATAN CHEVRON ORAL CHRONIC pes I NA NEG RESP
$139 DIFOLATAN CHEVRON TERATOLOGY RABBIT I NA REFLACED
J3681 DIFOLATAN CHEVRON TERATOLOGY RABBIT I NA REPLACED
J5051 DIFOLATAN CHEVRON TERATOLOGY RABBIT INA REPLACED v
J-5110 DIFOLATAN CHEVRON TERATOLOGY RABBIT I NA «REPLACE:
J-5758 _DIFOLATAN CHEVRON TERATOLOSY _ HAMPSTER I NA NEG RESF
H-S519 DIFOLATAN CHEVRON TERATOLOGY MONKEY v NES RESP
K-5519 DIFOLATAN CHEVRON / TERATCLOSY MONKEY I NA NEG RESF
651-6459 DIFOLATAN CHEVRON REPRO & RESIDUE HEN a NA NEG RESP
P-8692 DINOSEB VERTAC CHEK TERATOLOGY RAT I "NA NO RESF ;
B-1349 DIQUAT CHEVRON ORAL CHRONIC RAT ol NA REPLACED
8530-9549 DIQUAT CHEVRON ; REPRO & RESIDUE HEN P NEG RESF
8509-8241 — DIQUAT CHEVRON REPRO BUCK I NA REPLACED
8580-8242 — DIQUAT CHEVRON ; REPRO QUAIL I NA «REPLACED
8580-9546 — DIQUAT CHEVRON REPRO & RESIDUE HEN Y NA NEG RESP”
E~8920 " DISYSTON CHEMAGRO MUTAGENICITY HOUSE I NA REPLACED
39029 DISYSTON CHEMAGRO _ TERATOLOBY RABRIT I NA REFLACED
623-3859 = BOwWCD 270s DOW REPRODUCTION RAT | I NA REFLACED
C-14418 DREF AMON MONTEDISON ORAL CHRONIC DOG v NO RESF
621-1440 = DREPAMON MONTEDISON © ORAL CHRONIC RAT I NA NO RESP
622-01442  DREPAMON MONTEDISON REPRODUCTION RAT P NO RESF
651-7187 DREFAKON MONTEDISON TERATOLOGY RABBIT I NA NO RESP .
; B-1442 DREPAMON MONTEDISON 2 RAT P NO RESF
C-14418 DREF AKON MONTEDISON ORAL DOG v NO RESF
"£47135 EMBARK 3K ORAL =» SUBCHRONIC DOG v NO. RESP
621-03115 | ENDOTHALL © 3M/PENWALT ORAL CHRONIC RAT 1 NA NO RESP
621-0346 ENDOTHALL «= SM/PENWALT ORAL SUBACUTE RAT | NA. NO RESP
5-734 ENDOTHALL © -3M/PENWALT HEN v v NEG RESP
58532 ENDOTHALL © 3M/PENWALT HEN v v NEG RESP
8580-10332  EPN DUPONT NEURO HEN v NO RESP
8580-10430  EPN NISSAN/VELSICOL NEURO HEN y cK NEG RESF
8580-10526  EPN NISSAN/YELSICOL NEURO HEN § S REPLACES
580-8623  EPN NISSAN/VELSICOL NEURO HEN I NA REFLACED
B-304 ETHIOLATE GULF TERATOLOGY RAT I NA NEG RESP
B-305 ETHIOLATE GULF TERATOLOGY RAT y P NO RESP
B~9875 ETHIOLATE GULF ORAL SUBACUTE RAT I NA° NEG RESF
C-9876 ETHIOLATE GULF ORAL SUBACUTE DOG I NA NEG RESP
P-2461 ETHIGLATE © GULF CHOLINESTERASE RAT I NA NEG RESP
F-24463 ETHIOLATE GULF CHOLINESTERASE = RAT. I NA NEG RESP
A-9049 ETHION FHC DERMAL SUBACUTE RABBIT I NA REPLACED
B-1055 ETHION FMC TERATCLOGY RAT. I NA REPLACED
B-8706 ETHION FHC ORAL =. ~—s CHRONIC RAT I , NA REPLACEL
IST _NUA CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE
R-5349 FORMETENATE HCL NORAM CHOLINESTERASE RAT 1 NA DISCUSS oN
C-5346 FORMETENATE HCL = NORAM ORAL CHRONIC DOG I NA NGT REQ
C-8705 ETHION FUC ORAL ~ CHRONIC ; DOG . P NOT REQ .
- C-97§ ETHION FRC ; CHOLINESTERASE BOS . I NA REPLACES
E-1057A ETHION FxC MUTAGENICITY MOUSE V F REPLACED
F-8948 ETHION FHC CHOLINESTERASE HUMAN . Vv NO RESF
M9041 ETHION FAC DERMAL SUBACUTE "MONKEY I NA NOT REQ
2705 ETHION FHC . REPRODUCTION RAT 1. NA REFLACED
621-01058  ETHION FHC CARCINOGENICITY MOUSE I NA REPLACEB
1659 ETHION FRC NEURO HEN I NA REFLACED
J-5425 ETHION FHC ; HEN y P  . NO RESF
C-1657 -. ~ FENITROTHICN » CHOLINESTERASE p06 I NA NEG RESF
C-9997 FENITROTHION ORAL " SUBCHRONIC DOG I NA NEG RESP
F-9999 FENITROTRION ORAL SUBCHR&CHOLINEST | HUMAN I NA NEG RESE
J4052 FENITROTHION REFRODUCTION DUCK/QUAIL y P NO RESF
J-9995 FENITROTHICN . TERATOLOGY RABBIT . I NA NO RESP
S-9998 FENITROTHION ; TERATOLOGY RABBIT y . NO RESF .
19998 FENITROTHION ORAL CHRONIC BOG v NO RESF
$21-7168 FENITROTHION ORAL CHRONIC MONKEY I NA REFLACED
8520-9445 FENITROTHION NEURO HEN I NA NEG RESP :
601-7889 FENUALERATE SHELL - DERMAL SUBACUTE RABBIT I NA REFLACED
1553-07419 ’ FENUALERATE SHELL INHALATION SUBACUTE RAT I NA REPLACE:
B-5241 FLUORIDIFEN CIBA GEIGY ORAL RAT I NA NEG RESF
C5243 FLUOSISIFEN CIBA GEIGY ORAL DOG I . NA NEG RESP
A-2é82 FOLFET CHEVRON TERATCLOGY . = RABBIT I NA REFLACED
B-2566 FOLPET CHEVRON REFROLUCTION RAT I NA REPLACED
C-7111 FOLPET CHEVRON ORAL CHRONIC BOG 1 NA REFLACED
E-9099 FOLPET CHEVRON MUTAGENICITY MOUSE I NA REPLACED
J-139 FOLPET CHEVRON TERATOLOSY RABSIT. I NA REPLACED
J-5420 FOLPET CHEVRON TERATOLOGY RAEBIT if NA REPLACED
. A-5519 FOLPET CHEVRON . TERATOLOGY MONKEY I NA NEG RESF :
P-5758 FOLPET CHEVRON ~ TERATOLOGY HAMPSTER I NA NEG RESP
WCRF-152 FOLPET NORAK REPRODUCTION RABBIT I NA ” REPLACED
710 FOLPET CHEVRON ORAL CHRONIC RAT I NA ~—sOREPLACED
A-5344 FORMETENATE HCL NORAM DERMAL SUBACUTE RABBIT I NA DISCUSSION
A-9144 FORMETENATE HCL NORAM CHOLINESTERASE RAT S S DISCUSSION
B-5345 FORMETENATE HCL NORAM ORAL CHRONIC RAT I NA HISCUSSION
C-5250 FORMETENATE HCL NORAM CHOLINESTERASE DOG I NA DISSUSSTON
D-4879 FORMETENATE HCL NORAM , CHOLINESTERASE DOG I NA DISCUSSION
E-9145 FORMETENATE HCL = NORAM PLACENTAL TRANS RAT I NA DISCUSSION
I-7144 FORMETENATE HCL NORAM CHOLINESTERASE HUMAN I NA DISCUSSION
J9144 FORMETENATE HCL © NOKAM TERATOLOGY RABRIT I NA DISCUSSION
P-5347 FORHETENATE HCL == NORAR REPRODUCTION RAT I NA DISCUSSION
P-9140 FORMETENATE HCL NORAM MUTAGENICITY MOUSE ] NA DISCUSSION
£-5343 FORMETENATE HCL NORAM PATCH TEST HUMAN 1 NA DISCUSSION
J-5352 FORMETENATE HCL 9 NORAM NEURO HEN I NA DISCUSSION
J-5254 FORMETENATE HCL == NORAM DIETARY PHES/DK/QUL I NA - DISCUSSION
P-5921 FURLOE PPG REPRODUCTION RAT I NA NO RESP
BSZI-9082 GLUTARALDEHYDE 3M TERATOLOGY RAT ; I NA BISSUSSION ;
IBT_NUM CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE . .--
A-1549 GLYPHOSATE MONSANTO DERMAL SUBCHRONIE RABBIT a | NA REPLACED
A-2144 GLYPHOSATE MONSANTO DERHAL SUBCHRONIC RABBIT I NA. REPLACES
A-2468A - GLYPHOSATE MONSANTO DERMAL SUBCHRONIC RABBIT I NA REFLACEL
B-1020 GLYPHOSATE - MONSANTO ORAL. SUBCHRONIC RAT , Vv I NO RESP
~ -B+564 GLYPHOSATE MONSANTO” = sORAL CHRONIC RAT I ~ WA REPLACED
B-565 GLYPHOSATE MONSANTO REPRODUCTION RAT 7 OY I REPLACED
B-569 GLYFHOSATE MONSANTO CARCINOGENICITY MOUSE I NA REFLACED
C-1021 GLYPHOSATE MONSANTO ORAL SUBCHRONIC DOG V I NC RESF
£-5467 GLYPHOSATE MONSANTO ; MUTAGENICITY MOUSE I NA REPLACED
+565 GLYPHOSATE MONSANTO . ORAL CHRONIC bos y- I NO RESP
J-543 GLYPHOSATE MONSANTO TERATOLOSY RABEIT I NA REPLACED
; 601-5044 GLYPHOSATE MONSANTO ORAL SUBCHRONIC RABBIT I NA NCT REQ 7
601-6527 GLYPHOSATE HONSANTO CHOLINESTERASE RAT I NA NOT REQ
623-7568 GLYPHOSATE MONSANTO MUTAGENICITY RAT/MOUSE ) - NO RESP
632-7507 GLYPHOSATE MONSANTO AMES TEST I NA REPLACED
633-7801 GLYPHOSATE MONSANTO ASSAY RECOMBINATION I NA REPLACED
651-3917 SLYPHOSATE MONSANTO . REPROSRESIDUE HEN ) NO RESP
651-5275 GLYPHOSATE MONSANTO TERATOLOGY RABBIT I NA REFLACED
_ 663-6290 GLYPHOSATE MONSANTO INHALATION | SUBCHRONIC RAT I NA REPLACED
8533-8926 GLYPHOSATE MONSANTO MUTAGENICITY MOUSE I NA NEG RESP
8533-8923 GLYPHOSATE MONSANTO REPRODUCTION  . RAT I NA NO RESF
8545-8924 GLYPHOSATE MONSANTO FEEDING PILOT 3 CHRONIC = RAT P NEG RESF
8580-9921 GLYPHOSATE HONSANTO TERATOLOGY RABBIT I NA NEG RESF
8580-8922 GLYPHOSATE MONSANTO ORAL CHRONIC DOG P NEG RESF
A-2468B GLYPHOSATE . MONSANTO DERMAL RABBIT I RA REFLACED
E-1753 GLYPHOSATE MONSANTO > QUATL V V NEG RESF
53920 GLYPHOSATE MONSANTO SWINE v V NEG RESF
632-3894 GLYPHOSATE MONSANTO CATTLE vo. v NEG RESF
651-2918  GLYFHOSATE HONSANTO HEN y V NEG RESF
8589-9117 GLYPHOSATE MONSANTO NEURO —. HEN y NO RESF
A~B425 GLYPHOSINE MONSANTO DERMAL SUBCHRONIC RABBIT I NA NO RESP
: B-336 _GLYPHOSINE MONSANTO SUBCHRONIC RAT I. NA NEG RESF
B-3424 GLYFHOS INE MONSANTO ORAL SUBACUTE RAT S S NO RESP
B-9555 GLYPHOSINE MONSANTO ORAL CHRONIC RAT I NA NEG RESP
B-9558 GLYPHOSINE MONSANTO CARCINOGENICITY MOUSE I NA NEG RESF
B-9560 GLYPHOSINE MONSANTO REPRODUCTION RAT P NO RESP
C8425 GLYPHOSINE MONSANTO ORAL SUBCHRONIC DOG § S NO RESF ‘
; C-9554 GLYPHOSINE MONSANTO =—sORAL CHRONIC DOG I NA NEG RESP
£-9561 GLYPHOSINE MONSANTO MUTAGENICITY MOUSE I NA NEG RESP
J-9565 GLYPHOSINE MONSANTO TERATOLOGY RABBIT I NA NEG RESP
@580-9116  GLYPHOSTNE MONSANTO ©=—- NEURO HEN S S NO RESP
622-5557 GOOLRITE 3125 ORAL INUTERD EXPOSURE RAT V P NO RESP
611-5556 GOODRITE 3125 ORAL DOG V P NO RESF
540-888:  GOSSYPLURE CONREL ORAL SUBACUTE RAT S S . REFLACED
B580-8883  G0SSYPLURE CORREL ORAL SUBACUTE DOS S S REPLACED
611-8063  HARUALE UNIROVAL ORAL SUBCHRONIC DOG V NA REPLACED
622-8670 — HARUADE UNIROYAL ORAL SUBCHRONIC RAT y NA REPLACED
J-6513 HEPIACHOR EPOX = YELSICL REPRODUCTION. HEN J NA. «NEG RESP
424 HINOSAHN MOBAY MUTAGENICITY MOUSE I NA NEG RESP
C-5416 IRGASAN CIBA GEIGY DERMAL SUBACUTE DOG I NA NO RESF
TBT NUM CHEMICAL COMPAKY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE —_
72 IRGASAN CIBA GEIGY REPRODUCTION ~ RABBIT I NA NO RESF
P-7113 IRGASAN CIBA GEIGY REPRODUCTION RAT I NA NO RESF
622-06047 — IRGASAN CIBA GEIGY ORAL CHRONIC RAT f NA NO RESP
A-8434 IRGASAN | CIBA GEIGY DERMAL RABBIT I NA NC RESF
C-1435 IRGASAN CIBA GEIGY ORAL DOs i NA NO RESP
J-4915 IRGASAN CIBA GEIGY DERMAL MOUSE ‘1 NA NO RESP
602-02220 IRGASAN CIBA GEIGY DERMAL , MONKEY I NA NO RESF a
622-04554 — IRGASAN — CBA GEIGY ORAL RAT I NA NO RESP.
622-05278  IRGASAN CIRA GEIGY ORAL KICE I NA NO RESF
631-04784  IRGASAN CIBA GEIGY  DERKAL MONKEY I NA REFLACEL
A-S910 LASSO MONSANTO DERMAL SUBACUTE RABBIT I. | NA ° NEG RESF
B-1182 LASSO MONSANTO ORAL SUBCHRONIC MOUSE I NA NOT REQ
B-4477 LASSO KONSANTO ORAL SUBCHRONIC RAT I NA NOT REQ
B-5997 LASSO MONSANTO ORAL SUBCHRONIC RAT I NA NOT REQ 7)
C-1191 LASSS HONSANTO ORAL CHRONIC DOG I NA NOT REQ
C-447§ LASSO . MONSANTO ORAL SUBCHRONIC LOG I NA NCT REQ
C-5988 LASSO MONSANTO ORAL SUECHRONIE BOG I NA NOT REQ
E-1184 LASSD MONSANTO MUTAGENICITY MOUSE V CI NO RESP
J-i183 LASSO MONSANTO TERATOLOGY RABEIT I NA REPLACED
621-1180 LASSO MONSANTO ORAL CHRONIC RAT I NA REFLACED
621-1182" — LASSO MONSANTO CARCINOGENICITY. MOUSE I NA REPLACED .
622-1185 LASSO MONSANTO REPROBUCTION RAT I NA REPLACED
8535-8849 = LASSO MONSANTO i MUTAGENICITY MOUSE J ON, CI NO RESF
8533-8859 — LASSO MONSANTO MUTAGENICITY MICKORGANTSH I NA REFLACED ;
8573-8851  —LASSO MONSANTO MUTAGENICITY RAT Vv Cl NO RESP
8523-8852  — LASSO MONSANTO MUTAGENICITY MICRORGANISM I NA ’ REPLACED
653-6288 LASSO MONSANTO INHALATION RAT Vv NO RESP
A-7579 MACHETE MONSANTO DERMAL SUBCHRONIC RAKBIT I NA HOT REQ
A-7680 MACHETE MONSANTO DERMAL SUBCKRONIC * RABBIT P NO’ RESP
A-9946 MACHETE MONSANTO DERMAL SUBCHRONIC RABBIT a » NA NOT REQ
B-8702 MACHETE MONSANTO ORAL SUBACUTE RAT I NA REFLACED
C-2312 MACHETE MONSANTO QRAL CHRONIC DOG V Ch. ONEG RESF
C-8704 MACHETE KONSANTO ORAL SUBACUTE boc ti $ "NA NO RESF

E-2214 ~ MACHETE MONSANTO MUTAGENICITY MOUSE 1. NA NEG RESP
621-02511 MACHETE MONSANTO CARCINOGENICITY MOUSE I NA REPLACED
621-2216 MACHETE MONSANTO ORAL CHRONIC RAT . sf NA REFLACED
622-02313 MACHETE MCNSANTO REPRODUCTION RAT I NA REFLACED
633-8181 MACHETE MONSANTO RECOKBINATION SALMONELLA I NA NO RESP
651-2315 MACHETE MONSANTO TERATOLOGY =~ RABBIT I. . WA REPLACED
8535-08181 KACHETE MONSANTO , REVERSE MUTATION SALMOMELLA I. NA REFLACED
0590-9731 MACHETE MONSANTO REFRO & RESIDUE HEN V NA NO RESF
611-4855 MALONOBEN GULF ORAL SUBACUTE - —- BOG 1 NA NES RESP
623-8138 MALONOBEN SULF CARCINOGENICITY = RAT I NA, NEG RESP
622-4854 MALONCEEN SULT QRAL SUBACUTE RAT I NA NEG RESP
651-8137 MALONOBEN GULF CARCINOGENICITY © ADUSE I NA NEG RESP
T-1604 MBP NEUROTOXICITY ROUSE I . NA NEG RESP
E-8946 HESUROL CHEMAGRO MUTAGENICITY MOUSE I. NA- NEG RESP
105 MESUROL CHEMAGRO DEMYLINIATION HEN 1 NA NEG RESP
2570 KESUROL CHEMAGRO REPRODUCTION HEN I NA NEG RESP
16083 MESUROL CHEMAGRO NEURO ’ HEN I NA NEG RESF
B-8955 HETA SYSTOX-R  CHEMAGRO ORAL CHRONIC RAT if NA - ONO RESP
C-8986 META SYSTOX-R © CHEMAGRO ORAL CHRONIC BOG Vv cI NO RESP
9025 META SYSTOX-R © CHEMAGRO TERATOLOGY RABBIT | OWA. NO RESP .
P-8915 META SYSTOX-R  CHEMAGRO MUTAGENICITY MOUSE . I * NA NO RESP
B-7369 METHAZOLE VELSICOL ORAL SUBACUTE RAT I . NA NO RESF -
TBT.NUK = CHEMICAL COMPANY ROUTE TYPE: ‘ SPECIES © VALIDATE EVALUATE REPLACE
C-7370 METHAZOLE VELSICOL ORAL SUBACUTE DOG 1 NA NO RESE
E-2097A METHAZOLE © —-VELSICOL HUTAGENICITY HOUSE I NA NO RESF
E-2097B _ METHAZOLE VELSICOL MUTAGENICITY HOUSE I NA NO RESE
$32-03373  METHAZOLE VELSICOL MUTAGENICITY HOUSE I NA NG RESP
- Q522-822? = METHAZOLE VELSTEOL «= QRAL CHRONIC RAT P NES RESP
@S33-8240 = METHAZOLE «=—s«ELSICOL _> REPRODUCTION = RAT $NA REPLACE
B520-2238  METHAZOLE VELSICOL ORAL CHRONIC HOUSE I NA NEG RESF
4180 METHOMYL DUPONT DERMAL SUBACUTE RABBIT I NA REPLACED
A-1992 METHOFRENE ZOECON DERMAL “SUBACUTE RABBIT I NA NO RESF
H-1645 METHOPRENE ZOECON ORAL SUBACUTE = sORAT I NA NO RESP
B-1982 METHOPRENE © ZDECON TERATCLOGY | RAT I NA REPLACED
J-1983 METHOPRENE © ZCECON TERATOLOGY RABBIT 1 NA REPLACED Jf
A-3773 METOBROMURON © CIBA.GEIGY DERHAL SUBACUTE RABBIT I NA NES RES
B-3972 METDBROMURON © CIBA GEIGY ORAL CHRONIC RAT I NA NEG RESP
C3126 METOBRCMURON © CIEA GEIGY ORAL CHRONIC I NA NO RESP
C3759 METORROMURON © CIEA GEIGY ORAL CHRONIC Dos 1 NA NES RESE
P-3770 HETOBROMURON © CIBA GEIGY. REFRODUCTION RAT I NA NEG RESP
3768  —-- METOBROMURON © CIBA GEIGY ORAL/DERHL © SUBACUTE RAT 1 NA NO RESP
A-3774 METORRCMURON © CIEA GEIGY DERMAL RAEBIT | NA NEG RESP -
622-7925  METOLACHLOR  CIBA GEIGY CARCINOGENICITY MOUSE P NO RESF
422-7926  METOLACHLOK © CIBA GEIGY ORAL CHRONIC RAT 5 S - REPLACED
623-7928  METOLACHLOR © CIBA GEIGY REFRODUCTION RAT § § REFLACED
\A-6479 MONITOR CHEVRON DERMAL SUBACUTE RABBIT I NA NEG RESF
B-24428 = MONITOR CHEVRON CHOLINESTERASE RAT I NA REPLACED
B-5485 MONITOR CHEVRON ORAL CHRONIC RAT I NA REPLACED
B-5484 MONITOR CHEVRON CHOLINESTERASE RAT I NA REFLACED
#6485 MONITOR CHEVRON CHOLINESTERASE DOG I NA REFLACED
c-5468 MONITOR CHEVRON ORAL CHRONIC DOG I NA REPLACED
C-8128 MONITOR CHEVRON CHOLINESTERASE DOG I NA REPLACED
E-9517 MONITOR CHEVRON ° MUTAGENICITY HOUSE 1 NA REPLACED
1-7081 MONITOR CHEVRON CHOLINESTERASE DOG I NA REPLACED
+9515 MONITOR CHEVRON TERATOLOGY RABBIT I NA REPLACED
| N-9516 KONITOR CHEVRON INHALATION SUBACUTE RAT I NA NEG RESP
- P6255 KONITOR CHEVRON REPRODUCTION RAT 1 NA REPLACED
C-4486 MONITOR CHEVRON FEEDING RAT I NA REPLACED
$6480 MONITOR CHEVRON NEURO HEN I NA REPLACED
J-9546 MONITOR CHEVRON NEURO HEN 1 NA REPLACED
58708 HORESTAN CHEHAGRO SPERMATOGENESIS LOG § § NEG RESP
P-8913 HORESTAN CHEMAGRO MUTAGENICITY HOUSE I NA NEG RESP
651-02393 SMA DIAHOND SHAMROCK DIETARY SUBACUTE DUCK/QUAIL I NA REPLACED
B-2804 NALED CHEVRON REPRODUCTION RAT I m) REPLACED
B-2748 NALED CHEVRON ORAL CHRONIC RAT I NA REPLACED
B-3705 HALED "CHEVRON ORAL SUBCHRONIC RAT I NA REPLACED
C-1012 NALED CHEVRON ORAL SUBACUTE DOG I NA REPLACED
C1012 NALED CHEVRON DEMYELINATION DOG I WA NEG RESP
C-1240 WALED CHEVRON QRAL SUBACUTE 106 I NA REPLACED
C1446 NALED CHEVRON ORAL CHRONIC DOS I NA NEG RESP
0-2263 HALED CHEVROK ORAL - SUBACUTE cow I NA NEG RESP
D-2203 NALED CHEVRON CHOLINESTERASE RAT I NA” REPLACED
E-1022 NALED CHEVRON MUTAGENICITY HOUSE I HA NEG RESP
OFFS HALED CHEVRON NEUROTOX CHICKEN I NA NO RESP
1010 NALED =» CHEVRON QRAL SUBACUTE RAT I "NA REPLACED
1568s NALED CHEVRON FEEDING SUBACUTE - RAT I NA REPLACED
TBT_NUM CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE
8520-8991  NALED CHEVRON TERATOLOGY RABEIT I NA NEG RESF
965(2-82)  NALED CHEVRON INHALATION SUBACUTE GUINEA PIG I NA NEG RESP .
9$5(7-42) — NALED CHEVRON PECUTANECUS RABEIT if _ NA NEG RESF
B-1445 NALED CHEVRON ORAL RAT I NA NEG RESF ,
965(6-62)  NALED CHEVRON PATCH TEST HUMAN I NA NEG RESF a,
B-9068 NEMACUR - HOBAY , CARCINOGENICITY MOUSE I NA REPLACED
J-9024 NEMACUR HOBAY TERATOLOGY RABBIT J NA REPLACED
P-B914 NEMACUR KOBAY MUTAGENICITY MOUSE I NA REFLACED
621-6001  NEMEFENE SHELL ~ REPRODUCTION RAT I NA NO RESF
621-6002  NEMEFENE SHELL REPRODUCTION = RAT I NA NO RESP
623-6212 NEMEFENE SHELL TERATOLOGY RAT I NA NO RESP
$51-$000 NEMEFENE SHELL ORAL CHRONIC DOG I NA NO RESF a
C-8799 NICOTINE BLACK LEAF ORAL : ~ pOG ae NA NO’ RESF
J-875? NICOTINE BLACK LEAF HEN v v NEG RES:
J-9405 NICOTINE BLACK LEAF HEN P NO RESF
C-2772 NOREA BFC ORAL CHRONIC DOG I NA NEG RESE
771 NOREA BFC ORAL CRONIC RAT | NA NEG RESF
247s NOREA BFC REPRODUCTION RAT I NA. NEG RESF ;
9/62 NOREA BFC DERMAL SUBACUTE _ RABBIT I NA NEG RESP
9/82 NOREA BFC ORAL SUBCHRONIC RAT I NA SC. «NEG RESE
1773 NGREA BFC ORAL RAT I NA HEG RESF
B-1242 OHABINE OLIN TERATOLOGY RAT ! NA NO RESF
B-345 OMABINE OLIN: TERATOLOGY RAT I NA ss NQ.- RESP
621-4599 OMADINE OLIN ORAL SUBACUTE MONKEY I NA NO RESP
§22-3088 OMADINE OLIN TERATOLOGY RAT I NA NO RESP
622-4598 OMADINE -OLIN ORAL SUBACUTE RAT) I NA NO RESP
622-5693 OMADINE OLIN MUTAGENICITY MOUSE I NA NO RESP
622-8049 OMAD INE OLIN. TESTICULAR LESIO = MOUSE P NO RESP
623-8160 OMADINE OLIN TERATOLOGY RAT I NA NO RESP
623-8161 OMADINE OLIN MUTAGENICITY MOUSE I NA NO RESP
632-6372 OHADINE OLIN PLACENTAL TRANSF = RAT I NA NO RESP
632-6541 OMADINE OLIN PLACENTAL TRANSF PIG ] NA NO RESP
&Si-4i01A 9 OMADINE = sO TERATOLOGY PIG ; I NA NO RESP ,
; $51-4101B  OMADINE OLIN ; “TERATOLOGY PIG 1 NA JNO RESP
: 651-4401C § OMABINE OLIN - TERATGLOGY PIG I NA NO RESP
651-41010  OMABINE OLIN TERATOLOGY PIG I NA NO RESP
B-1707 OMITE-COMITE = UNIROYAL TERATOLOGY RAT I NA REPLACED
662-4206 OMITE-COMITE = UNTROYAL INHALATION = SUBCHRONIC RAT v . NO RESP
1201 QHITE-COMITE UNIROYAL HEN V _NO RESP
6513-05485 = OMITE-COMITE =: UNTROYAL : SWINE . V NO RESP
A-776 ORTHENE CHEVRON DERMAL SUBACUTE BIRD V 4 NO RESF
Brt1i6 ORTHENE CHEVRON CHOLINESTEASE RAT I NA REPLACED
B-190 ORTHENE CHEVRON TERATOLOGY RAT V P NO RESF
B-2442 ORTHENE CHEVRON CHOLINESTERASE RAT I NA REPLACED
B-8733 ORTHENE CHEVRON ORAL CHRONIC RAT . I NA REFLACED
B-3867 CRTHENE CHEVRON ORAL SUBCHROKIC RAT I NA REPLACED
B-9269 ORTHENE CHEVRON CARCINOGENICITY MICE sf NA REFLACED
B-9272, ss ORTHENE CHEVRON REPROBUCTION RAT I NA REFLACED
B-9526 ORTHENE CHEVRON CHOLINESTERASE RAT $ S REPLACED
C-8732 ORTHENE . CHEVRON ORAL CHRONIC DOG y P NO RESP
C-9527 ORTHENE CHEVRON ORAL SUBCHRONIC BOG if NA NEG RESP
£-193 ORTHENE CHEVRON MUTAGENICITY KICE I ' NA "REPLACED
J-1378 ORTHENE _ CHEVRON - REPRODUCTION QUAIL I NA NEG RESP
S291 ORTHENE CHEVRON TERATOLOGY RABEIT if NA —Ss«REPLACED
636-2498 ORTHENE CHEVRON CHOLINESTERASE HUMAN S NA NEG RESP
IBTNUM CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE =
651-4807 ORTHENE CHEVRON REPRODUCTION DUCK I NA REFLACED
J-2042 ORTHENE CHEVRON CATTLE y v HO RESE
372493 ORTHENE CHEVRON PIG y y NO RESF
5513 ORTHENE CHEVRON NEURO HEN I NA REPLACED
A-2791 PARAQUAT - CHEVRON INHALATION © SUBCHRONIC «=ss=«<s~St*séRACT/PIG/DOG I NA REPLACED
4-3359 PARAQUAT CHEVRON © DERAL SUBACUTE RABBIT I NA REPLACED
A-3485 PARAQUAT CHEVRON = DERMAL SUBACUTE RABBIT I NA REFLACED
B-1350 PARAQUAT CHEVRON = ORAL CHRONIC RAT I NA REFLACED
B-3796 PARAQUAT SUBACUTE COW I NA REFLACED
C-1351 PARAQUAT CHEVRON = ORAL CHRONIC Bog 5 OWA REFLACEL
D-2723 PARAQUAT CHEVRON «=©6-«ORAL.«Ssi(<ssSs=Sts«SUBARCUTEE cow ae or WA” sONEG RESP
D-3030. PARAQUAT CHEVRON INHALATION © SUBACUTE DOG I NA NEG RESP
D-3030 PARAQUAT CHEVRON INHALATION © SURACUTE GUINEA PIG I NA NEG RESP
1-3030 PARAQUAT CHEVRON «INHALATION © SUBACUTE RAT I NA REPLACED
$131 PARAQUAT CHEVRON , DUCK I NA NEG RESP
131 PARAQUAT CHEVRON oO PHEASANT - NA REFLACED
651-4020 PARAQUAT CHEVRON © DIETARY PHEASANT v P REPLACED
651-438!  PARAQUAT CHEVRON DIETARY PHEASANT v oP REPLACED
6515403 PARAQUAT CHEVRON . - HEN I NA NEG RESE
J-131 PARAQUAT CHEVRON DUCK 1 NA NEG RESF
J33 PARADUAT = = _CHEURON PHEASANT } NA REFACEL
H-2068 PENNCAP ¥ PENWALT ORAL SUECHRONIC RAT . v Cl NO RESF
J-204¢ =. PENNCAP PENWALT ORAL SUBCHRONIC DOs v NO RESF
621-4921 PENNCAF PENWALT ORAT CHRONIC RAT I NA NO RESF
h-2267 PERFLUIDONE a DERMAL SUBACUTE RABBIT 1 NA. ‘NEG RESF
562-9315  PERFLUINONE © 3M ' INHALATION SUBACUTE RAT I NA NO RESP
A-5652 PHENMEL PHA NOR AMC DERMAL SUECHRONIC RAEBIT v NO RESF
A-7571 PHENKEDIPHAM NOK AM C CHOLINESTERASE RAT v NO RESP
B-7149 PHENMEDIPHAM NOK AK C ORAL SUBCHRONIC RAT v NA REPLACED
C-7150 PHENMEDIPHAM NOK AK C ORAL SUBCHRONIC . «BOG v NA REPLACED
N-7657 PHENKEDIPHAM NOR AK C INKALATION  SUBCHRONIC RAT v NO RESP
B-2982 PHENTHOATE MONTEDISON ORAL CHRONIC RAT I NA NEG RESP
: C-8884 PHENTHOATE MONTEDISON ORAL CHRONIC DOG V c NO RESF
601-4413 PHENTHOATE MONTEDISON DERMAL SUBCHRONIC RABBIT s S NEG RESP
; 601-4524  PHENTHOATE KONTEDISON DERMAL SUBCHRONIC RABBIT I NA NEG RESP
622-4624  PHENTHOATE MONTEDISON ONCOGENICITY MOUSE I NA WEG RESP
622-5876  PHENTHOATE MONTEDISON MUTAGENICITY HOUSE 1 NA NES RESF
; 623-3513 PHENTHOATE HONTELISON REPRODUCTION RAT S S NEG RESP
623-2803  PHENTHOATE- MONTEDISON REPRODUCTION RAT S I NEG RESP
632-4157 PHENTHOATE MONTEDISON MUTAGENICITY HOUSE I NA NEG RESP
651-5785  PHENTHOATE MONTEDISON TERATOLOGY RAT v P NEG RESP
. 651-5875 PHENTHOATE HONTEDISON TERATOLOGY RABBIT I NA NEG RESP .
601-3002  PHENTHOATE MONTEDISON DERMAL RABBIT I NA NEG RESP
8580-9635 PHENTHOATE MONTEDISON NEURO _ HEN S s NEG RESF
C-1292 —»- PHORATE AKER CYANIMID CHOLINESTERASE DOG I NA NO RESP
B-2804 - PHOSPHAMIDON CHEVRON REFRODUCTION RAT I NA REPLACED
B-6760 PHOSPHAMIDON CHEVRON
CHOLINESTERASE RAT I NA NEG RESP ‘
C-1382 PHOSFHAKIDON CHEVRON
ORAL SUBACUTE DOG I NA NEG RESP ;
c-1444 PHOSPHAMTDON CHEVRON
pe CHRONIC DOG I NA REPLACED
-3082 PHOSEHAMIDON CHEVRON ; ,
CHOLINESTERASE RAT I NA NEG RESP ——
TBT.NUM = CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE.
T-3035 PHOSPHAMITON CHEVRON ;
INHALATION SUBACUTE RAT/DOG/G.F, I NA NEG ‘RESP
WCF 129 © PHOSPHAMIUON ©» CHEVRON
DEMYELINIATION HEN I NA NO RESP
WCRF 129k © PHOSPHAMIDON ©» CHEVRON .
DEMYELINIATION HEN I NA NEG RESP
1002 PHOSPHAMIDON © CHEVRON
DEHYELINIATION DOG I NA NEG RESP
: 10028 PHOSPHAMIDON CHEVRON
CHOLINESTERASE 006 I NA NEG RESP
2589 PHOSPHAMIDON CHEVRON
COMPARATIVE I NA NEG ‘RESP
A~3085 PHOSPHAMIDON CHEVRON | .
ORAL RAT I _ NA REPLACED
B-1443 PHOSPHAKIDON CHEVRON
ORAL RAT I NA NEG RESP
B-9799 PICLORAK boy _ TERATOLOGY MOUSE I NA REPLACED
C-1975 PICLORAM tow ORAL CHRONIC DOG I NA REPLACED
1974 PICLORAM - DOW ORAL CHRONIC RAT I NA REPLACED
2192 PICLORAM DoW PATCH TEST HUMAN TNA REPLACED
601-5447 PIK OFF CIBA GEIGY . DERMAL © ~ SUBACUTE RABBIT § _ (S$ NEG RESP
611-5277 PIK OFF CIBA GEIGY ORAL SUBCHRONIC DOG I NA NEG.-RESP
611-6090 PIK OFF CIBA GEIGY © ORAL SUBCHRONIC DOG I NA HEG.-RESP
622-5276 IK OFF CIBA GEIGY ORAL SUBCHRONIC RAT I NA NEG RESP
8533-9374 IK OFF CIBA GEIGY ORAL CHRONIS RAT § CS NEG RESP
8533-7375 PIKOFF © ——CTBA GEI6Y . REFRODUCTION RAT v Ch NEG RESF
9533-9743 IK OFF CIBA GEIGY TERATOLOGY RAT T° WA NEG RESE |
8535-1050? PIK OFF CIA GEIGY MUTAGENICITY SALMCNELLA I NA NEG -RESF
REAC-9374 — PIK_AFF IBA GEIGY LARCINOGENICITY. MOUSE J. NA NEG-REGP
G532-08317 PIPERONYL BUTOX GK TERATOLOGY RAT I HA NOT REQ
663-6080 PIPERONYL BUTOX GK INHALATION , MOUSE v NO RESF
B-1714 POLYRAK FUC ORAL - SUBACUTE RAT I HA «REPLACED
B-1715 POLYRAM FHC ORAL CHRONIC RAT I NA «REPLACED
B-17158 -POLYRAM FHC DRAL CHRONIC «= - =; «RAT I HA «REPLACED
B-2705 POLYRAM FAC REPRODUCTION RAT I NA REPLACED
B-2786 POLYRAK FAC ORAL ‘SUBACUTE RAT I NA «REPLACED
C4716 POLYRAK FAC ORAL CHRONIC DOG I NA NOT REQ
2178 POLYRAK FHC PERCUTAN SUBACUTE RABBIT I NA NO -RESP
2790 POLYRAK FRC ORAL SUBACUTE Dos § CS NO RESP
B-5346 POTASSIUM AZIDE PPG ORAL SUBACUTE RAT I NA NOT REQ
C-5367 POTASSIUM AZIDE PFG ORAL SUBACUTE DOG I WA NOT REO
622-3539 POTASSIUM AZIDE PPG TERATOLOGY RAT I NA NOT REO
B-6758 POTASSIUM HEXA —PENWALT ORAL SUBACUTE RAT I NA NOT REQ
C-6759 POTASSIUM HEXA PENWALT ORAL SUECHRONIC DOG I NA NOT RED
C-7380 POTASSIUM HEXA  PENWALT THYROID FUNCTION DOG I NA NOT REO
B-8282 PFG 124 PPG ORAL SUBCHRONIC DOs I NA NO RESP |
C-8262 PPG 124 PPG ORAL SUBACUTE TOX bos I NA ._-NEG RESP
B-8829 PRODIAMINE  - VELSICOL SUBCHRONIC RAT I NA NO RESP
E-399 PRODIAMINE VELSICOL MUTAGENICITY MOUSE sd NA NO RESP
601-6055 PRODIAMINE VELSICOL «=.‘DERMAL SUBACUTE RABBIT I NA NO RESP
621-6644 PRODIAMINE VELSICOL ORAL CHRONIC RAT § cs HO RESP .
623-6981  PRODIAKINE VELSICOL REPRODUCTION RAT I, HA HO RE...
TBT_NUM CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE
651-6115 © PRODIAMINE VELSICOL TERATOLOGY RABBIT I NA NO RESF
651-6224 PRODIAMINE VELSICOL ORAL SUBCHRONIC DOG I NA NO RESP
651-6843 PRODIAMINE VELSICOL CATARACTEGEN HEN I NA NO RESP
651-7145 PRODIAMINE VELSICOL CARCINOGENICITY MOUSE I HA NO RESF
B-904 PROFLURALIN CIBA GEIGY TERATOLOGY RAT V NA NOT REQ
C-476 PROFLURALIN CIBA GEIGY ORAL SUBCHRONIC tig v NEG RESP
P-475 PROFLURALIN CIBA GSEIGY ORAL SUBCHRONIC RAT V NA NEG RESF
A-875 PROFLURALIN * CIBA GEIGY DERMAL RABBIT I NA NEG RESP
B-904 PROMETON CIBA GEIGY © TERATOLOGY RAT $ P NO RESP
PROMETRYN FMC DERMAL RABBIT I NA NEG RESP
B~5623 PROPHAK PPG ORAL SUBACUTE RAT 1 NA REPLACED
7 C9634 PROPHAM PPG ORAL SUBACUTE DOG I NA NEG RESP
J-BS208 PROPHAK PFG . HEN y v NEG RESP 7’.
Bei274A PROWL AMER CYANIMID TERATOLOGY ~ RAT I NA REPLACED
B-2324 PROWL AMER CYANIMID TERATOLOGY RAT I _ NA REPLACEB |
8589-9771 = PROWL AMER CYANIMID CATARACTEGEN HEN v CM NEG RESP
663-4080 PYRETHRIN MGK INHALATION MOUSE V P HO RESP
S239 RABON SHELL . TERATOLOGY RABRIT I NA REFLACED
A-1320 RAKROD MONSANTO DERMAL SUBACUTE RABBIT 1 NA NOT REG
A-7183 RAMROL MONSANTO DERMAL SUBACUTE RABBIT I NA NEG RESF
8-1174-— RAMROD MONSANTO CARCINOGENICITY MOUSE I NA NEG RESP
B-5063 RAMROD MOKSANTO ORAL CHRONIC RAT I NA NOT REQ
B-5064 RAKROD BOXSANTO ORAL CHRONIC DOG I NA NOT REQ
B-S065 RAHROD MONSANTO REPRODUCTION - RAT 1 NA. NOT REQ
B-5083 RAMROD MONSANTO ORAL SUBCHRONIC RAT ; I. NA NCT REQ
B-5084 RAMROD MONSANTO ORAL SUBCHRONIC BOG I NA NOT REQ ,
C-1172 RAMROD MONSANTO ORAL CHRONIC DOG I NA
E-1177 RAMROD MONSANTO MUTAGENICITY MOUSE I NA NEG KESF
7S RAMROD MONSANTO TERATOLOGY RABBIT I NA NEG RESP
6214-11727 = RAMROD MONSANTO ORAL CHRONIC RAT I NA NEG RESP
622-1176 RAMROD MONSANTO REPRODUCTION RAT ] NA NEG RESF
663-6289 RAMROD MONSANTO INHALATION = SUBACUTE RAT 1 NA NEG RESP
E-1751 RAMROL MONSANTO QUAIL v v NEG RESP
J-7214 RARROD MONSANTO DIETARY QUAIL I NA NCT REQ
; 621-1174 RAMROD MONSANTO ORAL MOUSE I NA . REPLACED
; B-480% RANDOX MONSANTO ORAL SUBACUTE RAT I "NA NEG RESP
C-4807 RANDOX = MONSANTO ORAL SUBACUTE ’ BOG ] NA NEG RESP
621-06952 — RANDOX MONSANTO ORAL CHRONIC RAT I NA NEG RESF
_ 623-6993 RANDOX MONSANTO REPRODUCTION RAT I NA NEG RESP
623-7690 RANDOX MONSANTO MUTAGENICITY MOUSE Vv 0 NO RESP
651-0794 RANDOX MONSANTO TERATOLOGY RABBIT “T NA NES RESP
B-5580 RESHKETHRIN ORAL SUECHRONIS RAT I NA REPLACED
J-5579 RESMETHRIN TERATOLOEY RABBIT I NA REFLACED
J-6146 RESMETHRIN TERATOLOSY RABEIT I NA REPLACED
P-6178 RESMETHRIN TERATOLOSY MOUSE I NA REPLACED
RONNEL DOW TISS/SKEL TERATOLOGY RAT I NA NEG: RESP
A-2007 SANTOPHEN MONSANTO DERMAL SUBCHRONIC RABBIT I NA NO RESP
B-2010 SANTOFHEN HONSANTO ORAL SUBCHRONIC RAT § $ NQ RESF
C-2009 SANTOPHEN MONSANTO ORAL SUBCHRONIC DOG I NA. NQ RESF
C-2011 SANTOPHEN MONSANTO ORAL SUBCHRONIC DOG I NA _ NO RESP
E-2614 SANTOPHEN MONSANTO MUTAGENICITY MOUSE I NA NO RESP ;
2013 SANTOPHEN MONSANTO TERATOLOGY RABBIT I, NA NO RESP
N-2041 SANTOPHEN MONSANTO INHALATION SUBACUTE RAT I NA NO RESP -
TBT_NUM CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE ©
622-20128 SANTOPHEN MONSANTO REPRODUCTION , RAT P NO RES
622-2912C SANTOPHEN MONSANTO TERATOLOGY RAT I NA NO RESF
8542-8408 = SECTROL xs) TNAHLATION RAT I, NA REPLACE:
B-9069 SENCOR CHEMAGRO CARCINOGENICITY MOUSE I NA REPLACED
C-7760 SENCOR CHEMAGRO ORAL SUBACUTE DOG ¥ P NO RESF
E-8922 . SEXCOR CHEMAGRO "MUTAGENICITY MOUSE I NA REFLACED
1851 SENCOR CHEKAGRO TERATOLOGY RABBIT I NA REPLACED
Jo233 SENCOR CHEMAGRO TERATOLOGY RABBIT I NA REPLACED
9627 SENCOR CHEMAGRO TERATOLOGY RABBIT I NA REPLACED
B-9071 SIMAZINE- CIBA GEIGY "ORAL SUBCHRONIC RAT I NA = _ REPLACED
B-9244 SIMAZINE CIBA GEIGY ORAL SUBCHRONIC RAT I NA NOT REQ
8532-8859 SIMAZINE CIBA GEIGY ORAL SUBCHRONIC MOUSE I NA NEG RESF
8580-8997 SIMAZINE CIBA GEIGY CARCINOGENICITY MOUSE I NA BISCUSSION
§22-3546 SODIUM AZIDE PPG TERATOLOGY RAT 1 NA NOT REQ”
B-5664 SODIUM CHLORATE ORAL RAT I NA NEG RESF
C-5665 SODIUM CHLORATE ORAL BOG I NA NEG RESP
B-904 SUMITOL CIBA GEIGY TERATOLOGY RAT v NA HO RESP ,
8580-9380 SUPRACIDE CIBA GEIGY ORAL CHRONIC MOUSE § P REPLACED
A~7198 SUPRACIDE CiBA GEIGY DERKAL RABBIT V NA’ REFLACED
2705 * TEBION FHC REPRODUCTION RAT I HA NEG RESF
5-137 4B TERBUFCS AMER CYANIMIS TERATOLOGY RAT I NA NO RESP
A~904 TERBUTHYLAZINE § CIBA GEIGY TERATOLOGY RAT v " NEG RESP
B-3797 TERBUTHYLAZINE  CIBA GEIGY ORAL SUECHRONIC RAT I NA NEG RESF
B-4538 TERBUTHYLAZINE § CIBA GEIGY ORAL SUBCHRONIC RAT “I NA NES RESF
B~9210 TEREUTHYLAZINE § CIBA GEIGY ORAL CHRONIC RAT P - NEG RESP
B-8211 TERBUTHYLAZINE  CIBA GEIGY ORAL. CHRONIC RAT I NA NEG RESP
C~B270 TERBUTHYLAZINE § CIBA GEIGY ORAL _  SUPCHRONTC DOG I NA NEG RESP ,
C~9271 TERBUTHYLAZINE § CIBA GEIGY “ORAL CHRONIC DOG I NA NES RESF
P~8272 TERBUTHYLAZINE § CIBA GEIGY REPRODUCTION RAT P NEG RESF
4-8730 TERBUTHYLAZINE  CIBA GEIGY DERMAL RABEIT P NEG RESP
N~8750 . TERBUTHYLAZINE  CIBA GEIGY DERMAL RABBIT I NA NEG RESF
B~904 TERBUTRYN CIBA GEIGY TERATOLOGY RAT ¥ REPLACED
A-5456 TERBUTRYN _CIBA GEIGY DERMAL RABBIT I NA NOT REQ
B-3799 TERBUTRYN CIBA GEIGY - GRAL RAT I NA REFLACED
J-5285 TERBUTRYN CIBA GEIGY ORAL DOG I NA REPLACED
8533-10570  TERRAZOLE OLIN TERATOLOGY RAT § § » REPLACED
8531-8338 = THIDIAZURON NORAM ORAL SUBCHRONIC DOG 5 cs REPLACED
8532-9630  THIDIAZURON NORAM REPRODUCTION RAT v C NEG RESF
8550-8337 = THIDIAZURON NORAK ORAL SUBCHRONIC RAT § cs NOT REQ ;
8540-9361  THIDIAZURON NORAK ORAL CHRONIC RAT $ '§ REPLACED
8580-10725  THIBIAZURON NORA ; ONCOGENICITY “MOUSE Vv C NEG RESP
B~1056 THIODAH FAC TERATOLOGY RAT I NA REPLACED
B-2661 THIODAN FRC ORAL SUBACUTE RAT - I NA REPLACED
C-2665 THIODAN FAC ORAL SUBACUTE DOG I NA REPLACED
C-3758 THIODAN FHC ORAL CHRONI:: DOG V P NO RESF
C-8705 THIQDAN FAC ORAL CHRONIC DOG y PR NOT REQ
E-1057B THIODAN FAC MUTAGENICITY MOUSE v CI REPLACED
2705 THIODAN FHC REPRODUCTION RAT I NA REFLACED
J-4885 THIOBAN FRC HEN V V NEG RESP .
B-1390 THIOFANOX DIAMOND SHAMROCK ORAL SUBCHRONIC RAT [ HA . NO RESP
651-6885 THIGFANOX DIAMOND SHAMROCK NEUROTOX CHICKEN y P NO RESP
651-7054 THIOF ANOX DIAKOND SHAMROCK NEUROTOX CHICKEN ¥ P NOT REQ .
B-4008 TORAK BFC ORAL SUBACUTE RAT I, NA NEG RESF
B-4055 TORAK BFC ORAL SUBCHRONIC "RAT I NA NEG RESF -
IBT_NUM = CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE
B-4056 TORAK BFC CHOLINESTERASE = RAT § § NEG RESF
B-4345 TORAK BFC ORAL CHRONIC RAT I NA NES RESF
C4007 TORAK BFC ORAL SUBACUTE DOG I OWA NEG RESF
C-4350 TORAK BFC ORAL CHRONIC DOG I NA NEG RESP
E-4009 TORAK BFC CHOLINESTERASE RAT I NA NEG RESF
F-7110 TORAK BFC CHOLINESTERASE . HUMAN I. WA. NEG RESF
F-7493 TORAK - BFE _ _ CHOLINESTERASE © HUMAN I NA | NES RESP
4529 TORAK BFC TERATOLOGY RABBIT i NA NES ESSE
4-6336 TORAK BFC CHOLINESTETERATO MONKEY 1 NA NEG RESF
N-7310 TORAK BFC REPROBUCT ION I NA NEG RESE
F-4347 TORAK BFC REPRODUCTION RAT 1 NA REG RESP
WORF 158  TORAK BFC TERATOLOGY RABBIT I NA NEG RESP
_ 623-3751 TORAK BFC REPRO & TERATOLO -RAT P NEG \RESF
4-7308 TORAK BFC DERMAL RABBIT 1 NA NEG RESP
A-7848 TORAK BFC DERMAL RABBIT § NA NEG RESP.
6351 TORAK BFC NEURO . HEN I NA ss NEG- RESP
2330 TOXAPHENE BFC ORAL CHRONIC DOs I NA NEG ‘RESP
2367 TOXAPHENE BFC INHALATION SUBACUTE DOG I HA NES RESP
2367 TOXAPHENE BFC -  ENHALATION SUBACUTS _ RAT I NA NEG RESP
; 2367 TOXAPHENE BFC INHALATION SUBACUTE GUINEA PIS 1 NA NEG _-RESF
2476 TOXAPHENE HERCULES REPRODUCTION RAT I NA —-NO_-RESP
; 632-6451  TOXAPHENE BFC ORAL HEN ) "NA NEG RESP
A-8149 TRIALLATE MONSANTO DERMAL SUBCHRONIC - RABBIT I NA REPLACED
B-4834 . TRIALLATE MONSANTO ORAL SUBCHRONIC RAT I NA REPLACED!
C4835 TRIALLATE MONSANTO ORAL SUBCHRONIC DOG I NA REPLACED
622-5251  TRIALLATE MONSANTO ORAL CHRONIC RAT I NA -- NEG RESF -
622-5253 TRIALLATE - MONSANTO MUTAGENICITY MOUSE Y F NO RESP :
623-6842  TRIALLATE MONSANTO REPRODUCTION RAT v P NO RESP
651-5255  TRIALLATE MONSANTO TERATOLOGY RABBIT I NA —- REPLACED
8530-9030. TRIALLATE MONSANTO CHOLINESTERASE RAT V P NO RESP
8586-10581 TRIALLATE MONSANTO ORAL CHRONIC . BOG V P NO RESP
A-6678 TRIALLATE MONSANTO FISH I NA. REPLACED
A-6679 TRIALLATE BONSANTO FISH I NA REPLACED
J-576 TRIALLATE MONSANTO QUAIL I NA REPLACED
J-6677 TRIALLATE MONSANTO Cuatt I NA —sNOT-REQ
651-2842 — TRIALLATE MONSANTO ORAL UCK V F NO RESP
651-3023 TRIALLATE MONSANTO ORAL . QUAIL V.. P NO RESP
8532-10763 TRIALLATE MONSANTO ORAL MOUSE I NA NEG RESP
8580-10814 TRIALLATE ‘MONSANTO NEURO HEN I NA NEG-RESF
580-9120  TRIALLATE MONSANTO NEURO HEN ) NO RESF
622-5459 TRIFORINE - CHEVRON MUTAGENICITY MOUSE I NA NEG RESP
663-5460  TRIFORINE CHEVRON INHALATION SUBACUTE RAT I NA NEG -RESP
B~4634 TRIPHENYLTIN HY THOMPSON-HAYWARD ORAL SUBACUTE RAT 1 NA NOT REG
C-3964 TRIPHENYLTIN HYD THCMPSOX-HAYWARD ORAL SUBACUTE DOG I NA ROT _- REQ
C-4343 TRIPHENYLTIN HYD THOMPSON-HAYWARD GRAL SUBALUTE DOG I NA —s NOT -RE®
611-8069  TRIVAX UNIROYAL ORAL DOG y NA NEG -RESF
8532-8071 TRIVAX UNIROYAL ORAL RAT y NA NEG RESP
17721 VAPONA SHELL CHOLINESTERASE 006 I NA NEG RESP
1548 VAPONA SHELL ORAL SUBACUTE RAT 1 NA NEG -RESF
C~4805 VEGADEX MONSANTO ORAL SUBACUTE DOG I NA NEG: RESP
621-6954  VEGADEX MONSANTO ORAL CHRONIC RAT I NA . NEG RESP
623-6955  VEGADEX MONSANTO REPRODUCTION RAT I NA NEG -RESP
623-7092  VEGADEX MONSANTO MUTAGENICITY ROUSE I NA  —sNEG-RESE
651-7093  VEGALEX MONSANTO . TERATOLOGY RAT I. NA NEG RESP
TBT_NUK CHEMICAL COMPANY ROUTE TYPE SPECIES - VALIDATE EVALUATE REFLACE. —-

8530-9030  VEGADEX MONSANTO CHOLINESTERASE RAT V NA NO RESF

8532-10764 VEGADEX MONSANTO BRAL SUBCHRONIC MOUSE I NA NEG RESF

8580-10582 VEGADEX MONSANTO ORAL - CHRONIC boc 1 NA NEG RESP

B-4804 VEGADEX * MONSANTO ORAL RAT I NA REFLACED

8580-10815 VEGADEX MONSANTO NEURO HEN v NO RESF

8580-9118  YEGADEX MONSANTO NEURO HEN I -WA NEG RESF

651-6763 VEL "SANDOZ -  NUERO , HEN I NA NO RESF

A-1159 ss: VENDEX SHELL DERMAL SUBACUTE RABBIT I NA NEG RESP

8560-8838  VINYZENE VENTRON ORAL “SUBACUTE RAT 1 HA DISCUSSION ‘

622-07292  VORLEX ORAL SUBCHRONIC RAT V P NO RESP

623-07393  VORLEX REPRODUCTION RAT v P NO RESF
294-3 BOW DERMAL SUBACUTE RABBIT 1 NA NO RESP ;
4~AMINOPYRIDINE © AVITROL CORP SUBACUTE DOG/SWINE I NA. NO RESP “