{
  "strand": "Bibliography",
  "summary": "Assembled a complete, deduplicated bibliography for toxicologist John P. Frawley (FDA Division of Pharmacology late 1940s-1957; Hercules Inc. chief toxicologist 1956-on; SOT charter member; ISRTP officer). PubMed E-utilities returned 32 PMIDs under \"Frawley JP\"; CrossRef, Google Scholar, and HeinOnline filled gaps the captcha/coverage left. I confirmed roughly 24 publications attributable to the toxicologist (1950-1989) with DOIs where available, spanning his FDA anticholinesterase/chronic-toxicity work (with Fitzhugh, Nelson, Hagan, Fuyat) and his Hercules industry-funded work (with Calandra, Kinoshita, DuBois, Kay, Kohn). Decisive disambiguation: the 8-paper 1955 \"combat casualties\" cluster (AMA Arch Surg / Surgery / Annals of Surgery, co-authors Howard JM and Artz CP) belongs to a DIFFERENT John P. Frawley, a 1st Lt. Medical Service Corps officer on the Army Surgical Research Team (46th MASH) in Korea, and is EXCLUDED; the 2019 sea-fireflies paper (UCSB) is also a different person. The Naval Stores Review 74(12):4 (1965) item is, on the evidence, a trade-press write-up of his Naval Stores Work Conference talk (the Review's editor/publisher Sidney Baudier Jr. attended the conference per the proceedings registrant list), not a separate authored paper — graded as such. Major COI thread: co-author J.C. Calandra was president/director of Industrial Bio-Test Laboratories (IBT, later convicted of data fraud), so the Delnav (1963), BHT (1965 x2), and multigeneration-pesticide (1973) papers carry an IBT/industry-funding flag; the toxaphene work (1966) and food-packaging paper (1967) involve Hercules' own products.",
  "findings": [
    {
      "claim": "Fitzhugh OG, Nelson AA, Frawley JP. The chronic toxicities of technical benzene hexachloride and its alpha, beta and gamma isomers. J Pharmacol Exp Ther. 1950;100(1):59-66.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed MEDLINE record PMID 14774791 (efetch). Earliest located Frawley paper, FDA Division of Pharmacology era; chronic-toxicity methodology that recurs across his career. No DOI (pre-DOI era).",
      "citation": "PMID 14774791; J Pharmacol Exp Ther 100(1):59-66",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/14774791/"
    },
    {
      "claim": "Fitzhugh OG, Nelson AA, Frawley JP. A comparison of the chronic toxicities of synthetic sweetening agents. J Am Pharm Assoc. 1951;40(11):583-586.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 14907466 (efetch) and Wiley DOI 10.1002/jps.3030401117. Landmark FDA chronic-toxicity study (saccharin, cyclamate, dulcin, P-4000); a named assignment item, now verified.",
      "citation": "PMID 14907466; DOI 10.1002/jps.3030401117",
      "confidence": "high",
      "url": "https://onlinelibrary.wiley.com/doi/abs/10.1002/jps.3030401117"
    },
    {
      "claim": "Davidow B, Frawley JP. Tissue distribution, accumulation and elimination of the isomers of benzene hexachloride. Proc Soc Exp Biol Med. 1951;76(4):780-783.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 14844348 (efetch). FDA-era pharmacokinetics of BHC isomers; complements the 1950 BHC chronic-toxicity paper.",
      "citation": "PMID 14844348; Proc Soc Exp Biol Med 76(4):780-3",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/14844348/"
    },
    {
      "claim": "Frawley JP, Hagan EC, Fitzhugh OG. A comparative pharmacological and toxicological study of organic phosphate-anticholinesterase compounds. J Pharmacol Exp Ther. 1952;105(2):156-165.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 14928218 (efetch). FDA organophosphate-anticholinesterase work; foundation for his later pesticide/nerve-agent papers.",
      "citation": "PMID 14928218; J Pharmacol Exp Ther 105(2):156-65",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/14928218/"
    },
    {
      "claim": "Frawley JP. Nerve poisons. Int Rec Med Gen Pract Clin. 1956;169(1):41-42.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 13285953 (efetch). MEDLINE record carries no affiliation; attributed to the toxicologist on subject-matter grounds (consistent with his 1952/1957 anticholinesterase work, inconsistent with the surgeon's purely surgical output). Author identity not independently proven — medium confidence.",
      "citation": "PMID 13285953; Int Rec Med 169(1):41-2",
      "confidence": "medium",
      "url": "https://pubmed.ncbi.nlm.nih.gov/13285953/"
    },
    {
      "claim": "Frawley JP, Fuyat HN, Hagan EC, Blake JR, Fitzhugh OG. Marked potentiation in mammalian toxicity from simultaneous administration of two anticholinesterase compounds. J Pharmacol Exp Ther. 1957;121(1):96-106.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 13481831 (efetch). Classic FDA potentiation/synergy study; co-authors Fuyat, Hagan, Blake, Fitzhugh are all FDA Pharmacology figures, anchoring subject identity.",
      "citation": "PMID 13481831; J Pharmacol Exp Ther 121(1):96-106",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/13481831/"
    },
    {
      "claim": "Williams MW, Cook JW, Blake JR, Jorgensen PS, Frawley JP, Rider JA, Moeller HC, Swader J, Weilerstein RW. The effect of parathion on human red blood cell and plasma cholinesterase. AMA Arch Ind Health. 1958;18(5):441-445.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 13582239 (efetch). Multi-author human cholinesterase study; Frawley one of nine authors. Consistent with his anticholinesterase line of work during the FDA-to-Hercules transition.",
      "citation": "PMID 13582239; AMA Arch Ind Health 18(5):441-5",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/13582239/"
    },
    {
      "claim": "Fitzhugh OG, Bourke AR, Nelson AA, Frawley JP. Chronic oral toxicities of four stearic acid emulsifiers. Toxicol Appl Pharmacol. 1959;1(3):315-331.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 13659539; CrossRef DOI 10.1016/0041-008x(59)90116-4. A named assignment item, verified. Appears in inaugural volume of Toxicol Appl Pharmacol; bridges his FDA co-author network (Fitzhugh/Nelson) into food-additive safety.",
      "citation": "PMID 13659539; DOI 10.1016/0041-008X(59)90116-4",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/13659539/"
    },
    {
      "claim": "Frawley JP, Weir R, Tusing T, DuBois KP, Calandra JC. Toxicologic investigations on Delnav. Toxicol Appl Pharmacol. 1963;5:605-624.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 14068278 (efetch); also indexed in Google Scholar. IBT/COI FLAG: co-author J.C. Calandra was president of Industrial Bio-Test Laboratories; Delnav (dioxathion) was a commercial organophosphate insecticide — industry-sponsored toxicology.",
      "citation": "PMID 14068278; Toxicol Appl Pharmacol 5:605-24",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/14068278/"
    },
    {
      "claim": "Frawley JP, Wiebe AK, Klug ED, Shelanski MV. Studies on the gastro-intestinal absorption of purified sodium carboxymethylcellulose. Food Cosmet Toxicol. 1964;2:539-543.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 14249970 (efetch). Hercules era (Klug/Wiebe are Hercules cellulose chemists); CMC is a Hercules product line — industry-affiliated food-additive safety study.",
      "citation": "PMID 14249970; Food Cosmet Toxicol 2:539-43",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/14249970/"
    },
    {
      "claim": "Frawley JP. Emergency Exposure Limits. Am Ind Hyg Assoc J. 1964;25:578-586 (AIHA Toxicology Committee).",
      "grade": "secondary",
      "evidence": "Attributed to JP Frawley in Google Scholar; an Am Ind Hyg Assoc J 1964 item 'Emergency Exposure Limits' (vol 25, pp.578-586) is documented as an AIHA Toxicology Committee publication. Frawley likely contributed as a committee member; SOLE authorship not confirmed. Industrial-hygiene exposure-limit framing aligns with his Hercules HES role.",
      "citation": "Am Ind Hyg Assoc J 25:578-586 (1964); Google Scholar attribution",
      "confidence": "medium",
      "url": "https://scholar.google.com/scholar?q=author:%22JP+Frawley%22+emergency+exposure+limits"
    },
    {
      "claim": "Frawley JP, Kohn FE, Kay JH, Calandra JC. Progress report on multigeneration reproduction studies in rats fed butylated hydroxytoluene (BHT). Food Cosmet Toxicol. 1965;3(3):377-386.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 5893645; CrossRef DOI 10.1016/S0015-6264(65)80126-2. IBT/COI FLAG: co-author Calandra = IBT president; BHT is a Koppers/industry antioxidant food additive — sponsored reproduction toxicology.",
      "citation": "PMID 5893645; DOI 10.1016/S0015-6264(65)80126-2",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/5893645/"
    },
    {
      "claim": "Frawley JP, Kay JH, Calandra JC. The residue of butylated hydroxytoluene (BHT) and metabolites in tissue and eggs of chickens fed diets containing radioactive BHT. Food Cosmet Toxicol. 1965;3(3):471-474.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 5865682; CrossRef DOI 10.1016/S0015-6264(65)80133-X. IBT/COI FLAG: Calandra (IBT). Companion radiolabel residue study to the 1965 BHT reproduction paper.",
      "citation": "PMID 5865682; DOI 10.1016/S0015-6264(65)80133-X",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/5865682/"
    },
    {
      "claim": "Frawley JP. Our sacred food — a perspective. Food Cosmet Toxicol. 1965;3:117-119.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 14342787 (efetch). Opinion/editorial-style piece; same title later reused for his 1989 RTP editorial (PMID 2667039), indicating a personal leitmotif on food-safety regulation.",
      "citation": "PMID 14342787; Food Cosmet Toxicol 3:117-9",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/14342787/"
    },
    {
      "claim": "Frawley JP. Suds and sensitivity. Food Cosmet Toxicol. 1965;3:122-124.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 14342788 (efetch). Short commentary; consistent in venue/style with his other 1965 Food Cosmet Toxicol opinion pieces.",
      "citation": "PMID 14342788; Food Cosmet Toxicol 3:122-4",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/14342788/"
    },
    {
      "claim": "Frawley JP. Investigations establishing the safety of rosin products for food and food-packaging applications. Proc Naval Stores Work Conf (Gainesville FL, Oct 19-20 1964). USDA ARS; 1965. pp.65-70.",
      "grade": "CONFIRMED-primary",
      "evidence": "Local primary PDF (/mnt/data/Frawley/papers/Frawley - 1965 - Investigations establishing the safety of rosin products...pdf). Hercules-funded rosin safety work; states studies were 'conducted under contract by the Industrial Bio-Test Laboratories' (IBT/COI flag) — ~5,000 rats + 138 dogs.",
      "citation": "Proc Naval Stores Work Conf 1965, pp.65-70; local PDF",
      "confidence": "high",
      "url": "https://upload.wikimedia.org/wikipedia/commons/6/6e/Proceedings_of_the_Naval_Stores_Work_Conference_-_held_at_Gainesville%2C_Fla.%2C_October_19_and_20%2C_1964_(IA_proceedingsofnav7250nava).pdf"
    },
    {
      "claim": "Naval Stores Review 74(12):4 (1965) is NOT a distinct Frawley-authored paper but (on best evidence) a trade-press notice/write-up of his Naval Stores Work Conference rosin talk.",
      "grade": "absence-of-evidence",
      "evidence": "No authored Frawley item located in Naval Stores Review. The 1965 conference proceedings registrant list names 'Baudier, Sidney, Jr., Naval Stores Review' (the periodical's editor/publisher) as an attendee, indicating trade-press coverage of the conference rather than a separate Frawley paper. Could not retrieve the Review issue itself to confirm contents.",
      "citation": "Proceedings registrant list (local 1965 PDF); Naval Stores Review 74(12):4",
      "confidence": "medium",
      "url": "https://books.google.com/books/about/Naval_Stores_Reviews.html?id=0_8IAQAAMAAJ"
    },
    {
      "claim": "Kinoshita FK, Frawley JP, DuBois KP. Quantitative measurement of induction of hepatic microsomal enzymes by various dietary levels of DDT and toxaphene in rats. Toxicol Appl Pharmacol. 1966;9:505-513.",
      "grade": "CONFIRMED-primary",
      "evidence": "CrossRef DOI 10.1016/0041-008X(66)90011-1 (not in PubMed — TAP indexing gap for this era). COI FLAG: toxaphene is a Hercules product; established dose-related enzyme induction and a DDT threshold ~0.05 mg/kg/day. Co-author DuBois (Univ. Chicago) recurs in his organophosphate work.",
      "citation": "DOI 10.1016/0041-008X(66)90011-1; Toxicol Appl Pharmacol 9:505-13",
      "confidence": "high",
      "url": "https://doi.org/10.1016/0041-008X(66)90011-1"
    },
    {
      "claim": "Frawley JP. Scientific evidence and common sense as a basis for food-packaging regulations. Food Cosmet Toxicol. 1967;5(3):293-308.",
      "grade": "CONFIRMED-primary",
      "evidence": "Local primary PDF + PubMed PMID 4861454 + Semantic Scholar CorpusID 33759952. The de minimis / threshold-of-regulation foundational paper (0.2% / 0.1 ppm 'toxicologically insignificant'); cites Hercules and IBT unpublished data. Origin of the TTC citation lineage.",
      "citation": "PMID 4861454; Food Cosmet Toxicol 5(3):293-308; local PDF",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/4861454/"
    },
    {
      "claim": "Frawley JP. A Reasoned Approach to Regulation Based on Toxicologic Considerations. Food Drug Cosm Law J. 1968;23 (Food, Drug, Cosmetic Law Journal).",
      "grade": "secondary",
      "evidence": "Attributed to JP Frawley in Google Scholar; corroborated by HeinOnline handle hein.journals/foodlj23 (vol 23, 1968), section 41. Exact page range not confirmed from available (paywalled) sources. A law-journal companion to his 1967 food-packaging thesis — extends his regulatory-philosophy argument to a legal audience.",
      "citation": "Food Drug Cosm Law J 23 (1968); HeinOnline foodlj23 sec.41",
      "confidence": "medium",
      "url": "https://heinonline.org/hol-cgi-bin/get_pdf.cgi?handle=hein.journals/foodlj23&section=41"
    },
    {
      "claim": "Frawley JP. O. Garth Fitzhugh [obituary/tribute]. Food Cosmet Toxicol. 1968;6(2):121-122.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 4876430 (efetch). Frawley's tribute to his former FDA mentor and frequent co-author O. Garth Fitzhugh — biographical/relationship evidence linking the two careers.",
      "citation": "PMID 4876430; Food Cosmet Toxicol 6(2):121-2",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/4876430/"
    },
    {
      "claim": "DuBois KP, Kinoshita FK, Frawley JP. Quantitative measurement of inhibition of aliesterases, acylamidase, and cholinesterase by EPN and Delnav. Toxicol Appl Pharmacol. 1968;12(2):273-284.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 4299018 (efetch). Continues the Delnav/organophosphate enzyme-inhibition program with DuBois and Kinoshita; Delnav is a commercial insecticide (industry context).",
      "citation": "PMID 4299018; Toxicol Appl Pharmacol 12(2):273-84",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/4299018/"
    },
    {
      "claim": "Su MQ, Kinoshita FK, Frawley JP, DuBois KP. Comparative inhibition of aliesterases and cholinesterase in rats fed eighteen organophosphorus insecticides. Toxicol Appl Pharmacol. 1971;20(2):241-249.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 5133254 (efetch). Broad organophosphate esterase-inhibition survey; same DuBois/Kinoshita collaboration network. Industry-relevant pesticide screening.",
      "citation": "PMID 5133254; Toxicol Appl Pharmacol 20(2):241-9",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/5133254/"
    },
    {
      "claim": "Borzelleca JF, Drill VA, DuBois KP, Frawley JP, Goldberg L, Hayes WJ Jr, McCollister DD, Roudabush RL, Scala RA. Letter to the editor. Science. 1971;174(4009):545-546.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 17831286 (efetch). Multi-author letter by prominent industry/regulatory toxicologists (Borzelleca, Hayes, McCollister of Dow, Scala of Exxon, etc.); positions Frawley within the establishment toxicology community of the early 1970s.",
      "citation": "PMID 17831286; Science 174(4009):545-6",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/17831286/"
    },
    {
      "claim": "Kennedy GL Jr, Frawley JP, Calandra JC. Multigeneration reproductive effects of three pesticides in rats. Toxicol Appl Pharmacol. 1973;25(4):589-596.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 4795382 (efetch). IBT/COI FLAG: Calandra (IBT president) co-author; Kennedy later at DuPont/Haskell. Multigeneration pesticide reproduction study — the type of long-term study at the center of IBT's later fraud findings.",
      "citation": "PMID 4795382; Toxicol Appl Pharmacol 25(4):589-96",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/4795382/"
    },
    {
      "claim": "Frawley JP. The 1980s — a decade of change. Regul Toxicol Pharmacol. 1981;1(1):3-7.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 7186152; CrossRef DOI 10.1016/0273-2300(81)90064-7. THIS IS the previously-unidentified June 1981 RTP vol.1 article. Inaugural-issue contribution to the journal where he was an associate editor / ISRTP officer.",
      "citation": "PMID 7186152; DOI 10.1016/0273-2300(81)90064-7",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/7186152/"
    },
    {
      "claim": "Frawley JP. Editorial. Regul Toxicol Pharmacol. 1985;5(3):239.",
      "grade": "CONFIRMED-primary",
      "evidence": "CrossRef DOI 10.1016/0273-2300(85)90039-x; title returned as 'Editorial' by CrossRef metadata. A single-page editorial during his RTP editorial tenure; not in the initial PubMed-Frawley-JP set, recovered via CrossRef.",
      "citation": "DOI 10.1016/0273-2300(85)90039-X; Regul Toxicol Pharmacol 5(3):239",
      "confidence": "high",
      "url": "https://doi.org/10.1016/0273-2300(85)90039-X"
    },
    {
      "claim": "Frawley JP. Our sacred food — a perspective. Regul Toxicol Pharmacol. 1989;9(3):209-211.",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 2667039; CrossRef DOI 10.1016/0273-2300(89)90057-3. Reuse of his 1965 title (PMID 14342787) — a late-career restatement of his food-safety regulatory philosophy. Coincides with his ISRTP presidency (1989-90).",
      "citation": "PMID 2667039; DOI 10.1016/0273-2300(89)90057-3",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/2667039/"
    },
    {
      "claim": "EXCLUDED — eight 1955 'combat casualties' papers (AMA Arch Surg / Surgery / Annals of Surgery / Surg Gynecol Obstet) authored by a different John P. Frawley, a US Army surgical-research officer in Korea.",
      "grade": "CONFIRMED-primary",
      "evidence": "PMIDs 13258062, 13258061, 14397959, 14387372, 14373273, 14359060, 14350573, 14350570, 13238179 (efetch) — all co-authored with Howard JM and Artz CP on dextran/gelatin, adrenal/amylase/electrolyte response to wounds. 46thmash.com documents '1st Lt John P. Frawley' on the Army Surgical Research Team (46th MASH, July 1953). Wrong subject per fingerprint; excluded from the bibliography.",
      "citation": "PMIDs 13258062/13258061/14397959/14387372/14373273/14359060/14350573/14350570/13238179; 46thmash.com",
      "confidence": "high",
      "url": "https://46thmash.com/46th-mash-2/"
    },
    {
      "claim": "EXCLUDED — Hensley NM, ..., Frawley JP, ... Phenotypic evolution ... sea fireflies. Proc Biol Sci. 2019;286(1894):20182621. Different person (UCSB marine biologist).",
      "grade": "CONFIRMED-primary",
      "evidence": "PubMed PMID 30963873 (efetch); affiliation Dept of Ecology, Evolution & Marine Biology, UC Santa Barbara. 2019 date and field are incompatible with the toxicologist (active 1950-1989). Excluded.",
      "citation": "PMID 30963873; Proc Biol Sci 286(1894):20182621",
      "confidence": "high",
      "url": "https://pubmed.ncbi.nlm.nih.gov/30963873/"
    }
  ],
  "documents": [
    {
      "title": "Investigations Establishing the Safety of Rosin Products for Food and Food-Packaging Applications (Proc. Naval Stores Work Conference)",
      "docType": "conference proceedings paper",
      "sourceArchive": "Local PDF (/mnt/data/Frawley/papers) + Internet Archive scan of USDA ARS proceedings",
      "url": "https://upload.wikimedia.org/wikipedia/commons/6/6e/Proceedings_of_the_Naval_Stores_Work_Conference_-_held_at_Gainesville%2C_Fla.%2C_October_19_and_20%2C_1964_(IA_proceedingsofnav7250nava).pdf",
      "date": "1965",
      "fullTextObtained": true
    },
    {
      "title": "Scientific evidence and common sense as a basis for food-packaging regulations",
      "docType": "journal article",
      "sourceArchive": "Local PDF (/mnt/data/Frawley/papers); PubMed; Semantic Scholar",
      "url": "https://pubmed.ncbi.nlm.nih.gov/4861454/",
      "date": "1967",
      "bates": "CorpusID 33759952",
      "fullTextObtained": true
    },
    {
      "title": "A comparison of the chronic toxicities of synthetic sweetening agents",
      "docType": "journal article",
      "sourceArchive": "Wiley Online Library; PubMed",
      "url": "https://onlinelibrary.wiley.com/doi/abs/10.1002/jps.3030401117",
      "date": "1951",
      "fullTextObtained": false
    },
    {
      "title": "Chronic oral toxicities of four stearic acid emulsifiers",
      "docType": "journal article",
      "sourceArchive": "CrossRef; PubMed",
      "url": "https://doi.org/10.1016/0041-008X(59)90116-4",
      "date": "1959",
      "fullTextObtained": false
    },
    {
      "title": "Quantitative measurement of induction of hepatic microsomal enzymes by various dietary levels of DDT and toxaphene in rats",
      "docType": "journal article",
      "sourceArchive": "CrossRef (not in PubMed)",
      "url": "https://doi.org/10.1016/0041-008X(66)90011-1",
      "date": "1966",
      "fullTextObtained": false
    },
    {
      "title": "A Reasoned Approach to Regulation Based on Toxicologic Considerations",
      "docType": "law journal article",
      "sourceArchive": "HeinOnline (hein.journals/foodlj23); Google Scholar",
      "url": "https://heinonline.org/hol-cgi-bin/get_pdf.cgi?handle=hein.journals/foodlj23&section=41",
      "date": "1968",
      "fullTextObtained": false
    },
    {
      "title": "The 1980s — a decade of change",
      "docType": "journal editorial",
      "sourceArchive": "PubMed; CrossRef",
      "url": "https://doi.org/10.1016/0273-2300(81)90064-7",
      "date": "1981",
      "fullTextObtained": false
    },
    {
      "title": "Editorial [Regul Toxicol Pharmacol 5(3):239]",
      "docType": "journal editorial",
      "sourceArchive": "CrossRef",
      "url": "https://doi.org/10.1016/0273-2300(85)90039-X",
      "date": "1985",
      "fullTextObtained": false
    },
    {
      "title": "Our sacred food — a perspective [Regul Toxicol Pharmacol]",
      "docType": "journal editorial",
      "sourceArchive": "PubMed; CrossRef",
      "url": "https://doi.org/10.1016/0273-2300(89)90057-3",
      "date": "1989",
      "fullTextObtained": false
    }
  ],
  "openQuestions": [
    {
      "question": "Exact page range of the 1968 Food, Drug, Cosmetic Law Journal article 'A Reasoned Approach to Regulation Based on Toxicologic Considerations' (vol.23).",
      "searched": "Google Scholar (attribution confirmed); HeinOnline handle hein.journals/foodlj23 sec.41 (paywalled, fetcher got blank/403); JSTOR journal page (403). All gave the volume but not pinpoint pages.",
      "nextStep": "Open the HeinOnline PDF (hein.journals/foodlj23 §41) or the JSTOR stable URL via institutional access to read the masthead page/footer for the page range; or check the journal's annual index in HathiTrust (catalog Record/000496194)."
    },
    {
      "question": "Is 'Nerve poisons' (Int Rec Med Gen Pract Clin 1956;169(1):41-2) by the toxicologist or the Army surgeon?",
      "searched": "PubMed efetch (PMID 13285953) — no affiliation field; WebSearch for author affiliation returned nothing. Subject-matter favors the toxicologist but is not proof.",
      "nextStep": "Locate the 1956 full text (HathiTrust / a medical-library run of International Record of Medicine) to read the author byline/affiliation; or check a contemporaneous Hercules or FDA staff publication list."
    },
    {
      "question": "Whether 'Emergency Exposure Limits' (Am Ind Hyg Assoc J 1964;25:578-586) is solely Frawley's or an AIHA Toxicology Committee product on which he served.",
      "searched": "Google Scholar attributes it to JP Frawley; WebSearch shows the 1964 AIHA J item is an AIHA Toxicology Committee document. Authorship conflict unresolved.",
      "nextStep": "Retrieve the article's first page from Taylor & Francis (tandfonline) or an AIHA archive to read the byline/committee list and confirm Frawley's exact role."
    },
    {
      "question": "Contents of Naval Stores Review 74(12):4 (1965) — trade write-up vs. authored text.",
      "searched": "WebSearch for the Review item (miss); local proceedings PDF shows the Review's editor (S. Baudier Jr.) attended the conference, supporting a trade-notice interpretation.",
      "nextStep": "Consult a bound run of Naval Stores Review (e.g., Google Books id 0_8IAQAAMAAJ, or a forestry/USDA NAL library holding) to read the actual 74(12):4 text and confirm authorship."
    },
    {
      "question": "Are there additional Hercules-internal reports, SOT/ISRTP proceedings, or de minimis/threshold edited-volume chapters by Frawley not indexed in PubMed/CrossRef?",
      "searched": "WebSearch for 'de minimis/threshold' chapters returned the Rulis/Flamm threshold lineage but no Frawley-authored chapter; ToxicDocs not yet mined in this strand.",
      "nextStep": "Run WebSearch 'site:toxicdocs.org Frawley Hercules' and 'site:documentcloud.org poison papers Frawley' to surface internal reports/affidavits, and check SOT historical proceedings (toxicology.org) and ISRTP records for invited papers."
    }
  ],
  "searchLog": [
    "Frawley JP — PubMed (web) — hit (page-1 list of ~10)",
    "Frawley JP &retmax=100 — NCBI E-utilities esearch — hit (32 PMIDs)",
    "32 PMIDs batch 1 — E-utilities efetch MEDLINE — hit (full records)",
    "32 PMIDs batch 2 — E-utilities efetch MEDLINE — hit (full records)",
    "Fitzhugh Nelson Frawley 1951 synthetic sweeteners — WebSearch — hit (Wiley DOI 10.1002/jps.3030401117)",
    "PMID 14774791 (BHC 1950) — PubMed — hit (vol 100, 59-66)",
    "Frawley Regulatory Toxicology and Pharmacology 1981 volume 1 — WebSearch — hit (RTP vol1 confirmed)",
    "Frawley Naval Stores Review 1965 rosin — WebSearch — miss (no authored item)",
    "CrossRef author=Frawley + RTP 1981-1990 — api.crossref.org — hit (1981, 1985, 1989 DOIs)",
    "CrossRef author=John Frawley 1980-1995 — api.crossref.org — hit (same 3 RTP items)",
    "PMID 13285953 'Nerve poisons' MEDLINE — efetch — hit but no affiliation",
    "John P. Frawley surgeon Korea combat casualties — WebSearch — hit (46th MASH Army Surgical Research Team; different person)",
    "Frawley de minimis/threshold chapter — WebSearch — miss (only Rulis/Flamm lineage)",
    "ScienceDirect RTP vol1 issue1 — WebFetch — 403",
    "Kinoshita Frawley DuBois 1966 microsomal DDT toxaphene — WebSearch — hit (TAP 9:505-513)",
    "Frawley Emergency Exposure Limits AIHA 1964 — WebSearch — hit (AIHA J 25:578-586, committee doc)",
    "Frawley 'A Reasoned Approach...' Food Drug Cosmetic Law J 1968 — WebSearch — hit (journal confirmed, no pages)",
    "Google Scholar author:'JP Frawley' rosin/toxicology/packaging — WebFetch — hit (surfaced 1968 FDCLJ, 1964 EEL, 1966 toxaphene)",
    "CrossRef DOI 10.1016/0273-2300(85)90039-x — api.crossref.org — hit (title 'Editorial', 5(3):239)",
    "Semantic Scholar CorpusID:33759952 author graph — api — miss (HTTP 429 rate limited, repeated)",
    "esearch Kinoshita Frawley DuBois microsomal — E-utilities — miss (0 results; TAP indexing gap)",
    "esearch toxaphene DDT microsomal 1966 — E-utilities — miss (0; not in PubMed)",
    "CrossRef hepatic microsomal DDT toxaphene Kinoshita Frawley — api.crossref.org — hit (DOI 10.1016/0041-008X(66)90011-1)",
    "Calandra Industrial Bio-Test president — WebSearch — hit (IBT founder/president; COI anchor for Delnav/BHT/1973 papers)",
    "NLM FDA Food Drug Cosmetic Law articles page — WebFetch — miss (no Frawley listed)",
    "heinonline foodlj23 Frawley reasoned approach — WebSearch — hit (handle hein.journals/foodlj23 §41, vol 23)",
    "HeinOnline foodlj23 §41 PDF — WebFetch — miss (blank/paywalled)",
    "CrossRef stearic acid emulsifiers Fitzhugh Frawley — api.crossref.org — hit (DOI 10.1016/0041-008X(59)90116-4)",
    "CrossRef BHT multigeneration Frawley — api.crossref.org — hit (DOIs 10.1016/S0015-6264(65)80126-2 and 80133-X)",
    "J.P. Frawley 1970s chapter Hercules dioxin 2,4,5-T — WebSearch — miss (Agent Orange litigation context only)"
  ]
}