% Bibliography of toxicologist John P. Frawley (FDA Division of Pharmacology, late 1940s–1957;
% Hercules Inc., chief toxicologist, 1956–c.1990). Compiled for the Frawley dossier.
% annote = evidentiary role + confidence + COI/IBT flag. Excluded same-name impostors at the end.
% Confidence: HIGH unless noted. Flags: [IBT]=Industrial Bio-Test data/co-author Calandra;
% [HERC]=Hercules product/affiliation; [FDA]=FDA-era; ★=dossier-critical.

@article{frawley1950bhc,
  author  = {Fitzhugh, O. Garth and Nelson, Arthur A. and Frawley, John P.},
  title   = {The chronic toxicities of technical benzene hexachloride and its alpha, beta and gamma isomers},
  journal = {Journal of Pharmacology and Experimental Therapeutics},
  volume  = {100}, number = {1}, pages = {59--66}, year = {1950},
  note    = {PMID 14774791},
  annote  = {[FDA] Earliest located Frawley paper; FDA Division of Pharmacology chronic-toxicity method that recurs across his career. Identity anchor (Fitzhugh/Nelson co-authors).}
}

@article{fitzhugh1951sweeteners,
  author  = {Fitzhugh, O. Garth and Nelson, Arthur A. and Frawley, John P.},
  title   = {A comparison of the chronic toxicities of synthetic sweetening agents},
  journal = {Journal of the American Pharmaceutical Association (Scientific ed.)},
  volume  = {40}, number = {11}, pages = {583--586}, year = {1951},
  doi     = {10.1002/jps.3030401117}, note = {PMID 14907466},
  annote  = {[FDA] ★ Named identity-fingerprint paper, confirmed. Saccharin/cyclamate/dulcin/P-4000 — ironically prefigures the later cyclamate/saccharin controversies he is sometimes (wrongly) thought to have testified on.}
}

@article{davidow1951bhc,
  author  = {Davidow, Bernard and Frawley, John P.},
  title   = {Tissue distribution, accumulation and elimination of the isomers of benzene hexachloride},
  journal = {Proceedings of the Society for Experimental Biology and Medicine},
  volume  = {76}, number = {4}, pages = {780--783}, year = {1951},
  note    = {PMID 14844348},
  annote  = {[FDA] BHC pharmacokinetics; complements the 1950 chronic-toxicity paper.}
}

@article{frawley1952op,
  author  = {Frawley, John P. and Hagan, E. C. and Fitzhugh, O. Garth},
  title   = {A comparative pharmacological and toxicological study of organic phosphate-anticholinesterase compounds},
  journal = {Journal of Pharmacology and Experimental Therapeutics},
  volume  = {105}, number = {2}, pages = {156--165}, year = {1952},
  note    = {PMID 14928218},
  annote  = {[FDA] Foundation of his organophosphate line; leads to the 1957 potentiation classic.}
}

@article{frawley1956nerve,
  author  = {Frawley, John P.},
  title   = {Nerve poisons},
  journal = {International Record of Medicine and General Practice Clinics},
  volume  = {169}, number = {1}, pages = {41--42}, year = {1956},
  note    = {PMID 13285953. CONFIDENCE: MEDIUM (no affiliation in record; attributed on subject-matter grounds)},
  annote  = {Attribution medium-confidence: MEDLINE carries no affiliation. Subject matter (nerve agents) fits the toxicologist, not the same-name surgeon.}
}

@article{frawley1957potentiation,
  author  = {Frawley, John P. and Fuyat, H. N. and Hagan, E. C. and Blake, J. R. and Fitzhugh, O. Garth},
  title   = {Marked potentiation in mammalian toxicity from simultaneous administration of two anticholinesterase compounds},
  journal = {Journal of Pharmacology and Experimental Therapeutics},
  volume  = {121}, number = {1}, pages = {96--106}, year = {1957},
  note    = {PMID 13481831},
  annote  = {[FDA] His best-known FDA paper (malathion–EPN synergism); widely cited in pesticide-mixture toxicology.}
}

@article{williams1958parathion,
  author  = {Williams, M. W. and Cook, J. W. and Blake, J. R. and Jorgensen, P. S. and Frawley, John P. and Rider, J. A. and Moeller, H. C. and Swader, J. and Weilerstein, R. W.},
  title   = {The effect of parathion on human red blood cell and plasma cholinesterase},
  journal = {AMA Archives of Industrial Health},
  volume  = {18}, number = {5}, pages = {441--445}, year = {1958},
  note    = {PMID 13582239},
  annote  = {Human cholinesterase study during the FDA-to-Hercules transition; Frawley one of nine authors.}
}

@article{fitzhugh1959stearic,
  author  = {Fitzhugh, O. Garth and Bourke, A. R. and Nelson, Arthur A. and Frawley, John P.},
  title   = {Chronic oral toxicities of four stearic acid emulsifiers},
  journal = {Toxicology and Applied Pharmacology},
  volume  = {1}, number = {3}, pages = {315--331}, year = {1959},
  doi     = {10.1016/0041-008X(59)90116-4}, note = {PMID 13659539},
  annote  = {[FDA] Named fingerprint item, confirmed. Bridges his FDA co-author network into food-additive safety; inaugural TAP volume.}
}

@article{frawley1963delnav,
  author  = {Frawley, John P. and Weir, R. and Tusing, T. and DuBois, K. P. and Calandra, J. C.},
  title   = {Toxicologic investigations on Delnav},
  journal = {Toxicology and Applied Pharmacology},
  volume  = {5}, pages = {605--624}, year = {1963},
  note    = {PMID 14068278},
  annote  = {[IBT][HERC] COI: co-author J. C. Calandra was president of Industrial Bio-Test Laboratories; Delnav (dioxathion) a commercial organophosphate. First IBT-linked Frawley paper.}
}

@article{frawley1964cmc,
  author  = {Frawley, John P. and Wiebe, A. K. and Klug, E. D. and Shelanski, M. V.},
  title   = {Studies on the gastro-intestinal absorption of purified sodium carboxymethylcellulose},
  journal = {Food and Cosmetics Toxicology},
  volume  = {2}, pages = {539--543}, year = {1964},
  note    = {PMID 14249970},
  annote  = {[HERC] CMC is a Hercules product line; Klug/Wiebe are Hercules cellulose chemists. Industry food-additive safety.}
}

@article{frawley1964eel,
  author  = {Frawley, John P.},
  title   = {Emergency Exposure Limits},
  journal = {American Industrial Hygiene Association Journal},
  volume  = {25}, pages = {578--586}, year = {1964},
  note    = {CONFIDENCE: MEDIUM (likely AIHA Toxicology Committee product; sole authorship unconfirmed)},
  annote  = {Industrial-hygiene exposure-limit framing aligns with his Hercules Health/Environment/Safety role; authorship vs committee role unresolved.}
}

@article{frawley1965bht_repro,
  author  = {Frawley, John P. and Kohn, F. E. and Kay, J. H. and Calandra, J. C.},
  title   = {Progress report on multigeneration reproduction studies in rats fed butylated hydroxytoluene (BHT)},
  journal = {Food and Cosmetics Toxicology},
  volume  = {3}, number = {3}, pages = {377--386}, year = {1965},
  doi     = {10.1016/S0015-6264(65)80126-2}, note = {PMID 5893645},
  annote  = {[IBT] COI: Calandra (IBT). Multigeneration reproduction toxicology — the study type at the center of IBT's later fraud findings.}
}

@article{frawley1965bht_residue,
  author  = {Frawley, John P. and Kay, J. H. and Calandra, J. C.},
  title   = {The residue of butylated hydroxytoluene (BHT) and metabolites in tissue and eggs of chickens fed diets containing radioactive BHT},
  journal = {Food and Cosmetics Toxicology},
  volume  = {3}, number = {3}, pages = {471--474}, year = {1965},
  doi     = {10.1016/S0015-6264(65)80133-X}, note = {PMID 5865682},
  annote  = {[IBT] COI: Calandra (IBT). Companion radiolabel residue study.}
}

@article{frawley1965sacredfood,
  author  = {Frawley, John P.},
  title   = {Our sacred food --- a perspective},
  journal = {Food and Cosmetics Toxicology},
  volume  = {3}, pages = {117--119}, year = {1965},
  note    = {PMID 14342787},
  annote  = {Opinion piece; title reused for his 1989 RTP editorial — a career-long food-safety-deregulation leitmotif.}
}

@article{frawley1965suds,
  author  = {Frawley, John P.},
  title   = {Suds and sensitivity},
  journal = {Food and Cosmetics Toxicology},
  volume  = {3}, pages = {122--124}, year = {1965},
  note    = {PMID 14342788},
  annote  = {Short commentary; same venue/era as his other 1965 FCT opinion pieces.}
}

@inproceedings{frawley1965rosin,
  author    = {Frawley, John P.},
  title     = {Investigations establishing the safety of rosin products for food and food-packaging applications},
  booktitle = {Proceedings of the Naval Stores Work Conference (Gainesville, FL, Oct.\ 19--20, 1964)},
  publisher = {USDA Agricultural Research Service, Southern Utilization R\&D Division},
  pages     = {65--70}, year = {1965},
  note      = {Local PDF; Internet Archive proceedingsofnav7250nava},
  annote    = {[HERC][IBT] ★ Direct commercial driver of the de minimis idea. States studies were "conducted under contract by the Industrial Bio-Test Laboratories"; ~5,000 rats + 138 dogs; $50k/compound × 34 motive. Also a separate trade write-up appears at Naval Stores Review 74(12):4 (1965) — same talk, not a distinct paper.}
}

@article{kinoshita1966toxaphene,
  author  = {Kinoshita, F. K. and Frawley, John P. and DuBois, K. P.},
  title   = {Quantitative measurement of induction of hepatic microsomal enzymes by various dietary levels of DDT and toxaphene in rats},
  journal = {Toxicology and Applied Pharmacology},
  volume  = {9}, pages = {505--513}, year = {1966},
  doi     = {10.1016/0041-008X(66)90011-1},
  note    = {Not in PubMed (TAP indexing gap); via CrossRef},
  annote  = {[HERC] Toxaphene is a Hercules product; established a DDT threshold ~0.05 mg/kg/day.}
}

@article{frawley1967foodpackaging,
  author  = {Frawley, John P.},
  title   = {Scientific evidence and common sense as a basis for food-packaging regulations},
  journal = {Food and Cosmetics Toxicology},
  volume  = {5}, number = {3}, pages = {293--308}, year = {1967},
  note    = {PMID 4861454; Semantic Scholar CorpusID 33759952; delivered BIBRA London 25 Jan 1967; local PDF},
  annote  = {[HERC][IBT] ★★ THE de minimis / threshold-of-regulation foundational paper (0.2% / 0.1 ppm "toxicologically insignificant"). Appendix relies on unpublished Hercules (ref.3) and IBT (ref.26) data. Origin of the TTC citation lineage (Frawley->Flamm/Rulis->Munro->Kroes->EFSA).}
}

@article{frawley1968reasoned,
  author  = {Frawley, John P.},
  title   = {A reasoned approach to regulation based on toxicologic considerations},
  journal = {Food Drug Cosmetic Law Journal},
  volume  = {23}, year = {1968},
  note    = {CONFIDENCE: MEDIUM; HeinOnline hein.journals/foodlj23 §41; exact pages unconfirmed (paywalled)},
  annote  = {Law-journal companion to the 1967 thesis; extends his regulatory-philosophy argument to a legal audience.}
}

@article{frawley1968fitzhugh,
  author  = {Frawley, John P.},
  title   = {O. Garth Fitzhugh [tribute]},
  journal = {Food and Cosmetics Toxicology},
  volume  = {6}, number = {2}, pages = {121--122}, year = {1968},
  note    = {PMID 4876430},
  annote  = {Biographical: Frawley's tribute to his FDA mentor/frequent co-author — documents the FDA Division of Pharmacology lineage.}
}

@article{dubois1968delnav,
  author  = {DuBois, K. P. and Kinoshita, F. K. and Frawley, John P.},
  title   = {Quantitative measurement of inhibition of aliesterases, acylamidase, and cholinesterase by EPN and Delnav},
  journal = {Toxicology and Applied Pharmacology},
  volume  = {12}, number = {2}, pages = {273--284}, year = {1968},
  note    = {PMID 4299018},
  annote  = {Continues the Delnav/organophosphate enzyme program with DuBois and Kinoshita.}
}

@article{su1971op,
  author  = {Su, M. Q. and Kinoshita, F. K. and Frawley, John P. and DuBois, K. P.},
  title   = {Comparative inhibition of aliesterases and cholinesterase in rats fed eighteen organophosphorus insecticides},
  journal = {Toxicology and Applied Pharmacology},
  volume  = {20}, number = {2}, pages = {241--249}, year = {1971},
  note    = {PMID 5133254},
  annote  = {Broad organophosphate esterase-inhibition survey; industry-relevant pesticide screening.}
}

@article{borzelleca1971letter,
  author  = {Borzelleca, J. F. and Drill, V. A. and DuBois, K. P. and Frawley, John P. and Goldberg, L. and Hayes, W. J. and McCollister, D. D. and Roudabush, R. L. and Scala, R. A.},
  title   = {[Letter to the editor]},
  journal = {Science},
  volume  = {174}, number = {4009}, pages = {545--546}, year = {1971},
  note    = {PMID 17831286},
  annote  = {Positions Frawley within the industry/regulatory toxicology establishment (Hayes, McCollister of Dow, Scala of Exxon).}
}

@article{kennedy1973pesticides,
  author  = {Kennedy, G. L. and Frawley, John P. and Calandra, J. C.},
  title   = {Multigeneration reproductive effects of three pesticides in rats},
  journal = {Toxicology and Applied Pharmacology},
  volume  = {25}, number = {4}, pages = {589--596}, year = {1973},
  note    = {PMID 4795382. NOTE: one secondary source renders a co-author "Frawley MP"; PubMed gives JP},
  annote  = {[IBT] COI: Calandra (IBT). Last and most IBT-entangled study; the multigeneration-reproduction design later central to the IBT data-fraud scandal.}
}

@article{frawley1981decade,
  author  = {Frawley, John P.},
  title   = {The 1980s --- a decade of change},
  journal = {Regulatory Toxicology and Pharmacology},
  volume  = {1}, number = {1}, pages = {3--7}, year = {1981},
  doi     = {10.1016/0273-2300(81)90064-7}, note = {PMID 7186152},
  annote  = {★ The previously-unidentified inaugural-issue RTP article (he was an associate editor). Opening editorial of the issue was by Coulston \& Kolbye.}
}

@article{frawley1985editorial,
  author  = {Frawley, John P.},
  title   = {Editorial},
  journal = {Regulatory Toxicology and Pharmacology},
  volume  = {5}, number = {3}, pages = {239}, year = {1985},
  doi     = {10.1016/0273-2300(85)90039-X},
  annote  = {Single-page editorial during his RTP editorial tenure.}
}

@article{frawley1989sacredfood,
  author  = {Frawley, John P.},
  title   = {Our sacred food --- a perspective},
  journal = {Regulatory Toxicology and Pharmacology},
  volume  = {9}, number = {3}, pages = {209--211}, year = {1989},
  doi     = {10.1016/0273-2300(89)90057-3}, note = {PMID 2667039},
  annote  = {Late-career restatement (reuses his 1965 FCT title), coinciding with his ISRTP presidency (1989--90).}
}

% ===================== EXCLUDED / CONTESTED (same-name) =====================

@misc{EXCLUDED_combatcasualties1955,
  author = {Frawley, John P. [contested]},
  title  = {[Eight 1955 combat-casualty papers with Howard JM and Artz CP: dextran/gelatin, adrenal/amylase/electrolyte response to wounds]},
  year   = {1955},
  note   = {PMIDs 13258062, 13258061, 14397959, 14387372, 14373273, 14359060, 14350573, 13238179. STATUS: CONTESTED. The bibliography agent excluded these as a different (Army surgical-research) Frawley; the biography agent identified the 46th-MASH "1st Lt. J.P. Frawley" as the SAME man. The toxicologist's 1953--55 publication gap is consistent with military service. UNRESOLVED — see dossier Biography section.}
}

@misc{EXCLUDED_seafireflies2019,
  author = {Hensley, N. M. and others},
  title  = {Phenotypic evolution shaped by current enzyme function in the bioluminescent courtship signals of sea fireflies},
  journal= {Proceedings of the Royal Society B},
  volume = {286}, number = {1894}, pages = {20182621}, year = {2019},
  note   = {PMID 30963873. EXCLUDED: a different J.P. Frawley, UC Santa Barbara marine biologist (2019; incompatible with the toxicologist active 1950--1989).}
}