CPDB 'Rats and Mice' rows: 1534 | positive carcinogens (numeric TD50): 785 TD50 (mg/kg/day): median=19.3 geomean=16.5 min=2.35e-05 max=3.03e+04 --- Reproduction of Rulis's curve 5 (fraction of carcinogens with lifetime risk > 1e-6) --- at 5 ppb (a level 'suggested by some') : 72.7% exceed 1e-6 (excluded: 27.3%) at 1 ppb (Rulis: ~half on either side) : 52.7% exceed 1e-6 (excluded: 47.3%) at 0.5 ppb (the 1995 ToR rule) : 45.4% exceed 1e-6 (excluded: 54.6%) at 0.05 ppb = 50 ppt diet (Rulis's worked example): 20.3% exceed 1e-6 (excluded: 79.7%) level holding the least-potent 50% of carcinogens under 1e-6: 0.772 ppb (the most-potent 50% would exceed) level holding the least-potent 85% of carcinogens under 1e-6: 0.0293 ppb (the most-potent 15% would exceed) level holding the least-potent 90% of carcinogens under 1e-6: 0.0148 ppb (the most-potent 10% would exceed) level holding the least-potent 95% of carcinogens under 1e-6: 0.00386 ppb (the most-potent 5% would exceed) Rulis bookkeeping at 0.5 ppb: if 1 in 5 unknown migrants is a carcinogen, share of ToR decisions >1e-6 = 0.2 x 0.45 = 9.1% (=> ~91 of 100 decisions <= 1e-6) Frawley appendix: parsed ~41 distinct compound names (of 220) Frawley compounds that are CPDB carcinogens — exact-name matches: 2 = d c red no = toxaphene ...additional likely matches (substring): 16 ~ ponceau sx no -> s ~ polyoxyethylene stearate a -> s ~ citrus red no no -> s ~ sodmm alkylbenzenesulphonatc -> benzene ~ selenium -> selenium sulfide ~ sodium nitratc -> s ~ phosphorothioate -> s ~ terpene polychlorinates -> s ~ wood rosin dark -> s ~ sorbitan monostearate -> s ~ polyoxyethylene stearate -> s ~ ethanols triton x 405p -> s ~ sorbitan monopalmitate -> s ~ sulphonate -> s ~ ammonium sulphamate -> s ~ monostearate -> s